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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | The role of Toll-like receptors in non-infectious lung injury显示文摘在病原体识别的像使用费的受体(TLR ) 的角色在最近的年里是快速地先进的。然而,进在非传染的织物损害的 TLR 的功能的调查刚开始了。以前,我们和其它表明了那碎裂的 hyaluronan (哈) 在织物损害期间积累。CD44 被要求在织物损害期间清除 HA,并且损害了清理哈在不停的发炎的结果。另外,碎裂哈在损害地点由煽动性的房间刺激煽动性的基因的表示。最近,我们识别了那哈碎片要求 TLR2 和 TLR4 刺激老鼠巨噬细胞生产煽动性的 chemokines 和 cytokines。在一个非传染的肺损害模型,在 TLR2 和 TLR4 缺乏的老鼠显示出煽动性的房间的损害 transepithelial 迁居,增加的织物损害,提高的肺上皮的房间 apoptosis,和减少的幸存。在高分子的质量的表示上的肺上皮的房间哈对尖锐的肺损害和 apoptosis 的保护的老鼠,部分地通过 NF-kappaB 的 TLR 依赖的基础激活。在 TLR2 和 TLR4 的夸大的损害缺乏的老鼠看起来由于上皮的房间上的损害 HA-TLR 相互作用。这些研究识别那个主机矩阵部件哈并且 TLR 相互作用提供开始煽动性的回答的信号,维持上皮的房间完整,并且支持从尖锐的肺损害的恢复。房间研究(2006 ) 16:693-701。做 i:10.1038/sj .cr.7310085;出版联机 2006 年 8 月 8 日。 | Dianhua Jiang Jiurong Liang Yuhang Li Paul W Noble | 2006 | Cell Research2006，16，8： | 16 |
| 3 | Diffraction of plane SH waves by a semi-circular cavity in half-space显示文摘This paper presents a closed-form solution for diffraction of plane SH waves by a semi-circular cavity in half-space by using wave function expansion method. Accuracy of the solution is checked by the displacement residual and stress residual along the boundaries. Numerical results show that there are notable differences for response amplitudes between a semi-circular cavity and a whole-circular cavity in a half-space. | Jianwen Liang Hao Luo Vincent W Lee | 2010 | Earthquake Science2010，23，1： | 13 |
| 4 | Behavior of High Performance PVA Fiber Reinforced Cement Composites in Triaxial Compression显示文摘Based on an extensive experimental program,the paper studies the behavior of HPFRCC under triaxial compression. The experimental parameters are lateral confining pressure and PVA fiber content by volume. The test results indicate that ultimate strength and peak strain are significantly improved with the increases of confining pressure. The confining effect introduced by the fibers becomes minor in triaxial compression tests,where there is relatively high external confining pressure. The axial stress-strain curves with different confining pressure and different PVA fiber content by volume are obtained. Lateral confining pressure constraints the lateral expansion of HPFRCC,so there is a big plastic deformation with its ultimate strength improved. At lower confining pressure,PVA fiber content by volume has some effect on the decreased section of stress-strain curve. According to test results,the paper establishes formula of confining pressure with ultimate strength and axial peak strain respectively. | LI Y LIANG X W LIU Z J | 2010 | 武汉理工大学学报2010，32，17： | 10 |
| 5 | Alcohol use disorders and current pharmacological therapies: the role of GABAA receptors显示文摘 | Jing LIANG Richard W OLSEN | 2014 | Acta Pharmacologica Sinica2014，35，8： | 8 |
| 6 | Epidemiological serosurvey of Hepatitis B in China—Declining HBV prevalence due to Hepatitis B vaccination显示文摘 | Xiaofeng Liang Shengli Bi Weizhong Yang Longde Wang Gang Cui Fuqiang Cui Yong Zhang Jianhua Liu Xiaohong Gong Yuansheng Chen Fuzhen Wang Hui Zheng Feng Wang Jing Guo Zhiyuan Jia Jingchen Ma Huaqing Wang Huiming Luo Li Li Shuigao Jin Stephen C. Hadler Yu W | 2009 | Vaccine2009，，47： | 7 |
| 7 | 活性氧介导的肿瘤微环境在胰腺癌发生与发展中作用的研究进展显示文摘胰腺癌是一种在全世界范围内发病率和死亡率都很高的恶性肿瘤,当前缺少有效的手术方法和治疗药物。近年来,活性氧(reactive oxygen species,ROSs)已成为胰腺癌研究领域的热点。ROSs可调节肿瘤微环境(tumor microenvironment,TME)、肿瘤干细胞(cancer stem cells,CSCs)更新和上皮-间质转化(epithelial-mesenchymal transition,EMT)等过程,从而导致胰腺癌的耐药和复发。当前,包括免疫浸润、成纤维细胞、血管和细胞外基质在内的TME已成为肿瘤研究的热点。同时,已有大量文献报道ROSs介导的TME在胰腺癌的发生与发展中具有重要的作用,靶向调节ROSs可能是治疗胰腺癌的一种方法。因此,本文综述了ROSs在胰腺癌肿瘤发生和耐药中的调控作用、ROSs在胰腺癌信号转导中的作用以及ROSs在胰腺癌基质细胞中的作用,并总结了靶向调节ROSs的抗胰腺癌的潜在药物。 | 陶旭锋 Vay Liang W(Bill)Go 肖桂山 | 2021 | 生理学报2021，73，2： | 5 |
