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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 3 | Investigation on Uniaxial Tensile Instability of USIBOR1500 Steel Sheets at Elevated Temperature显示文摘In the sheet forming process with stretch, diffuse instability and localized instability usually occur in the process one after another. The necking rate has a great impact on the instability process and the forming limits of the rate sensitive material, such as USIBOR1500 steel sheets at elevated temperature. The available reports about this steel mainly focus on hot uniaxial tensile, martensitic transformation and forming process, but there are few investigations on instability behavior and forming limits. Based on Inoue Kachiro’s flow stress constitutive model at elevated temperature, combined with Swift’s diffuse instability rule and Hill’s localized instability rule, the relation is theoretically deduced between the diffuse necking rate along with the localized necking rate and the exponent of strain rate sensitivity together with the strain rate in the case of the USIBOR1500 steel sheets at elevated temperature. According to the time–temperature characteristics of the hot stamping process, tensile tests of the steel sheets were carried out on Gleeble3800, and the stress–strain curves were obtained at different temperatures and different strain rates. Then the values of the exponent of strain rate sensitivity and the hardening exponent were obtained through fitting the curves by least squares. The tests also helped to provide the distribution laws of the major strain of the specimens and the uniform strains as well as the necking width. The uniform strains obtained from the tests are matched well with the theoretical calculations. | MIN Junying LIN Jianping TIAN Haobin SUN Guohua XU Zhou | 2010 | Chinese Journal of Mechanical Engineering2010，23，1： | 9 |
| 4 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 5 | Spatial pattern and drivers of urbanization in China's mid-level developing urban agglomeration:A case study of Chang-Zhu-Tan显示文摘Urban agglomeration has become the main form of regional spatial organization in China.While most of the existing studies of urban agglomeration in China have focused on the eastern coastal areas,urban agglomeration with mid-level development in the rest of the country has been overlooke1.To better understand the urbanization process of the mid-level developing urban agglomeration,this study investigated the clustering pattern and the drivers of both urban population and firm dynamics during 2005-2015 in the Changsha-Zhuzhou-Xiangtan(Chang-Zhu-Tan)urban agglomeration of China using the methods ofkernel density estimation and geographic detection.Our results show that centralization was obvious,although decentralization also occurred in Chang-Zhu-Tan,and that the spatial agglomeration was promoted by several factors,such as administrative resources,location advantage,labor cost,and consumption capacity.Some problems hindering the development of this region were also discovered:administrative resources played a critical role in urbanization because small towns and villages did not receive enough attention,and the effect of local policy was not as beneficial as expected.These findings partly explain the relatively slow development of mid-level developing urban agglomerations and have important implications for promoting healthier urbanization. | Yanhua He Yi Lin Guohua Zhou Yixuan Zhu Kai Tang | 2021 | Regional Sustainability2021，2，1： | 6 |
| 6 | Numerical Investigation of an Oscillating Airfoil using Immersed Boundary Method显示文摘Based on the immersed boundary method,a numerical simulation for an oscillating airfoil is established and a preliminary analysis of the oscillating airfoil is presented with an emphasis on the physical understanding of fluid-structure interaction.In order to validate the method,two simulation cases:oscillating circular cylinder at low K-C number and two degrees of freedom oscillating cylinder are carried out first and the results are in good agreement with the previous researches.In the oscillating airfoil simulation,it is found that the reduced velocity U* is a very sensitive factor and especially U*~2.8 is the critical stable boundary in the present work.The method shows the predominance of time saving in computational process for such a complicated fluid-structure interaction problem. | Guohua Zhong Lin Du Xiaofeng Sun | 2011 | Journal of Thermal Science2011，20，5： | 5 |
