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| 1 | Comparison of different microsurgery methods for trigeminal neuralgia显示文摘Objective: To study the influence of different microsurgical methods on surgical outcomes and complications, and to improve the surgical outcomes for trigeminal neuralgia. Methods: The clinical data of 109 patients with trigeminal neuralgia, who were treated with microsurgery, were analyzed retrospectively. All patients were divided into 3 groups according to surgical modality: the trigeminal neuralgia decompression group(TND group, 19 patients), the TND and rhizotomy group(rhizotomy group,55 patients), and the TND and selective lesioning group(lesioning group, 35 patients).The mid-term and short-term effects of microsurgery, and the occurrences of complications, were compared between the 3 groups. Results: There were no statistical differences in the frequency of complications between the 3 groups(P > 0.05). Eighty-four patients were followed up for 6 to 33 months. The rate of pain disappearance was found to be 94.4% in the TND group, and 100% in both the rhizotomy and lesioning groups; thus, no significant differences were found between these 3 groups(P > 0.05). Additionally, 50% of the patients in the rhizotomy group and 3.6% of the patients in the lesioning group had facial numbness while no patients were affected with facial numbness in the TND group, and the differences between these 3 groups were significant(P < 0.05). Conclusions: Microsurgery is effective and safe for trigeminal neuralgia. The use of TND, in combination with selective lesioning, ensures therapeutic efficacy and improves the quality of life in postoperative patients. | Zihang Xie Lin Chen Yan Wang Zhiqiang Cui Shijie Wang Qiang Ao Yuqi Zhang Huancong Zuo | 2016 | Translational Neuroscience and Clinics2016，2，3： | 2 |
| 2 | Anti-oxidative effect of zinc in human umbilical cord mesenchymal stem cells显示文摘Human umbilical cord mesenchymal stem cells(HUC-MSCs)are pluripotent and functional in many biological processes,by which releasing secretary factors to promote the self-repairing of damaged tissue or developing into functional cell at local organ.However,there is a high risk that oxidative stress would reduce the pluripotency and factor-secretion during the preparation and transplantation.Therefore,reducing oxidative stress is expected to improve the efficacy of HUC-MSCs therapy.Zinc[Zn] is an essential trace element which involves in the resistance of oxidative stress.To investigate Zn-regulated signaling pathways,we have profiled the gene expression at transcriptome level in primary HUC-MSCs treated with zinc sulfate,followed with GO and KEGG gene enrichment analysis.Zn treatment improved signal pathways for mineral absorption,cell growth,and cell death.Zn deficiency was mimicked by TPEN administration,which suppressed cell proliferation and reduced the expression of HUC-MSCs surface stem cell markers CD73,CD90 and CD105 by flow cytometry.Nuclear factor erythrocyte 2 related factor 2(Nrf2)plays an important role in antioxidant biological processes.In vitro treatment of Zn significantly increased Nrf2 and Sirt3 expression at gene level and protein level respectively.Zn supplementation inhibited TPEN-induced failure of cell survival and reversed the reduction of Nrf2 and Sirt3 expression,which further reduced the production of ROS.Zn successfully presented its antioxidation effect by activating Nrf2/Sirt3 signaling pathway in HUC-MSCs.Zn supplementation may improve the efficacy of HUC-MSCs therapy with reduced oxidative stress. | Xiaodan Lu Yifan Lin Xiuying Lin Qiang Zhang Zihang Wang Xuguang Mi Ruobing Wang Xiaofang Zhang Xu Luan Yan Liu Bing Li YanTan Yanqiu Fang | 2021 | Biophysics Reports2021，7，2： | 0 |
| 3 | Design of a Microwave Filter Based on a Novel Negative Coupling Structure with Conical Through-Hole显示文摘This article introduces the design theory of ceramic waveguide filter and proposes a new type of negative coupling structure with a conical throughhole,which has fine-adjustment of negative coupling without significantly increasing the insertion loss of the filter.Based on this,the article proposes an eightcavity ceramic waveguide filter design for 5G base stations.It also presents a detailed discussion on the influence of the cross-coupling slot lengths L2 and L4 on the transmission zeros positions during the filter optimization process and the relevant change rules.For the proposed optimized filter,the observed performance indicators include the center frequency of 3.5 GHz,working bandwidth of 200 MHz,an insertion loss of≤2.0 dB,return loss of≥19 dB,and out-of-band nearend suppression and out-of-band far-end suppression of≥39 dB and≥63 dB,respectively.The test performance results obtained for the sample,with structural parameters as per the simulation model,were in good agreement with the simulation results. | Shunliang Meng Fei Liang Wenzhong Lu Zihang Lin Yuhao Yin Rong Zhang | 2022 | China Communications2022，19，2： | 0 |
| 4 | Neoproterozoic Diamictite of the Luoquan Formation from the North China Block and Their Implications显示文摘Glacial diamictite may provide important information on paleoenvironment and average composition of the upper continental crust(UCC).In this study,we report sedimentary facies,petrological and geochemical characteristics of Neoproterozoic diamictite from a profile of the Luoquan Formation on the southern margin of the North China Block(NCB).Upwards the sampling profile,lithostratigraphic strata vary from massive diamictite with poorly sorted carbonate gravels to laminated diamictite with small gravels of terrestrial detrital materials.Along the profile,CaO-MgO-LOI-Sr values decrease with the increase of SiO_(2)-Al2O_(3)-K2O contents.All these petrological and geochemical variations indicate a change from lodgement till deposition in the proximal of ice sheet to ice-rafting deposition in glacial-marine environment with less dolomite to supply their source.Together with previous studies on diamictite from other outcrops on the NCB,the deposition of Luoquan diamictite reflects that the glaciation on the NCB vanished and the ice-rafting effect weakened with glacial transgression process.In addition,significant co-variations of various elements with La and Al2O_(3)confirm the significant conservation of most analyzed elements during the sedimentary processes to produce diamictite. | Peishan Sui Weidong Sun Nan Han Lei Wang Shiwen Xie Zihang Huang Xiaohong Wang Hongmei Gong Jin Liu Jinyan Lin Yuanyuan Xiao | 2023 | Journal of Earth Science2023，34，4： | 0 |
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