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| 1 | COL4A3 mutations cause focal segmenta glomerulosclerosis显示文摘 | Jingyuan Xie Xiaoxi Wu Hong Ren Weiming Wang Zhaohui Wang Xiaoxia Pan Xu Hao Jun Tong Jun Ma Zhibin Ye Guoyu Meng Yufei Zhu Krzysztof Kiryluk Xiangyin Kong Landian Hu Nan Chen | 2014 | Journal of Molecular Cell Biology2014，8，6： | 15 |
| 2 | BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis显示文摘Leukotriene B4(LTB4)synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease(IBD).BLT1,a highaffinity receptor for LTB4,exhibits no effect on the progression of dextran sodium sulfate(DSS)-induced colitis,which mostly relies on innate immunity.Here,we reported that BLT1 regulates trinitrobenzene sulfonic acid(TNBS)-induced colitis,which reflects CD4+T-cell-dependent adaptive immune mechanisms of IBD.We found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells(DCs)and modulating the differentiation of Th1 and Th17.BLT1−/−mice displayed an alleviated severity of TNBS-induced colitis with reduced body weight loss and infiltrating cells in the lamina propria.BLT1 deficiency in DCs led to reduced production of proinflammatory cytokines,including IL-6,TNF-α,and IL-12,and these results were further confirmed via treatment with a BLT1 antagonist.The impaired cytokine production by BLT1−/−DCs subsequently led to reduced Th1 and Th17 differentiation both in vitro and in vivo.We further performed a conditional DC reconstitution experiment to assess whether BLT1 in DCs plays a major role in regulating the pathogenesis of TNBS-induced colitis,and the results indicate that BLT1 deficiency in DCs also significantly reduces disease severity.The mechanistic study demonstrated that BLT1-regulated proinflammatory cytokine production through the Gαiβγsubunit-phospholipase Cβ(PLCβ)-PKC pathway.Notably,we found that treatment with the BLT1 antagonist also reduced the production of proinflammatory cytokines by human peripheral blood DCs.Our findings reveal the critical role of BLT1 in regulating adaptive immunity and TNBS-induced colitis,which further supports BLT1 as a potential drug target for adaptive immunity-mediated IBD. | Jinfeng Zhou Weiming Lai Wanjie Yang Juping Pan Hu Shen Yingying Cai Cuixia Yang Ningjia Ma Yue Zhang Ru Zhang Xin Xie Zhongjun Dong Yuan Gao Changsheng Du | 2018 | Cellular & Molecular Immunology2018，15，12： | 9 |
| 3 | WheatOmics:A platform combining multiple omics data to accelerate functional genomics studies in wheat显示文摘Dear Editor,Mold-breaking progress in whole-genome sequencing and rapid accumulation of multi-omics data have revolutionized the research strategies of functional genomics in wheat(Wang et al.,2018).However,how to access these vast multi-omics data and to extract key information on genes of in-terest,is still challenging for most wet-lab or field wheat re-searchers who have little bioinformatic experiences and cannot access the expensive computational resources.Here,we pre-sent WheatOmics(http://gffzz513af15b15bc4712hboc6uqc0bvc0660v.ffgz.tsg.suse.edu.cn/,previously designated as Triticeae Multi-omics Center,http://gffzz601e21d286504235hboc6uqc0bvc0660v.ffgz.tsg.suse.edu.cn/),a free,web-accessible,and user-friendly platform.WheatOmics not only empowers the effective access to the visualized multi-omics data of user-interested genes but also offers several distinctive and practical toolkits that can ease almost every aspect of wheat functional genomics studies(Figure 1A). | Shengwei Ma Meng Wang Jianhui Wu Weilong Guo Yongming Chen Guangwei Li Yanpeng Wang Weiming Shi Guangmin Xia Daolin FU Zhensheng Kang Fei Ni | 2021 | Molecular Plant2021，14，12： | 9 |
