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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Prognostic Significance of Tumor-infiltrating CD8^+ or CD3^+ T Lymphocytes and Interleukin-2 Expression in Radically Resected Non-small Cell Lung Cancer显示文摘 | Chuntao Tian Shixin Lu Qingxia Fan Weijie Zhang Shunchang Jiao Xiao Zhao Zhiyong Wu Liang Sun Liuxing Wang | 2015 | Chinese Medical Journal2015，，1： | 11 |
| 3 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 4 | A Study of the Migration and Accumulation Efficiency and the Genesis of Hydrocarbon Natural Gas in the Xujiaweizi Fault Depression显示文摘摘要:为了在 Xujiaweizi 调查迁居和烃天然气的累积效率,并且为它的开始的分类提供新证据,指责消沉,在一个封闭系统的一个来源岩石热分解实验被设计并且执行了。基于这,为描述从有机物的产生和碳同位素分别在这期间处理的气体的运动模型被建立,校准然后外推到由联合 Xushen-1 的热历史数据很好的地质的条件。结果显示在 Xujiaweizi 差错消沉的煤措施是典型高效率的煤气的来源,从他们产生的天然气有高迁居和累积效率,并且因而,大规模天然气累积发生在区域。在 Xujiaweizi 差错消沉的高度 / 过去成熟的煤措施与高 13C1 价值产生 coaliferous 气体(>?20%) 在迟了的阶段,使碳成为器官的链烷气体的同位素作文反常地重。另外,通过天然气的 caprock 混合和驱散能导致否定的碳同位素顺序(13C1 > 13C2 > 13C3 > 13C4 ) 器官的链烷,气体,和驱散罐头也导致器官的链烷气体的反常地重的碳同位素作文。至于无机的 nonhydrocarbon 气体水库的发现,它能是仅仅服务一补助证据而非烃气体是无机的一条直接证据。作为结果,作为无机的气体在 Xujiaweizi 差错消沉分类烃天然气需要更充分的证据。 | LI Jijun LU Shuangfang XUE Haitao HUO Qiuli XU Qingxia | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 5 |
| 5 | The Impact of Aqueous Medium on Gas Yields and Kinetic Behaviors of Hydrogen Isotope Fractionation during Organic Matter Thermal Degradation显示文摘以便在有机物期间在煤气的收益和氢同位素分别的运动行为上认出水的媒介的影响热降级,金试管仪器被用来由与不同性质和比例的水混合 nC18 进行热模拟实验。天然气部件的收益,在每个部件和试验性的温度对加热的率的氢同位素作文之中的关系被获得了,并且结果显示在更高的温度条件下面,含水的实验在煤气的收益,更多什么时候流水上有明显的影响被增加,烃气体和 H2 的更高的数量被产出,并且水的存在显然与重烃气体的存在延长温度间隔。比由无水的实验产生了的,含水的实验产生的烃气体的氢同位素才显然轻,并且与增加的水的增加的数量,烃气体的 D 价值逐渐地减少。与煤气的收益相比, 5D 价值的变化对在热模拟实验的水的媒介更敏感。与增加的水的数量相比,然而,水的中等性质在煤气的收益上有更小的影响,它仍然在水的媒介的氢同位素作文上显示出 inherit 效果。通过模型模拟和同位素分别行为分析,氢同位素分别过程能被化学运动模型很好描述,这被验证。正常甲烷和包含 D 甲烷的反应部分的差别大,相应于一样的激活精力。正常甲烷的内容在有更低的激活精力的部分显然是更高的,当包含 D 甲烷的内容在有更高的激活精力的部分是更高的时。因此,它将导致更大的氢同位素分别振幅,和 D 价值将对成熟的变化更敏感。同时,从在含水的实验的 nC18 的甲烷产生的平均激活精力在无水的实验比那高,并且越增加的水的大数量,越 larger 甲烷产生反应的平均激活精力。这在形成历史和煤气来源的关联的煤气的水库的学习为它的探索申请打了基础,它在这取向显示研究和申请前景。 | LU Shuangfang WANG Min XUE Haitao LI Jijun CHEN Fangwen XU Qingxia | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 5 |
| 6 | Remediation of petroleum-contaminated soil after composting by sequential treatment with Fenton-like oxidation and biodegradation显示文摘 | Mang Lu Zhongzhi Zhang Wei Qiao Xiaofang Wei Yueming Guan Qingxia Ma Yingchun Guan | 2009 | Bioresource Technology2009，，7： | 1 |
| 7 | Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling显示文摘 | Dechun Jiang Xiangrong Bai Qingxia Zhang Wei Lu Yuqin Wang Lin Li Markus Müller | 2009 | European Journal of Clinical Pharmacology2009，，12： | 1 |
| 8 | A moonlighting function of choline kinase alpha 2 in the initiation of lipid droplet lipolysis in cancer cells显示文摘Cancer cells in the tumormicroenvironment,where nutrient availability is consistently changing during tumor progression,harness lipid metabolism to support their proliferation,survival,migration,invasion,and metastasis[1].When nutrients in the tumor microenvironment are sufficient,lipids such as triglycerides,steryl esters,and retinyl esters are stored in lipid droplets,which are dynamic lipid-rich cellular organelles surrounded by a single layer of polar and amphipathic phospholipids and structural proteins in the perilipin(PLIN)family. | Qingxia Ma Zhaoyuan Meng Ying Meng Rui Liu Zhimin Lu | 2021 | Cancer Communications2021，41，10： | 1 |
