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| 1 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 2 | Identification of the novel recessive gene pi55(t) conferring resistance to Magnaporthe oryzae显示文摘The elite rice cultivar Yuejingsimiao 2 (YJ2) is characterized by a high level of grain quality and yield, and resistance against Magnaporthe oryzae. YJ2 showed 100% resistance to four fungal populations collected from Guangdong, Sichuan, Liaoning, and Heilongjiang Provinces, which is a higher frequency than that shown by the well-known resistance (R) gene donor cultivars such as Sanhuangzhan 2 and 28zhan. Segregation analysis for resistance with F 2 and F 4 populations indicated the resistance of YJ2 was controlled by multiple genes that are dominant or recessive. The putative R genes of YJ2 were roughly tagged by SSR markers, located on chromosomes 2, 6, 8, and 12, in a bulked-segregant analysis using genome-wide selected SSR markers with F 4 lines that segregated into 3 resistant (R):1 susceptible (S) or 1R:3S. The recessive R gene on chromosome 8 was further mapped to an interval 1.9 cM/152 kb in length by linkage analysis with genomic position-ready markers in the mapping population derived from an F 4 line that segregated into 1R:3S. Given that no major R gene was mapped to this interval, the novel R gene was designated as pi55(t). Out of 26 candidate genes predicted in the region based on the reference genomic sequence of the cultivar Nipponbare, two genes that encode a leucine-rich repeat-containing protein and heavy-metalassociated domain-containing protein, respectively, were suggested as the most likely candidates for pi55(t). | HE XiuYing LIU XinQiong WANG Li WANGLing LIN Fei CHENG YongSheng CHEN ZhaoMing LIAO YaoPing PAN QingHua | 2012 | Science China(Life Sciences)2012，55，2： | 15 |
| 3 | miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro显示文摘Metastasis is a multistep process involving modification of morphology to suit migration, reduction of tumor cell adhesion to the extracellular matrix, increase of cell mobility, tumor cell resistance to anoikis, and other steps. MicroRNAs are well-suited to regulate tumor metastasis due to their capacity to repress numerous target genes in a coordinated manner, thereby enabling their intervention at multiple steps of the invasion-metastasis cascade. In this study, we identified a microRNA exemplifying these attributes, miR-124, whose expression was reduced in aggressive MDA-MB-231 and SK-3rd breast cancer cells. Down-regulation of miR-124 expression in highly aggressive breast cancer cells contributed in part to DNA hypermethylation around the promoters of the three genes encoding miR-124. Ectopic expression of miR-124 in MDA-MB-231 cells suppressed metastasis-related traits including formation of spindle-like morphology, migratory capacity, adhesion to fibronectin, and anoikis. These findings indicate that miR-124 suppresses multiple steps of metastasis by diverse mechanisms in breast cancer cells and suggest a potential application of miR-124 in breast cancer treatment. | Xiao-Bin Lv Yu Jiao Yanwei Qing Haiyan Hu Xiuying Cui Tianxin Lin Erwei Song Fengyan Yu | 2011 | Chinese Journal of Cancer2011，30，12： | 6 |
| 4 | A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis显示文摘 | Shicheng Su Qiang Liu Jingqi Chen Jianing Chen Fei Chen Chonghua He Di Huang Wei Wu Ling Lin Wei Huang Jin Zhang Xiuying Cui Fang Zheng Haiyan Li Herui Yao Fengxi Su Erwei Song | 2014 | Cancer Cell2014，，5： | 3 |
| 5 | Acidity adjustment of HZSM-5 zeolites by dealumination and realumination with steaming and citric acid treatments显示文摘 | Fang Yu Bao Xiaojun Lin Xiuying | 2006 | Journal of Physical Chemistry B2006，110，15： | 1 |
