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| 1 | MiR-375 suppresses invasion and metastasis by direct targeting of SHOX2 in esophageal squamous cell carcinoma显示文摘食道的有鳞的房间癌(ESCC ) 是在中国的最普通的组织学的类型。MicroRNAs 内长地在哺乳动物被表示并且由指向潜在的下游的基因在肿瘤侵略和转移起一个重要作用。在现在的学习, microarray 分析证明那 miR-375 表情是显然在 ESCC 的 downregulated 与那相比在正常食道的上皮纸巾。然后,酶记者试金证明 SHOX2 是 miR-375 的直接下游的目标,这个相互作用被营救实验证实。量的聚合酶链反应结果也证明那 SHOX2 表情是在 ESCC 房间和纸巾的 upregulated。进一步的分析证明 SHOX2 在 vivo 并且在 vitro 导致了 ESCC 的增长,侵略,和转移。而且,在 miR-375 和 SHOX2 之间的相互作用影响了 epithelial-to-mesenchymal 转变。我们断定 miR-375 可以由直接指向 SHOX2 压制 ESCC 的侵略和转移。miR-375/SHOX2 轴可以是为 ESCC 的一个新奇治疗学的目标。 | Jun Yi Li Jin Jing Chen BingFeng Zhenyue He Longbang Chen Haizhu Song | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 11 |
| 2 | MiR-630 inhibits invasion and metastasis in esophageal squamous cell carcinoma显示文摘食道的有鳞的房间癌(ESCC ) 在最好攻击的恶意之中并且在中国有高发生。MicroRNAs (miRNAs ) 是调整多重 tumorigenic 过程的小内长的 RNA,包括增长,侵略,转移和预后。用 miRNA 表示 proling 分析,我们发现 miR-630 在配对的正常食道的纸巾与那相比在三件 ESCC 织物样品是显著地下面调整的。微分 miR-630 表示随后用量的即时 PCR 被证实。决定 miR-630 下面规定是否能被看作诊断指示物和不利预示的因素,我们与 ESCC 在病人调查了在 miR-630 和 clinicopathological 特征之间的协会。减少的 miR-630 表示总的来说与穷人被联系,这被发现在这些病人的幸存。另外,我们也由指向蛞蝓探索了 miR-630 的生物功能并且调查了在 miR-630 表示和上皮间充质的转变(EMT ) 之间的关联在 vivo 并且在 vitro 的前进。,宫外的 miR-630 表示能禁止增长,侵略和转移 miR-630 击倒的导致的增长,侵略,转移和 EMT 特点。总的来说,我们的学习在 ESCC 作为一个批评新奇调节的人为 miR-630 支持一个角色。 | Li Jin Jun Yi Yanping Gao Siqi Han Zhenyue He Longbang Chen Haizhu Song | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 11 |
| 3 | Bevacizumab improves the antitumor efficacy of adoptive cytokine-induced killer cells therapy in non-small cell lung cancer models显示文摘 | Leilei Tao Guichun Huang Shujing Shi Longbang Chen | 2014 | Medical Oncology2014，，1： | 2 |
| 4 | Survivin: a potentialprognostic marker and chemoradiotherapeutic target for colorectalcancer显示文摘 | Xiaoyuan C Longbang C Jinghua W | 2010 | Ir J Med Sci2010，179，3： | 1 |
| 5 | Review of mesenchymal stem cells and tumors:executioner or coconspirator?显示文摘 | FENG Bing CHEN Longbang | 2009 | Cancer Biother Radiopharm2009，24，6： | 1 |
| 6 | Survivin : a potential prognostic maeker and chemoradiotherapeutie target for eolorectal cancer显示文摘 | Xiaoyuan C Longbang C Jinghua W | 2010 | J Med Sci2010，179，3： | 1 |
| 7 | miRNA-200c increases the sensitivity of breast cancer cells to doxorubicinthrough the suppression of E-cadherin-mediated PTEN/Akt signaling显示文摘 | Yong Chen Ying Sun Longbang Chen Xingxiang Xu Xizhi Zhang Buhai Wang Lingfeng Min Wei Liu | 2013 | Molecular Medicine Reports2013，，5： | 1 |
| 8 | Molecular Mechanism for COX-2 in Carcinogenesis显示文摘 | Guan Xiaoxiang Chen Longbang | 2004 | Chin J Cancer Prev Treat2004，11，5： | 1 |
| 9 | Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma显示文摘 | Guichun Huang Longbang Chen | 2010 | Journal of Cancer Research and Clinical Oncology2010，，8： | 1 |
| 10 | Mutations of phosphorylation sites SerlO and Thr187 of P27^kipl abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line 显示文摘 | Guan Xiaoxiang Chen Longbang Wang Jinghua | 2006 | Biochem Biophys Res Commun2006，347，： | 1 |
| 11 | p16 promoter hypermethylation is associated with increased breast cancerrisk显示文摘 | Li Wang Lin Tang Ruilian Xie Weiwei Nie Longbang Chen Xiaoxiang Guan | 2012 | Molecular Medicine Reports2012，，4： | 1 |
| 12 | Decreased miRNA-148a is associated with lymph node metastasis and poorclinical outcomes and functions as a suppressor of tumor metastasis in non-smallcell lung cancer显示文摘 | Yong Chen Lingfeng Min Xizhi Zhang Suwei Hu Buhai Wang Wei Liu Rui Wang Xuewen Gu Weigan Shen Houning Lv Jing Zou Yuexiang Chen Xingxiang Xu Longbang Chen | 2013 | Oncology Reports2013，，4： | 1 |
