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| 1 | Epidermal growth factor receptor (EGFR) T790M mutation identified in plasma indicates failure sites and predicts clinical prognosis in non-small cell lung cancer progression during first-generation tyrosine kinase inhibitor therapy: a prospective observational study显示文摘Introduction:Plasma circulating tumor DNA(ctDNA)is an ideal approach to detecting the epidermal growth factor receptor(EGFR)T790M mutation,which is a major mechanism of resistance to first-generation EGFR-tyrosine kinase inhibitor(TKI)therapy.The present study aimed to explore the association of ctDNA-identified T790M mutation with disease failure sites and clinical prognosis in non-small cell lung cancer(NSCLC)patients.Methods:Patients who progressed on first-generation TKIs were categorized into failure site groups of chest limited(CF),brain limited(BF)and other(OF).Amplification refractory mutation system(ARMS)and droplet digital PCR(ddPCR)were used to identify the T790M mutation in ctDNA.Prognosis was analyzed with Kaplan-Meier methods.Results:Overall concordance between the two methods was 78.3%.According to both ARMS and ddPCR,patients in the OF group had a significantly higher rate of T790M mutation than did patients in the BF and CF groups(P<0.001),and a significantly higher T790M mutation rate was also observed in OF-group patients than in those in the CF and BF groups(P<0.001).AZD9291 was found to be an excellent treatment option and yielded the longest survival for T790M+patients in all groups who had progressed on EGFR-TKIs;for other treatments,the prognosis of T790M−patient subgroups varied.Conclusions:The present study demonstrates that T790M mutation in ctDNA is associated with failure sites for NSCLC patients after EGFR-TKI therapy and indicates that both failure site and T790M mutational status greatly influ-ence treatment selection and prognosis. | Shirong Zhang Lucheng Zhu Bing Xia Enguo Chen Qiong Zhao Xiaochen Zhang Xueqin Chen Xufeng Chen Shenglin Ma | 2018 | Cancer Communications2018，38，1： | 12 |
| 2 | Initial Rotor Position Detection of 12/10 Flux-switching Permanent Magnet Motors显示文摘电机转子初始位置检测的精度直接决定其启动运行时的性能。针对12/10极永磁磁通切换型电机,在验证其凸极性的基础上,采用注入脉振高频信号实现转子初始位置估计。通过对传统高频脉振正弦电压信号注入的分析,研究了基于高频方波或三角波的注入方法,再利用电流差值调制或直接信号调制方法得到位置误差信号,同时根据磁路的饱和效应,通过对d轴电流过零点时间差值的累加,实现了磁极方向辨识。分析了位置误差信号的系数与初始位置检测收敛性的关系。通过实验验证了所提方法的正确性和可行性。 | XU Peilin DENG Zhiquan WANG Yu SONG Lucheng | 2013 | 中国电机工程学报2013，33，9： | 10 |
| 3 | Non-injection gram-scale synthesis of cesium lead halide perovskite quantum dots with controllable size and composition显示文摘金属卤化物 perovskites 是为太阳的收获和轻射出应用被认为候选人好的新奇 optoelectronic 材料。在这研究,我们为综合开发一条可再现、便宜的途径 highquality 铯铅卤化物 perovskite (CsPbX 3, X = Cl, Br,并且我或 Cl/Br 和 I/Br ) 由在空中的在 octadecene 的先锋的直接加热的 nanocrystals (NC ) 。试验性的结果证明同样准备的 CsPbX 3 nanocrystals 的粒子尺寸和作文能被反应温度的一个简单变化成功地调节。同样准备的 nanocrystals 的排放山峰位置能方便地从 UV 被调节到 NIR (360-700 nm ) 区域,和同样获得的样品(绿、红的排出物) 的量收益罐头活动范围直到 87% 。结构和同样获得的 NC 的化学作文被传播电子显微镜学, X 光检查衍射,和元素的分析描绘。这建议合成线路能与一个批反应产出大量高质量的 NC,并且能为基于 perovskite 的轻射出、光电的太阳能电池的进一步的应用程序铺平道路,通常在克规模上。 | Xu Chen Lucheng Peng Keke Huang Zhan Shi Renguo Xie Wensheng Yang | 2016 | Nano Research2016，9，7： | 8 |
| 4 | Large-scale synthesis of single-source, thermally stable, and dual-emissive Mn-doped Zn-Cu-ln-S nanocrystals for bright white light-emitting diodes显示文摘 | Lucheng Peng Dongze Li Zhuolei Zhang Keke Huang Ying Zhang Zhan Shi Renguo Xie Wensheng Yang | 2015 | Nano Research2015，8，10： | 7 |