| 7 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 8 | Innovations of phosphorus sustainability:implications for the whole chain显示文摘Phosphorus(P)is a non-renewable resource,therefore ensuring global food and environmental security depends upon sustainable P management.To achieve this goal,sustainable P management in the upstream and downstream sectors of agriculture from mineral extraction to food consumption must be addressed systematically.The innovation and feasibility of P sustainability are highlighted from the perspective of the whole P-based chain,including the mining and processing of P rock,production of P fertilizers,soil and rhizosphere processes involving P,absorption and utilization of P by plants,P in livestock production,as well as flow and management of P at the catchment scale.The paper also emphasizes the importance of recycling P and the current challenges of P recovery.Finally,sustainable solutions of holistic P management are proposed from the perspective of technology improvement with policy support. | Jianbo SHEN Liyang WANG Xiaoqiang JIAO Fanlei MENG Lin ZHANG Gu FENG Junling ZHANG Lixing YUAN Lin MA Yong HOU Tao ZHANG Weifeng ZHANG Guohua LI Kai ZHANG Fusuo ZHANG | 2019 | Frontiers of Agricultural Science and Engineering2019，6，4： | 4 |
| 9 | Toxic Effects of Three Heavy Metallic Ions on Rana zhenhaiensis Tadpoles显示文摘Heavy metal pollution is widespread in some areas of China and results in contamination of land, water, and air with which all living organisms interact. In this study, we used three heavy metallic ions(Cu2+, Pb2+ and Zn2+) to assess their toxicity effects on mortality, blood biomarker and growth traits(body length and body mass) of Rana zhenhaiensis tadpoles. The results showed that the toxicity levels of the three metallic ions were different when conducted with different experiment designs. For acute toxicity tests, Cu2+ was the most toxic with the highest tadpole mortality. The mortalities of tadpoles showed significant differences among the treatments at the same exposure time endpoints(24, 48, 72 and 96h). Results from repeated measures ANOVA indicated that metallic ion concentration, exposure time and their interactions significantly affected the mortalities of R. zhenhaiensis tadpoles. Also, the toxicity effects of all binary combinations of the three metallic ion treatments showed synergism. The half lethal concentrations(LC50) decreased with increasing exposure time during the experimental period, and the safe concentration(SC) values of Cu2+, Pb2+ and Zn2+ were different from each other. Combined and compared LC50 values with previous data reported, it is suggestes that the toxicity levels of metal pollution to anuran tadpoles should be species-and age-related. For blood biomarker tests, Zn2+ was the most toxic with the highest total frequencies of abnormal erythrocytic nucleus. All three metallic ions caused higher abnormal erythrocytic nucleus compared with control groups. In a chronic toxicity test, Pb2+ was the most toxic with lowest growth traits. Survival rate(except for 18 days), total body length and body mass showed significant differences among the treatments. These findings indicated that tadpoles of R. zhenhaiensis should be as a bioindicator of heavy metals pollution. | Li WEI Guohua DING Sainan GUO Meiling TONG Wenjun CHEN Jon FLANDERS Weiwei SHAO Zhihua LIN | 2015 | Asian Herpetological Research2015，6，2： | 3 |
| 10 | Effects of Predation by Invasive Western Mosquitofish(Gambusia affinis) on Survival of Eggs,Embryos and Tadpoles of Pelophylax nigromaculatus and Duttaphrynus melanostictus in South China显示文摘Alien species are one of the most serious threats to the decline and extinction of native amphibian populations. In this study, we examined the predation of invasive Western Mosquitofish Gambusia affinis on the eggs, embryos, and tadpoles of Duttaphrynus melanostictus and Pelophylax nigromaculatus in south China. Our results suggested that the survival of eggs and embryos remaining in the egg capsules of P. nigromaculatus and D. melanostictus was significantly higher than those removed from the egg capsule at 12-h intervals within 72 h in the presence of G. affinis. The survival of P. nigromaculatus eggs and embryos without egg capsules was significantly lower than those of D. melanostictus without egg capsules. The survival of P. nigromaculatus eggs and embryos with egg capsules was significantly higher than those of D. melanostictus with egg capsules from 24 h to 72 h except for 12 h. The survival of D. melanostictus tadpoles was significantly higher than that of P. nigromaculatus tadpoles