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| 1 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 2 | Antibiotic Prophylaxis for Gi Endoscopy显示文摘 | Mouen A. Kashab Ruben D. Acosta David H. Bruining Vinay Chandrasekhara Krishnavel V. Chithadi Mohamad A. Eloubeidi Robert D. Fanelli S.A.G.E.S. Representative Ashley L. Faulx Lisa Fonkalsrud Jenifer R. Lightdale V. Raman Muthusamy Shabana F. Pasha John R. | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 3 | Esophageal cancer显示文摘 | Charles J. Lightdale | 1999 | The American Journal of Gastroenterology1999，，1： | 1 |
| 4 | Optical coherence tomography in Barrett' s esophagus 显示文摘 | Lightdale C J | 2013 | Gastrointest Endosc Clin N2013，23，3： | 1 |
| 5 | Practice guidelines esophageal cancer显示文摘 | Lightdale CJ | 1999 | Am J Gastroenterol1999，94，1： | 1 |
| 6 | Fellow percep tions of training using computer based endoscopy simulators显示文摘 | Lightdale J R Newburg A R Mahoney L B | 2010 | Gastrointest Endosc2010，72，1： | 1 |
| 7 | Microstream capnography improves patient monitoring during moderate sedation:a randomized,controlled trial显示文摘 | Lightdale JR Goldmann DA Feldman HA | | 0，，06： | 1 |
| 8 | The role of endoscopy in Barrett’s esophagus and other premalignant conditions of the esophagus显示文摘 | John A. Evans Dayna S. Early Norio Fukami Tamir Ben-Menachem Vinay Chandrasekhara Krishnavel V. Chathadi G. Anton Decker Robert D. Fanelli Deborah A. Fisher Kimberly Q. Foley Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Jenifer Lightdale Phyllis M | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 9 | Photodynamic therapy for completely obstructing esophageal carcinoma 显示文摘 | Likier HM Levine JG Lightdale CJ | 1991 | Gastrointest Endosc1991，37，： | 1 |
| 10 | The Japanese experience with endoscopic ultrasonography in the staging of gastric cancer显示文摘 | Lightdale CJ Brennan MF | 1993 | Gastrointest Endosc1993，39，4： | 1 |
| 11 | A Multicenter, Randomized, Double-Blind, 8-Week Comparative Trial of Standard Doses of Esomeprazole (40 mg) and Omeprazole (20?mg) for the Treatment of Erosive Esophagitis显示文摘 | Colleen Schmitt Charles J. Lightdale Clara Hwang Bernard Hamelin | 2006 | Digestive Diseases and Sciences2006，，5： | 1 |
| 12 | Preoperative staging of esophageal cancer: comparison of endoscopic US and dynamic CT显示文摘 | Botet JF Lightdale CJ Zauber AG | 1991 | Radiology1991，181，： | 1 |
| 13 | A Multicenter, Randomized, Double-Blind, 8-Week Comparative Trial of Low-Dose Esomeprazole (20 mg) and Standard-Dose Omeprazole (20 mg) in Patients with Erosive Esophagitis显示文摘 | Charles J. Lightdale Colleen Schmitt Clara Hwang Bernard Hamelin | 2006 | Digestive Diseases and Sciences2006，，5： | 1 |
| 14 | Role of endoscopic ultrasonography in the staging and fallow-up of esophageal cancer显示文摘 | LIGHTDALE C J KULKARNI K G | 2005 | J Clin Oncol2005，23，20： | 1 |
| 15 | Global Assessment of Gastrointestinal Endoscopic Skills (GAGES): a valid measurement tool for technical skills in flexible endoscopy显示文摘 | Melina C. Vassiliou Pepa A. Kaneva Benjamin K. Poulose Brian J. Dunkin Jeffrey M. Marks Riadh Sadik Gideon Sroka Mehran Anvari Klaus Thaler Gina L. Adrales Jeffrey W. Hazey Jenifer R. Lightdale Vic Velanovich Lee L. Swanstrom John D. Mellinger Gerald M. F | 2010 | Surgical Endoscopy2010，，8： | 1 |
| 16 | Preoperative staging of esophageal cancer:comparison of endoscopic US and dynamic CT显示文摘 | Botet JF Lightdale CJ Zauber AG | 1991 | Radiology1991，181，： | 1 |
| 17 | Localization of pancreatic endocrine tumors by endoscopic ultrasonography显示文摘 | R?sch T Lightdale C J Botet JF | 1992 | N Engl J Med1992，326，： | 1 |
| 18 | Elevated serum gastrin is associated with a history of advanced neoplasia in Barrett's esopha- gus显示文摘 | Wang JS Varro A Lightdale CJ | 2010 | Am J Gastroenterol2010，105，5： | 1 |
| 19 | Gastroesophageal reflux:management guidance for the pediatrician显示文摘 | Lightdale JR Gremse DA | 2013 | Pediatrics2013，131，5： | 1 |
| 20 | Circumferential ablation of Barrett’s esophagus that contains high-grade dysplasia: a U.S. multicenter registry显示文摘 | Robert A. Ganz Bergein F. Overholt Virender K. Sharma David E. Fleischer Nicholas J. Shaheen Charles J. Lightdale Stephen R. Freeman Ronald E. Pruitt Shiro M. Urayama Frank Gress Darren A. Pavey M. Stanley Branch Thomas J. Savides Kenneth J. Chang V. Rama | 2008 | Gastrointestinal Endoscopy2008，，1： | 1 |
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