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| 1 | 100%RAP的温拌再生沥青混合料的路用性能研究显示文摘沥青路面施工行业一直存在较大的节能减排的压力。一方面可以通过降低沥青混合料的拌和、摊铺温度来实现;另一方面,废旧沥青路面材料(RAP)的回收也是一个可行方案,既可减少废物的生产,同时又有利于减少资源的消耗。该文开展了一项温拌沥青配合使用RAP集料的研究:在低于常规热拌混合料工艺温度的条件下,生产含有100%RAP温拌再生沥青混合料。使用100%RAP和不同乳化沥青含量制备几种温拌再生沥青混合料(WMRA),并通过室内试验对它们的性能进行了评估,如水敏感性、劲度模量、抗疲劳性能和抗车辙性能。结果表明:这些WMRA可替代常规热拌沥青混合料用于公路路面。 | 肖庆一 张靖洁 李宁利 张萌骐 Marisa Dinis-Almeida Joo CastroGomes Cesare Sangiorgi Salah E.Zoorob Márcia Lopes Afonso | 2017 | 中外公路2017，37，3： | 6 |
| 2 | No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil显示文摘AIM:To investigate the association between human papillomavirus(HPV)and esophageal squamous cell carcinoma(ESCC)in southern Brazil.METHODS:We studied 189 esophageal samples from125 patients from three different groups:(1)102 biopsies from 51 patients with ESCC,with one sample from the tumor and another from normal esophageal mucosa distant from the tumor;(2)50 esophageal biopsies from 37 patients with a previous diagnosis of head and neck squamous cell carcinoma(HNSCC);and(3)37 biopsies from esophageal mucosa with normal appearance from 37 dyspeptic patients,not exposed to smoking or alcohol consumption.Nested-polymerase chain reaction(PCR)with the MY09/11 and GP5/6 L1primers was used to detect HPV L1 in samples fixed in formalin and stored in paraffin blocks.All PCR reactions were performed with a positive control(cervicovaginal samples),with a negative control(Human Genomic DNA)and with a blank reaction containing all reagents except DNA.We took extreme care to prevent DNA contamination in sample collection,processing,and testing.RESULTS:The histological biopsies confirmed the diagnosis of ESCC in 52 samples(51 from ESCC group and 1 from the HNSCC group)and classified as well differentiated(12/52,23.1%),moderately differentiated(27/52,51.9%)or poorly differentiated(7/52,13.5%).One hundred twenty-eight esophageal biopsies were considered normal(51 from the ESCC group,42 from the HNSCC group and 35 from dyspeptic patients).Nine had esophagitis(7 from the HNSCC and 2 from dyspeptic patients).Of a total of 189 samples,only 6 samples had insufficient material for PCR analysis:1 from mucosa distant from the tumor in a patient with ESCC,3from patients with HNSCC and 2 from patients without cancer.In 183 samples(96.8%)GAPDH,G3PDH and/orβ-globin were amplified,thus indicating the adequacy of the DNA in those samples.HPV DNA was negative in all the 183 samples tested:52 with ESCC,9 with esophagitis and 122 with normal esophageal mucosa.CONCLUSION:There was no evidence of HPV infection in different ESCC from southern Brazil. | Luís Carlos Moreira Antunes Joo Carlos Prolla Antonio de Barros Lopes Marta Pires da Rocha Renato Borges Fagundes | 2013 | World Journal of Gastroenterology2013，19，39： | 4 |
| 3 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 4 | High C-reactive protein in Crohn’s disease patients predicts nonresponse to Infliximab treatment显示文摘 | Fernando Magro Eduardo Rodrigues-Pinto Jo?o Santos-Antunes Filipe Vilas-Boas Susana Lopes Amadeu Nunes Claudia Camila-Dias Guilherme Macedo | 2013 | Journal of Crohn’s and Colitis2013，，： | 2 |
| 5 | Multiresponse Optimization and Pareto Frontiers显示文摘 | Nuno Ricardo Costa Jo?o Louren?o Zulema Lopes Pereira | 2011 | Qual Reliab Engng Int2011，，7： | 1 |
| 6 | Olmesartan decreases IL-1βand TNF-αlevels;downregulates MMP-2,MMP-9,COX-2,and RANKL;and upregulates OPG in experimental periodontitis显示文摘 | Araújo AA Lopes de Souza G Souza TO | 2013 | Naunyn Schmiedebergs Arch Pharmacol2013，386，10： | 1 |
