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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 3 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 4 | Orally administered BZL-s RNA-20 oligonucleotide targeting TLR4 effectively ameliorates acute lung injury in mice显示文摘The global COVID-19 pandemic emerged at the end of December 2019.Acute respiratory distress syndrome(ARDS)and acute lung injury(ALI)are common lethal outcomes of bacterial lipopolysaccharide(LPS),avian influenza virus,and SARS-Co V-2.Toll-like receptor 4(TLR4)is a key target in the pathological pathway of ARDS and ALI.Previous studies have reported that herbal small RNAs(s RNAs)are a functional medical component.BZL-s RNA-20(Accession number:B59471456;Family ID:F2201.Q001979.B11)is a potent inhibitor of Toll-like receptor 4(TLR4)and pro-inflammatory cytokines.Furthermore,BZLs RNA-20 reduces intracellular levels of cytokines induced by lipoteichoic acid(LTA)and polyinosinic-polycytidylic acid(poly(I:C)).We found that BZL-s RNA-20 rescued the viability of cells infected with avian influenza H5N1,SARS-Co V-2,and several of its variants of concern(VOCs).Acute lung injury induced by LPS and SARS-Co V-2 in mice was significantly ameliorated by the oral medical decoctosome mimic(bencaosome;sphinganine(d22:0)+BZL-s RNA-20).Our findings suggest that BZLs RNA-20 could be a pan-anti-ARDS/ALI drug. | Dandan Zhao Yuhao Qin Jiaqi Liu Kegong Tang Shuaiyao Lu Zirui Liu Yexuan Lin Cong Zhang Fengming Huang Jiahui Chang Chang Li Mingyao Tian Yiming Ma Xiaoyun Li Congzhao Zhou Xiao Li Xiaozhong Peng Ningyi Jin Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 5 | Rechargeable alkali-ion cathode-flow battery显示文摘 | Lu Yuhao Goodenough John B | 2011 | Journal of Materials Chemistry2011，21，10： | 1 |
| 6 | Sulfur vs. tellurium: the heteroatom effects on the nonfullerene acceptors显示文摘The effect of chalcogen heteroatom variation on donor materials has been systematically investigated. However, this effect on acceptors has rarely been explored. Herein, nonfullerene acceptors BFPSP and BFPTP were reported by simply changing the chalcogen atoms from S to Te. The differences between BFPSP and BFPTP in light absorption, energy levels, excited-state lifetimes, energy loss, charge mobilities, morphology, and photovoltaic properties were systematically investigated to understand the heteroatom effects. More importantly, the electroluminescence spectra, external quantum efficiency of photovoltaics and TDDFTcalculations revealed that the triplet excited state(T1) in energy of BFPTP equals to the charge transfer(CT) state in PBDBT:BFPTP, which allows T1 excitons, generated by intersystem crossing, to split into free charges to contribute to the efficiency.This contribution provides a strategy for tuning the photophysical properties of nonfullerene acceptors and designing high performance triplet materials for OSCs. | Lei Yang Linqing Qin Yunxiao Xu Huotian Zhang Lei Lv Kepeng Chen Xinyu Sui Yangguang Zhong Yuan Guo Feng Gao Jianzhang Zhao Yuhao Li Xinfeng Liu Yuanping Yi Xinhui Lu Aidong Peng Hui Huang | 2019 | Science China Chemistry2019，62，7： | 1 |
| 7 | Thermodynamic anmlysis on lunar soil reduced by hydrogen显示文摘 | Lu Yuhao ManthaD Reddy RG | 2010 | Metanurgieal and Materi- als Transaetions B2010，41，： | 1 |
| 8 | A near-complete genome assembly of the allotetrapolyploid Cenchrus fungigraminus(JUJUNCAO)provides insights into its evolution and C4 photosynthesis显示文摘JUJUNCAO(Cenchrus fungigraminus;2n=4x=28)is a Cenchrus grass with the highest biomass production among cultivated plants,and it can be used for mushroom cultivation,animal feed,and biofuel production.Here,we report a nearly complete genome assembly of JUJUNCAO and reveal that JUJUNCAO is an allopolyploid that originated2.7 million years ago(mya).Its genome consists of two subgenomes,and subgenome A shares high collinear synteny with pearl millet.We also investigated the genome evolution of JUJUNCAO and suggest that the ancestral karyotype of Cenchrus split into the A and B ancestral karyotypes of JUJUNCAO.Comparative transcriptome and DNA methylome analyses revealed functional divergence of homeologous gene pairs between the two subgenomes,which was a further indication of asymmetric DNA methylation.The three types of centromeric repeat in the JUJUNCAO genome(CEN137,CEN148,and CEN156)may have evolved independently