in the presence of G. affinis. The survival of Gosner stage 26 tadpoles of P. nigromaculatus was significantly higher than that of Gosner stage 30 tadpoles from 12 h to 60 h, but there were no significant differences at 72 h. In contrast, the survival of Gosner stage 26 tadpoles of D. melanostictus was significantly lower than that of Gosner stage 30 tadpoles within 72 h, recording every 12 h. The increasing temperature caused a significant increase in predation by G. affinis on P. nigromaculatus eggs and embryos. The outer jelly capsule surrounding anurans eggs might serve as a mechanical defense against predation by G. affinis due to its large diameter, relatively stationary state and unpalatability. The differences in the vulnerability of P. nigromaculatus and D. melanostictus embryos and tadpoles to G. affinis probably due to differences in the unpalatability, black skin and activity. Based on the magnitude of predation by G. affinis on the eggs, embryos and tadpoles of these two species and the combined impact of temperature, we might speculate that invasive G. affinis and global warming would have more detrimental impacts on population viability of P. nigromaculatus than D. melanostictus in China. | Xiaoli FAN Zhihua LIN Xiang LI Li WEI Guohua DING | 2016 | Asian Herpetological Research2016，7，1： | 3 |
| 11 | Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis显示文摘环境暗示和细胞内部的 bioenergetic 状态深刻地影响细胞内部的 pH (pHi ) 。一个房间怎么对 pHi 变化作出回应维持 bioenergetic 动态平衡,留下逃犯。这里,我们显示出那 Smad5,发信号的形态基因的蛋白质(BMP ) 回答到 pHi 的骨头的一个描绘得好的下游的部件变化。冷、基本或张力亢进的条件增加 pHi,它接着在 Smad5 的 MH1 域以内声言不赞成控告的氨基酸簇,推动它到细胞质的从原子核的重定位。在另一方面,加热,酸或张力减退的条件减少 pHi,堵住 Smad5 的原子出口,并且因此引起它的原子累积。环境变化和 pHi 变化导致的 Smad5 的活跃 nucleocytoplasmic shuttling 独立于 BMP 发信号, carboxyl 终点 phosphorylation 和 Smad4。另外, Smad5 的脱离引起在区别识别了的神经发展过程人的 pluripotent 干细胞建模的细胞的 bioenergetic 动态平衡和破坏正常的长期、不可逆的 dysregulation。重要地,在 Smad5 缺乏的房间的这些新陈代谢、发展的赤字能仅仅由细胞质的 Smad5 被救。细胞质的 Smad5 身体上与 hexokinase 交往 1 并且加速 glycolysis。一起,我们的调查结果显示 Smad5 充当一个 pHi 送信人并且由调整细胞质的新陈代谢的机械维持房间的 bioenergetic 动态平衡。 | Yujiang Fang Zhongliang Liu Zhenyu Chen Xiangjie Xu Mengtao Xiao Yanyan Yu Yuanyuan Zhang Xiaobai Zhang Yanhua Du Cizhong Jiang Yuzheng Zhao Yiran Wang Beibei Fan Daniel Terheyden-Keighley Yang Liu Lei Shi Yi Hui Xin Zhang Bowen Zhang Hexi Feng Lin Ma Quanbin Zhang Guohua Jin Yi Yang Bin Xiang Ling Liu Xiaoqing Zhang | 2017 | Cell Research2017，27，9： | 2 |
| 12 | Sodium-rich NASICON-structured cathodes for boosting the energy density and lifespan of sodium-free-anode sodium metal batteries显示文摘Rechargeable sodium metal batteries(SMBs)have emerged as promising alternatives to commercial Li-ion batteries because of the natural abundance and low cost of sodium resources.However,the overuse of metallic sodium in conventional SMBs limits their energy densities and leads to severe safety concerns.Herein,we propose a sodium-free-anode SMB(SFA-SMB)configuration consisting of a sodium-rich Na superionic conductor-structured cathode and a bare Al/C current collector to address the above challenges.Sodiated Na_(3)V_(2)(PO_(4))_(3)in the form of Na_(5)V_(2)(PO_(4))_(3)was investigated as a cathode to provide a stable and controllable sodium source in the SFA-SMB.It provides not only remarkable Coulombic efficiencies of Na plating/stripping cycles but also a highly reversible three-electron redox reaction within 1.0–3.8 V versus Na/Na+confirmed by structural/electrochemical measurements.Consequently,an ultrahigh energy density of 400 Wh kg^(-1)was achieved for the SFA-SMB with fast Na storage kinetics and impressive capacity retention of 93%after 130 cycles.A narrowed voltage window(3.0–3.8 V vs.Na/Na+)further increased the lifespan to over 300 cycles with a high retained specific energy of 320 Wh kg^(-1).Therefore,the proposed SFA-SMB configuration opens a new avenue for fabricating next-generation batteries with high energy densities and long lifetimes. | Junxiong Wu Cong Lin Qinghua Liang Guodong Zhou Jiapeng Liu Gemeng Liang Man Wang Baohua Li Liang Hu Francesco Ciucci Qiang Liu Guohua Chen Xiaoliang Yu | 2022 | InfoMat2022，4，4： | 2 |