| 4 | Identification of the lower limit of high-quality source rocks and its relation to hydrocarbon accumulation——Taking the Beier Sag in the Hailaer Basin as an example显示文摘The theory of 'source rock control' has evolved from source-rock-control hydrocarbon accumulation, to effective source-rock-control hydrocarbon accumulation, and to high-quality source-rock-control hydrocarbon accumulation. However, there are problems, such as whether high-quality source rocks exist or not? What high-quality source rocks are, and how to identify them, are yet to be agreed upon. Aimed at this issue of concern to explorationists, and taking the Beier Sag in the Hailaer Basin as an example, this paper defines the high-quality source rocks and the lower limit for evaluation of high-quality source rocks, by using the inflection point on the relationship curve of hydrocarbon (oil) expulsion, which is calculated by the material balance principle, versus total organic carbon (TOC). The results show that when TOC is low, all source rocks have limited hydrocarbon expulsion and slow growth rate, thus they cannot be high-quality source rocks. However, when TOC rises to some threshold, hydrocarbon expulsion increases significantly with TOC. This inflection point should be the lower limit of high-quality source rocks: those with TOC greater than the inflection-point value are high-quality source rocks. In addition, the lower limit of high-quality source rocks is also related to the type and maturity of organic matters in the source rocks, as well as the mineral components of the source rocks affecting the residual hydrocarbons. Theoretically, the lower limit of high-quality source rocks depends on geological conditions rather than being a constant value. However, for the sake of simplicity and practicability, in this paper TOC=2.0% is regarded as the lower limit of high-quality source rocks. The examination of such standard in the work area indicates that the high-quality source rocks in members K 1 n 2 and K 1 n 1 of the Nantun formation contribute 76% and 82% to oil generation, and 96% and 91% to oil expulsion , respectively. The distribution of high-quality source rocks is also closely related to the distribution of hydrocarbon reservoirs in the region, demonstrating that high-quality source rocks control hydrocarbon accumulation. | Lu Shuangfang Chen Fangwen Li Jijun Wang Weiming Li Huiguang Cao Ruicheng Ma Yanling | 2012 | Petroleum Science2012，9，1： | 7 |
| 5 | Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells显示文摘Resveratrol,a natural compound extracted from the skins of grapes,berries,or other fruits,has been shown to have anti-tumor effects against multiple myeloma(MM)via promoting apoptosis and inhibiting cell viability.In addition to apoptosis,autophagy also plays a significant role in anti-tumor effects.However,whether autophagy is involved in anti-MM activity of resveratrol remains unclear.In this study,human MM cell lines U266,RPMI-8226,and NCI-H929 were treated with resveratrol.Cell Counting Kit-8 assay and colony formation assay were used to measure cell viability.Western blot analysis was used to detect apoptosis-and autophagy-associated proteins.3-Methyladenine(3-MA)was applied to inhibit autophagy.Results showed that resveratrol inhibited cell viability and colony formation via promoting apoptosis and autophagy in MM cell lines U266,RPMI-8226,and NCI-H929.Resveratrol promoted apoptosis-related proteins,Caspase-3 activating poly-ADP-ribose polymerase and Caspase-3 cleavage,and decreased the protein level of Survivin in a dose-dependent manner.Additionally,resveratrol upregulated the levels of LC3 and Beclin1 in a dose-dependent way,indicating that autophagy might be implicated in anti-MM effect of resveratrol.Furthermore,3-MA relieved the cytotoxicity of resveratrol by blocking the autophagic flux.Resveratrol increased the phosphorylation of adenosine monophosphate(AMP)-activated protein kinase and decreased the phosphorylation of mammalian target of rapamycin(mTOR)and its downstream substrates p70S6K and 4EBP1 in a dose-dependent manner,leading to autophagy.Therefore,our results suggest that resveratrol exerts anti-MM effects through apoptosis and autophagy,which can be used as a new therapeutic strategy for MM in clinic. | Ruye Ma Dandan Yu Yu Peng Hongfei Yi Yingcong Wang Taofang Cheng Bingqing Shi Guang Yang Weiming Lai Xiaosong Wu Ye Lu Jumei Shi | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 7 |
