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| 1 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 2 | Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats显示文摘AIM:To investigate the effect of Scutellariae Radix extract(SRE)on ulcerative colitis(UC)in rats induced by dextran-sulfate sodium(DSS).METHODS:Colitis was induced in male Sprague-Dawley(SD)rats(170-180 g)by 4% dextran sulfate sodium(DSS,wt/v;MW 54 000)in drinking water for 8 d.The treated rats received 4% DSS and SRE orally(100 mg/kg per day).Control rats received either tap water or SRE only.Macroscopic assessment which included body weight changes,fecal occult blood and stool consistency were determined daily.At the appointed time,the rats were sacrificed and the entire colons were removed.The colon length and the myeloperoxidase(MPO)activity were measured.The severity of colitis was graded by morphological and histological assessments.The ion transport activity of the colonic mucosa was assessed by electrophysiological technique.RESULTS:Rats treated with oral administration of 4% DSS regularly developed clinical and macroscopic signs of colitis.Treatment with SRE relieved the symptoms,including the reduction in body weight,shortening and ulceration of the colon.Administration of SRE also significantly reduced the histological damage induced by DSS.Moreover,the ISC responses of the colonic mucosato forskolin were suppressed after the induction of colitis.The stimulated ion transport activity of DSS-rats treated with SRE displayed significant improvement in the secretory responsiveness.CONCLUSION:SRE was effective in treating acute DSS-induced ulcerative colitis,as gauged by reduced clinical disease,improved macroscopic and histological damage scores,and enhanced recovery of normal colonic secretory function. | Ho-Lam Chung Grace Gar-Lee Yue Ka-Fai To Ya-Lun Su Yu Huang Wing-Hung Ko | 2007 | World Journal of Gastroenterology2007，13，42： | 6 |
| 3 | Mitochondria as therapeutic targets for cancer stem cells显示文摘Cancer stem cells(CSCs) are maintained by theirsomatic stem cells and are responsible for tumor initiation, chemoresistance, and metastasis. Evidence for the CSCs existence has been reported for a number of human cancers. The CSC mitochondria have been shown recently to be an important target for cancer treatment, but clinical significance of CSCs and their mitochondria properties remain unclear. Mitochondriatargeted agents are considerably more effective compared to other agents in triggering apoptosis of CSCs, as well as general cancer cells, via mitochondrial dysfunction. Mitochondrial metabolism is altered in cancer cells because of their reliance on glycolytic intermediates, which are normally destined for oxidative phosphorylation. Therefore, inhibiting cancer-specific modifications in mitochondrial metabolism, increasing reactive oxygen species production, or stimulating mitochondrial permeabilization transition could be promising new therapeutic strategies to activate cell death in CSCs as well, as in general cancer cells. This review analyzed mitochondrial function and its potential as a therapeutic target to induce cell death in CSCs. Furthermore, combined treatment with mitochondriatargeted drugs will be a promising strategy for the treatment of relapsed and refractory cancer. | In Sung Song Jeong Yu Jeong Seung Hun Jeong Hyoung Kyu Kim Kyung Soo Ko Byoung Doo Rhee Nari Kim Jin Han | 2015 | World Journal of Stem Cells2015，7，2： | 4 |
