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| 1 | Clogging processes caused by biofilm growth and organic particle accumulation in lab-scale vertical flow constructed wetlands显示文摘The accumulation of organic matter in substratum pores is regarded as an important factor causing clogging separately in the subsurface flow constructed wetlands.In this study,the developing process of clogging caused by biofilm growth or organic particle accumulation instead of total organic matter accumulation was investigated in two groups of lab-scale vertical flow constructed wetlands(VFCWs),which were fed with glucose(dissolved organic matter) and starch(particulate organic matter) influent.Results showed that the growth of biofilms within the substratum pores certainly caused remarkable reduction of effective porosity,especially for the strong organic wastewater,whereas its influence on infiltration rate was negligible.It was implied that the most important contribution of biofilm growth to clogging was accelerating the occurrence of clogging.In comparison with biofilm growth,particles accumulation within pores could rapidly reduce infiltration rate besides effective porosity and the clogging occurred in the upper 0-15 cm layer.With approximately equal amount of accumulated organic matter,the effective porosity of the clogged layer in starch-fed systems was far less than that of glucose-fed systems,which indicated that composition and accumulation mode in addition to the amount of the accumulated organic matter played an important role in causing clogging. | ZHAO Lianfang ZHU Wei TONG Wei | 2009 | Journal of Environmental Sciences2009，21，6： | 33 |
| 2 | Effect of nutrient level on phytoplankton community structure in different water bodies显示文摘Increasing levels of pollution within water bodies can cause eutrophication and an associated rapid growth in and reproduction of phytoplankton. Although most frequently occurring in bodies of water such as lakes and dams, in recent years an increasing number of river systems in China have suffered serious algal blooms. The community structure of phytoplankton may differ, however, dependent on the hydrodynamic conditions and nutrient levels within the water body. The field investigation results obtained from a stagnant river in Suzhou City and Taihu Lake, China, showed that in water with higher concentrations of nitrogen and phosphorus, Chlorophyta became the predominant species and in water with lower concentrations of nitrogen and phosphorus, Cyanobacteria became the predominant species. Growth experiments with competitive species, Microcystis aeruginosa Kutz and Scenedesmus quadricauda (Turp.), were conducted at three different nutrient levels. The biomass of algae in pure and mixed cultures was measured under conditions of different N/P ratios at oligotrophic, eutrophic and hypertrophic nutrient levels. The results indicated that the most suitable state for the growth and reproduction of M. aeruginosa and S. quadricauda were eutrophic conditions in both pure and mixed cultures. Under competition, however, the lower medium nutrient levels favoured M. aeruginosa, while the higher medium nutrient levels better suited S. quadricauda. Under similar hydrodynamic conditions, the community structure of phytoplankton in the water body was determined by the dominant species in competition for nutrients. | Wei Zhu Lei Wan Lianfang Zhao | 2010 | Journal of Environmental Sciences2010，22，1： | 25 |
| 3 | Gas-to-particle conversion of atmospheric ammonia and sampling artifacts of ammonium in spring of Beijing显示文摘PM2.5 and gaseous pollutants(SO2,HNO2,HNO3,HCl,and NH3) were simultaneously collected by Partisol- Model 2300 Sequential Speciation Sampler with denuder-filter pack system in the spring of 2013 in Beijing.Water-soluble inorganic ions and gaseous pollutants were measured by Ion Chromatography.Results showed that the concentrations of NH3,NH+ 4and PM2.5 had similar diurnal variation trends and their concentrations were higher at night than in daytime.The results of gas-to-particle conversion revealed that [NH3]:[NH+4] ratio was usually higher than 1; however,it was less than 1 and the concentration of NH+4 increased significantly during the haze episode,indicating that NH3 played an important role in the formation of fine particle.Research on the sampling artifacts suggested that the volatilization loss of NH+4 was prevalent in the traditional single filter-based sampling.The excess loss of HNO3 and HCl resulted from ammonium-poor