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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-kappaB signaling pathway in human hepatoeellular carcinoma cells显示文摘 | Liang J A Wu S L Lo H Y | 2009 | Mol Pharmacol2009，75，1： | 1 |
| 3 | Different patterns of atrial remodeling after catheter ablation of chronic atrial fibrillation 显示文摘 | LO L W TSAO H M LIN Y J | 2011 | J Cardiovasc Electrophysiol2011，22，4： | 1 |
| 4 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 5 | Diaehronous uplift of the Tibetan Plateau starting 40 Myr ago显示文摘 | Chung S L Lo C H Lee T Y | 1998 | Nature1998，394，： | 1 |
| 6 | Power systems fault diagnosis us- ing Petri nets显示文摘 | Lo K L Ng H S Trecat J | 1997 | IEE Proceddings-Generation Transmis- sion and Distribution1997，144，3： | 1 |
| 7 | Review of titania nanotubes synthesized via the hydrothermal treatment:Fabrication,modification,and application显示文摘 | Ou H H Lo S L | | 0，，01： | 1 |
| 8 | High performance thermoelectrics from earth-abundant materials: Enhanced figure of merit in PbS by second phase nanostructures 显示文摘 | Zhao L D Lo S H He J Q | 2011 | Journal of the American Chemical Society2011，133，20： | 1 |
| 9 | Supported Pd/Sn bimetallic nanoparlicles for reductive dechlorination of aqueous trichloroethylene 显示文摘 | Lin C J Liou Y H Lo S L | 2009 | Chemosphere2009，74，： | 1 |
| 10 | Adakites from continental collision zones: Melting of thickened lower crust beneath southern Tibet 显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q Zhang Q | 2003 | Geology2003，31，11： | 1 |
| 11 | Ultrasonic wire-bond quality monitoring using piezoelectric sensor显示文摘 | Or S W CHAN H L W LO V C YUEN C W | 1998 | Sensors and Actuators A: Physical1998，65，1： | 1 |
| 12 | Characteristics and adsorption properties of iron-coated sand显示文摘 | Lo S L Jeng H T Lai C H | 1997 | Water Science and Technology1997，35，7： | 1 |
| 13 | Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)- block-poly(D,L-lactide) polymer nanoparticles显示文摘 | Hsiue G H Lo C L Cheng C H | 2007 | Journal of Polymer Science PartA: Polymer Chemistry2007，45，： | 1 |
| 14 | Inhibition of HIV-1 replication with designed miRNAs expressed from RNA polymerase II promoters 显示文摘 | Lo H L Chang T Yam P | 2007 | Gene Ther2007，14，21： | 1 |
| 15 | The effect of humidity and state of water surfaces on deposition of aerosol particles onto a water surface显示文摘 | LO A K F ZHANG L M SIEVERING H | 1999 | Atmospheric Environment1999，33，28： | 1 |
| 16 | Dynamics of an Ultrasonic Transducer Used for Wire Bonding显示文摘 | Or S W Chan H L W Lo V C at el | 1998 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control1998，45，6： | 1 |
| 17 | Comparison of evidence- based practice between physicians and nurses: a national survey of regional hospitals in Taiwan显示文摘 | Chiu Y W Weng Y H Lo H L | 2010 | J Contin Educ Health Prof2010，30，： | 1 |
| 18 | Recent Developments in Stainless Steels显示文摘 | Lo K H Shek C H Lai J K L | | 0，，： | 1 |
| 19 | c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and-independent mechanisms显示文摘 | LO D GLIMCHER L H | 1998 | J Exp Med1998，188，： | 1 |
| 20 | Vancomycin MIC creep in MRSA isolates from 1997 to 2008 in a healthcare region in Hong Kong显示文摘 | Ho P L Lo P Y Chow K H et a l | 2010 | J Infect2010，60，11： | 1 |
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