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| 1 | Increased ATG5-ATG12 in hepatitis B virus-associated hepatocellular carcinoma and their role in apoptosis显示文摘AIM To investigate autophagy-related genes, particularly ATG12, in apoptosis and cell cycle in hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC) and non-HBV-HCC cell lines.METHODS The expression of autophagy-related genes in HBVassociated hepatocellular carcinoma and non-HBV-HCC cell lines and human liver tissues was examined by quantitative real-time reverse transcriptase-polymerase chain reaction(q RT-PCR) and western blotting. The silencing of target genes was used to examine the function of various genes in apoptosis and cell cycle progression. RESULTS The expression of autophagy related genes ATG5, ATG12, ATG9 A and ATG4 B expression was analyzed in Hep G2.2.15 cells and compared with Hep G2 and THLE cells. We found that ATG5 and ATG12 m RNA expression was significantly increased in Hep G2.2.15 cells compared to HepG 2 cells(P < 0.005). Moreover, ATG5-ATG12 protein levels were increased in tumor liver tissues compared to adjacent non-tumor tissues mainly from HCC patients with HBV infection. We also analyzed the function of ATG12 in cell apoptosis and cell cycle progression. The percentage of apoptotic cells increased by 11.4% in ATG12-silenced Hep G2.2.15 cells(P < 0.005) but did not change in ATG12-silenced HepG 2 cells under starvation with Earle's balanced salt solution. However, the combination blockade of Notch signaling and ATG12 decreased the apoptotic rate of HepG 2.2.15 cells from 55.6% to 50.4%(P < 0.05). CONCLUSION ATG12 is important for HBV-associated apoptosis and a potential drug target for HBV-HCC. Combination inhibition of ATG12/Notch signaling had no additional effect on HepG 2.2.15 apoptosis. | Areerat Kunanopparat Ingorn Kimkong Tanapat Palaga Pisit Tangkijvanich Boonchoo Sirichindakul Nattiya Hirankarn | 2016 | World Journal of Gastroenterology2016，22，37： | 11 |
| 2 | Highly sensitive EGFR mutation detection by specific amplification of mutant alleles 显示文摘 | Leelatian N Boonchoo P Wijitburaphat S | 2013 | Exp Mol Pathol2013，96，1： | 1 |
| 3 | A new bibenzyl from Dendrobium secundum 显示文摘 | Boonchoo S Natthacha D | 2011 | Journal of Biosciences2011，66，56： | 1 |
| 4 | A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus显示文摘 | Kittisak L Boonchoo S | 2001 | J Nat Prod2001，64，： | 1 |
| 5 | Phenolics with antiviral activity from Millettia Erythrocalyx and Artocarpus Lakoocha显示文摘 | Kittisak Likhitwitayawuid Boonchoo Sritularak Kanokwan Benchanak Vimolmas Lipipun Judy Mathew Raymond F. Schinazi | 2005 | Natural Product Research2005，，2： | 1 |
| 6 | Development of a combined technique using a rapid one-step immunochromatographic assay and indirect competitive ELISA for the rapid detection of baicalin 显示文摘 | Madan Kumar Paudel Waraporn Putalun Boonchoo Sritularak | 2011 | Analytica Chimica Acta2011，701，2： | 1 |
| 7 | Activity of fosfomycin against extended-spectrum-β-lactamase-producing Klebsiella pneumoniae and Escherichia coli in Maharaj Nakorn Chiang Mai Hospital显示文摘 | Tharavichitkul P Khantawa B Bousoung V Boonchoo M | 2005 | J Infect Dis Antimicrob Agents2005，22，： | 1 |
| 8 | Chemical transfor- mations of oxyresveratrol(trans-2,4,3', 5' -tetra-hydroxystilbene ) into a potent tyrosinase inhibitor and a strong eytotoxic agent显示文摘 | Kittisak L Acorn S Boonchoo S | 2006 | Bioorganie and Medicinal Chemistry Letters2006，16，21： | 1 |
| 9 | Early and late hearing out comes after CO2 laser stapedotomy 显示文摘 | Boonchoo R Puapermpoonsiri P | 2007 | J Med Assoe Thai2007，90，8： | 1 |
| 10 | Dendroflorin inhibits lung cancer cell migration显示文摘Lung cancer patients have high mortality rate due to the high incidence rate of metastasis. To achieve metastasize, cancer cells require an ability to migrate from initial to secondary site. Therefore, the promising compound with antimigrating effect might be a benefit for cancer metastasis (1)Dendroflorin, a potential active polyphenol compound, is extracted from Dendrobium brymerianum found in Thailand, Burma, Laos, and China. | Kesarin Busaranon Varisa Pongrakhananon Boonchoo Sritularak Pithi Chanvorachote | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
| 11 | The potential effect of gigantol on lung cancer metastasis显示文摘Lung cancer has been one of the most fundamental leading causes of death within the past 10 years[1].The severity of the disease is related to the metastatic potential and aberrant apoptosis of lung cancer cells.Metastasis is the process when cancer cells transport from their original tumor site and establish a secondary tumor elsewhere.These aggressive behaviors comprise their anoikis resistance and their migrate abilities[2].The process of a programmed cell death in an attached condition is called apoptosis whereas anoikis is a cellular mortality in a detached condition. | Thitita Unahabhokha Boonchoo Sritularak Pithi Chanvorachote Varisa Pongrakhananon | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
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