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| 1 | The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line显示文摘The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs.The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA(2.5 80 μmol/L) for 24,48 and 72 h,respectively.Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation.VEGF and VEGFR2 expression were studied by Western blotting.The binding mode of tanshinone IIA within thecrystal structure of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1.The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose-and time-dependent manner.Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control,and tanshinone IIAtreated cells accumulated at the S phase,which was higher than the vehicle control.Furthermore,the expression of VEGF and VEGFR2 was decreased in Western blot.Finally,molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and π–π stacking interactions with Val848.In conclusion,tanshinone IIA may suppress A549 proliferation,induce apoptosis and cell cycle arrest at the S phase.This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. | Jun Xie Jiahui Liu Heng Liu Shihui Liang Meigui Lin Yueyu Gu Taoli Liu Dongmei Wang Hui Gee Sui-lin Mo | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 26 |
| 2 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 3 | Coagulation efficiency and flocs characteristics of recycling sludge during treatment of low temperature and micro-polluted water显示文摘Drinking water treatment sludge,characterized as accumulated suspended solids and organic and inorganic matter,is produced in large quantities during the coagulation process.The proper disposal,regeneration or reuse of sludge is,therefore,a significant environmental issue.Reused sludge at low temperatures is an alternative method to enhance traditional coagulation efficiency.In the present study,the recycling mass of mixed sludge and properties of raw water (such as pH and turbidity) were systematically investigated to optimize coagulation efficiency.We determined that the appropriate dosage of mixed sludge was 60 mL/L,effective initial turbidity ranges were below 45.0 NTU,and optimal pH for DOMs and turbidity removal was 6.5-7.0 and 8.0,respectively.Furthermore,by comparing the flocs characteristics with and without recycling sludge,we found that floc structures with sludge were more irregular with average size growth to 64.7 μm from 48.1 μm.Recycling sludge was a feasible and successful method for enhancing pollutants removal,and the more irregular flocs structure after recycling might be caused by breakage of reused flocs and incorporation of powdered activated carbon into larger flocs structure.Applied during the coagulation process,recycling sludge could be significant for the treatment of low temperature and micro-polluted source water. | Zhiwei Zhou Yanling Yang Xing Li Wei Gao Heng Liang Guibai Li | 2012 | Journal of Environmental Sciences2012，24，6： | 12 |
| 4 | Three new species of imitator-group of the genus Macrophya(Hymenoptera,Tenthredinidae) from China显示文摘Three species, Macrophya circulotibialis Li, Liu & Heng, sp. nov., M. curvatitheca Li, Liu & Heng, sp. nov. and M. changbaina Li, Liu & Heng, sp. nov., of the imitator-group of the genus Macrophya Dahlbom(Hymenoptera, Tenthredinidae) from China are described as new to science. A key to all known species of the imitator-group from China is provided. The specimens examined in this study, including all holotypes and paratypes of the new species, are deposited in the Insect Collection of Central South University of Forestry and Technology, Changsha, Hunan, China, and the Department of Zoology, National Museum of Nature and Science, Amakubo, Tsukuba, Ibaraki, Japan. | Meng-Meng Liu Xue-Mei Heng Xiang-Mei Liang Yi-Hai Zhong Ze-Jian Li | 2015 | Zoological Systematics2015，40，2： | 11 |