within each subgenome,with some introgressions of CEN156 from the B to the A subgenome.We investigated the photosynthetic characteristics of JUJUNCAO,revealing its typical C4 Kranz anatomy and high photosynthetic efficiency.NADP-ME and PEPCK appear to cooperate in the major C4 decarboxylation reaction of JUJUNCAO,which is different from other C4 photosynthetic subtypes and may contribute to its high photosynthetic efficiency and biomass yield.Taken together,our results provide insights into the highly efficient photosynthetic mechanism of JUJUNCAO and provide a valuable reference genome for future genetic and evolutionary studies,as well as genetic improvement of Cenchrus grasses. | Huakun Zheng Baiyu Wang Xiuting Hua Ruiting Gao Yuhao Wang Zixin Zhang Yixing Zhang Jing Mei Yongji Huang Yumin Huang Hui Lin Xingtan Zhang Dongmei Lin Siren Lan Zhongjian Liu Guodong Lu Zonghua Wang Ray Ming Jisen Zhang Zhanxi Lin | 2023 | Plant Communications2023，4，5： | 1 |
| 9 | Upregulation of miR-15b in NAFLD models and in the serum of patients with fatty liver disease显示文摘 | Yuhao Zhang Xixiang Cheng Zhiqiang Lu Jingkun Wang Hongyan Chen Weiwei Fan Xin Gao Daru Lu | 2012 | Diabetes Research and Clinical Practice2012，，： | 1 |
| 10 | The electrochemical behavior of cobalt phthalocyanine/platinum as methanol-resistant oxygen-reduction electrocatalysts for DMFC 显示文摘 | Lu Yuhao Ramana G Reddy | 2007 | Electrochimica Acta2007，，52： | 1 |
| 11 | MR-seq:measuring a single cell's transcriptome repeatedly by RNA-seq显示文摘We described a novel single-cell RNA-seq technique called MR-seq(measure a single-cell transcriptome repeatedly),which permits statistically assessing the technical variation and identifying the differentially expressed genes between just two single cells by measuring each single cell twice. We demonstrated that MR-seq gave sensitivity and reproducibility similar to the standard single-cell RNA-seq and increased the positive predicate value. Application of MR-seq to early mouse embryos identified hundreds of candidate intra-embryonic heterogeneous genes among mouse 2-,4-and 8-cell stage embryos. MR-seq should be useful for detecting differentially expressed genes among a small number of cells. | Lu Yang Zhaochun Ma Chen Cao Yuhao Zhang Xinglong Wu Raymond Lee Boqiang Hu Lu Wen Hao Ge Yanyi Huang Kaiqin Lao Fuchou Tang | 2017 | Science Bulletin2017，62，6： | 1 |
| 12 | Stable cycling of practical high-voltage LiCoO_(2)pouch cell via electrolyte modification显示文摘Nitriles as efficient electrolyte additives are widely used in high-voltage lithium-ion batteries.However,their working mechanisms are still mysterious,especially in practical high-voltage LiCoO_(2)pouch lithium-ion batteries.Herein,we adopt a tridentate ligandcontaining 1,3,6-hexanetricarbonitrile(HTCN)as an effective electrolyte additive to shed light on the mechanism of stabilizing high-voltage LiCoO_(2)cathode(4.5 V)through nitriles.The LiCoO_(2)/graphite pouch cells with the HTCN additive electrolyte possess superior cycling performance,90%retention of the initial capacity after 800 cycles at 25℃,and 72%retention after 500 cycles at 45℃,which is feasible for practical application.Such an excellent cycling performance can be attributed to the stable interface:The HTCN molecules with strong electron-donating ability participate in the construction of cathode-electrolyte interphase(CEI)through coordinating with Co ions,which suppresses the decomposition of electrolyte and improves the structural stability of LiCoO_(2)during cycling.In summary,the work recognizes a coordinating-based interphase-forming mechanism as an effective strategy to optimize the performance of high voltage LiCoO_(2)cathode with appropriate electrolyte additives for practical pouch batteries. | Chao Tang Yawei Chen Zhengfeng Zhang Wenqiang Li Junhua Jian Yulin Jie Fanyang Huang Yehu Han Wanxia Li Fuping Ai Ruiguo Cao Pengfei Yan Yuhao Lu Shuhong Jiao | 2023 | Nano Research2023，16，3： | 0 |
