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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | 新型冠状病毒肺炎及其心血管效应:流行病学研究的系统综述显示文摘少数新型冠状病毒肺炎(新冠肺炎)患者病情严重,其特征是炎症、微血管损伤和凝血障碍,可能导致心肌损伤、静脉血栓栓塞症(venous thromboembolism, VTE)和动脉闭塞事件。有心血管病危险因素或既往有心血管病的个体可能面临更大的风险。目的:评估各种环境(包括社区、疗养院和医院)中,与新冠肺炎疑似或确诊病例相关的既往存在心血管合并症的患病率。研究者还评估了疑似或确诊新冠肺炎患者随后发生心血管并发症和临床事件的性质和发生率。 | Pellicori P Doolub G Wong CM Lee KS Mangion K Ahmad M Berry C Squire I Lambiase PD Lyon A McCon-nachie A Taylor RS Cleland JG 刘青(摘译) 练桂丽(审校) | 2021 | 中华高血压杂志2021，29，5： | 3 |
| 3 | Identification of an autoinhibitory domain ofp21-activated protein kinase 5显示文摘 | Ching YP Leong VY Wong CM | 2003 | J Biol Chem2003，278，33： | 1 |
| 4 | Age-period-cohort projections of breast cancer incidence in a rapidly transitioning Chinese population显示文摘 | Wong IO Cowling B J Schooling CM | | 0，，07： | 1 |
| 5 | High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease显示文摘 | Ng FH Wong SY Chang CM | 2003 | Aliment Pharmacol Ther2003，18，： | 1 |
| 6 | Aspirin resistance in cardiovascular disease: a review 显示文摘 | Appleberg M Ward Cm C | 2004 | Eur J Vasc Endovasc Surg2004，27，5： | 1 |
| 7 | Causes of pleural exudates in a regin with a high incidences of tuberculosis 显示文摘 | Liam CK Lim KH Wong CM | 2000 | Respirotory2000，5，1： | 1 |
| 8 | Asthma,atopy and tuberculin responses in Chinese schoolchildren in Hong Kong显示文摘 | Wong GW Hui DS Tam CM Chan HH Fok TF Chan-Yeung M | 2001 | Thorax2001，56，： | 1 |
| 9 | Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function:implications for a strategy of salvage transplantation显示文摘 | Poon RT Fan ST Lo CM Liu CL Wong J | | 0，，03： | 1 |
| 10 | Study of the efficacy and mechanism of ALA-mediated photodynamic therapy on human hepatocellular carcinoma cell显示文摘 | Yow CM Wong CK Huang Z | 2007 | Liver Int2007，27，2： | 1 |
| 11 | Application of the calcium fluorescence probe in the medical research 显示文摘 | Huong XF Wogn XF | 1997 | Di-si Junyi Daxue Xuebao (J Fourth Mil Med Univ)1997，18，： | 1 |
| 12 | High incidence of clopidogrel associated gastrointestinal bleeding in patients with previous peptic ulcer disease显示文摘 | Ng FH Wong SY Chang CM | 2003 | Aliment Pharmacul Ther2003，18，4： | 1 |
| 13 | Targeting malignant glioma survival signaling to improve clinical outcomes 显示文摘 | Wong ML Kaye AH Hovens CM | 2007 | Clin Neurosci2007，14，4： | 1 |
| 14 | Frequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas显示文摘 | Ko JM Wong CP Tang CM | 2001 | Cancer Letters2001，170，： | 1 |
| 15 | The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma显示文摘 | Chin KT Zhou HJ Wong CM | 2005 | Nucleic Acids Res2005，33，6： | 1 |
| 16 | Hypophosphataemic osteomalacia in patients on adefovir dipivoxil显示文摘 | GIRGIS CM WONG T NGU MC | 2011 | J Clin Gastro- enterol2011，45，5： | 1 |
| 17 | Hospitalization fatali-ty risk of influenza A( H1N1) : a aystematic review and me-ta-analysis显示文摘 | Wong JY Kelly H Cheung CM | 2015 | Am J Epidemiol2015，182，4： | 1 |
| 18 | Genetic and epigenetic aherations of DLC-1 gene in hepatocellular carcinoma 显示文摘 | Wong CM Lee JM Ching YP | 2003 | Cancer Res2003，63，22： | 1 |
| 19 | Body dysmorphic disorder, pathological gambling, and sexual compulsions显示文摘 | Hollander E Wong CM | 1995 | J Clin Psychiatry1995，56，4： | 1 |
| 20 | Autocrine stimulation by insulinlike growth factorⅠ is involved in the growth,tumorigenicity and chemoresistance of human esophageal carcinoma cells显示文摘 | Liu YC Leu CM Wong FH | 2002 | J Biomed Sci2002，9，6： | 1 |
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