aerosols and semivolatile inorganic species had severe losses in the clean day,whereas the mass of NH+ 4was usually overestimated during the single filter-based sampling due to the positive artifacts.Correlation analysis was used to evaluate the influence of meteorological conditions on the volatilization loss of NH+4.It was found that the average relative humidity and temperature had great effects on the loss of NH+4.The loss of NH+4 was significantly under high temperature and low humidity,and tended to increase with the increasing of absorption of gaseous pollutants by denuder.The total mass of volatile loss of NH+4,NO- 3and Cl- could not be ignored and its maximum value was 12.17 μg m-3.Therefore it is important to compensate sampling artifacts for semivolatile inorganic species. | WEI LianFang DUAN JingChun TAN JiHua MA YongLiang HE KeBin WANG ShuXiao HUANG XiaoFeng ZHANG YuanXun | 2015 | Science China Earth Sciences2015，58，3： | 11 |
| 4 | Probabilistic Automatic Outlier Detection for Surface Air Quality Measurements from the China National Environmental Monitoring Network显示文摘Although quality assurance and quality control procedures are routinely applied in most air quality networks, outliers can still occur due to instrument malfunctions, the influence of harsh environments and the limitation of measuring methods. Such outliers pose challenges for data-powered applications such as data assimilation, statistical analysis of pollution characteristics and ensemble forecasting. Here, a fully automatic outlier detection method was developed based on the probability of residuals, which are the discrepancies between the observed and the estimated concentration values. The estimation can be conducted using filtering—or regressions when appropriate—to discriminate four types of outliers characterized by temporal and spatial inconsistency, instrument-induced low variances, periodic calibration exceptions, and less PM_(10) than PM_(2.5) in concentration observations, respectively. This probabilistic method was applied to detect all four types of outliers in hourly surface measurements of six pollutants(PM_(2.5), PM_(10),SO_2,NO_2,CO and O_3) from 1436 stations of the China National Environmental Monitoring Network during 2014-16. Among the measurements, 0.65%-5.68% are marked as outliers. with PM_(10) and CO more prone to outliers. Our method successfully identifies a trend of decreasing outliers from 2014 to 2016,which corresponds to known improvements in the quality assurance and quality control procedures of the China National Environmental Monitoring Network. The outliers can have a significant impact on the annual mean concentrations of PM_(2.5),with differences exceeding 10 μg m^(-3) at 66 sites. | Huangjian WU Xiao TANG Zifa WANG Lin WU Miaomiao LU Lianfang WEI Jiang ZHU | 2018 | Advances in Atmospheric Sciences2018，35，12： | 10 |
| 5 | Composition of algal pigments in surface freshen layer after ice melt in the central Arctic显示文摘Seasonal meltwater input creates a thin freshen layer in surface seawater under ice,which largely shifts the algae assemblages.Our recent observation of photosynthetic pigments in the high Arctic showed that ice bottom and 5m of seawater under ice contained relatively high concentration of fucoxanthin,while chlorophyll b and lutein were the major diagnostic pigments in ice-water interface and 0 m of seawater under ice.Additionally,a notable change of dominant phytoplankton occurred in the top 5 m of seawater under ice,from chlorophytes-dominated at surface to diatoms-dominated at 5 m depth,which might attribute to the sharp salinity gradient(salinity from12.5 to 28.1) in the surface seawater under ice.Our results imply that phytoplankton community in surface layer under ice would become more chlorophytes in the future warming Arctic Ocean. | ZHUANG Yanpei JIN Haiyan GU Fan ZHANG Yang BAI Youcheng JI Zhongqiang LU Yong CHEN lianfang | 2017 | Acta Oceanologica Sinica2017，36，8： | 6 |