| 13 | Three-step learning strategy for designing 15Cr ferritic steels with enhanced strength and plasticity at elevated temperature显示文摘15Cr ferrite steels are urgently required in advanced Ultra-supercritical power plants but meet design challenges in balancing excellent strength and plasticity at high temperatures.We developed a three-step learning strategy based on mutually driven machine learning and purposeful experiments to complete this multi-objective task.Compared with traditional adaptive learning and local-interpolation learning,this step-by-step modular manner provides good transparency and interpretability of the information flow,which is ensured by identifying essential factors from an exquisitely prepared composition-microstructure dataset,and learning valuable knowledge about the composition-property relationship.The requirement of only two groups of experiments indicates the low cost and high efficiency of the strategy.Performing the strategy,we found that Ti is another key element affecting the Laves phase besides Mo and W,and their effects on ultimate tensile strength(UTS)and elongation were also uncovered.Importantly,several low-cost steels free of Co were successfully designed,and the best steel exhibited 156%,31%,and 62%higher UTS and elongation at 650°C than the typical 9Cr,15Cr,and 20Cr steels,respectively.Based on the advantages and success of the strategy in terms of alloy improvement,we believe the strategy suits other multi-objective design tasks in more materials systems. | Xiaobing Hu Yiming Chen Jianlin Lu Chen Xing Jiajun Zhao Qingfeng Wu Yuhao Jia Junjie Li Zhijun Wang Jincheng Wang | 2023 | Journal of Materials Science & Technology2023，，33： | 0 |
| 14 | Unidirectionally aligned bright quantum rods films,using T-shape ligands,for LCD application显示文摘Unidirectionally aligned nanorods(NRs)are of great importance for different applications,including displays,lighting,and photodetectors.Recently,many alignment techniques were studied to align quantum rods(QRs).However,the brightness of these films,due to the limited concentration of aligned quantum rods in the film,is not enough for their implementation as brightness enhancement films(BEFs)in displays.This can be ascribed to the poor miscibility of quantum rods in polymer and strong concentration dependence of the polarized emission.The ligands of NR are very important for the alignment and brightness.In this article,we proposed a ligand combination comprising T-shape promesogenic phosphonic acid,which on being photoaligned provides mutually parallel alignment of the quantum rods.The T-shape ligands enable the fabrication of hybrid films with a QRs concentration as high as 10 wt.%–20 wt.%retaining high brightness and luminescence polarization property.Later,we used these films in the in-plane switching(IPS)display backlight that shows the color gamut up to 121%of national television system committee(NTSC)(CIE1931),liquid-crystal display(LCD)efficiency up to 7.9%,power efficacy 103±2 nits/W,and the high brightness of~550±10 nits.Thus,the proposed ligands can be used for the alignment of a variety of nanorods. | Maksym F.Prodanov Chengbin Kang Swadesh K.Gupta Valerii V.Vashchenko Yuhao Li Minchao Qin Xinhui Lu Abhishek K.Srivastava | 2022 | Nano Research2022，15，6： | 0 |
| 15 | Experimental study of primary and secondary side coupling natural convection heat transfer characteristics of the passive residual heat removal system in AP1000显示文摘Passive residual heat removal heat exchanger(PRHR HX),which is a newly designed equipment in the advanced reactors of AP1000 and CAP1400,plays an important role in critical accidental conditions.The primary and secondary side coupling heat transfer characteristics of the passive residual heat removal system(PRHRS)determine the capacity to remove core decay heat during the accidents.Therefore,it is necessary to investigate the heat transfer characteristics and develop applicable heat transfer formulas for optimized design.In the present paper,an overall scaled-down natural circulation loop of PRHRS in AP1000,which comprises a scaleddown in-containment refueling water storage tank(IRWST)and PRHR HX models and a simulator of the reactor core,is built to simulate the natural circulation process in residual heat removal accidents.A series of experiments are conducted to study thermal-hydraulic behaviors in both sides of the miniaturized PRHR HX which is simulated by 12 symmetric arranged C-shape tubes.For the local PRHR HX heat transfer performance,traditional natural convection correlations for both the horizontal and vertical bundles are compared with the experimental data to validate their applicability for the specific heat transfer condition.Moreover,the revised natural convection heat transfer correlations based on the present experimental data are developed for PRHR HX vertical and lower horizontal bundles.This paper provides essential references for the PRHRS operation and further optimized design. | Zhimin QIU Daogang LU Jingpin FU Li FENG Yuhao ZHANG | 2021 | Frontiers in Energy2021，15，4： | 0 |
