|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 3 | Role of the crystallite phase of TiO2 in heterogeneous photocatalysis for phenol oxidation in water显示文摘 | Ding Z Lu G Q Greenfield P F | 2000 | J Phys Chem B2000，104，19： | 1 |
| 4 | Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats 显示文摘 | Yang X F Wang N P Lu W H | 2003 | Acta Pharmacol Sin2003，24，10： | 1 |
| 5 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 6 | Characterization of a novel thermophilic lipase with positional non-specificity from Burkholderia cepacia显示文摘 | Lu Y P Lu F X Wang X | 2009 | Ann Microbiol2009，59，3： | 1 |
| 7 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 8 | Electronic structure and thermal properties of doped CaMnO3 systems显示文摘 | ZHANG F P ZHANG X LU Q M | 2011 | Journal of Alloys and Compounds2011，509，10： | 1 |
| 9 | A novel alkaline and low-temperature lipase of Burkholderia cepacia isolated from Bohai in China for detergent formulation 显示文摘 | Wang H K Liu R J Lu F P | 2009 | Annals of Microbiology2009，59，1： | 1 |
| 10 | CPW-fed slot-loop coupled patch antenna on narrow substrate 显示文摘 | LU S W HUANG T F HSU P | 1999 | Electron Lett1999，35，： | 1 |
| 11 | Assessment of liver tumor response by high-field (3 T) MRIafter radiofrequency ablation:short-and midterm evolution of diffusion parameters within the ablation zone显示文摘 | Lu TL Becce F Bize P | 2012 | Eur J Radiol2012，81，9： | 1 |
| 12 | Activated anti-tumor immu- nity in cancer patients after high intensity focused ultrasound ablation显示文摘 | Wu F Wang Z B Lu P | 2004 | Ultrasound Med Biol2004，30，9： | 1 |
| 13 | Preparation and high temperature thermoelectric properties of Caa-, Ag, Co409+a oxides 显示文摘 | Zhang F P Zhang X Lu Q M | 2011 | Solid State Ionies2011，201，1： | 1 |
| 14 | First report of twig canker on peach caused by Phomopsis amygdale in China显示文摘 | DAI F M ZENG R LU J P | 2012 | Plant disease2012，96，2： | 1 |
| 15 | Does the anti-arrhythmic effect of ischemic preconditioning in rat sin-volve the L-arginine nitric oxide pathway显示文摘 | Lu HR Remeysen P Declerck F | 1995 | J Cardio Vasc Pharmacol1995，25，4： | 1 |
| 16 | Genetic purity testing of two-line hybrid rice seeds by ultrathin-layer isoelectric focusing of proteins显示文摘 | Zhao T Yan M Lu Y P Yang F Huang J Wang X F | 2005 | Seed Science and Technology2005，33，： | 1 |
| 17 | Extracellular enzyme activities during regulated hydrolysis of high-solid organic wastes显示文摘 | Zhang B He P J Lu F | 2007 | Water Research2007，41，19： | 1 |
| 18 | Field Simulation of in Situ Water Content and Temperature Changes Due to Ground-atmospheric Interactions 显示文摘 | Cui Y J Lu Y F Delage P | 2005 | Geotechnique2005，55，55： | 1 |
| 19 | Unsupervised texture segmentation via wavelet transform显示文摘 | Lu C S Cheng P C Chen C F | 1996 | Pattern Recognition1996，30，5： | 1 |
| 20 | Non-linearly dynamicmodeling of an axially moving beam with a tip mass显示文摘 | Fung R F Lu P Y Tseng C C | 1998 | Journal of Sound and Vibration1998，218，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员