| 7 | Application of Mid- and Near-Infrared Spectroscopy for the Control and Chemical Evaluation of Brine Solutions and Traditional Sea Salts显示文摘 | Andrea C. Galvis-Sánchez Inês C. Santos Raquel B. R. Mesquita Jo?o A. Lopes António O. S. S. Rangel Ivonne Delgadillo | 2013 | Food Analytical Methods2013，，2： | 1 |
| 8 | Early flow propagation velocity for assessment of diastolic function in myocardial infarction treated with acute reperfusion显示文摘 | Lopes LR Joo I Vinhas H | 2008 | Rev Port Cardiol2008，27，1： | 1 |
| 9 | Gastrointestinal Symptoms and Nutritional Status in Women and Men on Maintenance Hemodialysis显示文摘 | Luciana Ferreira Silva Gildete Barreto Lopes Cácia Mendes Matos Katherine Quadros Brito Maurício Kauark Amoedo Matheus Freitas Azevedo Meiry Jane Sá Araújo Márcia Silva Martins Antonio Alberto Lopes | 2012 | Journal of Renal Nutrition2012，，3： | 1 |
| 10 | Olmesartan decreases IL-1β and TNF-αlevels;downregulates MMP-2,MMP-9 ,COX-2,and RANKL;and upregulates OPG in experimental periodontitis显示文摘 | Araújo AA Lopes de Souza G Souza TO | 2013 | Naunyn Schmiedebergs Arch Pharmacol2013，386，10： | 1 |
| 11 | Validation of the Century model to estimate the impact of agriculture on soil organic carbon in Southern Brazil显示文摘 | Elisandra Solange Oliveira Bortolon Jo?o Mielniczuk Carlos Gustavo Tornquist Fabíola Lopes Homero Bergamaschi | 2011 | Geoderma2011，，： | 1 |
| 12 | Control of stomatal aperture and carbon uptake by deficit irrigation in two grapevine cultivars显示文摘 | Claudia R. de Souza Jo?o P. Maroco Tiago P. dos Santos M. Lucília Rodrigues Carlos Lopes Jo?o S. Pereira M. Manuela Chaves | 2004 | Agriculture Ecosystems and Environment2004，，2： | 1 |
| 13 | Disseminated cutaneous herpes simplex infection in a patient with Crohn’s disease under azathioprine and steroids: First case report and literature review显示文摘 | Jo?o Santos-Antunes Candida Abreu Fernando Magro Rosa Coelho Filipe Vilas-Boas Patrícia Andrade Susana Lopes Guilherme Macedo | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 14 | 'All-on-4' immediate-function concept for completely edentulous maxillae:a clinical report on the medium (3 years) and long-term (5 years) outcomes显示文摘 | Maló P de Araújo Nobre M Lopes A | | 0，，1： | 1 |
| 15 | Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial显示文摘 | Renato D Lopes Sana M Al-Khatib Lars Wallentin Hongqiu Yang Jack Ansell M Cecilia Bahit Raffaele De Caterina Paul Dorian J Donald Easton Cetin Erol Justin A Ezekowitz Bernard J Gersh Christopher B Granger Stefan H Hohnloser John Horowitz Elaine M Hylek Jo | 2012 | The Lancet2012，，9855： | 1 |
| 16 | Retroperitoneal and Lateral Pelvic Lymphadenectomy Mapped by Lymphoscintigraphy for Rectal Adenocarcinoma Staging显示文摘 | Quadros CA Lopes A Ara jo L | | 0，，08： | 1 |
| 17 | Validation of the Century model to estimate the impact of agriculture on soil organic carbon in Southern Brazil显示文摘 | Elisandra Solange Oliveira Bortolon Jo?o Mielniczuk Carlos Gustavo Tornquist Fabíola Lopes Homero Bergamaschi | 2011 | Geoderma2011，，： | 1 |
| 18 | Road paving, fire regime feedbacks, and the future of Amazon forests显示文摘 | Daniel Nepstad Georgia Carvalho Ana Cristina Barros Ane Alencar Jo?o Paulo Capobianco Josh Bishop Paulo Moutinho Paul Lefebvre Urbano Lopes Silva Elaine Prins | 2001 | Forest Ecology and Management2001，，3： | 1 |
| 19 | Optimal operation and hydro storage sizing of a wind–hydro power plant显示文摘 | Edgardo D. Castronuovo Jo?o A. Pe?as Lopes | 2004 | International Journal of Electrical Power and Energy Systems2004，，10： | 1 |
| 20 | Nodular infection of the hair caused by Malassezia furfur显示文摘 | Lopes JO Alves SH Benevenga JP | 1994 | Mycopathologia1994，125，3： | 1 |
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