| 8 | A series solution for surface motion amplification due to underground group cavities:Incident P waves显示文摘A series solution for surface motion amplification due to underground group cavities for incident plane P waves isderived by Fourier-Bessel series expansion method. It is shown that underground group cavities significantly am-plify the surface ground motion nearby. It is suggested that the effect of subways on ground motion should be con-sidered when the subways are planned and designed. | LIANG Jian-wen(梁建文) ZHANG Hao(张浩) Vincent W Lee | 2004 | Acta Seismologica Sinica(English Edition)2004，17，3： | 3 |
| 9 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 10 | Corrosion resistance of tannic acid,d-limonene and nano-ZrO_(2)modified epoxy coatings in acid corrosion environments显示文摘The protection of rusted carbon steel in acid corrosion environments is of great significance for equipment to keep safe operation.In this work,we presented a method to protect the rusted steel by ru st conversion treatment and epoxy coating.Tannic acid was selected as rust conversion agent.Tannic acid,D-limonene and nano-ZrO_(2)were used to improve the corrosion resistance of epoxy coatings.The Raman spectra,Xray diffraction and 3 D confocal images were used to characterize the rust conversion reaction.Ad hesion test showed that the loss of wet adhesion of the optimal coating was relatively low due to the addition of tannic acid,limonene and nano-ZrO(2).The corrosion resistance of five different coatings was investigated by scanning electron microscopy(SEM)and electrochemical analysis.Results show that after 264 h acid immersion,the low frequency resistance of the optimal coating consisting of rust conversion treatment and additives is 10^(7)Ωcm^(2),three orders magnitude higher than that of the pristine coating.Moreover,SEM indicates that the optimal coating possesses a smooth surface and an unbroken interface between substrate and coating.Accordingly,the corrosion-resistant mechanism of the hybrid coating is proposed. | Junwei Chang Zhenyu W ang En-hou Han Xinlei Liang Gang Wang Zuyao Yi Na Li | 2021 | Journal of Materials Science & Technology2021，，6： | 3 |
| 11 | 纳米碳化钒强化TWIP钢加工硬化机制研究显示文摘弥散分布的纳米碳化钒颗粒能明显提高TWIP钢的屈服强度,但同时将在一定程度上降低加工硬化率。采用一个修正的物理模型来研究纳米碳化钒颗粒对一种实验室等级的FeMnC奥氏体TWIP钢加工硬化率的影响。试验发现在塑性变形过程中弥散分布的纳米碳化钒颗粒会加快位错累积速率,但也会降低孪晶形成速率。与不含析出相的TWIP钢相比,在小应变时含纳米碳化钒颗粒的TWIP钢加工硬化率较高,但随着应变量的增加其硬化率减小的速度高于不含析出相的TWIP钢,因此在高应变条件下含纳米碳化钒颗粒的TWIP显示出较低的钢加工硬化率。 | Liang ZY Huang M X Yen H W Scott C P 魏世同(翻译) | 2014 | 钢铁钒钛2014，35，1： | 3 |
| 12 | Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer显示文摘 | Zhang XM Miao XP Liang G Hao BT Wang YG Tan W Li Y Guo YL He FC Wei QY Lin DX | 2006 | 中国生物学文摘2006，20，4： | 2 |
| 13 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 14 | Introduction and constitutive expression of rice chitinase gene in bread wheat using biolistic bombardment and the bar gene as a selectable maker显示文摘 | Chen W P Gu X Liang G H Muthukrishnan S Chen P D Liu D J Giu B S | 1998 | Theor Appl Genet1998，97，12： | 2 |
| 15 | An Object Oriented Approach to Design with Modules 显示文摘 | O'Grady P Liang W | 1998 | Computer Integrated Manufacturing Systems1998，11，4： | 2 |
| 16 | Role and relevance of polarity and hindrance of vinyl monomers in graft copolymerization onto potato starch显示文摘 | Fu Z S Liang W D Yang A M | 2002 | J Appl Polym Sci2002，85，4： | 2 |
| 17 | Flocculation of sterically stabilized polystyrene latex particles by adsorbing and nonadsorbing poly(acrylic acid)显示文摘 | LIANG W TADROS T F | 1996 | Langmuir1996，10，2： | 2 |
| 18 | Adjuvant intraportal venous chemotherapy for patients with hepatocellular carcinoma and portal vein tumor thrombi following hepatectomy plus portal thrombectolny 显示文摘 | Liang L J Hu W J Yin X Y | 2008 | World J Surg2008，32，4： | 1 |
| 19 | Fine mapping and characterization of quantitative trait loci Hd4 and Hd5 controlling heading date in rice显示文摘 | LIN H X LIANG Z W SASAKI T | 2003 | Breeding Science2003，53，： | 1 |
| 20 | DEA models for supply chain efficiency evaluation显示文摘 | Liang L Feng Y Cook W D Zhu J | 2006 | Annals of Operations Research2006，145，1： | 1 |
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