| 5 | Study on Adjoint-Based Optimization Method For Multi-Stage Turbomachinery显示文摘Adjoint-based optimization method is a hotspot in turbomachinery.First,this paper presents principles of adjoint method from Lagrange multiplier viewpoint.Second,combining a continuous route with thin layer RANS equations,we formulate adjoint equations and anti-physical boundary conditions.Due to the multi-stage environment in turbomachinery,an adjoint interrow mixing method is introduced.Numerical techniques of solving flow equations and adjoint equations are almost the same,and once they are converged respectively,the gradients of an objective function to design variables can be calculated using complex method efficiently.Third,integrating a shape perturbation parameterization and a simple steepest descent method,a frame of adjoint-based aerodynamic shape optimization for multi-stage turbomachinery is constructed.At last,an inverse design of an annular cascade is employed to validate the above approach,and adjoint field of an Aachen 1.5 stage turbine demonstrates the conservation and areflexia of the adjoint interrow mixing method.Then a direct redesign of a 1+1 counter-rotating turbine aiming to increase efficiency and apply constraints to mass flow rate and pressure ratio is taken. | Weiwei Li Yong Tian Weilin Yi Lucheng Ji Weiwei Shao Yunhan Xiao | 2011 | Journal of Thermal Science2011，20，5： | 6 |
| 6 | Model study of relationship between local temperature and artificial heat release显示文摘In recent decades,it presents a more obvious temperature rise in urban area along with the global warming.City is generally the center of human society,so the study on urban temperature variation will be helpful to our city development planning that is to reduce urban warming.The study is also helpful to a more comprehensive understanding of the causes of climate warming,which could provide a theoretical support to the government to make more reasonable international energy policies.Local temperature rise has different mechanisms with the global warming:large quantities of artificial heat release from the energy consumption will stay in urban areas for a period of time,which will inevitably influence the short-term trend of the local temperature change.Based on that view,a structural thermodynamic model was established in this paper to investigate the effect of the artificial heat release on the urban local temperatures.In the model,the city environment was divided into Human,Local,Outer three blocks,and then the heat and temperatures of the blocks were analyzed based on the laws of thermodynamics.After that,the effect of artificial heat release in Human block on the local temperatures was clarified.The model shows that the artificial heat release has an approximately linearly promoting effect on the local temperature rise,and the more the heat release is,the stronger the effect is.In addition,a validation of that model was carried out based on some national statistical data.The data of temperatures and artificial heat release of some provincial capitals of China were analyzed with linear regression extrapolation method and Pearson correlation statistical method.The results show that in most capital cities,the temperature variations basically depend on the artificial heat release in a linear relationship,which usually becomes more apparent with the increase of the artificial heat release in both spatial and temporal dimensions.The conclusions of the statistics have good conformity with the model and the rationality of the model is verified. | NIU Qiang NIE ChaoQun LIN Feng LI Ling JI LuCheng | 2012 | Science China(Technological Sciences)2012，55，3： | 5 |