| 6 | WO_3/ZrO_2 Strong Acid as a Catalyst for the Decomposition of Chlorofluorocarbon (CFC-12)显示文摘 | HUA Weiming ZHANG Feng MA Zhen TANG Yi GAO Zi | 2000 | Chemical Research in Chinese Universities2000，16，2： | 7 |
| 7 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 8 | White blood cell count and the incidence of hyperuricemia:insights from a community-based study显示文摘Hyperuricemia(HUA)is a risk factor for chronic kidney disease(CKD).The relationship between HUA and white blood cell(WBC)count remains unknown.A sampling survey for CKD was conducted in Sanlin community in 2012 and 2014.CKD was defined as proteinuria in at least the microalbuminuric stage or an estimated GFR of 60 mL/(min·1.73 m2).HUA was defined as serum uric acid>420µmol/L in men and>360µmol/L in women.This study included 1024 participants.The prevalence of HUA was 17.77%.Patients with HUA were more likely to have higher levels of WBC count,which was positively associated with HUA prevalence.This association was also observed in participants without CKD,diabetes mellitus,hyperlipidemia,or obesity.Multivariate logistic regression analysis showed that WBC count was independently associated with the risk for HUA in male and female participants.Compared with participants without HUA,inflammatory factors such as high-sensitivity C-reactive protein,tumor necrosis factor-α,and interleukin 6 increased in participants with HUA.Hence,WBC count is positively associated with HUA,and this association is independent of conventional risk factors for CKD. | Jian Liu Pingyan Shen Xiaobo Ma Xialian Yu Liyan Ni Xu Hao Weiming Wang Nan Chen | 2019 | Frontiers of Medicine2019，13，6： | 3 |
| 9 | Preparation of protein-loaded microspheres with size ≤ 10 μm by electrostatic droplet generation technology显示文摘The development of non-injection route for protein drugs, especially oral administration, has been the main focus of controlled release of drugs. To overcome obstacles unsolved such as enzyme degradation and penetration barrier of intestinal epi- thelium, technologies using microspheres as carrier of protein drugs have been proven potential to realize oral administration. It has been demonstrated that microspheres can not only protect proteins, but also facilitate the penetration and absorption through Peyer’s patches when the size is smaller than 10 μm. Therefore, the objective of this paper is to prepare protein-loaded microspheres with size ≤ 10 μm. Electrostatic droplet generation technology was used with insulin and hemoglobin as drug models and so- dium alginate as microsphere material. By decreas- ing the surface tension of feed solution by adding surfactant, and improving electric field distribution by changing the shape of container and electrode for gelation solution, protein-loaded microspheres with mean size less than 10 μm were successfully pro- duced through needle with diameter of 400 μm. The microspheres showed good sphericity and narrow size distribution. The mean standard variance of size distribution was 1.61. The encapsulation efficiency of proteins was over 70%. Moreover, the significance analysis of factors influencing the size of protein loaded microspheres was carried out through or- thogonal experiments, which showed that output voltage (U), needle diameter (D) and the distance between needle tips to the surface of gelation solu- tion (δ ) influenced significantly the size of micro-spheres. Finally, the statistic analysis showed that when confidence level was α=0.05, and α=0.1, con- fidence interval of microsphere size can be (6.2545, 10.1735) and (6.6022, 9.8258) correspondingly, suggesting that there is good repeatability and reli- ability for improving electrostatic droplet generation technology to prepare protein-loaded microspheres with size ≤10 μm. | XUE Weiming LIU Xiudong YU Weiting MA Xiaojun | 2006 | Chinese Science Bulletin2006，51，3： | 3 |
