|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 3 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 4 | The effect of liquid channeling on distillation plate efficiency显示文摘 | Porter K E Lockett M J Lim C T | 1972 | Trans IchemE1972，50，： | 2 |
| 5 | Muskmelon fruit soluble acid invertase and sucrose phosphate synthase activity and polypeptide profiles during growth and maturation显示文摘 | LESTER G E ARIAS L S L LIM M G | 2001 | J Amer Soc Hort Sci2001，126，： | 1 |
| 6 | Global health: challenges and opportunities for Singapore 显示文摘 | JAHNCKE E LIM M K SEOW A | 2010 | Singapore Med2010，51，7： | 1 |
| 7 | Engineering and kinetic characterisation of two glucosy|transferases from Arabidopsis thaliana 显示文摘 | Weis M Lim E K Bruce N C | 2008 | Biochimie2008，90，： | 1 |
| 8 | Effects of temperature and salinity on Vibrio vulnificus population dynamics as assessed by quantitative PCR显示文摘 | RANDA A M POLZ F M LIM E | 2004 | Appl Environ Microbiol2004，70，： | 1 |
| 9 | Stability characteristics of Pt1Ni1/C as cathode catalysts in membrane electrode assembly of polymer electrolyte membrane fuel cell显示文摘 | CHO Y H JEON T Y YOO S J LEE K S AHN M KIM O H CHO Y H LIM J W JUNG N YOON W S CHOE H SUNG Y E | 2012 | Electrochim Acta2012，59，： | 1 |
| 10 | Pd-Pt bimetallic nanodendrites with high activity for oxygen reduction显示文摘 | Lim B Jiang M Cho E C | 2009 | Science2009，324，： | 1 |
| 11 | An Experimental Study of Round Jets in Cross-Flow 显示文摘 | Kelso R M Lim T T Perry A E | 1996 | Journal of Fluid Me- chanics1996，306，： | 1 |
| 12 | Abiotic and biotic stress tolerance in Arabidopsis overexpressing the multiprotein bridging factor la(MBFIa) transcriptional coactivator gene显示文摘 | KIM M J LIM G H KIM E S | 2007 | Biochemical and Biophysical Research Communications2007，354，2： | 1 |
| 13 | Prognostoic significance of Bcl-2 and P53 expression in advanced laryngeal squamous cell carcinoma显示文摘 | Eriedman M Lim JW Manders E | 2001 | Head Neck2001，23，4： | 1 |
| 14 | In virto maturation and in virto fertilization of bovine oocytes cultured in a chemically defined,protein-free medium:effects of carbohydrates and amino acids显示文摘 | LIM J M LEE B C LEE E S | 1999 | Reprod Fertile Dev1999，11，2： | 1 |
| 15 | PDE4 inhibitor, roflumilast protects cardiomyocytes againstNO-induced apoptosis via activation of PKA and Epac dualpathways显示文摘 | Kwak H J Park K M Choi H E Chung K S Lim H J Park HY | 2008 | Cell Signal2008，20，： | 1 |
| 16 | Gas and particlecirculation in an internally circulating fluidized bedmembrane reactor cold model 显示文摘 | Xie D Lim C J Grace J R Adris A E M | 2009 | Chemical EngineeringScience2009，64，： | 1 |
| 17 | Wear of spray-deposited hypereutectic aluminum-silicon alloy显示文摘 | LIM S C GUPTA M LENG Y F LACERNIA E J | 1997 | Material Processing Technology1997，63，： | 1 |
| 18 | Effects of bacterial blight on soybean yield显示文摘 | Park E W Lim S M | 1986 | Plant Disease1986，70，3： | 1 |
| 19 | The Role of CD4+ CD25bright Regulatory T Cells in the Maintenance of Pregnancy, Premature Rupture of Membranes,and Labor显示文摘 | Seol H J Oh M J Lim J E | 2008 | Yonsei Med J2008，49，3： | 1 |
| 20 | An experimental study of round jets in cross-flow 显示文摘 | KELSO R M LIM T T PERRY A E | 1996 | Journal of Fluid Meehanies1996，306，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员