| 5 | Therapy to Obese Type 2 Diabetes Mellitus:How Far Will We Go Down the Wrong Road?显示文摘Traditional glucose-lowering chemical agents, including various types of insulin and insulin secretagogues, insulin sensitizers, gliptins, etc., are based on diabetic pathogenesis of insulin resistance(IR) and islet insufficiency. Numerous evidence-based medical studies have shown that these traditional hypoglycemic chemical agents do not provide cardiovascular benefit to patients with type 2 diabetes mellitus(T2 DM) and may even increase the risk of all-cause mortality. Based on research evidence published to date, these studies show that overload of energy could increase the incidence and prevalence of T2 DM, and reduction in the heat load can significantly reduce the incidence of T2 DM. Therefore, the essence of T2 DM is heat overload, meaning heat overload is the etiology of obese T2 DM. At the same time, results of numerous studies show that heat overloading is the cause of IR. IR and islet dysfunction are protective factors in intervening with heat overload.These drugs, which are based on the mechanisms of IR and islet insufficiency, increase caloric reserve and cause or worsen obesity, which is equivalent to exacerbating the basic etiology and the cardiovascular risk factor of T2 DM. Thus, a reasonable strategy for prevention and treatment of obese T2 DM appears to promote the negative balance of calories and the elimination of caloric reserves. Chinese herbal medicines can promote negative balance of heat in many aspects, which can bring new hope for prevention and treatment of T2 DM. | HENG Xian-pei LI Xiu-jun LI Liang YANG Liu-qing WANG Zi-ta HUANG Su-ping | 2020 | Chinese Journal of Integrative Medicine2020，26，1： | 9 |
| 6 | Hysteroscopy and directed biopsy in the diagnosis of endometrial carcinoma显示文摘背景诊断 hysteroscopy 和指导活体检视广泛地被用来评估反常子宫的流血。我们试图探索 hysteroscopy 的价值并且在子宫内膜的 carcinoma.Methods 的诊断指导了活体检视在北京大学人的医院里被对待的有子宫内膜的癌的 287 个病人,中国北京被散布进 2 个组:组 A (90 个病人) 被检验使用 hysteroscopy 和指导活体检视,和组 B (197 个病人) 用部分膨胀和刮术(D&C ) 被检验。二个方法,积极的腹细胞学的率和 2 个组的预后的诊断诚实是在组 A 的 compared.Results,(88/90 )97.8% 在外科前病理地病人被诊断;率是 88.8%(175/197 ) 为组 B。2 个组之间的差别是统计上重要的(P 0.05 ) 。百分之百,为为检测颈的参与的二个方法的敏感,特性,积极预兆的价值和否定预兆的价值百分之百是 77.8% 并且 97.6% 为组 Aand 65.3% , 92.6% , 74.4% 和 90.0% 为组 B 分别地。积极的腹细胞学率是 5.6%(5/90 ) 在组 A 并且 6.09%(12/197 ) 在组 B。差别不是统计上重要的(P 0.05 ) 。3 年、 5 年的全面幸存率是 91.4%(33/36 ) 并且 82.4%(14/17 ) 为组 A 并且 95.6%(87/91 ) 并且 86.7%(39/45 ) 为组 B。二个组 .Conclusion 与部分 D&C , hysteroscopy 和指导活体检视相比提供了的幸存率( P 0.05 )之间没有统计上重要的差别在外科和发现颈的参与前的改进病理学的诊断精确性更精确在子宫内膜的癌病人,但是它没增加积极的腹细胞学率或影响这些病人的预后。 | ZHU Hong-lan LIANG Xu-dong WANG Jian-liu CUI Heng WEI Li-hui | 2010 | Chinese Medical Journal2010，，24： | 8 |
| 7 | Cu(OAc)_2 catalyzed Sonogashira cross-coupling reaction in amines显示文摘简单 Cu (OAc ) 联合协议的 2 催化 Sonogashira 被介绍。有终端炔属羟的许多芳基卤的政变石楠顺利被进行负担得起相应需要的产品在,这被发现对优秀收益中等,用 Cu (OAc ) 2 作为催化剂和 Et3N 作为溶剂。 | Sheng Mei Guo Chen Liang Deng Jin Heng Li | 2007 | Chinese Chemical Letters2007，18，1： | 8 |
| 8 | Multi-scale strength analysis of bolted connections used in integral thermal protection system显示文摘Efficient and accurate strength analysis of bolted connections is essential in analyzing the integral thermal protection system(ITPS) of hypersonic vehicles, since the system bears severe loads and structural failures usually occur at the connections. Investigations of composite mechanical properties used in ITPS are still in progress as the architecture of the composites is complex. A new method is proposed in this paper for strength analysis of bolted connections by investigating the elastic behavior and failure strength of three-dimensional C/C orthogonal composites used in ITPS. In this method a multi-scale finite element method incorporating the global–local method is established to ensure high efficiency in macro-scale and precision in meso-scale in analysis.Simulation results reveal that predictions of material properties show reasonable accuracy compared with test results. And the multi-scale method can analyze the strength of connections efficiently and accurately. | Heng LIANG Yuqing WANG Mingbo TONG Junhua ZHANG | 2018 | Chinese Journal of Aeronautics2018，31，8： | 8 |
