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| 1 | Contrasting trends of PM2.5 and surface-ozone concentrations in China from 2013 to 2017显示文摘Although much attention has been paid to investigating and controlling air pollution in China,the trends of air-pollutant concentrations on a national scale have remained unclear.Here,we quantitatively investigated the variation of air pollutants in China using long-term comprehensive data sets from 2013 to 2017,during which Chinese government made major efforts to reduce anthropogenic emission in polluted regions.Our results show a significant decreasing trend in the PM2.5 concentration in heavily polluted regions of eastern China,with an annual decrease of〜7%compared with measurements in 2013.The measured decreased concentrations of SO2>NO2 and CO(a proxy for anthropogenic volatile organic compounds)could explain a large fraction of the decreased PM2.5 concentrations in different regions.As a consequence;the heavily polluted days decreased significantly in corresponding regions.Concentrations of organic aerosol;nitrate;sulfate,ammonium and chloride measured in urban Beijing revealed a remarkable reduction from 2013 to 2017;connecting the decreases in aerosol precursors with corresponding chemical components closely.However;surface-ozone concentrations showed increasing trends in most urban stations from 2013 to 2017;which indicates stronger photochemical pollution.The boundary-layer height in capital c让ies of eastern China showed no significant trends over the Beijing-Tianjin-Hebei,Yangtze River Delta and Pearl River Delta regions from 2013 to 2017;which confirmed the reduction in anthropogenic emissions.Our results demonstrated that the Chinese government was successful in the reduction of particulate matter in urban areas from 2013 to 2017,although the ozone concentration has increased significantly;suggesting a more complex mechanism of improving Chinese air quality in the future. | Yonghong Wang Wenkang Gao Shuai Wang Tao Song Zhengyu Gong Dongsheng Ji Lili Wang Zirui Liu Guiqian Tang Yanfeng Huo Shili Tian Jiayun Li Mingge Li Yuan Yang Biwu Chu Tuukka Petaja Veli-Matti Kerminen Hong He Jiming Hao Markku Kulmala Yuesi Wang Yuanhang Zhang | 2020 | National Science Review2020，7，8： | 51 |
| 2 | Isolation and Identification of Cancer Stem-Like Cells from Murine Melanoma Cell Lines显示文摘In current study,cancer stem-like cells in the murine melanoma B16F10 cells were investigated.CD phenotypes of the B16F10 cells were analyzed by flow cytometry,and the specific CD phenotype cells from the B16F10 cells were isolated by MACS.Then we used colony formation assay in soft agar media,the cell growth assay in serum-free culture media as well as the tumorigenicity investigation of the specific CD phenotype cells in C57BL/6 mice, respectively,to identify cancer stem-like cells in the B16F10 cells.The results showed that the B16F10 cells could form spherical clones in serum-free culture media,and the rate of clonegenesis of CD133 + ,CD44 + and CD44 + CD133 + cells was higher than that of CD133 - ,CD44 - and CD44 + CD133 - cells in soft agar media,respectively. The tumorigenic potential of CD133 + ,CD44 + ,CD44 + CD133 + cells and CD44 + CD133 + CD24 + cells was stronger than that of CD133 - ,CD44 - ,CD44 + CD133 - cells and CD44 + CD133 + CD24 - cells in mice,respectively.In conclusion,the CD44 + CD133 + CD24 + cells have some biological properties of cancer stem-like cells or are highly similar to the characteristics of cancer stem cells(CSC).These results provide an important method for identifying cancer stem-like cells in B16F10 cells and for further cancer target therapy. | Jun Dou Meng Pan Ping Wen Yating Li Quan Tang Lili Chu Fengshu Zhao Chuilian Jiang Weihua Hu Kai Hu Ning Gu | 2007 | Cellular & Molecular Immunology2007，4，6： | 25 |