| 7 | 第一代酪氨酸激酶抑制剂治疗中发生进展的非小细胞肺癌血浆表皮生长因子受体(EGFR)T790M突变提示了失败部位并预测了临床预后:一项前瞻性观察研究显示文摘背景与目的血浆循环肿瘤DNA(circulating tumor DNA,ctDNA)是检测表皮生长因子受体(epidermal growth factor receptor,EGFR)T790M突变的理想方法。T790M突变是第一代EGFR酪氨酸激酶抑制剂(tyrosine kinase inhibitor,TKI)耐药的主要机制。本研究旨在探讨ctDNA来源的T790M突变与非小细胞肺癌(non-small cell lung cancer,NSCLC)患者疾病失败部位及临床预后的关系。方法第一代TKI治疗发生进展的患者被分为局限胸内进展(chest limited,CF)、局限颅内进展(brain limited,BF)和其他部位进展(other,OF)组。采用扩增阻滞突变系统(amplification refractory mutation system,ARMS)和微滴式数字PCR(droplet digital PCR,ddPCR)对ctDNA中T790M突变进行了检测。采用Kaplan-Meier法分析了预后。结果 2种方法的总体一致性为78.3%。根据ARMS和ddPCR,OF组患者的T790M突变率明显高于BF组和CF组(P <0.001),OF组的T790M突变丰度也明显高于CF组和BF组(P <0.001)。AZD9291是T790M+患者最佳治疗选择,为EGFR-TKI治疗后进展的所有组中T790M+患者提供了最长的生存期;接受其他治疗的T790M-患者亚组的预后各不相同。结论本研究表明ctDNA中T790M突变与NSCLC患者EGFR-TKI治疗失败部位相关,失败部位和T790M突变状态对治疗选择和预后都有很大影响。 | Shirong Zhang Lucheng Zhu Bing Xia Enguo Chen Qiong Zhao Xiaochen Zhang Xueqin Chen Xufeng Chen Shenglin Ma | 2018 | 癌症2018，37，9： | 4 |
| 8 | An aerodynamic design and numerical investigation of transonic centrifugal compressor stage显示文摘In the present paper,the design of a transonic centrifugal compressor stage with the inlet relative Mach number about 1.3 and detailed flow field investigation by three-dimensional CFD are described.Firstly the CFD program was validated by an experimental case.Then the preliminary aerodynamic design of stage completed through in-house one-dimensional code.Three types of impellers and two sets of stages were computed and analyzed.It can be found that the swept shape of leading edge has prominent influence on the performance and can enlarge the flow range.Similarly,the performance of the stage with swept impeller is better than others.The total pressure ratio and adiabatic efficiency of final geometry achieve 7:1 and 80% respectively.The vane diffuser with same airfoils along span increases attack angle at higher span,and the local flow structure and performance is deteriorated. | Weilin Yi Lucheng Ji Yong Tian Weiwei Shao Weiwei Li Yunhan Xiao | 2011 | Journal of Thermal Science2011，20，3： | 2 |
| 9 | Application of New Empirical Models Based on Mathematical Statistics in the Through-Flow Analysis显示文摘The through-flow analysis is an important part in the compressor design process.In this part,lots of empirical models are used to predict the compressor aerodynamic performances.These models are all based on the early experimental results of low-load and low-speed compressors;so,they may not be suitable for modern compressor performance estimations.In this study,several empirical models were reviewed,and two new models to estimate the minimum blade profile loss and minimum-loss deviation angle were established using mathematical statistics.Then,the original models with poor accuracy were replaced by these two models in through-flow program.Next,three compressors(Rotor 67,Stage 35,and a 4-stage repeating stage)were simulated using both the original and new models.The final results show that the new models have better accuracy in estimating the performance parameters than the original models.This indicates that it is feasible to use mathematical statistical methods to establish the empirical models,and this method provides an idea for the improvement of other empirical models in through-flow program. | FEI Teng JI Lucheng | 2021 | Journal of Thermal Science2021，30，6： | 2 |
| 10 | Unsteady Numerical Simulation of Hot Streak/Blades Interaction and Film Cooling显示文摘Deeply research on management and application of hot streak is an important way to breakthrough technique obstacle of aero engine hot components.Numerical method is a useful instrument to investigate the correlative problems.Firstly the paper developed independently three dimensional unsteady parallel computational code-MpiTurbo based on Fortran 90 and MPI at Linux operating system.Then unsteady numerical simulation was carried out to investigate impacts of the factors,which included circumferential locations of hot streak and clocking positions of blade rows,on the thermal environment of a 1+1 counter-rotating turbine.The results clearly indicated that clocking positions of hot streak/blade row and blade row/blade row had great influence on the time-averaged temperature distribution of the third blade