| 9 | The role of dynamic transport in the formation of the inverted charge structure in a simulated hailstorm显示文摘The inverted charge structure formation of a hailstorm was investigated using the Advanced Weather Research and Forecasting(WRF-ARW) model coupled with electrification and discharge schemes. Different processes may be responsible for inverted charge structure in different storms and regions. A dynamical-derived mechanism of inverted charge structure formation was confirmed by the numerical model: the inverted structure was formed by strong updraft and downdraft under normal-polarity charging conditions such that the graupel charged negatively in the main charging region in the middle-upper level of the cloud. The simulation results showed the storm presented a normal charge structure before and after hail-fall; while during the hail-fall stage, it showed an inverted charge structure—negative charge region in the upper level of the cloud and a positive charge region in the middle level of the cloud—appearing at the front edge near the strong updraft in the hailstorm. The charging processes between the two particles mainly occurred at the top of the cloud, where the graupel charged negatively and ice crystals positively due to the strong updraft. When the updraft air reached the top of the storm, it would spread to the rear and front. The light ice crystals were transported backward and forward more easily. Meanwhile, the positively charged ice crystals were transported downward by the frontal subsidence, and then a positive charge region formed between the ?10 and ?25°C levels. Subsequently, a negative charge region materialized in the upper level of the cloud, and the inverted charge structure formed. | XU Liang Tao ZHANG Yi Jun LIU Heng Yi ZHENG Dong WANG Fei | 2016 | Science China Earth Sciences2016，59，7： | 8 |
| 10 | Chemical cleaning of fouled PVC membrane during ultrafiltration of algal-rich water显示文摘Cleaning of hollow-fibre polyvinyl chloride (PVC) membrane with different chemical reagents after ultrafiltration of algal-rich water was investigated. Among the tested cleaning reagents (NaOH, HCl, EDTA, and NaClO), 100 mg/L NaClO exhibited the best performance (88.4% ± 1.1%) in removing the irreversible fouling resistance. This might be attributed to the fact that NaClO could eliminate almost all the major foulants such as carbohydrate-like and protein-like materials on the membrane surface, as confirmed by Fourier transform infrared spectroscopy analysis. However, negligible irreversible resistance (1.5% ± 1.0%) was obtained when the membrane was cleaning by 500 mg/L NaOH for 1.0 hr, although the NaOH solution could also desorb a portion of the major foulants from the fouled PVC membrane. Scanning electronic microscopy and atomic force microscopy analyses demonstrated that 500 mg/L NaOH could change the structure of the residual foulants on the membrane, making them more tightly attached to the membrane surface. This phenomenon might be responsible for the negligible membrane permeability restoration after NaOH cleaning. On the other hand, the microscopic analyses reflected that NaClO could effectively remove the foulants accumulated on the membrane surface. | Yan Zhang Jiayu Tian Heng Liang Jun Nan Zhonglin Chen Guibai Li | 2011 | Journal of Environmental Sciences2011，23，4： | 7 |
| 11 | Chemokines and their receptors play important roles in the development of hepatocellular carcinoma显示文摘The chemokine system consists of four different subclasses with over 50 chemokines and 19 receptors. Their functions in the immune system have been well elucidated and research during the last decades unveils their new roles in hepatocellular carcinoma(HCC). The chemokines and their receptors in the microenvironment influence the development of HCCby several aspects including:inflammation,effects on immune cells,angiogenesis,and direct effects on HCC cells. Regarding these aspects,pre-clinical research by targeting the chemokine system has yielded promising data,and these findings bring us new clues in the chemokine-based therapies for HCC. | Chun-Min Liang Long Chen Heng Hu Hui-Ying Ma Ling-Ling Gao Jie Qin Cui-Ping Zhong | 2015 | World Journal of Hepatology2015，7，10： | 7 |
| 12 | Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China显示文摘 | Xu-Ying Luo Ying-Hong Hu Xiang-Yuan Cao Yan Kang Li-Ping Liu Shou-Hong Wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan Li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia Li-Hong Li Yu-Min Liang Bing-Yu Qin Xian-Dong Wang Jian Xiong Li-Mei Yan Zheng-Ping Yang Chen-Ming Dong Dong-Xin Wang Qing-Yuan Zhan Shuang-Lin FU Lin Zhao Qi-Bing Huang Ying-Guang Xie Xiao-Bo Huang Guo-Bin Zhang Wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin Yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou | 2016 | Chinese Medical Journal2016，，14： | 6 |
