| 1 | Design and validation of the THMC China-Mock-Up test on buffer material for HLW disposal显示文摘According to the preliminary concept of the high-level radioactive waste(HLW) repository in China,a large-scale mock-up facility,named China-Mock-Up was constructed in the laboratory of Beijing Research Institute of Uranium Geology(BRIUG).A heater,which simulates a container of radioactive waste,is placed inside the compacted Gaomiaozi(CMZ)-Na-bentonite blocks and pellets.Water inflow through the barrier from its outer surface is used to simulate the intake of groundwater.The numbers of water injection pipes,injection pressure and the insulation layer were determined based on the numerical modeling simulations.The current experimental data of the facility are herein analyzed.The experiment is intended to evaluate the thermo-hydro-mechano-chemical(THMC) processes occurring in the compacted bentonite-buffer during the early stage of HLW disposal and to provide a reliable database for numerical modeling and further investigation of engineered barrier system(EBS),and the design of HLW repository. | Yuemiao Liu Like Ma Dan Ke Shengfei Cao Jingli Xie Xingguang Zhao Liang Chena Panpan Zhang | 2014 | Journal of Rock Mechanics and Geotechnical Engineering2014，6，2： | 2 |
| 5 | The advantages of penehyclidine hydrochloride over atropine in acute organophosphorus pesticide poisoning:A meta-analysis显示文摘Background:Penehyclidine hydrochloride(PHC)has been used for many years as an anticholinergic drug for the treatment of acute organophosphorus pesticide poisoning(AOPP).The purpose of this meta-analysis was to explore whether PHC has advantages over atropine in the use of anticholinergic drugs in AOPP.Methods:We searched Scopus,Embase,Cochrane,PubMed,ProQuest,Ovid,Web of Science,China Science and Technology Journal Database(VIP),Duxiu,Chinese Biomedical literature(CBM),WanFang,and Chinese National Knowledge Infrastructure(CNKI),from inception to March 2022.After all qualified randomized controlled trials(RCTs)were included,we conducted quality evaluation,data extraction,and statistical analysis.Statistics using risk ratios(RR),weighted mean difference(WMD),and standard mean difference(SMD).Results:Our meta-analysis included 20,797 subjects from 240 studies across 242 different hospitals in China.Compared with the atropine group,the PHC group showed decreased mortality rate(RR=0.20,95%confidence intervals[CI]:0.16–0.25,P<0.001),hospitalization time(WMD=-3.89,95%CI:-4.37 to-3.41,P<0.001),overall incidence rate of complications(RR=0.35,95%CI:0.28–0.43,P<0.001),overall incidence of adverse reactions(RR=0.19,95%CI:0.17–0.22,P<0.001),total symptom disappearance time(SMD=-2.13,95%CI:-2.35 to-1.90,P<0.001),time for cholinesterase activity to return to normal value 50–60%(SMD=-1.87,95%CI:-2.03 to-1.70,P<0.001),coma time(WMD=-5.57,95%CI:-7.20 to-3.95,P<0.001),and mechanical ventilation time(WMD=-2.16,95%CI:-2.79 to-1.53,P<0.001).Conclusion:PHC has several advantages over atropine as an anticholinergic drug in AOPP. | Siyao Zeng Lei Ma Lishan Yang Xiaodong Hu Cheng Wang Xinxin Guo Yi Li Yi Gou Yao Zhang Shengming Li Shaotong Zhang Xiaoxuan Wu Meihong Li Jing Lei Bingqian Li Chengfei Bi Like Ma Qingpeng Luo | 2023 | Journal of Intensive Medicine2023，3，2： | 0 |
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