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| 1 | Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells显示文摘Objective:Pancreatic ductal adenocarcinoma(PDAC)is a deadly malignancy,due in large part to its resistance to conventional therapies,including radiotherapy(RT).Despite RT exerting a modest antitumor response,it has also been shown to promote an immunosuppressive tumor microenvironment.Previous studies demonstrated that focal adhesion kinase inhibitors(FAKi)in clinical development inhibit the infiltration of suppressive myeloid cells and T regulatory(T regs)cells,and subsequently enhance effector T cell infiltration.FAK inhibitors in clinical development have not been investigated in combination with RT in preclinical murine models or clinical studies.Thus,we investigated the impact of FAK inhibition on RT,its potential as an RT sensitizer and immunomodulator in a murine model of PDAC.Methods:We used a syngeneic orthotopic murine model to study the effect of FAKi on hypofractionated RT.Results:In this study we showed that IN10018,a small molecular FAKi,enhanced antitumor response to RT.Antitumor activity of the combination of FAKi and RT is T cell dependent.FAKi in combination with RT enhanced CD8+T cell infiltration significantly in comparison to the radiation or FAKi treatment alone(P<0.05).FAKi in combination with radiation inhibited the infiltration of granulocytes but enhanced the infiltration of macrophages and T regs in comparison with the radiation or FAKi treatment alone(P<0.01).Conclusions:These results support the clinical development of FAKi as a radiosensitizer for PDAC and combining FAKi with RT to prime the tumor microenvironment of PDAC for immunotherapy. | Arsen Osipov Alex B.Blair Juliane Liberto Jianxin Wang Keyu Li Brian Herbst Yao Xu Shiqi Li Nan Niu Rufiaat Rashid Ding Ding Yanan Liu Zaiqi Wang Christopher L.Wolfgang Richard A.Burkhart Daniel Laheru Lei Zheng | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | Update on gingival overgrowth by cyelosporine A in renal transplants显示文摘 | Ciavarella D Guiglia R Campisi G Di Cosola M Di Liberto C Sabatucci A | 2007 | Med Oral Patol Oral Cir Bueal2007，12，： | 1 |
| 3 | Group lI metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain显示文摘 | Di Liberto V Bonomo A Frinchi M | 2010 | Neuroseience2010，165，3： | 1 |
| 4 | Impact of phase ratio,polydimethylsiloxane volume and size,and sampling tempera ture and time on headspace sorptive extraction recovery of some volatile compounds in the essential oil field显示文摘 | Bicchia C Cordero C Liberto E | 2005 | Journal of Chromatography A2005，107，2： | 1 |
| 5 | Phenotypic and geno- typic evaluation of slime production by conventional and molecu-lar microbiological techniques 显示文摘 | Liberto MC Matera G Quirino A | 2009 | Microbiol Res2009，164，5： | 1 |
| 6 | Development of a dynamic balancing machine 显示文摘 | LIBERTO E SALVADOR L M | 1998 | International Journal of Mechanical Engineering Education1998，26，2： | 1 |
| 7 | Pro-regenerative properties of cytokine-activated astrocytes显示文摘 | Liberto CM Albrecht PJ Herx LM | 2004 | Neurochemistry2004，89，6： | 1 |
| 8 | Metacognitive Strategy Training for ESL Reading显示文摘 | B G Pharis J C Liberto | 1989 | TESOL Quarterly1989，，4： | 1 |
| 9 | Education and Italian regional development 显示文摘 | LIBERTO A D | 2006 | Economics of Education Review2006，，11： | 1 |
| 10 | Atypical neuroleptic malignant syndrome associated with olanzapina显示文摘 | Reeves RR TooresR Liberto V | 2002 | Pharmacotheraph2002，22，： | 1 |
| 11 | Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea显示文摘 | Rakotoson MG Di Liberto G Audureau E | 2015 | Orphanet J Rare Dis2015，10，1： | 1 |
| 12 | Growth factor-dependent induction of p21 (CIP1) by the green tea polyphenol, epigallocatechin gallate显示文摘 | Liberto M Cobrinik D | 2000 | Cancer Lett2000，154，2： | 1 |
| 13 | Metacognitive strategy training for ESL reading显示文摘 | Carrell P L Pharis B G Liberto JC | 1989 | TESOL Quarterly1989，23，： | 1 |
| 14 | Mutually exclu- sive cyelin-dependent kinase 4/cyclin DI and eyelin-de- pendent kinase 6/cyelin D2 pairing inactivates retinoblas- toma protein and promotes cell cycle dysregnlation in mul- tiple myeloma显示文摘 | Ely S Di Liberto M Niesvizky R | 2005 | Cancer Res2005，65，11： | 1 |
| 15 | A critical role for PKC zeta in endothelin-l-induced uterine contractions at the end of pregnancy显示文摘 | Di Liberto G Dallot E Eude-Le Parco I | 2003 | Am J Physiol Cell Physiol2003，285，3： | 1 |
| 16 | Metacognitive strategy training for ESL reading显示文摘 | Carrell P.L Pharis B.G Liberto J.C | | 0，，23： | 1 |
| 17 | Compartmentalization of hepatitis C vires genotypes between plasma and peripheral blood mononuclear cells 显示文摘 | Roque-Afonso AM Ducoulombier D Di Liberto G | 2005 | J Virol2005，79，10： | 1 |
| 18 | Damping exces- sive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-l-related receptor, a negative regulator of IL 1/TLR signaling显示文摘 | Garlanda C Di Liberto D Vecchi A | 2007 | J Immunol2007，179，5： | 1 |
| 19 | Metacognitive strategy training for ESL read- ing显示文摘 | Carrell Pharis Liberto | 1989 | TESOL Quarterly1989，，4： | 1 |
| 20 | Riboflavin and collagen: New crosslinking methods to tailor the stiffness of hydrogels 显示文摘 | Tirella A Liberto T Ahluwalia A | 2012 | Materials Letters2012，74，： | 1 |
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