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| 1 | Highly Configurable Floating-Point FFT IP Core with Reusing Method显示文摘A highly configurable fast Fourier transform intellectual property core (FFT IP core) that can be mounted on Avalon bus of Nios II processor is designed in this paper, by the means of custombuilt components in SOPC Builder. Not only the data number can be configured to 2n and the data width can be configured as integer or floating-point number of 32 bits, but also the number of inner butterfly units is configurable, which can effectively resolve the contradiction between speed and hardware resource occupancy. The IP core is designed by butterfly computing elements of a mixed radix-4 and radix-2 algorithm and applies the inplace addressing scheme and reusing method to reduce hard-ware resources consumption. Functional simulation by Quartus Ⅱplatform proves that the results calculated by FFT IP core are ac-cordant with the Matlab results. Hardware test on DE2 development board by timestamp timer demonstrates that the FFT IP core costs only 34.8 μs to achieve FFT of 512 sampled data with precision of 32-bit floating point. It is demonstrated that the IP core has the advantages of feasible configuration, easy use, and high precision. | LIU Sanjun SUN Linjiao LI Shaowu YI Jinqiao MIAO Yuzhuang | 2013 | Wuhan University Journal of Natural Sciences2013，18，1： | 2 |
| 2 | Effect of Eu 2 O 3 concentration on luminescent properties of Ce/Tb/Eu co-doped calcium borosilicate glass for white LED显示文摘 | Linjiao Ren Xiaohua Lei Xiaoqing Du Lei Jin Weimin Chen Yong'an Feng | 2013 | Journal of Luminescence2013，，： | 1 |
| 3 | Effect of sintering temperature on the luminescent properties of Eu 2+ /Dy 3+ co-doped high silica glass显示文摘 | Linjiao Ren Xiaoqing Du Xiaohua Lei Lei Jin Weimin Chen | 2013 | Journal of Non-Crystalline Solids2013，，： | 1 |
| 4 | Effect of Eu 2 O 3 concentration on luminescent properties of Ce/Tb/Eu co-doped calcium borosilicate glass for white LED显示文摘 | Linjiao Ren Xiaohua Lei Xiaoqing Du Lei Jin Weimin Chen Yong’an Feng | 2013 | Journal of Luminescence2013，，： | 1 |
| 5 | Current research status of tumor cell biomarker detection显示文摘With the annual increases in the morbidity and mortality rates of tumors,the use of biomarkers for early diagnosis and real-time monitoring of tumor cells is of great importance.Biomarkers used for tumor cell detection in body fluids include circulating tumor cells,nucleic acids,protein markers,and extracellular vesicles.Among them,circulating tumor cells,circulating tumor DNA,and exosomes have high potential for the prediction,diagnosis,and prognosis of tumor diseases due to the large amount of valuable information on tumor characteristics and evolution;in addition,in situ monitoring of telomerase and miRNA in living cells has been the topic of extensive research to understand tumor development in real time.Various techniques,such as enzyme-linked immunosorbent assays,immunoblotting,and mass spectrometry,have been widely used for the detection of these markers.Among them,the detection of tumor cell markers in body fluids based on electrochemical biosensors and fluorescence signal analysis is highly preferred because of its high sensitivity,rapid detection and portable operation.Herein,we summarize recent research progress in the detection of tumor cell biomarkers in body fluids using electrochemical and fluorescence biosensors,outline the current research status of in situ fluorescence monitoring and the analysis of tumor markers in living cells,and discuss the technical challenges for their practical clinical application to provide a reference for the development of new tumor marker detection methods. | Liying Jiang Xinyi Lin Fenghua Chen Xiaoyun Qin Yanxia Yan Linjiao Ren Hongyu Yu Lingqian Chang ang Wang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 6 | Single-molecule RNA capture-assisted droplet digital loop-mediated isothermal amplification for ultrasensitive and rapid detection of infectious pathogens显示文摘To minimize and control the transmission of infectious diseases,a sensitive,accurate,rapid,and robust assay strategy for application on-site screening is critical.Here,we report single-molecule RNA capture-assisted digital RT-LAMP(SCADL)for point-of-care testing of infectious diseases.Target RNA was captured and enriched by specific capture probes and oligonucleotide probes conjugated to magnetic beads,replacing laborious RNA extraction.Droplet generation,amplification,and the recording of results are all integrated on a microfluidic chip.In assaying commercial standard samples,quantitative results precisely corresponded to the actual concentration of samples.This method provides a limit of detection of 10 copies mL−1 for the N gene within 1 h,greatly reducing the need for skilled personnel and precision instruments.The ultrasensitivity,specificity,portability,rapidity and user-friendliness make SCADL a competitive candidate for the on-site screening of infectious diseases. | Liying Jiang Xianghao Lan Linjiao Ren Zhiyuan Jin Xuchen Shan Mingzhu Yang Lingqian Chang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 7 | Genetic architecture of leaf morphology revealed by integrated trait module