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| 1 | Co-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis显示文摘AIM: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.METHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and MUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including χ2 tests, uni- and multi-variate survival analyses were performed.RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern, whereas MUC2 showed an almost exclusive supranuclear reactivity. Both antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (MUC2) of the carcinomas. The presence of both molecules did not correlate with WHO,significantly stronger vlUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with MUC2 positivity. A prognostic impact of CDX2 or MUC2 was not observed. CONCLUSION: CDX2 and MUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype. | Kristina Roessler Stefan P.M(o|¨)nig Paul M.Schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o|¨)lscher Hans P.Dienes Stephan E.Baldus | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium显示文摘Orthopedic implants rely on facilitating a robust interaction between the implant material surface and the surrounding bone tissue.Ideally,the interface will encourage osseointegration with the host bone,resulting in strong fixation and implant stability.However,implant failure can occur due to the lack of integration with bone tissue or bacterial infection.The chosen material and surface topography of orthopedic implants are key factors that influence the early events following implantation and may ultimately define the success of a device.Early attachment,rapid migration and improved differentiation of stem cells to osteoblasts are necessary to populate the surface of biomedical implants,potentially preventing biofilm formation and implant-associated infection.This article explores these early stem cell specific events by seeding human mesenchymal stem cells(MSCs)on four clinically relevant materials:polyether ether ketone(PEEK),Ti6Al4V(smooth Ti),macro-micro rough Ti6Al4V(Endoskeleton®),and macro-micro-nano rough Ti6Al4V(nanoLOCK®).The results demonstrate the incorporation of a hierarchical macro-micro-nano roughness on titanium produces a stellate morphology typical of mature osteoblasts/osteocytes,rapid and random migration,and improved osteogenic differentiation in seeded MSCs.Literature suggests rapid coverage of a surface by stem cells coupled with stimulation of bone differentiation minimizes the opportunity for biofilm formation while increasing the rate of device integration with the surrounding bone tissue. | Emily G.Long Merve Buluk Michelle B.Gallagher Jennifer M.Schneider Justin L.Brown | 2019 | Bioactive Materials2019，4，1： | 8 |
| 3 | 压力蒸汽灭菌的参数释放显示文摘医院消毒供应室是医院感染预防与控制的关键环节,其工作质量与医院感染的发病率密切相关,直接影响到医疗服务质量。随着消毒供应从一简单工种逐渐发展为一门专业,以及提供社会化服务的趋势越来越明显,传统的消毒供应管理方式已明显不能满足现代化医院管理的需要。为从各个方面贯彻落实《医院感染管理办法》,卫生部医政司决定制定《医院消毒供应中心管理规范》(以下简称《规范》),以加强医疗机构消毒供应工作的管理,预防和控制疾病的医源性传播,保障医疗安全。卫生部医院管理研究所护理中心受卫生部委托,牵头组织有关专家起草《规范》。为使消毒供应管理相关的各方面领导者了解国际消毒供应管理的进展,并征求对《规范(征求意见稿)》的修改意见,卫生部医院管理研究所护理中心于2006年7月在北京召开了“《医院消毒供应管理规范》征求意见暨全国消毒供应管理工作研讨会”。来自英国、美国、瑞士、德国、泰国的专家从消毒供应的国家标准、国际标准、医院消毒供应的管理、消毒技术、监测技术等方面的介绍,使与会代表了解了国际消毒供应管理的进展;来自国内部分省市和医院的经验介绍,以及起草组关于三省市的调研报告、《规范》框架的介绍,使大家了解了我国消毒供应管理的进展、现状、存在的问题和《规范》的主要思路。代表们对《规范(征求意见稿)》认真讨论,提出了很好的意见和建议。本期所刊出的一组文章均来自于这次大会,由国际消毒学专家向大家介绍在压力蒸汽灭菌方面的前沿信息,清洗消毒机的国际标准;泰国专家介绍泰国在消毒供应管理方面的经验;我国四川大学华西医院、北京大学第一医院、北京协和医院分别介绍在区域化消毒供应中心创建、质量管理的追溯系统及环节质量管理方面的经验,以期为广大护理管理人员提供指导和借鉴。 | Philip M.Schneider 张正焘 黄靖雄 | 2007 | 中国护理管理2007，7，1： | 6 |
| 4 | Pharmacokinetics of marbofloxacin in dogs after oral and parenteral administration显示文摘 | M.SCHNEIDER V.THOMAS B.BOISRAME J.DELEFORGE | 2008 | Journal of Veterinary Pharmacology and Therapeutics2008，，1： | 2 |
| 5 | Severe fetal cytomegalovirus infection associated with cerebellar hemorrhage显示文摘 | J. U.Ortiz E.Ostermayer T.Fischer B.Kuschel M.Rudelius K. T. M.Schneider | 2004 | Ultrasound Obstet Gynecol2004，，4： | 1 |
| 6 | 2005年CNC加工中心显示文摘2005年5月开幕的汉诺威木工展是世界著名的木材工业和森林科学占市场主导地位的博览会。2000多家厂商利用这样的机会在博览会上展示他们的产品。其中很重要的一部分木材加工机床是CNC加工中心。回顾这个展览会可以对将来的用户一个市场的概览,大家可以从技术数据上对市场可以提供什么样的设备有一个总体印象。 | S.Martynenko M.Schneider 林桐(译) 卢镇华(校) | 2006 | 木工机床2006，，1： | 1 |