| 4 | A facile one-step approach to hierarchically assembled core-shell-like MnO2@MnO2 nanoarchitectures on carbon fibers: An efficient and flexible electrode material to enhance energy storage显示文摘层次核心似壳的 MnO 2 nanostructures (NS ) 在碳布(CC ) 上习惯于六角形的 nanoplate 穿的锚 MnO 2(HNPA ) 纤维。NS 被一出新奇一步舞准备电气化学的免职方法。在为 30 min 的 -2.0 V 的外部 cathodic 电压下面,层次核心似壳的 MnO 2-NS-decorated MnO 2 HNPA (MnO 2 NSs@MnO 2 HNPA ) 一致地与可靠粘附在 CC 上被种。阶段纯净和样品的词法性质被各种各样的物理化学的技术描绘。在经常的外部 cathodic 电压, CC 上的 MnO 2 NSs@MnO 2 HNPA 的生长为不同时间时期被带。当为 pseudocapacitors 作为一个灵活、柔韧、没有文件夹的电极利用了时,显示出的 CC 上的层次核心似壳的 MnO 2 NSs@MnO 2 HNPA 清楚地在 1 M Na 2 那么 4 电解质答案。结果显示 CC 上的 MnO 2 NSs@MnO 2 HNPA 在 CC (在 0.5 A/g 当前的密度的 112.1 F/g ) 上与赤裸的 MnO 2 HNPA 的相比与优秀骑车稳定性在 0.5 A/g 的当前的密度有 244.54 F/g 的一个最大的特定的电容。我们相信 pseudocapacitive 电极的优异费用存储表演能主要被归因于有一个大特定的表面区域的层次 MnO 2 NSs@MnO 2 HNPA 积木,提供为有效电气化学的反应的另外的 electroactive 地点。纺织品上的层次 pseudocapacitive 材料的生长的灵巧、单个步的途径基于电极为高效的灵活精力存储设备的制造开创可能性。 | Goli Nagaraju Yeong Hwan Ko Sung Min Cha Sang Hyuk Im Jae Su Yu | 2016 | Nano Research2016，9，5： | 3 |
| 5 | Skin diseases in the Da Qing Diabetes Study:a cross-sectional study显示文摘Background:The prevalence of skin diseases and diabetes mellitus(DM)are prominent around the world.The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM(T2DM)is limited,leading to limited recognition of the correlations between skin diseases and T2DM.Methods:We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st,2016.The subjects were categorized into three groups:Normal glucose tolerance(NGT),impaired glucose tolerance(IGT),and T2DM.The prevalence and clinical characteristics of skin diseases were recorded and investigated.Results:In this cross-sectional study,383 individuals with ages ranging from 53 to 89-year-old were recruited.The overall prevalence of skin diseases was 93.5%,and 75.7%of individuals had two or more kinds of skin diseases.Additionally,there were 47 kinds of comorbid skin diseases in patients with T2DM,of which eight kinds of skin diseases had a prevalence>10%.The prevalence of skin diseases in NGT,IGT,and T2DM groups were 93.3%,91.5%,and 96.6%,respectively;stratified analysis by categories showed a statistically significant difference in'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.The duration of T2DM also significantly associated with the prevalence of'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.Subsequently,the prevalence of'disturbances of pigmentation'was higher in males than females in NGT(P<0.01)and T2DM(P<0.01)groups.In addition,the difference in the prevalence of'disturbances of pigmentation'was also significant in NGT and T2DM groups(P<0.01).Conclusions:There was a high prevalence of skin diseases in the Da Qing Diabetes Study.To address the skin diseases in the Da Qing Diabetes Study,increased awareness and intervention measures should be implemented. | Chang-Bing Shen Xin Qian Rui-Xing Yu Xue-Lei Ji Yin-Juan Shi Jing Gao Cheng-Xu Li Ke-Ke Li Wen-Min Fei Xue Shen Zi-Yi Wang Yang Han Xiao-Li Ning Randy Ko Yi-Hsiang Hsu Xian-Yong Yin Guang-Wei Li Yong Cui | 2021 | Chinese Medical Journal2021，，10： | 2 |
| 6 | Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes显示文摘 | Wen-Liang Yu Wen-Chien Ko Kuo-Chen Cheng Ching-Chien Lee Chien-Cherng Lai Yin-Ching Chuang | 2008 | Diagnostic Microbiology & Infectious Disease2008，，1： | 2 |
