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| 1 | Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients显示文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations. | Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern | 2017 | World Journal of Gastroenterology2017，23，40： | 4 |
| 2 | Mechanisms ot cytokine induced NO mediated cardiac fibroblast apoplosis显示文摘 | Tian B Liu J Bitterman PB | 2002 | Am J Physiol2002，283，5： | 1 |
| 3 | Core bioactive components Promoting blood circulation in the traditional Chinese medicine Compound Xueshuantong capsule(CXC)based on the relevance analysis between chemical HPLC fingerprint and in vivo biological effects显示文摘 | Liu H Liang JP Li PB | 2014 | PLo S ONE2014，9，11： | 1 |
| 4 | Mechanisms of cytokine induced NO-mediated cardiac fibroblast apoptosis 显示文摘 | Tian B Liu J Bitterman PB | 2002 | Am J Physiol Heart Circ Physiol2002，283，5： | 1 |
| 5 | Endoscopic diagnosis and treat-ment of post- cholecysteclomy syndrome 显示文摘 | Zhou PB Liu FL Yao LQ | 2003 | Hepatobiliary PancreatDis Int2003，2，1： | 1 |
| 6 | Amino acid-induned gene expression profiling in ehmal beta-cell line INS-1 E cells显示文摘 | Liu Z Luo Y Jeppesen PB et a1 | 2011 | Diabetes Metal)Res Rev2011，27，2： | 1 |
| 7 | Transplanted human embryonic neural stem cells survive,migrate,differentiate and increase endogenous nestin expression in adult rat cortical peri-infarction zone显示文摘 | Zhang PB Liu J Liu Y | | 0，，04： | 1 |
| 8 | Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer显示文摘 | Bai L Sagiv Y Liu Y Freigang S Yu KO Teyton L Porcelli SA Savage PB Bendelac A | 2009 | Proc Natl Acad Sci USA2009，106，10： | 1 |
| 9 | Core bioactive components promoting blood circulation in the traditional Chinese medicine Compound Xueshuantong capsule(CXC)based on the relevance analysis between chemical HPLC fingerprint and in vivo biological effects显示文摘 | Liu H Liang JP Li PB | 2014 | PLo S ONE2014，9，11： | 1 |
| 10 | Gene expression profile of multiple myeloma cell line treated by realgar显示文摘 | Wang MC Liu SX Liu PB | 2006 | J Exp Clin Cancer Res2006，25，： | 1 |
| 11 | Mechanisms of cytokine induced NO-mediated cardiac fibroblast apoptosis显示文摘 | Tian B Liu J Bitterman PB | | 0，，05： | 1 |
| 12 | Amino acid-induced gene ex-pression profiling in clonal {3-cell line INS-IE cells 显示文摘 | Liu Z LuoY Jeppesen PB | 2011 | DiabetesMetab Res Rev2011，27，2： | 1 |
| 13 | Mechanisms of cytokine induced NO-mediated cardiac fibroblast apoptosis显示文摘 | Tian B Liu J Bitterman PB | 2002 | Am J Physiol2002，283，5： | 1 |
| 14 | Mechanistic studies on the an-tidiabetic activity of a polysaccharide-rich extract of Radix Ophio-pogonis显示文摘 | DING LW LI PB LIU BS | 2012 | Phytother Res2012，26，1： | 1 |
| 15 | Impact the sorption 显示文摘 | Chi V L Chen V T Liu X of environmental conditions on behavior of Pb (11) onto attapulgite Radioanalytical and Nuclear Chemistry 2 | | Journal of 0130，295，： | 1 |
| 16 | Time dependent changes in diabetic cystopathy in rats include compensated and decompensated bladder function 显示文摘 | Daneshqari F Liu G Imrey PB | 2006 | J Urol2006，176，1： | 1 |
| 17 | Comparative protein binding of naringin and its aglycone naringenin in rat,dog and human plasma显示文摘 | Liu MH Zou W Li PB | 2012 | Afr J Pharm Pharmaco2012，6，12： | 1 |
| 18 | Valproie acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy显示文摘 | Gurpur PB Liu J Burkin DJ | 2009 | Am J Pathol2009，174，3： | 1 |
| 19 | The relationship be- tween cortical inhibition, antipsychotic treatment, and the symptoms of schizophrenia显示文摘 | Liu SK Fitzgerald PB Daigle M | 2009 | Biological Psychiatry2009，65，6： | 1 |
| 20 | Michamism of cytokine induced NO mediated cardiac fibroblast apoptosis 显示文摘 | Tian B Liu J Bitterman PB | 2002 | Am J Physiol Heart Circ Physiol2002，283，5： | 1 |
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