| 7 | Staging of esophageal carcinoma: Length of tumor and number of involved regional lymph nodes. Are these independent prognostic factors?显示文摘 | ElfriedeBollschweiler Stephan E.Baldus WolfgangSchr?der Paul M.Schneider Arnulf H.H?lscher | 2006 | J Surg Oncol2006，，5： | 1 |
| 8 | High-throughput multiplexed fluorescence-activated droplet sorting显示文摘Fluorescence-activated droplet sorting(FADS)is one of the most important features provided by droplet-based microfluidics.However,to date,it does not allow to compete with the high-throughput multiplexed sorting capabilities offered by flow cytometery.Here,we demonstrate the use of a dielectrophoretic-based FADS,allowing to sort up to five different droplet populations simultaneously.Our system provides means to select droplets of different phenotypes in a single experimental run to separate initially heterogeneous populations.Our experimental results are rationalized with the help of a numerical model of the actuation of droplets in electric fields providing guidelines for the prediction of sorting designs for upscaled or downscaled microsystems. | Ouriel Caen Simon Schütz M.S.Suryateja Jammalamadaka Jérémy Vrignon Philippe Nizard Tobias M.Schneider Jean-Christophe Baret Valérie Taly | 2018 | Microsystems & Nanoengineering2018，4，1： | 1 |
| 9 | 应用人工合成的HIV nef蛋白肽制备抗nef单抗显示文摘本文用人工合成的HIV nef蛋白肽免疫Belb/c小鼠,应用活体融合法制备了11个抗nef单克隆抗体。ELISA测定表明,11个单抗均能与nef肽和nef蛋白反应,其中3、7、9、10和11号抗体与nef肽和nef蛋白的反应性相近似;4、5、6和7号抗体与nef蛋白的反应性明显比肽强。所有单抗均不与HIV的其它蛋白反应。应用免疫荧光检测抗nef单抗与HIV感染细胞的反应性表明,大部分抗体均与细胞浆着色,而无一般膜荧光的典型征象。 | 史良如 J.Enzman M.Schneider H.Brüster P.Wernet | 1990 | 免疫学杂志1990，6，3： | 1 |
| 10 | 脂肪酸及脂肪酸酯氢化制脂肪醇用铜-铬催化剂显示文摘序言早在55年,Adkins和Connor就发现亚铬酸铜具有氢化催化活性。这是一类多用途非均相催化剂,能用于不同的反应。例如,加氢和脱氢,甲醇蒸汽重整或甲醇分解,水煤气转换反应或氧化反应。通常的制备方法是用铬酸铵的氨溶液自硝酸铜溶液中沉淀,然后将中间产物碱式铬酸铵铜沉淀加热分解: 在适宜的温度范围内,碱式铬酸铵铜分解成氧化铜和亚铬铜(CuCr2O4)(因本文所述铜铬催化剂为氧化铜和亚铬酸铜(CuCr2O4)的络合物,故以下简称铜-铬或铜铬催化剂)。 | M.Schneider 李伟年 | 1989 | 日用化学品科学1989，17，5： | 0 |
| 11 | 在线控制泥浆质量显示文摘本文论述了使用水力掘进盾构在挖掘隧道过程中检测泥浆质量的方法。在现场控制泥浆质量仍然耗时费力。采用在线粘度计监控质量是一种更流行的方法。在挖掘隧道过程中在分离设备中检验了这种方法的适用性。 | M.Schneider J.Duck T.Neeβe J.Pier H.Tiefel F.Donhauser | 2003 | 隧道(中文版)2003，，11： | 0 |
| 12 | Monitoring of Tumor Response to Neoadjuvant Radio-Chemotherapy of Esophageal Carcinoma by F-18-FDG-PET显示文摘Introduction: For clinical assessment of neoadjuvant radiochemotherapy of esophageal cancer reliable in-vivo methods are necessary. Therefore, the capabilities of F-18-Fluorodesoxyglucose-PET in comparison to histomorphological grading of tumor regression were studied. Methods: In 33 patients with locally advanced esophageal carcinoma (uT3, uN0-1, cM0) F-18-FDG-PET was performed before and 2 weeks after radiochemotherapy. All tumors were resected by transthoracic en-bloc esophagectomy 3–4 weeks after induction therapy. A subgroup of 11 patients underwent weekly PET scan during neoadjuvant therapy. PET was performed in a dedicated scanner 1.3 h after administration of 370 MBq F-18-FDG. Data analysis based on maximum SUV data derived from individual regions of interest in pre- and posttherapeutic images. PET data were compared to histomorphological grading parameters for tumor regression whithin the resected tissues. Results: The comparison of histopathological tumor regression after neoadjuvant therapy and PET SUV di?erences showed a signi?cant χ2 P -value of 0.006. There was a signi?cant decrease 五笔字型计算机汉字输入技术 of the SUV data from 9.1±3.5 to 4.3±1.9 (P <0.0001). In therapy responders SUV was diminished by 59 % and in non-responders by 34 %. Longitudinal SUV measurement during neoadjuvant therapy showed a strong SUV decrease already after one and two weeks (P =0.021 and 0.003). Conclusion: The recent data of the FDG-PET follow-up after neoadjuvant therapy show that PET is able to predict therapy response. Longitudinal PET data advocate that it may be possible to recognize response also very early during radiochemotherapy. | Peter Theissen Paul M.Schneider Stephan E.Baldus Alexandra Jost Markus Dietlein Rolf P.Muller Arnulf H.Holscher Harald Schicha | 2004 | The Chinese-German Journal of Clinical Oncology2004，3，4： | 0 |
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