| 6 | A novel method for enhan- cing on-stream stability of fluid catalytic cracking ( FCC ) gasoline hydro-upgrading catalyst:Post-treatment of HZSM-5 zeolite by com- bined steaming and citric acid teaching显示文摘 | Lin Xiuying Fan Yu Liu Zhihong | 2007 | Catalysis Today2007，125，： | 1 |
| 7 | The isolation of Pi1, an allele at the Pik locus which confers broad spectrum resistance to rice blast显示文摘 | Lixia Hua Jianzhong Wu Caixia Chen Weihuai Wu Xiuying He Fei Lin Li Wang Ikuo Ashikawa Takashi Matsumoto Ling Wang Qinghua Pan | 2012 | Theoretical and Applied Genetics2012，，5： | 1 |
| 8 | Study on the toughening mechanism of rubber toughened epoxy 显示文摘 | Sun Yishi Zhao Shiqi Lin Xiuying | 1986 | Chinese Journal of Polymer Science1986，，3： | 1 |
| 9 | Maternal high salt-diet increases offspring's blood pressure with dysfunction of NO/PKGI signaling pathway in heart tissue显示文摘Background:High salt-diets have become significant threats to human health,resulting in hypertension and cardiovascular diseases.Hypertensive disorders during pregnancy are complicated,since the maternal cardiovascular system undergoes extensive physiological changes during pregnancy.High-salt diets during pregnancy can disturb the intrauterine environment and negatively affect fetal development.Therefore,we explored how high-salt diets during pregnancy could affect the offspring.Methods:Rats were divided into three groups and fed with low,normal,and high salt diets.The offspring were separated into three groups after weaning based on dietary salt concentration.The blood pressure and urine protein content of both dams and offspring were measured.To evaluate cardiac function,we used Masson staining and immunodetection to confirm the fibrosis status.Finally,we extracted protein from cardiac tissue to test the expression levels of the Nitric Oxide(NO)/cGMP-dependent protein kinase I(PKGI)pathway and the angiotensin receptor.Results:High-salt diets increased blood pressure,and offspring previously exposed to high-salt environments were predisposed to hypertension.High-salt diets were also found to induce cardiac fibrosis and exacerbate fibrosis in offspring and alter the epithelial-mesenchymal transition(EMT).Under these conditions,the NO/PKGI pathway was activated in cardiac tissue and the type-1angiotensin II receptor(AT1R)was upregulated,though the type-2 angiotensin II receptor(AT2R)had the opposite effect.Conclusion:High-salt diets induce high blood pressure and increase predisposition to hypertension in offspring.They are accompanied by cardiac fibrosis,which could be caused by the activation of NO/PKGI and upregulation of AT1R. | Minshan Huang Xiuying Li Luwen Ren Lin Huang Jiahong Pan Jinlin Yao Lili Du Dunjin Chen Jingsi Chen | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，2： | 1 |
| 10 | Interfacial Molecular Recognition Between Polysaccharides and Calcium Carbonate During Crystallization显示文摘 | Lin Yang Xiuying Zhang Zhaojiang Liao | 2003 | Journal of Inorganic Biochemistry2003，97，4： | 1 |
| 11 | Interfacial molecular recognition between polysaccharides and calcium carbonate during crystallization 显示文摘 | Yang Lin Zhang Xiuying Liao Zhaojiang | 2003 | Journal of Inorganic Biochemistry2003，97，： | 1 |
| 12 | A novel method for enhancing on - stream stability of fluid catalytic cracking ( FCC ) gasoline hydro- upgrading catalyst: Post- treatment of HZSM -5 zeolite by combined steaming and citric acid leaching显示文摘 | Lin Xiuying Yu Fan Liu Zhihong | 2007 | Catalysis To- day2007，125，34： | 1 |