| 9 | The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma显示文摘Objective:In this post-hoc analysis,we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal squamous cell carcinoma(ESCC)patients.Methods:A total of 109 patients enrolled in the anlotinib group in a phase 2 trial were included.The tumor response was assessed by computed tomography at week 3,week 6,and then every 6 weeks until progressive disease was observed.The primary endpoint of the study was progression free survival(PFS).The secondary endpoints included overall survival(OS)and objective response rate(ORR).Results:In all patients,the median PFS was 3.02 months[95%confidence interval(CI):2.63–3.65 months]and the OS was 6.11 months(95%CI:4.40–7.79 months).The ORR was 7.34%(95%CI:3.22%–13.95%).A total of 59(54%)patients were diagnosed with treatment-induced hypertension(Group A),and the remaining patients(n=50,46%)were in Group B.Baseline prognostic factors were similar between the 2 groups.Patients in Group A had a longer PFS and OS and higher ORR.When stratifying patients using a previously known history of hypertension,treatment-induced hypertension was a predictor only for patients without previous hypertension,who had longer PFS[hazard ratio(HR):0.40,95%CI:0.24–0.68]and OS(HR:0.37,95%CI:0.21–0.67).Conclusions:We showed,for the first time,a correlation between treatment-induced hypertension and better prognoses in recurrent or metastatic ESCC patients treated with anlotinib,without a previously known history of hypertension.Treatment-induced hypertension may be a simple and low cost predictor for anlotinib antitumor efficacy in these patients,which may also reflect the intended target inhibition. | Yan Song Juxiang Xiao Wentao Fang Ping Lu Qingxia Fan Yongqian Shu Jifeng Feng Shu Zhang Yi Ba Yang Zhao Ying Liu Chunmei Bai Yuxian Bai Yong Tang Jie He Jing Huang | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 10 | Water Role and Its Influence on Hydrogen Isotopic Composition of Natural Gas during Gas Generation显示文摘In order to discuss the role and influence of water during the generation of natural gas,the participation mechanism of water during the evolution of organic matter and its influences were summarized.In addition,we carried out an anhydrous cracking experiment of oil extracted from the Feixianguan Formation source rock in a closed system,which led to the establishment of the kinetic models for describing carbon and hydrogen isotopic fractionation during gas generation from organic matter.The models were c... | Jijun LI Shuangfang LU Wei WU Haitao XUE Qingxia XU Jie GENG Yinghua YU | 2011 | Acta Geologica Sinica(English Edition)2011，85，5： | 1 |
| 11 | Effect of polycarboxylate ether comb-type polymer on viscosity and interfacial properties of kaolinite clay suspensions显示文摘 | Ling Zhang Qingye Lu Zhenghe Xu Qingxia Liu Hongbo Zeng | 2012 | Journal of Colloid And Interface Science2012，，1： | 1 |
