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| 1 | Use of second generation contrast-enhanced ultrasound in the assessment of focal liver lesions显示文摘Ultrasound (US) is often the first imaging modality employed in patients with suspected focal liver lesions. The role of US in the characterisation of focal liver lesions has been transformed with the introduction of specific contrast media and the development of specialized imaging techniques. Ultrasound now can fully characterise the enhancement pattern of hepatic lesions, similar to that achieved with contrast enhanced multiphasic computed tomography (CT) and magnetic resonance imaging (MRI). US contrast agents are safe, well-tolerated and have very few contraindications. Furthermore, real-time evaluation of the vascularity of focal liver lesions has become possible with the use of the newer microbubble contrast agents. This article reviews the enhancement pattern of the most frequent liver lesions seen, using the second generation US contrast media. The common pitfalls for each type of lesion are discussed. The recent developments in US contrast media and specific imaging techniques have been a major advance and this technique, in view of the intrinsic advantages of US, will undoubtedly gain popularity in the years to come. | Stanislas HX Morin Adrian KP Lim eremy FL Cobbold Simon D Taylor-Robinson | 2007 | World Journal of Gastroenterology2007，13，45： | 16 |
| 2 | Imaging of liver cancer显示文摘Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality. | Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 3 | Non-invasive splenic parameters of portal hypertension:Assessment and utility显示文摘BACKGROUND Portal hypertension is a major complication of cirrhosis that is associated with significant morbidity and mortality.The present gold-standard method to risk stratify and observe cirrhosis patients with portal hypertension is hepatic venous pressure gradient measurement or esophagogastroduodenoscopy.However,these methods are invasive,carry a risk of complications and are associated with significant patient discomfort.Therefore,non-invasive splenic parameters are of clinical interest as potential useful markers in determining the presence of portal hypertension.However,diagnostic accuracy and reproducibility remains unvalidated.AIM To assess the diagnostic accuracy of spleen stiffness,area and diameter in predicting the presence of portal hypertension.METHODS Of 50 patients with varying liver disease pathologies were prospectively recruited from the St.Mary’s Hospital Liver Unit in London;25 with evidence of portal hypertension and 25 with no evidence of portal hypertension.Liver stiffness,spleen stiffness,spleen diameter and spleen area were measured using the Philips Affiniti 70 elastography point quantification point shear wave elastography system.The aspartate aminotransferase-to-platelet-ratio-index(APRI)score was also calculated.Performance measures,univariate and multivariate logistic regression were used to evaluate demographic,clinical and elastography variables.Interclass correlation coefficient was used to determine the reproducibility of splenic area and diameter.RESULTS On univariate and individual performance,platelet count[area under the receiver operating characteristic(AUROC)0.846,P value<0.001],spleen area(AUROC 0.828,P value=0.002)and APRI score(AUROC 0.827,P value<0.001)were the most accurate variables in identifying the presence of portal hypertension.On multivariate logistic regression models constructed,the combination of spleen area greater than 57.90 cm2 and platelet count less than 126×10^9 had 63.2%sensitivity and 100%specificity,100%positive predictive value and 100%negative predictive value.An alternative combination of spleen stiffness greater than 29.99 kPa and platelet count less than 126×10^9 had 88%sensitivity,75%specificity,78.6%positive