| 6 | MiR-135a biogenesis and regulation in malignancy:a new hope for cancer research and therapy显示文摘MicroRNAs(miRNAs)are evolutionarily conserved small non-coding RNAs that affect posttranscriptional regulation by binding to the 3′-untranslated region of target messenger RNAs.MiR-135a is a critical miRNA that regulates gene expression,and many studies have focused on its function in cancer research.MiR-135a is dysregulated in various cancers and regulates cancer cell proliferation and invasionvia several signaling pathways,such as the MAPK and JAK2/STAT3 pathways.MiR-135a has also been found to promote or inhibit the epithelial-mesenchymal transition and chemoresistance in different cancers.Several studies have discovered the value of miR-135a as a novel biomarker for cancer diagnosis and prognosis.These studies have suggested the potential of therapeutically manipulating miR-135a to improve the outcome of cancer patients.Although these findings have demonstrated the role of miR-135a in cancer progression and clinical applications,a number of questions remain to be answered,such as the dual functional roles of miR-135a in cancer.In this review,we summarize the available studies regarding miR-135a and cancer,including background on the biogenesis and expression of miR-135a in cancer and relevant signaling pathways involved in miR-135a-mediated tumor progression.We also focus on the clinical application of miR-135a as a biomarker in diagnosis and as a therapeutic agent or target in cancer treatment,which will provide a greater level of insight into the translational value of miR-135a. | Zhe Cao Jiangdong Qiu Gang Yang Yueze Liu Wenhao Luo Lei You Lianfang Zheng Taiping Zhang | 2020 | Cancer Biology & Medicine2020，17，3： | 4 |
| 7 | Current epidemiology of pancreatic cancer: Challenges and opportunities显示文摘Pancreatic cancer(PC) is an increasingly common disease worldwide. Having a better understanding of worldwide and regional epidemiologic features and risk factors of PC is essential to identify new approaches for prevention,early diagnosis, surveillance, and treatment. In this article, we review the epidemiologic features and risk factors for PC and discuss opportunities and challenges of PC future treatment. | Wenhao Luo Jinxin Tao Lianfang Zheng Taiping Zhang | 2020 | Chinese Journal of Cancer Research2020，32，6： | 3 |
| 8 | Ultrasound-enhanced fluorescence imaging and chemotherapy of multidrugresistant tumors using multifunctional dendrimer/carbon dot nanohybrids显示文摘Development of innovative nanomedicine enabling enhanced theranostics of multidrug-resistant(MDR)tumors remains to be challenging.Herein,we report the development of a newly designed multifunctional yellowfluorescent carbon dot(y-CD)/dendrimer nanohybrids as a platform for ultrasound(US)-enhanced fluorescence imaging and chemotherapy of MDR tumors.Generation 5(G5)poly(amidoamine)dendrimers covalently modified with efflux inhibitor of D-α-tocopheryl polyethylene glycol 1000 succinate(G5-TPGS)were complexed with one-step hydrothermally synthesized y-CDs via electrostatic interaction.The formed G5-TPGS@y-CDs complexes were then physically loaded with anticancer drug doxorubicin(DOX)to generate(G5-TPGS@y-CDs)-DOX complexes.The developed nanohybrids display a high drug loading efficiency(40.7%),strong y-CD-induced fluorescence emission,and tumor microenvironment pH-preferred DOX release profile.Attributing to the DOX/TPGS dual drug design,the(G5-TPGS@y-CDs)-DOX complexes can overcome the multidrug resistance(MDR)of cancer cells and effectively inhibit the growth of cancer cells and tumors.Furthermore,the introduction of US-targeted microbubble destruction technology was proven to render the complexes with enhanced intracellular uptake and anticancer efficacy in vitro and improved chemotherapeutic efficacy and fluorescence imaging of tumors in vivo due to the produced sonoporation effect.The developed multifunctional dendrimer/CD nanohybrids may represent an advanced design of nanomedicine for US-enhanced theranostics of different types of MDR tumors. | Dan Li Lizhou Lin Yu Fan Long Liu Mingwu Shen Rong Wu Lianfang Du Xiangyang Shi | 2021 | Bioactive Materials2021，6，3： | 3 |
| 9 | Analysis of dynamic stress intensity factors of thick-walled cylinder under internal impulsive pressure显示文摘Dynamic stress intensity factors are evaluated forthick-walled cylinder with a radial edge crack under internalimpulsive pressure. Firstly, the equation for stress intensityfactors under static uniform pressure is used as the referencecase, and then the weight function for a thick-walled cylindercontaining a radial edge crack can be worked out. Secondly,the dynamic stresses in uncracked thick-walled cylindersare solved under internal impulsive pressure by using modeshape function method. The solution consists of a quasi-staticsolution satisfying inhomogeneous boundary conditions anda dynamic solution satisfying homogeneous boundary conditions,and the history and distribution of dynamic stresses inthick-walled cylinders are derived in terms of Fourier-Besselseries. Finally, the dynamic stress intensity factor equationsfor thick-walled cylinder containing a radial edge crack subjectedto internal impulsive pressure are given by dynamicweight function method. The finite element method is utilizedto verify the results of numerical examples, showingthe validity and feasibility of the proposed method. | Aijun Chen Lianfang Liao Dingguo Zhang | 2009 | Acta Mechanica Sinica2009，25，6： | 3 |