| 13 | Species Diversity and Elevational Distribution of Amphibians in the Xianxialing and Wuyishan Mountain Ranges,Southeastern China显示文摘The species diversity and altitudinal distribution of amphibians along an eleva tional gradient of 200-1600 m in the Xianxialing and Wuyishan Mountain Ranges in Southeastern China were investiga ted through time-constra ined visual surveys along 32 transect lines in 9 survey areas,in which the ha bitat types were also recorded.A total of 27 amphibian species belonging to 19 genera,7 families,and 2 orders were found.The species diversity of the amphibians plateaued at low elevation,and the altitudinal boundary of their distribution was at 800 m.Their species compositions were dissimilar in the two mountain ranges probably beca use the annual average temperature and annual rainfall were different in both areas.The eleva tional Rapoport's rule demonstrated that the species range size of the amphibians expanded as the elevation increased in both mountain ranges.The results of the cross species method supported the rule only when the influence of the low-frequency occurrence proba bility of an investigated species was excluded,whereas those of the Steven's method strongly corroborated the rule rega rdless of the incidental occurrence or absence of the species. | Zhiqiang CHEN Yun TANG Yingying WANG Yindie LI Longhui LIN Guohua DING | 2020 | Asian Herpetological Research2020，11，1： | 2 |
| 14 | A rare chronic constrictive pericarditis with localized adherent visceral pericardium and normal parietal pericardium: a case report显示文摘经典紧缩的心包炎(CP ) 被含纤维的结疤和内脏的心包和顶骨心包的粘附描绘,它导致限制心脏的充满。然而,与正常厚度心包并且没有石灰化诊断 CP 仍然是挑战。在发达世界上的占优势的原因是 cardiac 以后外科跟随的自发或病毒的心包炎并且放射以后。肺结核在开发国家仍然是 CP 的一个普通原因。在这份报告,我们在一个中年的人与顶骨心包的正常厚度描述自发的局部性的紧缩的内脏的心包的一个稀罕案例。与 unexplained 权利心失败和 echocardiography 介绍的病人看中等 bi-atrial 增大哪个应该与限制心肌症被识别。在 10 月保守治疗以后,正确的心失败的前进正在留下。pericardiectomy 被执行,病人恢复了。这个案例用作一个提示与 unexplained 权利心失败在病人考虑 CP,以便及时调查和治疗能被开始。 | Qingqiang Ni Lin Yun Rui Xu Guohua Li Yucai Yao Jiamin Li | 2016 | Frontiers of Medicine2016，10，3： | 1 |
| 15 | Modification of graphene platelets and their tribological properties as a lubricant additive 显示文摘 | Jinshan Lin Liwei Wang Guohua Chen | 2011 | Tribology Letters2011，4，1： | 1 |
| 16 | Injectable and thermosensitive hydrogels mediating a universal macromolecular contrast agent with radiopacity for noninvasive imaging of deep tissues显示文摘It is very challenging to visualize implantable medical devices made of biodegradable polymers in deep tissues.Herein,we designed a novel macromolecular contrast agent with ultrahigh radiopacity(iodinate content>50%)via polymerizing an iodinated trimethylene carbonate monomer into the two ends of poly(ethylene glycol)(PEG).A set of thermosensitive and biodegradable polyester-PEG-polyester triblock copolymers with varied polyester compositions synthesized by us,which were soluble in water at room temperature and could spontaneously form hydrogels at body temperature,were selected as the demonstration materials.The addition of macromolecular contrast agent did not obviously compromise the injectability and thermogelation properties of polymeric hydrogels,but conferred them with excellent X-ray opacity,enabling visualization of the hydrogels at clinically relevant depths through X-ray fluoroscopy or Micro-CT.In a mouse model,the 3D morphology of the radiopaque hydrogels after injection into different target sites was visible using Micro-CT imaging,and their injection volume could be accurately obtained.Furthermore,the subcutaneous degradation process of a radiopaque hydrogel could be non-invasively monitored in a real-time and quantitative manner.In particular,the corrected degradation curve based on Micro-CT imaging well matched with the degradation profile of virgin polymer hydrogel determined by the gravimetric method.These findings indicate that the macromolecular contrast agent has good universality for the construction of various radiopaque polymer hydrogels,and can nondestructively trace and quantify their degradation in vivo.Meanwhile,the present methodology developed by us affords a platform technology for deep tissue imaging of polymeric materials. | Xiaohui Wu Xin Wang Xiaobin Chen Xiaowei Yang Qian Ma Guohua Xu Lin Yu Jiandong Ding | 2021 | Bioactive Materials2021，6，12： | 1 |
| 17 | Electrical-thermal switching effect in high-density polyethylene/graphite nanosheets conducting composites显示文摘 | Zhou Lichun Lin Jinshan Chen Guohua | 2008 | J Mater Sci2008，43，： | 1 |
| 18 | Endothelium-independent vasodilation effect of hydroxysafflor yellow A in thoracic aorta of Wistar rats显示文摘 | Zhang Lin Nie Peihe Zhang Guohua | | 0，，11： | 1 |
| 19 | Polymerlayered silicate nanocomposites: an overview 显示文摘 | Guohua Chen Xiuqin Chen Zhiyong Lin | 1999 | Journal of Ma terials Science Letters1999，18，： | 1 |
| 20 | Circular chromatic number and a generalization of construction of Mycielski 显示文摘 | Lam P B Lin Wensong Gu Guohua | 2003 | J Combin Theory Ser B2003，89，2： | 1 |
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