row.Therefore,it can be effective for improving thermal environment of turbine to optimize blade parameters and clocking positions.Lastly film cooling layout was designed by the repetitious steady simulation based on source term method.And the flow structure detail was given by the unsteady simulation. | Weilin Yi,Lucheng Ji and Yunhan Xiao Research Center for Energy and Power,Chinese Academy of Sciences,Beijing,China Key Laboratory of Advanced Energy and Power,Chinese Academy of Sciences,(Institute of Engineering Thermophysics),Beijing,China P.O.Box 2706,Beijing 100190,China | 2010 | Journal of Thermal Science2010，19，5： | 2 |
| 11 | Discovering a formula for the high temperature oxidation behavior of FeCrAlCoNi based high entropy alloys by domain knowledge-guided machine learning显示文摘A mathematical formula of high physical interpretation,and accurate prediction and large generaliza-tion power is highly desirable for science,technology and engineering.In this study,we performed a domain knowledge-guided machine learning to discover high interpretive formula describing the high-temperature oxidation behavior of FeCrAlCoNi-based high entropy alloys(HEAs).The domain knowledge suggests that the exposure time dependent and thermally activated oxidation behavior can be described by the synergy formula of power law multiplying Arrhenius equation.The pre-factor,time exponent(m),and activation energy(Q)are dependent on the chemical compositions of eight elements in the FeCrAlCoNi-based HEAs.The Tree-Classifier for Linear Regression(TCLR)algorithm utilizes the two exper-imental features of exposure time(t)and temperature(T)to extract the spectrums of activation energy(Q)and time exponent(m)from the complex and high dimensional feature space,which automatically gives the spectrum of pre-factor.The three spectrums are assembled by using the element features,which leads to a general and interpretive formula with high prediction accuracy of the determination coefficient R^(2)=0.971.The role of each chemical element in the high-temperature oxidation behavior is analytically illustrated in the three spectrums,thereby the discovered interpretative formula provides a guidance to the inverse design of HEAs against high-temperature oxidation.The present work demonstrates the sig-nificance of domain knowledge in the development of materials informatics. | Qinghua Wei Bin Cao Lucheng Deng Ankang Sun Ziqiang Dong Tong-Yi Zhang | 2023 | Journal of Materials Science & Technology2023，，18： | 1 |
| 12 | Empirical research on the technology opportunities analysis based on morphology analysis and conjoint analysis显示文摘 | LI XIN WANG JIWU HUANG LUCHENG | 2010 | Foresight2010，，2： | 1 |
| 13 | Gonadotropin-inhibitory hormone (GnIH) and its receptor in the female pig: cDNA cloning, expression in tissues and expression pattern in the reproductive axis during the estrous cycle显示文摘 | Xun Li Juan Su Zhihai Lei Yangyang Zhao Mengmeng Jin Rui Fang Lucheng Zheng Yang Jiao | 2012 | Peptides2012，，2： | 1 |
| 14 | Poly(NGisopropylacrylamide)GbasedverticallysandwichGtypedhydrogelwithfasttemGperature-responsespeedanditscontrolledGreleasecharacGteristics显示文摘 | LuCheng XiaoXincai | 2012 | JournalofWuhanUniversityofTechnology(MaterialsScienceEdition)2012，02，： | 1 |
