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9篇 您的检索式：作者名="Ludovic T"

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		题名	作者	年代	出处	被引量
	1	Spatial and temporal distribution of pesticide air concentrations in Canadian agricultural regions 显示文摘	YAO Y LUDOVIC T HARNER T	2006	Atmospheric Environment2006，40，23：	1
	2	Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH.	Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet	2022	Bone Research2022，10，1：	1
	3	On the high cycle fatigue behavior of a type 304L stainless steel at room temperature 显示文摘	Ludovic V Jean-Christophe L R Said T	2012	International Journal of fatigue2012，38，：	1
	4	DC-SIGN is the major mycobacterium tuberculosis receptor on human dendritic cells显示文摘	Ludovic T Olivier S Herrmann JL	2003	J Exp Med2003，197，：	1
	5	MIL-96, a porous aluminum trimesate 3D structure on strutted from a hexagonal network of 18-membered rings and tri- nuclearunits 显示文摘	Loiseau T Ludovic L L Volkringer C	2006	J Am Chem Soc2006，128，10：	1
	6	Use of Functional(M eth)Acrylic Cross-linked Polymer M icroparticles as Toughening Agents for Expoy/Diamine Thermosets显示文摘	Ludovic Valette Jean-Pierre Pascault Magny Benot	2003	M acromolecular M aterials and Engineering2003，228，11：	1
	7	A new criterion for elasto-plasfic transition in nanomaterials: Application to size and composite effects on Cu-Nb nanocomposite wires显示文摘	LUDOVIC T STEVEN VAN P PIERRE-OLIVIER R FLORENCE L VANESSA V BERND S HELENA VAN S	2009	Acta Materialia2009，57，：	1
	8	Trends in cardio- vascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies 显示文摘	Christophe M Emmanuel T Ludovic T		Rheumatology (Oxford)0，48，10：	1
	9	CD13/N-aminopeptidase is involved in the development of dendritic cells and macrophages from cord blood CD34+ cells显示文摘	Michelle R Ludovic T Jean C G	2000	Blood2000，95，：	1

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