in Catalpa bungei显示文摘Leaves are crucial for maintaining plant growth and development via photosynthesis,and their function is simultaneously regulated by a suite of phenotypic traits.Although much is known about the genetic architecture of individual leaf traits,unraveling the genetic basis of complex leafmorphology remains a challenge.Based on the functional correlation and coordination ofmulti-traits,we divided 15 leaf morphological traits into three modules,comprising size(area,length,width,and perimeter),shape(leaf lobes,aspect ratio,circularity,rectangularity,and the relevant ratios),and color(red,green,and blue)for an ornamental tree species,Catalpa bungei.A total of 189 significant single-nucleotide polymorphisms were identified in the leaves of C.bungei:35,82,and 76 in the size,shape,and color modules,respectively.Four quantitative trait loci were common between the size and shape modules,which were closely related according to phenotype correlation,genetic mapping,and mRNA analysis.The color module was independent of them.Synergistic changes in the aspect ratio,leaf lobe,and circularity suggest that these traits could be the core indicators of the leaf shape module.The LAS and SRK genes,associated with leaf lobe and circularity,were found to function in plant defense mechanisms and the growth of leaves.The associations between the SRK and CRK2 genes and the leaf lobe and circularity traits were further verified by RT-qPCR.Our findings demonstrate the importance of integrating multi-trait modules to characterize leaf morphology and facilitate a holistic understanding of the genetic architecture of intraspecific leaf morphology diversity. | Miaomiao Zhang Bingyang Liu Yue Fei Xiaowei Yang Linjiao Zhao Chaozhong Shi Yueying Zhang Nan Lu Chuangye Wu Wenjun Ma Junhui Wang | 2023 | Horticulture Research2023，10，4： | 0 |
| 8 | Embryological Studies on Narcissus tazetta var.chinensis显示文摘Chinese narcissus(Narcissus tazetta var.chinensis Roem)blooms but has no seeds.Embryological studies on the species were conducted to discover the causes of its sterility.Its anther wall is composed of four layers of cells,and its tapetum is of the secretory type.The cytokinesis of microspore mother cells is of the successive type,and the tetrad is tetrahedral.During meiosis of microspore mother cells,some chromosomes lagged,and several micronuclei were found in tetrads.Only 27.7%of the pollen grains contained full cytoplasm,and 1.3%of them germinated in culture medium.No pollen grain,however,could germinate on the stigma.The ovary is trilocular with axile placenta,and the ovules are bitegmic,tenuinucellate,and anatropous.Its embryo sac is of the polygonum type.Most embryo sacs degenerated,and only about 4.5%of the ovules contained a normal embryo sac with an egg cell,two synergids,three antipodal,and a central cell containing two polar nuclei.One reason for the sterility of Chinese narcissus is the abnormality of microsporogenesis and megasporogenesis,in which only a few functional pollen grains and embryo sacs are produced.The other reason is that the pollen grains cannot germinate on the stigma. | Ge Lili Wu Jian Chen Linjiao Wang Rui Tian Huiqiao | 2006 | Frontiers in Biology2006，1，1： | 0 |
| 9 | Aptamer-induced in-situ growth of acetylcholinesterase-Cu_(3)(PO_(4))_(2)hybrid nanoflowers for electrochemical detection of organophosphorus inhibitors显示文摘Enzyme-inorganic hybrid nanoflowers(HNFs)have shown excellent sensing capabilities due to their large specific surface area as well as the simplicity and mildness of the preparation process.However,coupling HNFs to electrodes to fabricate a uniform and controllable enzymatic electrochemical sensing interface remains a challenge.Here,we proposed an aptamer-induced insitu fabrication strategy for preparing an HNF-based electrochemical sensor with ideal performance.Central to this strategy is the introduction of acetylcholinesterase(AChE)-specific binding aptamer(Apt),which induces the in-situ growth of AChE-copper phosphate(Cu_(3)(PO_(4))_(2))HNFs on the surface of carbon paper(CP).In addition,a dense gold nanoparticle(AuNP)layer was electrodeposited on the CP for anchoring Apt and further extending the electroactive surface area.The prepared AChECu_(3)(PO_(4))_(2)HNF/Apt/AuNP/CP biosensor exhibited a wide detection range from 1 to 107 pM for the four organophosphorus inhibitors,including isocarbophos,dichlorvos,methamidophos,and parathion,with detection limits down to 0.016,0.028,0.071,and 0.113 pM,respectively.With the reactivation of pralidoxime chloride,the electrode can still recover 98.1%of the response after five times of repeated use.In real sample detection,the biosensor achieved high recoveries from 96.45%to 100.13%.The detection target may be extendable to other AChE inhibitors(e.g.,drugs for Alzheimer’s disease).This study demonstrates for the first time the feasibility of using aptamers as an inducer to fabricate an electrochemical enzyme sensing interface in-situ.This strategy can be used to fabricate other enzyme-based biosensors and therefore has broader applications. | Limin Yang Linjiao Qu Xiaolong Zhang Mingming Li Zhen Liu | 2023 | Nano Research2023，16，10： | 0 |
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