| 15 | Influence of Reynolds Number on the Unsteady Aerodynamics of Integrated Aggressive Intermediate Turbine Duct显示文摘The ultra-high bypass ratio turbofan engine attracts more and more attention in modern commercial engine due to advantages of high efficiency and low Specific Fuel Consumption(SFC). One of the characteristics of ultra-high bypass ratio turbofan is the intermediate turbine duct which guides the flow leaving high pressure turbine(HPT) to low pressure turbine(LPT) at a larger diameter, and this kind of design will lead to aggressive intermediate turbine duct(AITD) design concept. Thus, it is important to design the AITD without any severe loss. From the unsteady flow's point of view, in actual operating conditions, the incoming wake generated by HPT is unsteady which will take influence on boundary layer's transition within the ITD and LPT. In this paper, the three-dimensional unsteady aerodynamics of an AITD taken from a real engine is studied. The results of fully unsteady three-dimensional numerical simulations, performed with ANSYS-CFX(RANS simulation with transitional model), are critically evaluated against experimental data. After validation of the numerical model, the physical mechanisms inside the flow channel are analyzed, with an aim to quantify the sensitivities of different Reynolds number effect on both the ITD and LPT nozzle. Some general physical mechanisms can be recognized in the unsteady environment. It is recognized that wake characteristics plays a crucial role on the loss within both the ITD and LPT nozzle section, determining both time-averaged and time-resolved characteristics of the flow field. Meanwhile, particular attention needs to be paid to the unsteady effect on the boundary layer of LPT nozzle's suction side surface. | LIU Hongrui LIU Jun JI Lucheng DU Qiang LIU Guang WANG Pei | 2018 | Journal of Thermal Science2018，27，3： | 1 |
| 16 | The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro显示文摘 | Xun Li Juan Su Rui Fang Lucheng Zheng Ruipeng Lei Xiaoye Wang Zhihai Lei Mengmeng Jin Yang Jiao Yuanlong Hou Tingting Guo Zhiyu Ma | 2013 | Molecular and Cellular Endocrinology (-)2013，，1： | 1 |
| 17 | Shunt removal and patching for crystalline silicon solar cells using infrared imaging and laser cutting 显示文摘 | Zhang Lucheng Shen Hui Yang Zhuojian | 2010 | Progress in Photovoltaics: Research and Applications2010，18，1： | 1 |
| 18 | SWOT Analysis of Information Technology Industry in Beijing,China Using Patent Data显示文摘 | Huang Lucheng Wang Kangkang Wu Feifei ect | | 0，，7333： | 1 |
| 19 | A novel phase-locked loop based on frequency detector and initial phase angle detector显示文摘 | WANG Liang JIANG Qirong HONG Lucheng | 2013 | IEEE Trans on Power Electronics2013，28，10： | 1 |
| 20 | An improved prediction model for corner stall in axial compressors with dihedral effect显示文摘Corner stall predictions are important and difficult in axial compressors.However,all of the prediction models have proved to be ineffective for advanced compressor blades,which tend to use the combined sweep and dihedral.As for the prediction parameter DL,although it effectively modeled the effects of the adverse pressure gradient and secondary flow,it failed to predict the corner stall of curved blades because the model failed to consider the intersection of the boundary layer at the corner region.In this paper,the shape factor gradientψof the boundary layer at the corner region was investigated by numerically studying specially shaped expansion pipes under different adverse pressure gradients.The improved prediction parameter DJ was presented based on the model of ψ and the circumferential pressure gradient ζ.A comparison of the critical range of the prediction parameters DL and DJ was investigated using the NACA65 cascade database,which was established by a numerical method.Then,the stall criterion was validated according to the experimental results of various test facilities with different blade geometries and experimental conditions.The results show that the improved prediction parameter is able to predict the corner separation/stall flows and is in good agreement with the experimental results for axial compressors with three-dimensional designed blades. | Jiabin LI Lucheng JI | 2020 | Chinese Journal of Aeronautics2020，33，5： | 1 |
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