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| 1 | The identities and anti-herpes simplex virus activity of Clinacanthus nutans and Clinacanthus siamensis显示文摘Objective:To distinguish the difference among the Clinacanthus nutans(Burm.f.)Lindau(C.nutans)and Clinacanthus siamensis Bremek(C.siamensis)by assessing pharmacognosy characteristics,molecular aspect and also to evaluate their anti-herpes simplex virus(HSV)type 1 and type 2 activities.Methods:Macroscopic and microscopic evaluation were performed according to WHO Geneva guideline.Stomatal number,stomatal index and palisade ratio of leaves were evaluated.Genomic DNA was extracted by modified CTAB method and ITS region was amplified using PGR and then sequenced.Dry leaves were subsequently extracted with n-hexane,dichloromethane and methanol and antiviral activity was performed using plaque reduction assay and the cytotoxicity of the extracts on Vero cells was determined by MTT assay.Results:Cross section of midrib and stem showed similar major components.Leaf measurement index of stomatal number,stomatal index and palisade ratio of C.nutans were 168.32±29.49,13.83±0.86 and 6.84±0.66,respectively,while C.siamensis were 161.60±18.04,11.93±0.81and 3.37±0.31,respectively.The PCR amplification of ITS region generated the PGR product approximately 700 bp in size.There were 34 polymorphisms within the ITS region which consisted of 11 Indels and 23 nucleotide substitutions.The IC_(50)values of C.nutans extracted with n-hexane,dichloromethane and methanol against HSV-1 were(32.05±3.63)μg/mL,(44.50±2.66)μg/mL,(64.93±7.00)μg/mL,respectively where as those of C.siamensis were(60.00±11.61)μg/mL,(55.69+4.41)μg/mL,(37.39±5.85)μg/mL,respectively.Anti HSV-2 activity of n-hexane,dichloromethane and methanol C.nutans leaves extracts were(72.62±12.60)μg/mL,(65.19±21.45)μg/mL,(65.13±2.22)μg/mL,respectively where as those of C.siamensis were(46.52±4.08)μg/mL,(49.63±2.59)μg/mL,(72.64±6.52)μg/mL,respectively.Conclusions:The combination of macroscopic,microscopic and biomolecular method are able to authenticate these closely related plants and both of them have a potency to be an anti-HSV agent. | Paween Kunsorn Nijsiri Ruangrungsi Vimolmas Lipipun Ariya Khanboon Kanchana Rungsihirunrat | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，4： | 6 |
| 2 | Development of polyurethane foam dressing containing silver and asiaticoside for healing of dermal wound显示文摘Polyurethane foam dressings for dermal wounds were formulated with natural polyols in order to improve the foam characteristics and the release of 2 active agents,silver and asiaticoside(AS)as an antimicrobial agent and an herbal wound healing agent,respectively.The foam was instantly formed by interaction of polyols and diisocyanate.Hydroxypropyl methylcellulose,chitosan and sodium alginate were individually mixed with themain polyols,polypropylene glycol,in the formulation while the active componentswere impregnated into the obtained foam dressing sheets.Although the type and amount of the natural polyols slightly affected the pore size,water sorption-desorption profile and compression strength of the obtained foam sheets,a prominent effect was found in the release of both active components.Among natural polyols formulations,foam sheets with alginate showed the highest silver and AS release.Non-cytotoxicity of these foam sheets to human fibroblast cells was confirmed.Antimicrobial testing on four bacteria strains showed that 1mg/cm^2 silver in formulations with 6%of natural polyols and without natural polyols had sufficient content of the silver release with comparable inhibition zone and significantly larger zone than other formulations.In pig study,the foam dressing with 6%alginate,1mg/cm^2 silver and 5%AS could improve wound healing in both the percentage of the wound closure and histological parameters of the dermal wound without any dermatologic reactions.In conclusion,this innovative foam dressing had potential to be a good candidate for wound treatment. | Nantaporn Namviriyachote Vimolmas Lipipun Yada Akkhawattanangkul Phingphol Charoonrut Garnpimol C.Ritthidej | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 6 |