| 16 | Insight analysis of the cross-sensitization of multiple fish parvalbumins via the Th1/Th2 immunological balance and cytokine release from the perspective of safe consumption of fish显示文摘Objectives:Parvalbumin(PV)is the primary allergen found in fish and is highly conserved.According to some studies,some patients with fish allergy are allergic to only one species of fish but are tolerant to others;however,the underlying mechanism has not been identified.Materials and Methods:The cross-reactivity of these seven fish parvalbumins based on turbot PV-treated mice was determined using BALB/c mouse and RBL-2H3 cell models.Meanwhile,immunoinformatic tools were used to assess cross-reactivity.Results:The results indicated that the seven species of fishes(turbot,large yellow croaker,sea bass,grass carp,common carp,conger eel and Japanese eel)studied exhibited varying degrees of cross-reactivity,with the highest cross-reactivity being between turbot and bass and the lowest being between turbot and conger eel.The bioinformatics analysis revealed that the sequence homology of parvalbumin between conger eel and turbot was the lowest,which may account for the conger eel and turbot cross-reaction being so limited.Parvalbumin was a potent cross-reactive allergen found in turbot,large yellow croaker,sea bass,grass carp,common carp,conger eel and Japanese eel,and the cross-reactivity between conger eel and turbot parvalbumin was the weakest.Conclusion:This study demonstrated that the cross-reactivity between conger eel PV and turbot PV was the weakest. | Yeting Wu Youyou Lu Yuhao Huang Hong Lin Xuewen Dang Yujie Jing Zhaocheng Meng Xiangchen Wang Zhenxing Li | 2022 | Food Quality and Safety2022，6，4： | 0 |
| 17 | The co-transport of Cd(Ⅱ) and nZnO in saturated soil packed column:effects of ionic strength and pH显示文摘The rapid development and widespread use of ZnO nanoparticles(nZnO) in various industries have raised concerns about their potential environmental impact.Therefore,understanding the fate and role of nZnO in the natural environment is crucial for mitigating their hazardous effects on the environment and human safety.The purpose of the present study was to provide scientific support for understanding and eliminating the joint risk of nanoparticle and heavy metal pollution in the soil environment by revealing the co-transport characteristics of Cd(Ⅱ) and ZnO nanoparticles(nZnO) in soil under different ionic strength(IS) and pH.The impacts of different IS and pH on the co-transport of Cd(Ⅱ) and nZnO in a20 cm long with an inner diameter of 2.5 cm acrylic column packed with 10 cm high soil samples were investigated in the present study.In the above system,a500 μg L^(-1) Cd(Ⅱ) loaded nZnO suspension pulse with varying IS or pH was introduced into the soil column for leaching over 5 PVs,followed up by 5 PVs background solutions without nZnO.The IS was 1,10,or 50 mM NaCl,with pH6,or the pH was 6,7 or 8 with 1 mM NaCl.Meanwhile,Sedimentation experiments for nZnO,adsorption of Cd(Ⅱ) on soil,and nZnO,DLVO theory calculation for the same background condition were conducted.The presence of nZnO significantly increased the mobility of Cd(Ⅱ) as a result of its strong adsorption capacity for nZnO-associated Cd(Ⅱ).However,with the increase of IS,the co-transport of nZnO and Cd(Ⅱ) was decreased and the retention of nZnO in the soil column due to more nZnO attended to aggregate and sediment during the transport and the decrease in the adsorption capacity of nZnO for Cd(Ⅱ) by competition of Na^(+).When pH was 6,7,and 8,the co-transport of nZnO and Cd(Ⅱ) increased with higher pH due to the lower electrostatic attraction between nZnO and soil under higher pH.Meanwhile,the DLVO theory was fitted to describe the above co-transport process of nZnO and Cd(Ⅱ).More attention should be paid to the presence of nZnO on the migration of Cd(Ⅱ) in the natural soil to control the potential risk of nanoparticles and heavy metals to the environment.The risk of co-transport of nZnO and Cd(Ⅱ) might be controlled by adjusting IS and pH in the soil solution. | Min Liao Guo Bin Yixin Luo Yuhao Zhang Kangyou Hu Xiongxiong Lu Xiaomei Xie | 2024 | Acta Geochimica2024，43，1： | 0 |