| 12 | Establishment of Indirect ELISA Diagnosis Technique based on the VP1 Protein of Foot and Mouth Disease Virus Serotype A显示文摘The VP1 protein of foot-and-mouth disease virus serotype A was prokaryotically expressed and purified to replace the traditional virus antigen for establishing a fast,safe,effective indirect ELISA method,so as to detecting antibody of foot-and-mouth disease virus serotype A. Western-Blot test showed that the VP1 recombinant protein could be used as detective antigen as it can be specifically recognized by bovine positive serum of FMDV serotype A. By employing matrix titration method,the optimal parameters were obtained as follows: 1 mg / L VP1 protein as coating antigen,Vserum∶ Vblocking solution = 1∶50 dilution for serum and Vsecondary enzyme-linked antibodies∶Vblocking solution = 1∶2 000 for enzyme combined antibodies. The results showed that the sensitivity and specificity of this method were 94. 32% and 99. 09% respectively,the coefficients of variations in intra-assay and inter-assay reproducibility tests was lower than 8%. Compared with liquid phase blocking ELISA kits,the agreement of 201 serum samples reached 92. 54%. The VP1-ELISA method established here is specific,sensitive,stable and simple,which can be used to monitor the antibody level of FMD serotype A. | Lu Qingxia Liu Chang Jin Qianyue Guo Guanpeng Xing Guangxu Liu Yunchao Deng Ruiguang Zhang Gaiping | 2014 | Animal Husbandry and Feed Science2014，6，6： | 1 |
| 13 | Analysis of hydrological drought frequency for the Xijiang river Basin in south china using observed streamflow data显示文摘 | WU Zhiyong LIN Qingxia LU Guihua | | Natural Hazards0，，： | 1 |
| 14 | Research Progress of Using Phage Display Technology to Screen Virus Affinity Peptides显示文摘Development and application of phage display technology and research progress of virus affinity peptide were summarized in the paper,and a preliminary outlook for future development was put forward. The paper laid a foundation for development of polypeptide drugs and polypeptide vaccine. | Zhang Nana Zheng Guanmin Wang Fangyu Ren Tingting Hao Huifang Zhang Yifang Zhang Gaiping Lu Qingxia | 2016 | Animal Husbandry and Feed Science2016，8，4： | 0 |
| 15 | High intensity focused ultrasound in combination with chemotherapy by the regime of PFC: a clinical study for advanced gastric carcinoma显示文摘Objective: To evaluate the recent curative efficacy and security of High intensity focused ultrasound (HIFU) in combination with chemotherapy(PFC) in patients with advanced gastric carcinoma. Method: Sixty patients with measurable advanced gastric carcinoma,proved pathologically, were divided into Group A and Group B. Group A: Patients were treated by HIFU(FEP-BY01) in combination with chemotherapy(PFC, paclitaxel, cisplatin and 5-fluorouracil). Group B: Patients were treated with the single regime of PFC. Results: All cases could be evaluated. In group A, 5 patients achieved complete response, 17 patients achieved partial response,and a response rate was 73.3%. The stable disease(SD) and the inefficiency all were 13.3%(4/30) respectively, and msurvival time(MST) was 13.9 months. In group B, 2 patients achieved complete response, 14 patients achieved partial response,and a response rate was53.3%. The stable disease(SD) was 23.3%(7/30). The inefficiency all were 23.3%(7/30) respectively, and median survival time was 9.6 months. There was significant difference between two groups’ MST(P<0.05). Major toxicities included bone marrow depression, nausea, vomiting and alopecia, without significant differences between two groups(P>0.05). Conclusion: This study shows that HIFU in combination with chemotherapy(PFC) was a new efficent and secure therapy for the patients with advanced gastric carcinoma. It was observed that the MST was prolonged. Prospective trials should be warranted to determine the result. | Qingxia Mu Yongqian Shu Puwen Huang Kaihua Lu Rongsheng Wang | 2005 | Journal of Nanjing Medical University2005，19，4： | 0 |