| 13 | Realumination of dealuminated HZSM- 5 zeolite by citric acid treatment and its application in preparing FCC gasoline hydro - upgrading catalyst 显示文摘 | Fan Yu Lin Xiuying Shi Gang | | Micro- porous and Mesoporous Materials0，98，13： | 1 |
| 14 | A novel method for enhancing on-stream stability of fluid catalytic cracking (FCC) gasoline hydro-upgrading catalyst: Post-treatment of HZSM-5 zeolite by combined steaming and citric acid leaching显示文摘 | Xiuying Lin Yu Fan Zhihong Liu Gang Shi Haiyan Liu Xiaojun Bao | 2007 | Catalysis Today2007，，3： | 1 |
| 15 | An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoY-2 variants显示文摘The wide transmission and host adaptation of SARS-CoV-2 have led to the rapid accumulation of mutations,posing significant challenges to the effectiveness of vaccines and therapeutic antibodies.Although several neutralizing antibodies were authorized for emergency clinical use,convalescent patients derived natural antibodies are vulnerable to SARS-CoV-2 Spike mutation. | Xiaojing Chi Xinhui Zhang Shengnan Pan Yanying Yu Yujin Shi Tianli Lin Huarui Duan Xiuying Liu Wenfang Chen Xuehua Yang Lan Chen Xiaoqian Dong Lili Ren Qiang Ding Jianwei Wang Wei Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 16 | The Warming Climate Aggravates Atmospheric NitrogenPollution in Australia显示文摘Australia is a warm country with well-developed agriculture and a highly urbanized population.How these specific features impact the nitrogen cycle,emissions,and consequently affect environmental and human health is not well understood.Here,we find that the ratio of reactive nitrogen(Nr)losses to air over losses to water in Australia is 1.6 as compared to values less than 1.1 in the USA,the European Union,and China.Australian Nr emissions to air increased by more than 70%between 1961 and 2013,from 1.2 Tg N yr^(-1) to 2.1 Tg N yr^(-1).Previous emissions were substantially underestimated mainly due to neglecting the warming climate.The estimated health cost from atmospheric Nr emissions in Australia is 4.6 billion US dollars per year.Emissions of Nr to the environment are closely correlated with economic growth,and reduction of Nr losses to air is a priority for sustainable development in Australia. | Yi Sun Baojing Gu Hans JMvan Grinsven Stefan Reis Shu Kee Lam Xiuying Zhang Youfan Chen Feng Zhou Lin Zhang Rong Wang Deli Chen Jianming Xu | 2021 | Research2021，，1： | 1 |
| 17 | HVS-based Imperceptibility Evalu- ation for Steganography显示文摘 | Ma Xiuying Lin Jiajun | 2009 | Social Informatics and Telecomm- unications Engineering2009，18，1： | 1 |
| 18 | Human immunodeficiency virus type 1 tat accelerates kaposi sarcoma-associated herpesvirus kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice显示文摘Kaposi sarcoma-associated herpesvirus(KSHV) is necessary but not sufficient to cause Kaposi sarcoma(KS).Coinfection with human immunodeficiency virus type 1(HIV-1), in the absence of antiretroviral suppressive therapy, drastically increases the risk of KS.Previously, we identified that HIV-1 transactivative transcription protein(Tat) was an important cofactor that activated lytic cycle replication of KSHV.Here, we further investigated the potential of Tat to influence tumorigenesis induced by KSHV Kaposin A, a product of KSHV that was encoded by the open reading frame K12(a KSHV-transforming gene).By using colony formation in soft agar, H-3-TdR incorporation, cell cycle, and microarray gene expression analyses, we demonstrated that Tat enhanced proliferation as well as mitogen-activated protein kinase, signal transducer and activator of transcription 3, and phosphatidylinositol 3-kinase/protein kinase B signaling induced by Kaposin A in NIH3T3 cells.Animal experiments further demonstrated that Tat accelerated tumorigenesis by Kaposin A in