| 18 | White-light-driven fluorescence switch for super-resolution imaging guided photodynamic and photoacid therapy显示文摘Photocaged fluorophores with photoactivatable characteristics presented important applications in imaging the biological structures and processes.Taking advantage of their super-resolution imaging merits to manipulate and visualize anti-cancer treatment is always a goal of modern clinical medicine.Traditional photodynamic therapy(PDT) is a noninvasive treatment but limited in intracellular oxygen content.Type I PDT and photoacid therapy(PAT) are two effective supplements of traditional PDT especially in hypoxic condition.Herein,a novel white-light-driven fluorescence switch(7H-dibenzo[c,g]carbazol-7-yl)(2-iodophenyl)methanone(2IB) was designed and synthesized as an unprecedent “all in one” platform for stochastic optical reconstruction microscopy(STORM) imaging guided Type Ⅰ/Ⅱ PDT and PAT.The experimental and theoretical studies revealed that the working mechanism is based on two competing paths under excitation:photosensitization and photocyclization reaction.Efficient intersystem crossing(ISC) ensured the generation of reactive oxygen species(ROS) for PDT,while low energy barrier facilitated the photocyclization reaction that simultaneously yielded emissive fluorophores(2IBC) and H^(+) for super-resolution imaging and photoacid,respectively.Impressively,the fluorescent intensity of mitochondria-targeted 2IBC was positively correlated with treatment efficacy,which is beneficial to spatiotemporally visualized therapeutic process and outcome.As a result,superior anti-tumor performance was achieved in vitro and in vivo.This contribution provided a multifunctional nanodrug paradigm for multimode cancer diagnosis and treatment. | Hao Chen Kaikai Wen Yu Lu Xin Zhang Yuhao Shi Qinqin Shi Han Ma Qian Peng Hui Huang | 2022 | Science China Chemistry2022，65，12： | 0 |
| 19 | Design of a Microwave Filter Based on a Novel Negative Coupling Structure with Conical Through-Hole显示文摘This article introduces the design theory of ceramic waveguide filter and proposes a new type of negative coupling structure with a conical throughhole,which has fine-adjustment of negative coupling without significantly increasing the insertion loss of the filter.Based on this,the article proposes an eightcavity ceramic waveguide filter design for 5G base stations.It also presents a detailed discussion on the influence of the cross-coupling slot lengths L2 and L4 on the transmission zeros positions during the filter optimization process and the relevant change rules.For the proposed optimized filter,the observed performance indicators include the center frequency of 3.5 GHz,working bandwidth of 200 MHz,an insertion loss of≤2.0 dB,return loss of≥19 dB,and out-of-band nearend suppression and out-of-band far-end suppression of≥39 dB and≥63 dB,respectively.The test performance results obtained for the sample,with structural parameters as per the simulation model,were in good agreement with the simulation results. | Shunliang Meng Fei Liang Wenzhong Lu Zihang Lin Yuhao Yin Rong Zhang | 2022 | China Communications2022，19，2： | 0 |
| 20 | Design and implementation of the galvanometer scanning system for reflectance confocal and stimulated Raman scattering microscopy显示文摘We report on two strategies to design and implement the galvanometer-based laser-scanning mechanisms for the realization of reflectance confocal microscopy(RCM) and stimulated Raman scattering(SRS) microscopy systems. The RCM system uses a resonant galvanometer scanner driven by a home-built field-programmable gate array circuit with a novel dual-trigger mode and a home-built high-speed data acquisition card. The SRS system uses linear galvanometers with commercially available modules. We demonstrate video-rate high-resolution imaging at 11 frames per second of in vivo human skin with the RCM system and label-free biomolecular imaging of cancer cells with the SRS system. A comparison of the two strategies for controlling galvanometer scanners provides scientific and technical reference for future design and commercialization of various laser-scanning microscopes using galvanometers. | 王方雨 Yuhao Yuan 孙强 戴明 艾莉 Fake Lu | 2020 | Chinese Optics Letters2020，18，12： | 0 |
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