| 3 | Fine-Tuning of MiR528 Accumulation Modulates Flowering Time in Rice显示文摘In plants,microRNA (miRNA) functions in the post-transcriptional repression of target mRNAs have been well explored.However,the mechanisms regulating the accumulation of miRNAs remain poorly under.stood.Here,we report that distinct mechanisms regulate accumulation of a monocot-specific miRNA,rice (Oryza sativa) miR528.At the transcriptional level,miR528 accumulated to higher levels in older plants than in young seedlings and exhibited aging-modulated gradual accumulation and diurnal rhythms in leaves;at the post-transcriptional level,aging also modulated miR528 levels by enhancing pri-miR528 alter.native splicing.We found that miR528 promotes rice flowering under long-day conditions by targeting RED AND FAR-RED INSENSITIVE2 (OsRFI2).Moreover,natural variations in the MIR528 promoter region caused differences in miR528 expression among rice varieties,which are correlated with their different binding affinities with the transcription factor OsSPL9 that activates the expression of miR528.Taken together,our findings reveal rice plants have evolved sophisticated modes fine-tuning miR528 levels and provide insight into the mechanisms that regulate MIRNA expression in plants. | Rongxin Yang Pingchuan Li Hailiang Mei Dong Wang Jing Sun Chao Yang Lili Hao Shouyun Cao Chengcai Chu Songnian Hu Xianwei Song Xiaofeng Cao | 2019 | Molecular Plant2019，12，8： | 12 |
| 4 | Habitat-induced reciprocal transformation in the root phenotype of Oriental ginseng is associated with alteration in DNA methylation显示文摘Oriental ginseng is an important medicinal plant that grows in 2 major forms or ecotypes,wild and domesticated.Each form differs conspicuously in root phenotype,but can be converted from one type to another by habitat.Here we show that the habi tat-induced transformation of ginseng root phenotype was accompanied by alteration in cytosine methylation at a large number of 5′-CCGG-3′sites detected by the methylation-sensitive polymorphism(MSAP)marker.The collective CG and CHG methylation levels of all 4 landraces of the domesticated form were significantly lower than those of the wild form.Interestingly,artificially transplanted ginseng plants recreated in both directions the methylation levels(at least in CHG)of their natural counterparts.The methylation differences between the 2 ginseng ecotypes were validated at 2 isolated MSAP loci bearing homology to a 5S rRNA gene or a copia retrotransposon.Our results implicate a link between epigenetic variation and habitat-induced phenotypic flexibility in Oriental ginseng. | NGEZAHAYO Frederic WANG XiaoLi YU XiaoMing JIANG LiLi CHU YunJie SHEN BaiHua YAN ZhongKai LIU Bao | 2011 | Chinese Science Bulletin2011，56，16： | 7 |
| 5 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 6 | Epistatic effect between ACACA and FABP2 gene on abdominal fat traits in broilers显示文摘Epistasis is generally defined as the interaction between two or more genes or their mRNA or protein products to influence a single trait. Experimental evidence suggested that epistasis could be important in the determination of the genetic architecture of complex traits in domestic animals. Acetyl-coenzyme A carboxylase alpha (ACACA) and fatty acid binding protein 2 (FABP2) are both key factors of lipogenesis and transport. They may play a crucial role in the weight variability of abdominal adipose tissue in the growing chicken. In this study, the polymorphisms of c.2292G>A in ACACA and c.-561A>C in FABP2 were detected among individuals from two broiler lines which were divergently selected for abdominal fat content. Epistasis between the two SNPs on abdominal fat weight (AFW) and abdominal fat percentage (AFP) was analyzed. The additive × additive epistatic components between these two SNPs were found significant or suggestively significant on both AFW and AFP in lean lines of the 9th and 10th generation; whereas, it was not significantly associated with either AFW or AFP in fat lines. At the same time, there were not any other significant epistatic components found in both generations or in both lines. Significant epistatic effects between these two SNPs found only in the lean lines could partly be due to the fact that the abdominal fat traits in these two experimental lines have been greatly modified by strong artificial selection. The results suggested that the epistasis mode may be different between the lean and fat chicken lines. Our results could be helpful in further understanding the genetic interaction between candidate genes contributing to phenotypic variation of abdominal fat content in broilers. | Guo Hu 1, Shouzhi Wang 1, Jianwei Tian, Lili Chu, Hui Li College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China | 2010 | Journal of Genetics and Genomics2010，37，8： | 5 |