| 16 | Paclitaxel and cisplatin with or without cetuximab in metastatic esophageal squamous cell carcinoma:a randomized,multicenter phase II trial显示文摘Lack of effective targeted therapy in metastatic esophageal squamous cell carcinoma(ESCC)underscores the urgent need for identifying new treatment approaches for this challenging disease.We sought to assess the addition of cetuximab to paclitaxel-cisplatin chemotherapy for first-line treatment in patients with metastatic ESCC.In this randomized,multicenter,open-label,phase II clinical trial,patients were randomized to receive paclitaxel-cisplatin(TP)(paclitaxel[175 mg/m^(2) intravenously(i.v.)on day 1 of every 3-week cycle]and cisplatin[75 mg/m^(2) i.v.on day 1 of every 3-week cycle])and TP plus cetuximab(CTP)(cetuximab,400 mg/m^(2) i.v.on day 1 of week 1,followed by 250 mg/m^(2) weekly). | Zhihao Lu Yanqiao Zhang Qingxia Fan Yueyin Pan Da Jiang Ping Lu Jingdong Zhang Xianglin Yuan Jifeng Feng Shujun Yang Wenbin Yue Lin Zhao Yunhua Xu Jinhua Luo Lin Shen | 2022 | The Innovation2022，3，3： | 0 |
| 17 | Governing glutaminolysis by regulation of glutaminase succinylation显示文摘Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,succinylation,crotonylation,propionylation,butyrylation,glutarylation,malonylation,β-hydroxybutyrylation,and 2-hydroxyisobutyrylation in histones and other proteins(Li et al.,2018a;Xu et al.,2021).Among these acylations,succinylation is a commonly occurred modification,and histone H3K79 succinylation is identified in the transcription start sites of more than 7,000 genes,implying its critical role in the expression regulation of a large number of genes(Wang et al.,2017).Protein succinylation requires the highenergy metabolite,succinyl-coenzyme A(CoA). | Qingxia Ma Hongfei Jiang Leina Ma Ying Meng Dong Guo Yingying Tong Zhimin Lu | 2022 | Protein & Cell2022，13，3： | 0 |
| 18 | Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer显示文摘Sonodynamic therapy(SDT)has aroused considerable momentum in cancer therapy due to its abilities of deep penetration,low toxicity,and noninvasion,while insufficient tumor accumulation of sonosensitizers is a major obstacle for SDT effect.Here,we developed a 4T1 cancer cell-macrophage hybrid membrane(HM)-camouflaged sonosensitizer nanoplatform by encapsulating photochlor(HPPH)-loaded albumin nanoparticles(PHNPs).The experimental results proved that the HM-coated biomimetic NPs(PHNPs@HM)could express the characteristic membrane proteins of both cancer cells and macrophages,remarkedly enhancing the effective targeting and endocytosis to 4T1 cells through homologous adhesion recognition and immune escaping.Meanwhile,as a novel sonosensitizer,HPPH could generate amount of reactive oxygen species(ROS)under ultrasound(US)irradiation and exhibit obvious SDT efficiency to inhibit 4T1 tumor growth through ROS-induced cell apoptosis.This study provides a novel and multifunctional biomimetic sonosensitizer system to enhance SDT efficiency. | Lishan Zhang Ting Yin Baozhen Zhang Chong Yan Chengyu Lu Lanlan Liu Ze Chen Hui Ran Qingxia Shi Hong Pan Aiqing Ma Lintao Cai | 2022 | Nano Research2022，15，5： | 0 |
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