| 1 | Novel Function of TNF Cytokines in Regulating Bone Marrow B Cell Survival显示文摘Two newly identified tumor necrosis factor (TNF) family cytokines, B cell activation factor from the TNF family (BAFF) and a proliferation-inducing ligand (APRIL), have recently been shown to enhance the maturation and survival of peripheral B cells. However, whether BAFF and APRIL are expressed in the bone marrow (BM) microenvironment and if these two cytokines modulate early B cell development remain unclear.In the present study, we have detected the abundant expression of BAFF and APRIL transcripts in BM non-lymphoid cells. Low levels of BAFF and APRIL mRNA are also found in developing B cells. Furthermore,we have determined the expression patterns of BAFF receptors during B lymphopoiesis. In cultures, both recombinant BAFF and APRIL significantly promote the survival of precursor B cells whereas only BAFF can suppress apoptosis of immature B cells. These findings suggest that BAFF and APRIL, in addition to their well established role in regulating peripheral B cell growth, can modulate the survival of developing B cells in the BM. Cellular & Molecular Immunology. 2004;1(6):447-453. | MinZhang King-HungKo QueenieLaiKwanLam CherryKamChunLo DanielJiaLinXu LijunShen BojianZheng GopeshSrivastava LiweiLu | 2004 | Cellular & Molecular Immunology2004，1，6： | 1 |
| 2 | The Pre-B Cell Receptor and Its Function during B Cell Development显示文摘The process of B cell development in the bone marrow occurs by the stepwise rearrangements of the V, D, and Jsegments of the Ig H and L chain gene loci. During early B cell genesis, productive IgH chain generearrangement leads to assembly of the pre-B cell receptor (pre-BCR), which acts as an important checkpointat the pro-B/preB transitional stage. The pre-BCR, transiently expressed by developing precursor B cells,comprises the Ig μH chain, surrogate light (SL) chains VpreB and λ5, as well as the signal-transducing heterodimer Igα/Igβ. Signaling through the pre-BCR regulates allelic exclusion at the Ig H locus, stimulates cell proliferation, and induces differentiation to small post-mitotic pre-B cells that further undergo the rearrangement of the IgL chain genes. Recent advances in elucidating the key roles of pre-BCR in B cell development have provided a better understanding of normal B lymphopoiesis and its dysregulated state leading to B cell neoplasia. | MinZhang GopeshSrivastava LiweiLu | 2004 | Cellular & Molecular Immunology2004，1，2： | 1 |
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