| 13 | 体外棘孢木霉与辣椒疫霉菌的拮抗互作(英文)显示文摘目的:筛选出对辣椒疫霉菌具有高效拮抗作用的木霉生防菌株,研究其对辣椒菌菌丝体和卵孢子的作用机制,评价其应用于辣椒疫病的生防潜力。创新点:首次在超微结构水平上报道棘孢木霉菌菌丝能重寄生于辣椒疫霉菌的卵孢子,为木霉生防菌的应用提供了科学理论依据。方法:从土壤中分离木霉菌株,采用对峙培养法筛选木霉生防菌株。通过形态学和多基因序列(ITS、tef1和rpb2)进行鉴定,明确获得木霉菌株的种类。通过细胞学和超微结构观察,研究木霉生防菌对辣椒疫霉菌菌丝和卵孢子的拮抗机制。结论:本研究筛选出了对辣椒疫霉菌菌丝具有高效拮抗作用的一个木霉菌株(CGMCC 6422),被鉴定为棘孢木霉菌(Trichoderma asperellum)。细胞学和超微结构显示,该菌株能塌陷辣椒疫霉菌的菌落,通过缠绕和穿透辣椒疫霉菌的菌丝体,引起菌丝体解体;首次观察到该菌株能侵染辣椒疫霉菌的卵孢子,并引起卵孢子完全降解。综上所述,筛选出的木霉生防菌株CGMCC 6422具有应用于防治辣椒疫病的生防潜力。 | Heng JIANG Liang ZHANG Jing-ze ZHANG Mohammad Reza OJAGHIAN Kevin D.HYDE | 2016 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2016，17，4： | 6 |
| 14 | Resveratrol inhibits collagen Ⅰ synthesis by suppressing IGF-1R activation in intestinal fibroblasts显示文摘AIM:To investigate whether resveratrol(3,4,5-trihydroxy-trans-stilbene)inhibits collagenⅠsynthesis induced by insulin growth factor-1(IGF-1)in intestinal fibroblasts,and to explore the possible molecular mechanisms.METHODS:Male Sprague-Dawley rats were randomly divided into two groups:a control group and a2,4,6-trinitrobenzenesulfonic acid(TNBS)-induced colitis group.After 21 d of TNBS administration,the degree of inflammation and fibrosis in colon was measured by HE staining and Masson’s trichrome staining.Western blotting was used to examine collagenⅠ,IGF-1 and silent information regulator 1(SIRT1)protein expression in colitis tissues.Western blotting and quantitative realtime polymerase chain reaction were used to characterize collagenⅠprotein and col1a2 mRNA expression in mouse intestinal fibroblasts and CCD-18Co cells treated with IGF-1.A MEK inhibitor(U0126)was used to determine whether IGF-1-induced collagenⅠexpression was mediated by extracellular signal-regulated kinase 1/2(ERK1/2)-dependent mechanism.Effects of resveratrol on collagenⅠprotein level,insulin growth factor-1receptor(IGF-1R)and ERK1/2 phosphorylation levels were also examined after IGF-1 treatment in fibroblasts.To evaluate whether SIRT1 was necessary for the anti-fibrosis effect of resveratrol,cells were transfected with SIRT1-specific small interfering RNAs,wildtype SIRT1,and deacetylase-inactive mutant SIRT1.RESULTS:CollagenⅠand IGF-1 expression was increased,and SIRT1 expression was decreased(0.67±0.04 vs 1.05±0.07,P<0.001)in TNBS-induced colitis compared with the control group.In vitro,IGF-1 could induce collagenⅠexpression,mainly through the ERK1/2 signal pathway.Resveratrol reduced basal and IGF-1-induced collagenⅠ?gene and protein expression in intestinal fibroblasts.Overexpression of wild-type SIRT1,not deacetylase-inactive mutant SIRT1,decreased expression of collagenⅠinduced by IGF-1.Moreover,silencing SIRT1 restored collagen?Ⅰ?expression in fibroblasts challenged with resveratrol.However,disruption of SIRT1 did not influence the anti-fibrotic effects of resveratrol and IGF-1-induced collagenⅠexpression.Further analysis revealed that resveratrol significantly decreased phosphorylation of IGF-1R and its downstream signaling molecules by inhibiting IGF-1 binding to its receptor.CONCLUSION:Our data suggest that resveratrol effectively inhibits collagenⅠsynthesis in IGF-1-stimulated fibroblasts,partly by inhibiting IGF-1R activation,and SIRT1 is also responsible for the process. | Ping Li Mei-Lan Liang Ying Zhu Yao-Yao Gong Yun Wang Ding Heng Lin Lin | 2014 | World Journal of Gastroenterology2014，20，16： | 6 |
| 15 | Meteorological applications of precipitable water vapor measurements retrieved by the national GNSS network of China显示文摘In this study, the Global Navigation Satellite System(GNSS) network of China is discussed,which can be used to monitor atmospheric precipitable water vapor(PWV). By the end of2013, the network had 952 GNSS sites, including 260 belonging to the Crustal Movement Observation Network of China(CMONOC) and 692 belonging to the China Meteorological Administration GNSS network(CMAGN). Additionally, GNSS observation collecting and data processing procedures are presented and PWV data quality control methods are investigated. PWV levels as determined by GNSS and radiosonde are compared. The results show that GNSS estimates are generally in good agreement with measurements of radiosondes and water vapor radiometers(WVR). The PWV retrieved by the national GNSS network is used in weather forecasting, assimilation of data into numerical weather prediction models, the validation of PWV estimates by radiosonde, and plum rain monitoring.The network is also used to monitor the total ionospheric electron content. | Liang Hong Cao Yunchang Wan Xiaomin Xu Zhifang Wang Haishen Hu Heng | 2015 | Geodesy and Geodynamics2015，6，2： | 6 |