athymic nu/nu mice.Cells obtained from primary tumors of nude mice succeeded inducing tumors in immunocompetent mice.These data suggest that Tat can accelerate tumorigenesis induced by Kaposin A.Our data present the first line of evidence that Tat may participate in KS pathogenesis by collaborating with Kaposin A in acquired immunodeficiency syndrome(AIDS)-related KS(AIDS-KS) patients.Our data also suggest that the model for Kaposin and Tat-mediated oncogenesis will contribute to our understanding of the pathogenesis of AIDS-KS at the molecular level and may even be important in exploring a novel therapeutic method for AIDS-KS. | Chen, Xiuying Cheng, Lin Jia, Xuemei Yao, Shuihong Lv, Zhigang Qin, Di Fang, Xin Lu, Chun Nanjing Med Univ, Dept Microbiol & Immunol, Nanjing 210029, Peoples R China.Chen, Xiuying Lu, Chun Nanjing Med Univ, Lab Reprod Med, Nanjing 210029, Peoples R China.Chen, Xiuying Lu, Chun Nanjing Med Univ, Key Lab Pathogen Biol Jiangsu Prov, Nanjing 210029, Peoples R China.Chen, Xiuying Lu, Chun Key Lab Lab Med Jiangsu Prov, Nanjing 210029, Peoples R China.Chen, Xiuying Lei, Yongliang Lishui Ctr Dis Control & Prevent, Lishui 323000, Zhejiang, Peoples R China.Cheng, Lin Huanghe Sci & Technol Coll, Dept Microbiol & Immunol, Zhengzhou 450006, Peoples R China.Zeng, Yi Youjiang Med Coll Nationalities, Dept Microbiol & Immunol, Bose 533000, Peoples R China. | 2010 | 南京医科大学学报(自然科学版)2010，30，1： | 1 |
| 19 | Quantitative trait loci (QTL) of stem strength and related traits in a doubled-haploid population of wheat (Triticum aestivum L.)显示文摘 | Lin Hai Huijun Guo Shihe Xiao Guoliang Jiang Xiuying Zhang Changsheng Yan Zhiyong Xin Jizeng Jia | 2005 | Euphytica (-)2005，，1： | 1 |
| 20 | Anti-oxidative effect of zinc in human umbilical cord mesenchymal stem cells显示文摘Human umbilical cord mesenchymal stem cells(HUC-MSCs)are pluripotent and functional in many biological processes,by which releasing secretary factors to promote the self-repairing of damaged tissue or developing into functional cell at local organ.However,there is a high risk that oxidative stress would reduce the pluripotency and factor-secretion during the preparation and transplantation.Therefore,reducing oxidative stress is expected to improve the efficacy of HUC-MSCs therapy.Zinc[Zn] is an essential trace element which involves in the resistance of oxidative stress.To investigate Zn-regulated signaling pathways,we have profiled the gene expression at transcriptome level in primary HUC-MSCs treated with zinc sulfate,followed with GO and KEGG gene enrichment analysis.Zn treatment improved signal pathways for mineral absorption,cell growth,and cell death.Zn deficiency was mimicked by TPEN administration,which suppressed cell proliferation and reduced the expression of HUC-MSCs surface stem cell markers CD73,CD90 and CD105 by flow cytometry.Nuclear factor erythrocyte 2 related factor 2(Nrf2)plays an important role in antioxidant biological processes.In vitro treatment of Zn significantly increased Nrf2 and Sirt3 expression at gene level and protein level respectively.Zn supplementation inhibited TPEN-induced failure of cell survival and reversed the reduction of Nrf2 and Sirt3 expression,which further reduced the production of ROS.Zn successfully presented its antioxidation effect by activating Nrf2/Sirt3 signaling pathway in HUC-MSCs.Zn supplementation may improve the efficacy of HUC-MSCs therapy with reduced oxidative stress. | Xiaodan Lu Yifan Lin Xiuying Lin Qiang Zhang Zihang Wang Xuguang Mi Ruobing Wang Xiaofang Zhang Xu Luan Yan Liu Bing Li YanTan Yanqiu Fang | 2021 | Biophysics Reports2021，7，2： | 0 |
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