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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Cold-inducible zinc finger-containing glycinerich RNA-binding protein contributes to the enhancement of freezing tolerance in Arabidopsis thaliana显示文摘 | KIM Y O KIM J S KANG H | 2005 | Plant J2005，42，6： | 1 |
| 3 | Potent inhibitory effect offlavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity显示文摘 | Heo H J Kim D O Choi S J | 2004 | J Agric Food Chem2004，52，13： | 1 |
| 4 | Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes 显示文摘 | Kim H Haluzik M Gavrilova O | 2004 | Diabetologia2004，47，12： | 1 |
| 5 | Red blood cell engineering in stroma and serum/plasma-free conditions and long term storage显示文摘 | Kim H O Baek E J | | 0，，1： | 1 |
| 6 | Monitoring of selected veterinary antibiotics in environmental compartments near a composting facility in Gangwon Province,Korea显示文摘 | Ok Y S Kim S C Kim K R Lee S S Moon D H Lim K J Sung J K Hur S O Yang J E | | 0，，： | 1 |
| 7 | Surface modification of graphite by coke coating for reduction of initial irreversible capacity in lithium secondary batteries显示文摘 | YOON S H KIM H SEUNG M O | 2001 | Journal of Power Sources2001，94，： | 1 |
| 8 | Phase-field model for solidification of temaryalloyscoupled with thermodynamic database显示文摘 | Kobayassi H Mmchiko O Kim SG | 2003 | ScriptaMater2003，48，： | 1 |
| 9 | Bone marrow edema and associated pain in early stage osteonecrosis of the femoral head: prospective study with serial MR images显示文摘 | KOOK H AHN I O KIM R | 1999 | Radiology1999，213，： | 1 |
| 10 | Surface analysis of clinically failed dental implant fixture显示文摘 | CHOE H C HONG K S KO Y M KIM B O | 2006 | J Kor Inst Met & Mater2006，44，： | 1 |
| 11 | Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia oflnonotus obliquus显示文摘 | KIM Y O PARK H W KIM J H | 2006 | Life Science2006，79，1： | 1 |
| 12 | Model development for nutrient loading from paddy rice fields 显示文摘 | CHUNG S O KIM H S KIM J S | 2003 | Agricultural Water Management2003，2，： | 1 |
| 13 | Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice显示文摘 | N Tsuboyama-Kasaoka M Takahashi K Tanemura H Kim T Tange H Okuyama M Kasai S Ikemoto O Ezaki | 2000 | Diabetes2000，，49： | 1 |
| 14 | Phase Ⅱ trial of neoadjuvant paclitaxel and cisplatin in uterine cervical cancer 显示文摘 | Park D C Kim J H Lew Y O | 2004 | Gynecol Oncol2004，92，1： | 1 |
| 15 | Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2diabetes显示文摘 | Kim H Haluzik M Gavrilova O | 2004 | Diabetologia2004，47，12： | 1 |
| 16 | Consumption of whole grain and legume powder reduces insulin demand,lipid peroxidation,and plasma homocysteine concentrations in patients with coronary artery disease:randomized controlled clinical trial显示文摘 | Jang Y Lee J H Kim O Y | 2001 | Art Thromb Vasc Biol2001，21，： | 1 |
| 17 | Heuristic algorithms for scheduling independent tasks on nonidentical processors显示文摘 | Ibarra O H Kim C E | 1977 | Journal of the ACM1977，24，2： | 1 |
| 18 | Heuristic algorithms for scheduling independent tasks on nonidentical processors显示文摘 | Ibarra O H Kim C E | 1977 | Journal of the ACM1977，24，2： | 1 |
| 19 | Anaplastic lymphoma kinase translocation:a predictive biomarker of permetrexed in patients with non-small cell lung cancer 显示文摘 | Lee J O Kim T M Lee S H | 2011 | J Thorac Oncol2011，6，： | 1 |
| 20 | Stability characteristics of Pt1Ni1/C as cathode catalysts in membrane electrode assembly of polymer electrolyte membrane fuel cell显示文摘 | CHO Y H JEON T Y YOO S J LEE K S AHN M KIM O H CHO Y H LIM J W JUNG N YOON W S CHOE H SUNG Y E | 2012 | Electrochim Acta2012，59，： | 1 |
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