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| 1 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 2 | Prospective study of functional bone marrow-sparing intensity modulated radiation therapy with concurrent chemotherapy for pelvic malignancies 显示文摘 | Liang Y Bydder M Yashar CM | 2013 | Int J Radiat Oncol Biol Phys2013，85，2： | 1 |
| 3 | Enhancement of learning behaviour by a potent nitric oxide-guanylate cyclase activator YC-1显示文摘 | Chien WL Liang KC Teng CM | 2005 | Eur J Neurosci2005，21，6： | 1 |
| 4 | Upregulation of estrogen receptors in the forebrain of aromatase knockout (ArKO) mice显示文摘 | Agarwal VR Sinton CM Liang C | 2000 | Mol Cell Endocrinol2000，162，12： | 1 |
| 5 | Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole 显示文摘 | Chien WL Liang KC Teng CM | 2003 | Sol Phannacol2003，63，6： | 1 |
| 6 | Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator,3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole显示文摘 | Chien WL Liang KC Teng CM | 2003 | Mol Pharmacol2003，63，6： | 1 |
| 7 | Calcination and Sintering Characteristics of Limestone Under O2/CO2 Combustion Atmosphere 显示文摘 | Chen CM Zhao CS Liang C Pang KL | 2007 | Fuel Processing Technology2007，88，2： | 1 |
| 8 | Impact factors for ditiqcult ce- cal intubation during colonoscopy显示文摘 | Liang CM Chiu YC Wu KL | 2012 | Surg Laparosc Endosc Per- cutan Tech2012，22，5： | 1 |
| 9 | Glutathione regulates interleukin-2 activity on cytotoxic T-cells显示文摘 | Liang CM Lee N Cattell D | 1989 | J Biol Chem1989，264，13： | 1 |
| 10 | Prospective study of functional bone marrow-sparing intensity modulated radiation therapy with concurrent chemotherapy for pelvic malignancies显示文摘 | Liang Y Bydder M Yashar CM | 2013 | Int J Radiat Oncol Bioi Phys2013，85，2： | 1 |
| 11 | EMMPRIN (extracellular matrix metalloproteinase inducer),a human tumor -cell -derived protein,is induced upon monocyte differentiation and is expressed in human atheroma显示文摘 | Terry CM Liang L Lu XK | 2002 | Arterioscler Thromb Vasc Biol2002，22，7： | 1 |
| 12 | MieroRNAq25b suppresse- sed human liver cancer cell proliferation and metastasis by directly targeting oneogene LIN28B2显示文摘 | Liang L Wong CM Ying Q | 2010 | Hepatology2010，52，5： | 1 |
| 13 | Enhancement of the immunity to foot-and-mouth disease virus by DNA priming and protein boosting immunization显示文摘 | SHIEH JJ LIANG CM CHEN CY | 2001 | Vaccine2001，19，2829： | 1 |
| 14 | Isovitexin suppresses lipopolysaccharide mediated indueible nitric oxide synthase through inhibition of NF- kappa B in mouse macrophages显示文摘 | Lin CM Huang ST Liang YC | 2005 | Planta Med2005，71，8： | 1 |
| 15 | F-spondin plays a critical role in murine neuroblastoma survival by maintaining IL-6 expres- sion 显示文摘 | Cheng YC Liang CM Chen YP | 2009 | J Neurochem2009，110，： | 1 |
| 16 | Modeling VOC-odor exposure risk in livestock buildings显示文摘 | Liang HM Liao CM | 2007 | Chemosphere2007，68，： | 1 |
| 17 | Enhancement of the immunity to foot-and-mouth disease virus by DNA priming and protein boosting immunization显示文摘 | Shieh JJ Liang CM Chen CY et a1 | 2001 | Vaccine2001，19，2829： | 1 |
| 18 | MicroRNA-125b suppressesed hu-man liver cancer cell proliferation and metastasis by directly targe-ting oncogene LIN28B2显示文摘 | Liang L Wong CM Ying Q | 2010 | Hepatology2010，52，5： | 1 |
| 19 | MieroRNA 126b suppressesed human liver Cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2 显示文摘 | Liang L Wong CM Ying Q | 2010 | Hepatology2010，52，5： | 1 |
| 20 | MicroRNA-125b sup- pressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2显示文摘 | LIANG L WONG CM YING Q | 2010 | Hepatology2010，52，5： | 1 |
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