| 7 | Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China显示文摘Hyperphenylalaninemia 是在 15 000 实时出生影响约 1 的新陈代谢的最普通的先天的错误之一。在汉语之中, BH4 缺乏导致 hyperphenylalaninemia 比在白种人普通得多。准确诊断为治疗并且基因建议是重要的。在 2000,为苯酮尿的新生的屏蔽由在在整个整个国家的中国的法律是强制的。然而,它还没在香港特别行政区的新生的屏蔽节目被包括,中国。在香港汉语之中的 hyperphenylalaninemia 上的出版数据大部分正在缺乏。我们与严重 6-pyruvoyl-tetrahydropterin synthase (PTPS ) 报导一个 1 岁的香港中国女孩缺乏。病人与婴儿的 hypotonia 介绍了并且作为服的麻痹被误诊。她有的很温和的 hyperphenylalaninemia (95 mol/L ) ,显著地高的 phenylalnine-to-tyrosine 比率(3.1 ) ,和 1109 mlU/L 的提高的催乳激素。基因分析证实了同型结合的已知的引起疾病的变化磅 NM_000317.1:c.259CT;NP_000308.1:p。在 proband 的 P87S。根据我们的本地经验,当 PTPS 缺乏的 hyperphenylalaninemia 线索的估计的流行被报导在 29 542 实时出生,不是本氨基丙酸 hydroxylase 的一个单个案例是 1 时,缺乏被报导了。而且,有在社区以及在医药专业人员之中的继承新陈代谢的疾病的了解的一般缺乏。很经常,临床的怀疑的一个低索引将在诊断,多重不必要、昂贵的调查,延长病态和焦虑导致延期到影响的家庭。我们强烈建议为 hyperphenylalaninemia 屏蔽的那个扩展新生儿应该为在香港特别行政区出生的每个婴儿被实现,中国。 | Chloe Miu Mak Chun-hung Ko Ching-wan Lam Wai-ling Lau Wai-kwan Siu Sammy Pak-lam Chen Chun-yiu Law Chi-kong Lai Chak-man Yu Albert Yan-wo Chan | 2011 | Chinese Medical Journal2011，，16： | 2 |
| 8 | Terrain classification strategy of a quadruped robot for gait transition and adaptation in a field terrain 显示文摘 | Yu S N Ko K J Kim K S | 2013 | Advanced Science Letters2013，19，1： | 1 |
| 9 | Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells显示文摘 | Yu C C Ko F Y Yu C S | 2012 | Int J Oncology2012，41，3： | 1 |
| 10 | Cross aldolization between benzaldehyde and n -heptaldehyde to a - peutylin namaldehyde over calcined Mg - A1 hydrotalcites显示文摘 | JuiI - Yu ShinYi - Shiau Annan- Ko | 2001 | React Kinet Catal Lett2001，172，2： | 1 |
| 11 | Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy 显示文摘 | Ko SH Kwon HS Yu JM | 2010 | Diabet Med2010，7，9： | 1 |
| 12 | Characterization of the thromboxane (TP-) receptor subtype involved inrolpifera- tion in cultured vascular smooth muscle cells of rat显示文摘 | Ko FN Yu SM Kang YF | 1995 | Br JPharmacol1995，116，2： | 1 |
| 13 | A magnetic bead-based serum proteomic fingerprinting method for parallel analytical analysis and micropreparative purification 显示文摘 | Wong MY Yu KO Poon TC | 2010 | Electrophoresis2010，31，10： | 1 |
| 14 | Experimental study of vibration mitigation of bridge stay cables显示文摘 | XU Y L ZHAN S KO J M YU Z | 1999 | Journal of Structural Engineering1999，125，9： | 1 |
| 15 | Prospective evaluation of multidetector-row CT angiography for the diagnosis of vasospasm following subarachnoid hemorrhage:a comparison with digital subtraction angiography显示文摘 | Chaudhary S R Ko N Dillon W P Yu M B Liu S Criqui G I | 2008 | Cerebrovasc Dis2008，25，12： | 1 |
| 16 | Pressure criterion for placement of distal perfusion catheter to prevent limb ischemia during adult extracorporeal life support 显示文摘 | Huang SC Yu HY Ko WJ | 2004 | J Thorac Cardiovasc Surg2004，128，5： | 1 |
| 17 | Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways 显示文摘 | Ko Y J Yu YM Kim GB | 2009 | Eukaryot Cell2009，8，8： | 1 |
| 18 | Heterogeneity of hypoxi- a-mediated decrease in I and increase in (cyt) in pulmonary arterys mooth muscle cells显示文摘 | Platoshyn O Yu Y Ko EA | 2007 | Am J Physiol Lung Cell Mol Physiol2007，293，2： | 1 |
| 19 | Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective effect under oxidative stress显示文摘 | Yu CJ Ko CJ Hsieh CH | 2014 | J Proteomics2014，99，： | 1 |
| 20 | Yield stress of nanocrystalline materials:role of grain grainboundary dislocations,triple junctions and coble creep显示文摘 | Gutkin M Yu Ovid' ko I A | 2004 | Philosophical Magazine2004，84，9： | 1 |
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