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| 1 | Clinical and molecular features of young-onset colorectal cancer显示文摘Colorectal cancer(CRC) is one of the leading causes of cancer related mortality worldwide. Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC syndromes only explain a minority of young-onset CRC cases. There is evidence to suggest that young-onset CRC have a different molecular profile than late-onset CRC. While the pathogenesis of young-onset CRC is well characterized in individuals with an inherited CRC syndrome, knowledge regarding the molecular features of sporadic young-onset CRC is limited. Understanding the molecular mechanisms of young-onset CRC can help us tailor specific screening and management strategies. While the incidence of late-onset CRC has been decreasing, mainly attributed to an increase in CRC screening, the incidence of young-onset CRC is increasing. Differences in the molecular biology of these tumors and low suspicion of CRC in young symptomatic individuals, may be possible explanations. Currently there is no evidence that supports that screening of average risk individuals less than 50 years of age will translate into early detection or increased survival. However, increasing understanding of the underlying molecular mechanisms of young-onset CRC could help us tailor specific screening and management strategies. The purpose of this review is to evaluate the current knowledge about young-onset CRC, its clinicopathologic features, and the newly recognized molecular alterations involved in tumor progression. | Veroushka Ballester Shahrooz Rashtak Lisa Boardman | 2016 | World Journal of Gastroenterology2016，22，5： | 9 |
| 2 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 3 | The Stool DNA Test Is More Accurate Than the Plasma Septin 9 Test in Detecting Colorectal Neoplasia显示文摘 | David A. Ahlquist William R. Taylor Douglas W. Mahoney Hongzhi Zou Michael Domanico Stephen N. Thibodeau Lisa A. Boardman Barry M. Berger Graham P. Lidgard | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 4 |
| 4 | A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Etanercept in the Treatment of Alcoholic Hepatitis显示文摘 | Nicholas C. Boetticher Craig J. Peine Paul Kwo Gary A. Abrams Tushar Patel Bashar Aqel Lisa Boardman Gregory J. Gores William S. Harmsen Craig J. McClain Patrick S. Kamath Vijay H. Shah | 2008 | Gastroenterology2008，，6： | 2 |
| 5 | 769 Novel Methylated DNA Markers Predict Site of Gastrointestinal Cancer显示文摘 | John B. Kisiel William R. Taylor Tracy C. Yab Douglas W. Mahoney Zhifu Sun Sumit Middha Hongzhi Zou Thomas C. Smyrk Yvonne Romero Lisa Boardman Gloria M. Petersen David A. Ahlquist | 2013 | Gastroenterology2013，，5： | 1 |
| 6 | A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Etanercept in the Treatment of Alcoholic Hepatitis显示文摘 | Nicholas C. Boetticher Craig J. Peine Paul Kwo Gary A. Abrams Tushar Patel Bashar Aqel Lisa Boardman Gregory J. Gores William S. Harmsen Craig J. McClain Patrick S. Kamath Vijay H. Shah | 2008 | Gastroenterology2008，，6： | 1 |
| 7 | Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer显示文摘 | Xiaoyi Huang Tiezheng Yuan Meihua Liang Meijun Du Shu Xia Rachel Dittmar Dian Wang William See Brian A. Costello Fernando Quevedo Winston Tan Debashis Nandy Graham H. Bevan Sherri Longenbach Zhifu Sun Yan Lu Tao Wang Stephen N. Thibodeau Lisa Boardman Man | 2014 | European Urology2014，，： | 1 |
| 8 | Increased risk for cancer in patients with the Peutz-Jeghers syndrome 显示文摘 | Lisa A Boardman MD Stephen N Thibodeau P | 1998 | Ann Intern Med1998，128，11： | 1 |
| 9 | <ce:link locator='fx1'/> Colorectal Cancer Risks in Relatives of Young-Onset Cases: Is Risk the Same Across All First-Degree Relatives?显示文摘 | Lisa A. Boardman Bruce W. Morlan Kari G. Rabe Gloria M. Petersen Noralane M. Lindor Sandra K. Nigon Julia Goldberg Steven Gallinger | 2007 | Clinical Gastroenterology and Hepatology2007，，10： | 1 |
| 10 | Clinicopathologic Features and Treatment Outcomes in Cronkhite–Canada Syndrome: Support for Autoimmunity显示文摘 | Seth Sweetser David A. Ahlquist Neal K. Osborn Schuyler O. Sanderson Thomas C. Smyrk Suresh T. Chari Lisa A. Boardman | 2012 | Digestive Diseases and Sciences2012，，2： | 1 |
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