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		题名	作者	年代	出处	被引量
	1	Novel Function of TNF Cytokines in Regulating Bone Marrow B Cell Survival显示文摘Two newly identified tumor necrosis factor (TNF) family cytokines, B cell activation factor from the TNF family (BAFF) and a proliferation-inducing ligand (APRIL), have recently been shown to enhance the maturation and survival of peripheral B cells. However, whether BAFF and APRIL are expressed in the bone marrow (BM) microenvironment and if these two cytokines modulate early B cell development remain unclear.In the present study, we have detected the abundant expression of BAFF and APRIL transcripts in BM non-lymphoid cells. Low levels of BAFF and APRIL mRNA are also found in developing B cells. Furthermore,we have determined the expression patterns of BAFF receptors during B lymphopoiesis. In cultures, both recombinant BAFF and APRIL significantly promote the survival of precursor B cells whereas only BAFF can suppress apoptosis of immature B cells. These findings suggest that BAFF and APRIL, in addition to their well established role in regulating peripheral B cell growth, can modulate the survival of developing B cells in the BM. Cellular & Molecular Immunology. 2004;1(6):447-453.	MinZhang King-HungKo QueenieLaiKwanLam CherryKamChunLo DanielJiaLinXu LijunShen BojianZheng GopeshSrivastava LiweiLu	2004	Cellular & Molecular Immunology2004，1，6：	1

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