| 13 | Mutations of phosphorylation sites Ser10 and Thr187 of P27^kip1 abolish cytoplasmic redistribution but do not abrogate GO/1 phase arrest in the HepG2 cell hne显示文摘 | Guan Xiaoxiang Chen Longbang Wang Jinghua | 2006 | Biochem Biophys Res Commun2006，347，： | 1 |
| 14 | p16 promoter hypermethylation is associated with increased breast cancerrisk显示文摘 | Li Wang Lin Tang Ruilian Xie Weiwei Nie Longbang Chen Xiaoxiang Guan | 2012 | Molecular Medicine Reports2012，，4： | 1 |
| 15 | 局部热疗联合腔内化疗对恶性胸腔积液的疗效观察(英文)显示文摘Objective: The aim of our study was to assess the efficacy of regional hyperthermia combined with intrapleural chemotherapy and to evaluate the effect on the immunologic cells and vascular endothelial growth factor (VEGF) in patients with malignant pleural effusion. Methods: The 102 patients with malignant pleural effusion were included in this study: 52 patients undergoing regional hyperthermia with intrapleural chemotherapy (HICT), and 50 patients treated with intrapleural chemotherapy (ICT). Chemotherapy was administered into the thoracic cavity weekly through a tube with CDDP (dose = 40 mg/m2), and hyperthermia was performed twice a week for 60 minutes following the ICT. We evaluated the response rates and side-effects after 4 weeks. Before and after the treatment, T cell subsets and NK cells were detected by flow cytometry and VEGF was measured with ELISA kits. Results: Compared HICT to ICT, the overall response rates of the whole group, breast cancers and lung cancers were 80.8% vs 54% (P < 0.01), 86.7% vs 56.3% (P > 0.05) and 78.4% vs 52.9% (P < 0.05) respectively. The ratios of CD4+, CD4+/CD8+ and NK cells increased and the concentration of VEGF decreased more significantly after HICT. Conclusion: We concluded that combined regional hyperthermia with intrapleural chemotherapy could control the malignant pleural effusion effectively with mild toxicity. The levels of the T cell subset, NK cells and VEGF in both blood and effusion changed obviously. | Haizhu Song Longbang Chen Jinghua Wang Qu Zhang Xiaoyuan Chu Huaicheng Geng Xiaoxiang Guan | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，6： | 0 |
| 16 | 吉非替尼一线治疗细支气管肺泡癌致出血性膀胱炎(英文)显示文摘A 45-year-old man with bronchioloalveolar carcinoma was treated with gefitinib. The most severe side effect was hemorrhagic cystitis but he had a dramatic response. | Haizhu Song Longbang Chen | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，6： | 0 |
| 17 | Ezrin和Survivin在非小细胞肺癌的表达及其相关性研究(英文)显示文摘Objective: The aim of this study was to explore expression and correlation of Ezrin and survivin in non-small cell lung cancer (NSCLC). Methods: Expression of Ezrin and survivin were detected and analyzed by Envision method of immu- nohistochemical staining in 86 NSCLC. Results: The strong expression rate of Ezrin in NSCLC was 60.5% and significantly correlated with lymph node metastasis (P < 0.05), but no associated with gender, histologic subtype, TNM stages, differen- tiation and smoking. Meanwhile, the positive expression rate of survivin in NSCLC was 65.1% and significantly correlated with TNM stages and lymph node metastasis (P < 0.05), but no associated with gender, histologic subtype, differentiation and smoking. And expression of Ezrin and survivin were positively correlated in NSCLC (r = 0.384). Conclusion: Ezrin and survivin may play synergetic roles in the process of carcinogenesis of NSCLC, and their expression may be significantly associated with NSCLC metastasis. Detection of Ezrin and survivin may be valuable for diagnosing lung cancer metastasis and providing evidence for clinical treatment. | Jinghua Wang Min Zhang Longbang Chen Weisun Huang Henghui Ma | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，7： | 0 |
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