| 10 | Construction of mesoporous ceria-supported gold catalysts with rich oxygen vacancies for efficient CO oxidation显示文摘Bearing unique redox nature and high oxygen storage capacity,ceria(CeO_(2))has always been a promising CO oxidation catalyst support for gold(Au)catalysts and the like.Herein,a series of Au-CeO_(2)-P(P stands for pH value)samples was prepared by a co-precipitation method with the assistance of an alkaline environment and amino groups functionalized ordered mesoporous polymer(OMP-NH_(2)).Afterward,all samples described above were characterized that the Au-CeO_(2)-P catalysts are made of Au-Ce-O solid solution and Au nanoparticles(NPs)supported on CeO_(2).It turns out that OMP-NH_(2) is not just a simple sacrificial template for mesoporous structure,but also plays an important role as an amino source,explaining the presence of rich oxygen vacancies.Due to the concentration of oxygen vacancies in Au-Ce-O solid solution is the key factor for the oxygen mobility of CO oxidation,the catalytic results also demonstrate that the catalytic activity of Au-CeO_(2)-P catalysts is related to the concentration of their oxygen vacancies.Moreover,Au-CeO_(2)-9.6 with a highest concentration of oxygen vacancies(as high as 13.98%)in Au-CeO_(2)-P catalysts exhibits the best catalytic activity(complete conversion at 10℃). | Xin Shen Wang Li Shunmin Ding Xiaohua Ma Shaohua Wu Weiming Xiao Rong Zeng Sanguo Hong Chao Chen | 2022 | Journal of Rare Earths2022，40，3： | 2 |
| 11 | Precise methods for conducted EMI modeling,analysis,and prediction显示文摘Focusing on the state-of-the-art conducted EMI prediction, this paper presents a noise source lumped circuit modeling and identification method, an EMI modeling method based on multiple slope approximation of switching transitions, and dou-ble Fourier integral method modeling PWM conversion units to achieve an accurate modeling of EMI noise source. Meanwhile, a new sensitivity analysis method, a general coupling model for steel ground loops, and a partial element equivalent circuit method are proposed to identify and characterize conducted EMI coupling paths. The EMI noise and propagation modeling provide an accurate prediction of conducted EMI in the entire frequency range (0―10 MHz) with good practicability and generality. Finally a new measurement approach is presented to identify the surface current of large dimensional metal shell. The proposed analytical modeling methodology is verified by experimental results. | MA WeiMing ZHAO ZhiHua MENG Jin PAN QiJun ZHANG Lei | 2008 | Science China(Technological Sciences)2008，51，6： | 2 |
| 12 | A new technique for modeling and analysis of mixed-mode conducted EMI noise显示文摘 | Meng Jin Ma Weiming | 2004 | IEEE Transactions on Power Electronics2004，19，6： | 1 |
| 13 | AC impedance of an isolated flat conductor显示文摘 | Zhao Zhihua Ma Weiming | 2002 | IEEE Transactions on Electromagnetic Compatibility2002，44，3： | 1 |
| 14 | Stability of a synchronous generator with diode-bridge rectifier and back-EMF load 显示文摘 | Hu An Liu Dezhi | 2000 | IEEE Transactions on Energy Conversion2000，15，4： | 1 |
| 15 | A new critical formula and mathematical model of double-tap interphase reactor in a six- phase tap-changer diode rectifier 显示文摘 | PAN Qijun MA Weiming LIU Dezhi | 2007 | IEEE Transactions on In- dustrial Electronics2007，54，1： | 1 |
| 16 | A novel stand-alone deal stator-winding induction generator with static excitation regulation 显示文摘 | Wang Dong Ma Weiming Xiao Fei | 2005 | IEEE Transactions on Energy Conversion2005，20，4： | 1 |
| 17 | Analysis of the DC-link capacitor current of power cells in cascaded H- bridge invertem for High-voltage drives 显示文摘 | SUN Le WU Zhenxing MA Weiming | 2014 | IEEE Transac- tions on Power Electronics2014，29，12： | 1 |
| 18 | Coupling model and impedancecalculation of the steel ground loops with proximity effect显示文摘 | Zhao Zhihua Ma Weiming | 2006 | IEEE Trans on EMC2006，48，3： | 1 |
| 19 | Power converters EMI analysis in-cluding IGBT nonlinear switching transient model显示文摘 | Meng Jin Ma Weiming | 2006 | IEEETrans on Industrial Electronics2006，53，5： | 1 |
| 20 | Investigation of phase unbalance char- acteristics in the linear induetion coil launcher显示文摘 | LU Junyong MA Weiming | 2011 | IEEE Trans- actions on Plasma Science2011，39，1： | 1 |
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