| 7 | Tunable luminescence,energy transfer and excellent thermal stability of SrMg2(PO4)2:Ce^3+,Tb^3+ phosphors for LEDs显示文摘A series of novel SrMg2(PO4)2:Ce^3+,Tb^3+(SMP:Ce^3+,Tb^3+)phosphors with tunable emission spectra were produced via high temperature solid phase method.XRD,fluorescence spectrum and fluorescence lifetime for SMP:Ce^3+,Tb^3+were studied in detail.Under the excitation at 308 nm,SMP:Ce^3+,Tb^3+samples can emit high efficiency tunable blue-green light by controlling the proportion of dopant concentration.Through the spectral overlap and the regular change of fluorescence lifetime,it is proved that there is a significant energy transfer between Ce^3+and Tb^3+in SMP matrix and the energy transfer mechanism is determined to be an electric dipole-dipole interaction with energy transmission efficiency of 55%.In additional,Commission International de L’Eclairage(CIE)color coordinates and thermal stability were studied.All above findings suggest that SMP:Ce^3+,Tb^3+can be regarded as the potential bluish green phosphor for LED applications. | Wanxin Mi Jun Zheng Peng Qiao Lili Cao Siqi Chu Hongping Ma | 2021 | Journal of Rare Earths2021，39，1： | 4 |
| 8 | 'Some Properties of the Generalized Stut- tering Poisson Distribution and its Applications'显示文摘 | Zhang Huiming Chu Lili andDiao Yu | 2015 | 数学科学研究2015，，1： | 1 |
| 9 | Study of immunotherapy of murine myeloma by an IL-21-based tumor vaccine in BALB/c mice显示文摘 | Dou Jun Chu Lili Zhao Fengshu | 2007 | Cancer Biol Ther2007，612，： | 1 |
| 10 | Diagnostic performance of different specimens in detecting enterovirus A71 in children with hand,foot and mouth disease显示文摘Hand,foot and mouth disease(HFMD)is a major public health problem among children in the Asia-Pacific region.The optimal specimen for HFMD virological diagnosis remains unclear.Enterovirus A71(EV-A71)neutralizing antibody titres detected in paired sera were considered the reference standard for calculating the sensitivity,specificity,positive and negative predictive value of throat swabs,rectal swabs,stool,blood samples and cerebrospinal fluid(CSF)by RT-PCR or ELISA assay.In this study,clinical samples from 276 HFMD patients were collected for analysing the sensitivity of different kind of specimens.Our results showed that stool had the highest sensitivity(88%,95%CI:74%–96%)and agreement with the reference standard(91%).The order of diagnostic yield for EV-A71 infection was stool samplerectal swab>throat swab>blood sample>CSF sample,and using a combination of clinical samples improved sensitivity for enterovirus detection.The sensitivity of ELISA for IgM antibody detection in sterile-site specimens was significantly higher than that of RT-PCR(serum/plasma:62%vs.2%,CSF:47%vs.0%)(P<0.002).In conclusion,our results suggest that stool has the highest diagnostic yield for EV-A71-infected HFMD.If stool is unavailable,rectal swabs can be collected to achieve a similar diagnostic yield.Otherwise,throat swabs may be useful in detecting positive samples.Although IgM in blood or CSF is diagnostically accurate,it lacks sensitivity,missing 40%–50%of cases.The higher proportion of severe cases and shorter interval between onset and sampling contributed to the increase in congruency between clinical testing and the serological reference standard. | Yonghong Zhou Chongchen Zhou Kai Wang Qi Qiu Yibing Cheng Yu Li Peng Cui Lu Liang Peng Li Xiaowei Deng Lili Wang Wen Zheng Hui Gong Fang Wang Meng Xu Justin Jang Hann Chu Lance Turtle Hongjie Yu | 2023 | Virologica Sinica2023，38，2： | 1 |
| 11 | Java-based search engine technology in Web information mining application显示文摘 | CHU Lili | 2010 | Joumal of Liaoning Technical University(Natural Science)2010，，29： | 1 |
