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| 1 | Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery显示文摘Heparosan is a natural precursor of heparin biosynthesis in mammals. It is stable in blood circulation but can be degraded in lysosomes, showing good biocompatibility and long circulation features. So heparosan can be designed as anticancer drug carriers to increase tumor selectivity and improve the therapeutic effect. A novel redox-sensitive heparosancystamine-vitamin E succinate(KSV) micelle system was constructed for intracellular delivery of doxorubicin(DOX). Simultaneously, the redox-insensitive heparosan-adipic acid dihydrazide-vitamin E succinate copolymer(KV) was synthesized as control. DOX-loaded micelles(DOX/KSV) with an average particle size of 90–120 nm had good serum stability and redox-triggered depolymerization. In vitro drug release test showed that DOX/KSV micelles presented obvious redox-triggered release behavior compared with DOX/KV. Cytotoxicity and cell uptake were investigated using MGC80-3 tumor cells and COS7 fibroblast-like cells. The cell survival rate of blank micelles was more than 90%, and the cytotoxicity of DOX/KSV in MGC80-3 cells was higher than in COS7 cells, indicating that the carrier has better biocompatibility and less toxicity side effect. The cytotoxicity of DOX/KSV against MGC80-3 cells was significantly greater than that of free DOX and DOX/KV. Furthermore, compared with DOX/KV in MGC80-3 cells, DOX/KSV micelles uptook more anticancer drugs and then released DOX faster into the cell nucleus. The micelles were endocytosed by multiple pathways, but clathrin-mediated endocytosis was the main pathway. Therefore, heparosan polysaccharide could be a potential option as anticancer carrier for enhancing efficacy and mitigating toxicity. | Lipeng Qiu Lu Ge Miaomiao Long Jing Mao Kamel SAhmed Xiaotian Shan Huijie Zhang Li Qin Guozhong Lv Jinghua Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，1： | 2 |
| 2 | Synthesis, Characterization, and Reactivity of Metalla- Chalcogenirenium Compounds显示文摘Chalcogenirenium cations,featuring an unsaturated three-membered organic ring,are limited but known to be synthesizable from alkynes with bulky electron-donating groups.Metalla-chalcogenirenium compounds have been synthesized as stable compounds through the reactions of a cyclic metal-carbyne complex-metallapentalyne with PhSCI,PhSeCI or PhTeCI.As a result of the high strain in the three-membered metallacycles,the metalla-chalcogenirenium cations react readily with the base or chloride ions.These reactions furnish a series of unprecedented chalcogenirenium cations with intact M=C bonds.The intrinsic stabilization effect of aromaticity is further elucidated by density functional calculations. | Ming Luo Yapeng Cai Xinlei Lin Lipeng Long Hong Zhang Haiping Xia | 2021 | Chinese Journal of Chemistry2021，39，6： | 1 |
| 3 | Microfiber Mach-Zehnder interferometer based on long period grating for sensing applications显示文摘 | TAN Yanzhen SUN Lipeng JIN Long | 2013 | Optics Express(S1094-4087)2013，21，1： | 1 |
| 4 | miR-143 is downregulated in cervical cancer and promotes apoptosis andinhibits tumor formation by targeting Bcl-2显示文摘 | Lipeng Liu Xiaohua Yu Xiaofang Guo Zhi Tian Min Su Yu Long Chunxia Huang Feng Zhou Meiling Liu Xinhua Wu Xiaochun Wang | 2012 | Molecular Medicine Reports2012，，3： | 1 |
| 5 | Transition-metal-switchable divergent synthesis of nitrile-containing pyrazolo[1,5-a]pyridines and indolizines显示文摘Palladium-catalyzed oxidative formal [4 + 1] annulation of pyridine-substituted acrylonitriles toward divergent fused N-heterocycles synthesis is reported. The heterodifunctionalization reaction with Cu(OAc);and urea as the nitrogen source accesses to nitrile-substituted pyrazolo[1,5-a]pyridines in moderate to good yields, while the homodifunctionalization reaction with FeBr;leads to synthesis of nitrilesubstituted indolizines in excellent yields. | Chongjiu Lu Min Ye Min Li Zhijierong Zhang Yuxin He Lipeng Long Zhengwang Chen | 2021 | Chinese Chemical Letters2021，32，12： | 0 |
| 6 | Carbolong Chemistry: Planar CCCCX-Type (X = N, O, S) Pentadentate Chelates by Formal [3+1] Cycloadditions of Metalla-Azirines with Terminal Alkynes显示文摘Three-membered unsaturated rings have been widely utilized in organic synthesis due to their inherent highly strained structures.Although much research has been applied to ring-expansion reactions of such strained ring systems,pathways other than[3+2]cycloadditions have rarely been observed in their reactions with alkynes,and to date,no[3+1]cycloadditions of isolated three-membered unsaturated rings with alkynes have been reported.Here we demonstrate an unprecedented[3+1]cycloaddition in which a fused metalla-azirine is used as a template to generate a series of planar CCCCX-type(X=N,O,S)pentadentate carbolong complexes 3–6.A series of substituted alkynes was tested for further exploration of the scope and mechanism for the[3+1]cycloaddition reactions.Complexes 3–6 represent rare examples of planar pentadentate complexes that assemble fourπ-conjugated fused rings by one bridgehead atom.These novel complexes are thermally stable in air and absorb ultraviolet,visible,and near-infrared light,and thus are potentially applicable in photoelectric devices and pharmaceuticals. | Ming Luo Yuhui Hua Kaiyue Zhuo Lipeng Long Xinlei Lin Zhihong Deng Zhenyang Lin Hong Zhang Dafa Chen Haiping Xia | 2021 | CCS Chemistry2021，3，2： | 0 |
| 7 | Superconductivity of a cuprate with compressed local octahedron显示文摘Since the historical discovery of high Tc superconductivity(HTS)of La2CuO4 in 1986[1],the superconductivity me chanism of copper oxides remains one of the biggest mysteries in the field of condensed matter physics[2-10].High-Tc cuprates crystallize into layered perovskite structure,as well as copper oxygen octahedron coordination.In octahedron symmetry,the 3d orbitals of Cu^2+with a 3d^9 configuration degenerate into two top eg and three lower t2g orbitals. | WenMin Li LiPeng Cao JianFa Zhao XianCheng Wang RunZe Yu YouWen Long QingQing Liu ChangQing Jin | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 0 |
| 8 | Orbital selection of the double [CuO2] layer compound Ca3Cu2O4Cl2显示文摘The discovery of high-temperature copper oxide superconductors(HTS)by Bednorz and Muller[1]in 1986 opened up a new field of superconductivity.Since then,several different families of materials have been discovered with greatly increased superconducting critical temperature(Tc)[2].Oxychloride cuprates,Can+1CunO2wCl2,are one such type of parent compound of high Tc cuprate superconductors.There are two members in this family known so far that can exist at ambient pressure:Ca2CuO2Cl2(single[Cu02]layer CCOC)and Ca3Cu2O4Cl2(double[CuO2]layer CCOC).Both are composed of a[CuO2]plane with the apical oxygen replaced by chlorine atoms. | JianFa Zhao LiPeng Cao WenMin Li Jun Zhang GuangYang Dai Shuang Yu QingQing Liu XianCheng Wang GuoQiang Zhao YaTing Jia Lei Duan YouWen Long Hong-Ji Lin Chien-Te Chen Liu-Hao Tjeng ZhiWei Hu RunZe Yu ChangQing Jin | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，10： | 0 |
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