predictive value and 85.7%negative predictive value.An interclass correlation coefficient value of 0.98(95%CI:0.94-0.99,P value<0.001)and 0.96(95%CI:0.91-0.99,P value<0.001)were determined for inter-operator variability for spleen area and diameter respectively.CONCLUSION Spleen area,spleen stiffness and platelet count may be useful markers to assess the presence of portal hypertension in patients of various etiologies. | Ayesha Karim Ahmad Sebastiana Atzori James Maurice Simon D Taylor-Robinson Adrian KP Lim | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 4 | Role of microbubble ultrasound contrast agents in the non-invasive assessment of chronic hepatitis C-related liver disease显示文摘长期地感染丙肝病毒的病人经常得长期的肝疾病,对肝损伤的严厉的评价在认为病毒的根除是治疗以前被要求。这篇文章检验从标准答案肝活体检视当前可得到的各种各样的评价方法到血清学的标记和成像。超声是在临床的实践的最广泛地使用的成像形式之一并且已经是为肝疾病的一个首要的诊断工具。Microbubble 超声对比代理人允许更高的分辨率要获得的图象和对要执行的微脉管的变化的功能的评价。在确定的这些代理人的角色肝的损害的状态作为与丙肝在病人决定肝疾病的阶段和等级的一个可行方法被讨论。尽管当前限制了到专家中心,提高对比的超声将不可避免地在临床的背景增加的微水泡的可获得性。 | Scott Grier Adrian KP Lim Nayna Patel Jeremy FL Cobbold Howard C Thomas Isobel J Cox Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，22： | 2 |
| 5 | Fracture patterns in the maxillofacial region: a four-year retrospective study显示文摘 | Park KP Lim SU Kim JH | 2015 | J Korean Assoc Oral Maxillofac Surg2015，41，6： | 1 |
| 6 | Human nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region显示文摘 | Lim KP Hong WJ | 2004 | J Biol Chem2004，279，54： | 1 |
| 7 | Over-expression of MAGED4B increases cell migration and growth in oral squamous cell carcinoma and is associated with poor disease outcome显示文摘 | Chong CE Lim KP Gan CP | 2012 | Cancer Lett2012，321，1： | 1 |
| 8 | Radiologial feature in a patient with kimura's disease显示文摘 | Lim WE Tan NG Tan Kp | 1997 | Singapore Med J1997，38，3： | 1 |
| 9 | Radiological feature in a patient with Kimura's disease显示文摘 | Lim WE Tan NG Tan KP | 1997 | Singapore Med J1997，38，3： | 1 |
| 10 | Over expression of MAGEIMb increases cell migration and growth in oral squamous cell carcino- ma and is associated with poor disease outcome 显示文摘 | Chang CE Lim KP Gan CP | 2012 | Cancer Lett2012，321，1： | 1 |
| 11 | Alterations of the p14ARF- p53-MDM2 pathway in oral squamous cell carcinoma: MDM2 overexpression is a common event显示文摘 | Lim KP Sharifah H Lau SH | 2005 | Oncol Rep2005，14，4： | 1 |
| 12 | Establishment and characterization of Asian oral cancer cell lines as in vitro models to study a disease prevalent in Asia显示文摘 | Hamid S Lim KP Zain RB | 2007 | Int J Mol Med2007，19，3： | 1 |
| 13 | Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β显示文摘 | Hassona Y Cirillo N Lim KP | 2013 | Carcinogenesis2013，34，6： | 1 |
| 14 | Identification and biosynthesis of fibrinogen in human uterine cervix carcinoma cells显示文摘 | Lee SY Lee KP Lim JW | 1996 | Thromb Haemost1996，75，3： | 1 |
| 15 | Pneumocystis jirovecii pneumonia 13 years post renal transplant following a recurrent cytomegalovirus infection显示文摘 | Muhammad Iqbal AH Lim SK Ng KP | 2012 | Transpl Infect Dis2012，14，4： | 1 |
| 16 | Hemagglutinin -neuraminidase sequence and phylogenetic analyses of mumps virus isolates from a vaccinated population in Singapore 显示文摘 | Lim CS Chan KP Gob KT | 2003 | J Med Virol2003，70，2： | 1 |
| 17 | BRAF- V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups显示文摘 | Berres ML Lim KP Peters T | 2014 | J Exp Med2014，211，4： | 1 |
| 18 | Potential interactions between cilostazol and probucol: a two-part, single-dose, open-label study in healthy Korean male volunteers显示文摘 | Kim KP Kim BH Lim KS | 2009 | Clin Ther2009，31，10： | 1 |
| 19 | Penile metastasis:an unusual presentation of metastatic colonic cancer显示文摘 | Banerjee GK Lim KP Cohen NP | | 0，，06： | 1 |
| 20 | Radiological feature in patient with kimura's disease 显示文摘 | Lim WEH Tan NG Tan KP | 1997 | Singapore Med J1997，38，： | 1 |
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