| 3 | Synthesis and anti-herpes simplex viral activity of monoglycosyl diglycerides显示文摘 | Wicharn Janwitayanuchit Khanit Suwanborirux Chamnan Patarapanich Sunibhond Pummangura Vimolmas Lipipun Tirayut Vilaivan | 2003 | Phytochemistry2003，，7： | 2 |
| 4 | Inhibitoryactivity of oxyresveratrol on wild-type and drug-resistant varicella-zoster virus replication in vitro显示文摘 | Sasivimolphan P Lipipun V Likhitwitayawuid K | 2009 | Antiviral Res2009，84，1： | 1 |
| 5 | Inhibi- tory activity of oxyresveratml on wild-type and drug-resistant vari- eella-zoster virus replication in vitro 显示文摘 | Sasivimolphan P Lipipun V Likhitwitayawuid K | 2009 | Antiviral Res2009，84，1： | 1 |
| 6 | Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo显示文摘 | Vimolmas Lipipun Masahiko Kurokawa Rutt Suttisri Pagorn Taweechotipatr Pornpen Pramyothin Masao Hattori Kimiyasu Shiraki | 2003 | Antiviral Research2003，，3： | 1 |
| 7 | Anti-herpes simplex vi-rus(HSV-1)activity of oxyresveratrol derived from Thai medicinalplant:mechanism of action and therapeutic efficacy on cutaneousHSV-1 infection in mice显示文摘 | Chuanasa T Phromjai J Lipipun V | 2008 | Antiviral Res2008，80，1： | 1 |
| 8 | A new antiviral and antimicrobial sesquiterpene from Glyptopetalum sclerocarpum显示文摘 | Sotanaphun U Lipipun V Suttisri R Bavovada R | 1999 | Planta Med1999，65，3： | 1 |
| 9 | Anti-herpes simplex vi- res ( HSV-1 ) activity of oxyresveratrol derived from Thai medicinal plant:mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice 显示文摘 | Chuanasa T Phromjai J Lipipun V | 2008 | Antiviral Res2008，80，1： | 1 |
| 10 | Inhibitory activity of oxyresveratrol on wild-type and drug-resistant varicella-zoster virus replication in vitro显示文摘 | Sasivimolphan P Lipipun V Likhitwitayawuid K | 2009 | Antiviral Research2009，84，1： | 1 |
| 11 | Anti-herpes simplex virus (HSV-1) activity of oxyresveratrol derived from Thai medicinal plant: Mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice显示文摘 | Taksina C Phromjai J Lipipun V | 2008 | Antiviral Research2008，80，1： | 1 |
| 12 | Inhibitory activity of oxyresveratrol on wild-type and drug-resistant varicella-zoster virus replication in vitro显示文摘 | Pattaraporn Sasivimolphan Vimolmas Lipipun Kittisak Likhitwitayawuid Masaya Takemoto Pornpen Pramyothin Masao Hattori Kimiyasu Shiraki | 2009 | Antiviral Research2009，，1： | 1 |
| 13 | Anti-herpes simplex virus (HSV-1) activity of oxyresveratrol derived from Thai medicinal plant: Mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice显示文摘 | Taksina Chuanasa Jurairatana Phromjai Vimolmas Lipipun Kittisak Likhitwitayawuid Mikiko Suzuki Pornpen Pramyothin Masao Hattori Kimiyasu Shiraki | 2008 | Antiviral Research2008，，1： | 1 |
| 14 | Phenolics with antiviral activity from Millettia Erythrocalyx and Artocarpus Lakoocha显示文摘 | Kittisak Likhitwitayawuid Boonchoo Sritularak Kanokwan Benchanak Vimolmas Lipipun Judy Mathew Raymond F. Schinazi | 2005 | Natural Product Research2005，，2： | 1 |
| 15 | Quinone - methide triterpenoids from Glyptopetalum scleracarpum显示文摘 | Sotanaphun U Suttisri R Lipipun V | 1998 | Phytochemistry1998，49，6： | 1 |
| 16 | Antigenic analysis of Asian birnavirus isolates using monoclonal antibodies 显示文摘 | Lipipun V Caswell-Reno P Hsu Y L Wu J L Tung M C Reno P W Wattanavijarn W Nicholson B L | 1989 | Fish Pathol1989，24，： | 1 |
| 17 | Studies on the constituents of seeds of Pachyrrhizus erosus and their anti herpes simplex virus(HSV) activities显示文摘 | Phrutivorapongkul A Lipipun V Ruangrungsi N | 2002 | Chemical and Pharmaceutical Bulletin2002，50，4： | 1 |
| 18 | Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo显示文摘 | LIPIPUN V KUROKAWA M SUTTISRI R | 2003 | Antiviral Res2003，60，3： | 1 |
| 19 | Studies on the chemical constituents of stem bark of Millettia leucantha: isolated of new chalcones with cytotoxic, antiherpes simplex virus and anti-inflammatory activities显示文摘 | Phrutivorapongkul A Lipipun V Ruangrungsi N | 2003 | Chem Pharm Bull2003，51，2： | 1 |
| 20 | Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo显示文摘 | LIPIPUN V KUROKAWA M SUTTISRI R | 2003 | Antiviral Res2003，60，3： | 1 |
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