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| 1 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 2 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 3 | Primary bílateral adrenal B-cell lymphoma associated with EBV and JCV infection显示文摘 | Barzon L Trevisan M Marino F | 2009 | Infect Agent Cancer2009，4，4： | 1 |
| 4 | Epidemiology of non-alco- holic fatty liver disease 显示文摘 | Bellentani S Scaglioni F Marino M | 2010 | J Dig Dis2010，28，1： | 1 |
| 5 | Catecholamine production and tyrosine hydroxylase expression in peripheral blood mononuclear cells from multiple sclerosis patients:effect of cell stimulation and possible relevance for activation-induced apoptosis显示文摘 | Cosentino M Zaffaroni M Marino F | 2002 | J Neuroimmunol2002，133，： | 1 |
| 6 | Phenylselenenyl sulfate induced cyclization of allylhydrazines, synthesis of pyrazole derivatives显示文摘 | Tiecco M Testaferri L Marino F | 1997 | Tetrahedron1997，53，12： | 1 |
| 7 | Expression of p53 and Ki-67 as prognostic factors for survival of men with colorectal cancer显示文摘 | Lumachi F Orlando R Marino F | 2012 | An- ticancer Res2012，32，9： | 1 |
| 8 | Efficacy of lamivudine to prevent hepatitis reactivation in hepatitis B virusinfected patients treated for non-Hodgkin lymphoma 显示文摘 | Persico M De Marino F Russo GD | 2002 | Blood2002，99，2： | 1 |
| 9 | Ni3Al intermetallic compound as second phase in Al2O3 ceramic composites显示文摘 | SGLAVO V M MARINO F ZHANG B R | 1997 | Mater Sci Eng1997，，： | 1 |
| 10 | Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function 显示文摘 | Marino G Ugalde A P Fern6ndez A F | 2010 | Proc Natl Acad Sci U S A2010，107，16： | 1 |
| 11 | Endogenous catecholamine synthesis,metabolism,storage and uptake in human neutrophils显示文摘 | Marino F Bombefli R | 1999 | Life Sciences1999，64，11： | 1 |
| 12 | Liquid-phase hot-pressing and WC-partide reinforcement of SiC-Si composites显示文摘 | Zhang B-R Marino F Ferraris M | 1994 | Journal of the European Ceramic Society1994，14，： | 1 |
| 13 | Cardiovascular remodeling,apoptosis,and drugs显示文摘 | BUEMI M CORICA F MARINO D | 2000 | Am J Hypertens2000，13，： | 1 |
| 14 | On the myths of optical burst switching显示文摘 | MARINO P P NERI F | 2011 | IEEE Transaction on Communication2011，59，9： | 1 |
| 15 | Response to glu cocorticoids and toxicity in childhood acute lymphoblastic leu kemia: role of polymorphisms of genes involved in glucocorticoid response显示文摘 | Marino S Verzegnassi F Tamaro P | 2009 | Pediatr Blood Cancer2009，53，6： | 1 |
| 16 | Kinetic mechanism and mierostruerure during the formation of Si3N4 matrix in Si3N4 MoSi2 composites显示文摘 | Beruto D T Ferrari A Giordani M Marino F | 2003 | Materials Science and Engineering2003，，355： | 1 |
| 17 | Aspect ratio impact on RF and DC performance of state-of-the-art short-channel GaN and InGaAs HEMTs显示文摘 | Guerra D Akis R Marino F A | 2010 | IEEE Electron Device Lett2010，31，11： | 1 |
| 18 | Endogenous catecholamine synthesis,metabolism,storage,and uptake in human peripheral blood mononuclear cells显示文摘 | Cosentino M Bombelli R | 1999 | Experimental Hematology1999，27，6： | 1 |
| 19 | Anti-P110 autoantibidies identify a subtype of 'seronegative' myastheniagravis with prominent oculobulbar involvement显示文摘 | Scuderi F Marino M Colonna L | 2002 | Lab Invest2002，82，： | 1 |
| 20 | Iron chelation therapy asso- ciated with improvement of hematopoiesis in transfusion-dependent patients 显示文摘 | Oliva EN Ronco F Marino A | 2010 | Transfusion2010，50，7： | 1 |
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