| 16 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 17 | Three Cases of COVID-19 Variant Delta With and Without Vaccination——Chengdu City,Sichuan Province,April-May,2021显示文摘On April 26,2021,a 33-year-old male Chinese sailor returning from India via Kathmandu,Nepal,tested positive for the coronavirus disease 2019(COVID-19)by Chengdu Customs and was confirmed positive by Chengdu CDC(Case A).On May 2,2021,a housewife in the same flight tested positive for COVID-19 by Pengzhou CDC in Sichuan Province during her quarantine period and was confirmed positive by Chengdu CDC the next day(Case B). | Heng Chen Yi Mao Zhenhua Duan Liang Wang Yue Cheng Yingxue Dai Haixia Luo Wenjun Xie Shuangfeng Fan Yuzhen Zhou Jingpei Xu Lan Feng Liwen Hu Zhu Liu Xian Liang Liangshuang Jiang Xiaoli Tuo | 2021 | China CDC weekly2021，3，25： | 5 |
| 18 | Ozone vertical variations during a typhoon derived from the OMI observations and reanalysis data显示文摘Typhoon is considered to play a key role in the dynamical exchange processes taking place between the troposphere and stratosphere.In this paper,the impact of typhoon on the ozone distribution in the upper troposphere and middle stratosphere is investigated using ozone profiles measured by Aura’s Ozone Monitoring Instrument and meteorological fields from reanalysis data.During the passage of Typhoon Hai-Tang in 2005 over the western North Pacific,low values of ozone column above 200 hPa and ozone mixing ratio between the upper troposphere and the middle stratosphere(from 200 to 50 hPa)are observed right above the typhoon’s track,a result due to the strong upward propagation of air associated with overshooting convection in typhoon.A comparative analysis of different stages of Hai-Tang suggests that in the region where typhoon has higher intensity the troposphere-to-stratosphere transport is enhanced.These results indicated that the typhoon has a significant impact on the ozone variation in the upper troposphere and the middle stratosphere. | FU YunFei XIAN Tao Lü DaRen LIU GuoSheng HENG ZhiWei SUN Liang LIU Qi WANG Yu YANG YuanJian | 2013 | Chinese Science Bulletin2013，58，32： | 5 |
| 19 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 20 | Key technologies for construction of Jinping traffic tunnel with an extremely deep overburden and a high water pressure显示文摘Jinping traffic tunnel is one of the deepest traffic tunnels in the world with a maximum overburden of 2 375 m and the overburden over 73% of its total length is larger than 1 500 m.The tunnel is 17.5 km long and designed to provide a shortcut road between two hydropower stations:Jinping I and Jinping II of the Jinping Hydropower Project,located on Yalong River,Liangshan State,Sichuan Province,China.The tunnel is so deep that building any shafts is impossible.The construction starts from both ends(east and west ends),and the construction length from the west end is 10 km with a blind heading.This paper deals with an overview of this project and analysis of the engineering features,as well as key technologies developed and applied during the construction,including geological prediction,rock burst prevention under a super high in-situ stress,sealing of groundwater with a high pressure and big flow rate,ventilation for a blind heading of 10 km,wet spraying of shotcrete at zones of rock burst and rich water,etc.The application of the new technologies to the construction achieved a high quality tunnel within the contract period. | Shougen CHEN Heng ZHANG Xinrong TAN Liang CHEN | 2011 | Journal of Modern Transportation2011，19，2： | 5 |
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