| 10 | Response of phytoplankton community to different water types in the western Arctic Ocean surface water based on pigment analysis in summer 2008显示文摘Nutrients and photosynthesis pigments were investigated in the western Arctic Ocean during the 3rd Chinese Arctic Research Expedition Cruise in summer 2008.The study area was divided into five provinces using the Kmeans clustering method based on the physical and chemical characteristics of the sea water,and to discuss the distribution of the phytoplankton community structure in these provinces.CHEMTAX software was performed using HPLC pigments to estimate the contributions of eight algal classes to the total chlorophyll a(TChl a).The results showed that on the Chukchi Shelf,the Pacific Ocean inflow mainly controlled the Chl a biomass and phytoplankton communities by nutrient concentrations.The high nutrient Anadyr Water and Bering Shelf Water(An W and BSW) controlled region have high Chl a levels and the diatom dominated community structure.In contrast,in the region occupied by low-nutrient like Alaska Coastal Water(ACW),the Chl a biomass was low,with pico-and nano-phytoplankton as dominated species,such as prasinophytes,chrysophytes and cryptophytes.However,over the off-shelf,the ice cover condition which would affect the physical and nutrient concentrations of the water masses,in consequence had a greater impact on the phytoplankton community structure.Diatom dominated in ice cover region and its contribution to Chl a biomass was up to 75%.In the region close to the Mendeleev Abyssal Plain(MAP),controlled by sea-ice melt water with relatively high salinity(MW-HS),higher nutrient and Chl a concentrations were found and the phytoplankton was dominated by pico-and nano-algae,while the diatom abundance reduced to 33%.In the southern Canada Basin,an ice-free basin(IfB) with the lowest nutrient concentrations and most freshened surface water,low Chl a biomass was a consequence of low nutrients.The ice retreating and a prolonged period of open ocean may not be beneficial to the carbon export efficiency due to reducing the Chl a biomass or intriguing smaller size algae growth. | JIN Haiyan ZHUANG Yanpei LI Hongliang CHEN lianfang GAO Shengquan JI Zhongqiang ZHANG Yang | 2017 | Acta Oceanologica Sinica2017，36，8： | 2 |
| 11 | An effective robot trajectory planning method using a genetic algorithm显示文摘 | Tian Lianfang Collins C | 2004 | Mechatronics2004，14，： | 1 |
| 12 | An effective robot trajectory planning method using a genetic algorithm显示文摘 | Tian Lianfang Collins C | 2004 | Mechatronics2004，14，： | 1 |
| 13 | 显示文摘 | DU Youru ZHAO Sui SHEN Lianfang | 2002 | Rep NMR Spectro2002，48，： | 1 |
| 14 | Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12–19‐year cohort study显示文摘 | Hui‐YingRao De‐GuiSun Rui‐FengYang FengLiu JianWang BoFeng NanWu Ji‐LianFang Guang‐JunSong HuiMa FangGuo Jiang‐HuaWang Xiao‐BoLi QianJin HongQin HuiZhuang LaiWei | 2012 | Journal of Gastroenterology and Hepatology2012，，3： | 1 |
| 15 | Finite element method based simulation of stress-strain field in the quenching process显示文摘 | Li Huiping Zhao Guoqun He Lianfang | 2008 | Materials Science and Enginee-ring A2008，478，12： | 1 |
| 16 | Solution of non-linear thermal transient problems by a new adaptive time-step method in quenching process 显示文摘 | LI Huiping ZHAO Guoqun HE Lianfang | 2009 | Applied Mathematical Modeling2009，33，1： | 1 |
| 17 | An effective robot trajectory plan- ning method using a genetic algorithm显示文摘 | Tian Lianfang Collins C | 2004 | Mechatronics2004，14，5： | 1 |
| 18 | Mutipath source routing in wireless Ad hoc networks显示文摘 | Lei Wang LianFang Zhang YanTai Shu | | 0，，： | 1 |
| 19 | Strategies for maximizing free-radical grafting reaction yields 显示文摘 | Hu Guohua Li Huxi Feng Lianfang | 2003 | Journal of Applied Polymer Science2003，88，7： | 1 |
| 20 | Solution of non-linear thermal transient problems by a new adaptive time-step method in quenching process显示文摘 | Li Huiping Zhao Guoqun He Lianfang | 2009 | Applied Mathematical Modelling2009，33，1： | 1 |
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