| 12 | Study of immunotherapy of murine myeloma by an IL-21-based tumor vaccine in BALB/c mice显示文摘 | Dou Jun Chu Lili Zhao Fengshu | 2007 | Cancer Biol Ther2007，6，： | 1 |
| 13 | Industrial choices for protein production by large-scale cell culture显示文摘 | Lily Chu David K Robinson | 2001 | Current Opinion in Biotechnology2001，，2： | 1 |
| 14 | Diverse transformations of sulfur in seabird-affected sediments revealed by microbial and stable isotope analyses显示文摘Microbial communities,sulfur isotope of sulfides(δ^(34)S_(AVS)and δ^(34)S_(CRS)),and sulfur and oxygen isotopes of sulfate(δ^(34)S_(SO_(4))and δ^(18)O_(SO_(4)))in sediments were analyzed to reveal the biogeochemical transformations of sulfur in a seabird-affected lake Y2 and a se abird-free YO from Fildes Peninsula,Antarctic Peninsula.The microbial communities in Y2 were mainly associated with penguin activities,while those in YO were limited by nutrients.The much enriched δ^(34)S_(SO_(4))recorded at depth of 30,41,and 52 cm in Y2indicates very strong sulfate reduction therein.The sulfur-degrading bacteria Pseudomonas in 0-23 cm of Y2 was 3.5 time s as abundant as that of sulfur oxidizing bacteria(SOB),indicating remarkable remineralization of organic sulfur.The abundant SOB and ^(34)S-depleted sulfate indicate considerable sulfur oxidation in 34-56-cm layer in Y2.In YO sediments,the highest abundance of Desulfotalea and the most enriched δ^(34)S_(SO_(4))(35.2‰)and δ^(34)S_(CRS)(2.5‰)indicate the strongest sulfate reduction in 28-cm layer.High abundance of Pseudomonas indicates active remineralization of organic sulfur in 3-5-cm layer in YO.The medium δ^(34)S_(SO_(4))and considerable abundance of SOB and sulfate-reducing bacteria(SRB)indicate concurrence of sulfur oxidation and sulfate reduction in other layers in YO.Therefore,a high level of organic matter input from penguin populations supported the diverse microbial community and transformations of sulfur in aquatic ecosystems in Antarctica. | Lili SHEN Tao HUANG Yuanqing CHEN Zhuding CHU Zhouqing XIE | 2023 | Journal of Oceanology and Limnology2023，41，1： | 0 |
| 15 | 复兴西路上的石库门显示文摘街边梧桐枝叶成荫,仿佛记录着岁月的印痕。这好似上海的隐秘花园,把邻近的喧嚣全都隔离开了,只盛放属于自己的气息:那是夹缠着过去和现代、东方和西方的混合体,仿佛因为有着岁月的沉淀,呼吸都会缓慢下来。 | Andrea Mingfai Chu Lily 朱明晖 | 2006 | 缤纷2006，0，7： | 0 |
| 16 | Evaluation of a Regional Ensemble Data Assimilation System for Typhoon Prediction显示文摘An ensemble Kalman filter(EnKF) combined with the Advanced Research Weather Research and Forecasting model(WRF) is cycled and evaluated for western North Pacific(WNP) typhoons of year 2016. Conventional in situ data, radiance observations, and tropical cyclone(TC) minimum sea level pressure(SLP) are assimilated every 6 h using an 80-member ensemble. For all TC categories, the 6-h ensemble priors from the WRF/EnKF system have an appropriate amount of variance for TC tracks but have insufficient variance for TC intensity. The 6-h ensemble priors from the WRF/EnKF system tend to overestimate the intensity for weak storms but underestimate the intensity for strong storms. The 5-d deterministic forecasts launched from the ensemble mean analyses of WRF/EnKF are compared to the NCEP and ECMWF operational control forecasts. Results show that the WRF/EnKF forecasts generally have larger track errors than the NCEP and ECMWF forecasts for all TC categories because the regional simulation cannot represent the large-scale environment better than the global simulation. The WRF/EnKF forecasts produce smaller intensity errors and biases than the NCEP and ECMWF forecasts for typhoons, but the opposite is true for tropical storms and severe tropical storms. The 5-d ensemble forecasts from the WRF/EnKF system for seven typhoon cases show appropriate variance for TC track and intensity with short forecast lead times but have insufficient spread with long forecast lead times. The WRF/EnKF system provides better ensemble forecasts and higher predictability for TC intensity than the NCEP and ECMWF ensemble forecasts. | Lili LEI Yangjinxi GE Zhe-Min TAN Yi ZHANG Kekuan CHU Xin QIU Qifeng QIAN | 2022 | Advances in Atmospheric Sciences2022，39，11： | 0 |
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