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| 1 | Suppression of Jasmonic Acid-Mediated Defense by Viral-Inducible MicroRNA319 Facilitates Virus Infection in Rice显示文摘MicroRNAs (miRNAs ) 是植物开发和主人病毒相互作用的枢轴的调节的人。然而,角色和涉及病毒的感染和主人危险性的特定的 miRNAs 的行动模式仍然保持大部分不清楚。在这研究,我们给那瑞斯看引起 miR319 的增加的累积,但是减少的破旧绝技病毒(RRSV ) 感染调整 miR319 的 TCP (TEOSINTE BRANCHED/CYCLOIDEA/PCF ) 的表示基因,特别 TCP21,在米饭植物。转基因的米饭植物 overexpressing miR319 或 downregulating TCP21 展出了像疾病的显型并且与野类型的植物比较显示出显著地更高的危险性到 RRSV。相反,仅仅温和的疾病症状在感染 RRSV 的线 overexpressing TCP21 并且特别在转基因的植物 overexpressing 被观察 miR319 抵抗的 TCP21。miR319 的 RRSV 感染和 overexpression 在米饭与 JA 生合成和信号相关的基因的 downregulated 表示一起引起了减少的内长的 jasmonic 酸(JA ) 层次。然而,有甲基 jasmonate 的米饭植物的治疗减轻了 RRSV 引起并且减少了病毒累积的疾病症状。一起拿,我们的结果建议由在米饭的 RRSV 感染的 miR319 的正式就职压制调停 JA 的防卫便于病毒感染和症状开发。 | Chao Zhang Zuomei Ding Kangcheng Wu Liang Yang Yang Li Zhen Yang Shan Shi Xiaojuan Liu Shanshan Zhao Zhirui Yang Yu Wang Luping Zheng Juan Wei Zhenguo Du Aihong Zhang Hongqin Miao Yi Li Zujian Wu Jianguo Wu | 2016 | Molecular Plant2016，9，9： | 27 |
| 2 | The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells显示文摘Neogambogic 酸(NGA ) ,在 garcinia 的活跃成分,能在 anticancer 效果禁止一些稳固的肿瘤和结果的生长。我们假设那 NGA 可能为人的乳癌房间线 MCF-7 房间的增长的抑制负责。在 vitro 调查它的 anticancer 机制, MCF-7 房间与 NGA 的各种各样的集中被对待。试金显示出的 MTT (甲基 thiazolyl tetrazolum ) 的结果有 NGA 的那治疗显著地以一种剂量依赖者方式减少了 MCF-7 房间的增长。NGA 能增加 anti-apoptotic 蛋白质 Bcl-2 的表示由 mitochondrial transmembrane 损坏伴随了的 apoptosis 相关的蛋白质 FasL, caspase-3, caspase-8, caspase-9,和 Bax 和减少的表示。MCF-7 房间上的 NGA 的 antiproliferative 效果由于 Fas/FasL 和细胞色素 C 小径的 G0/G1 拘捕,增加的 apoptosis 和激活。这些结果提供重要卓见进 NGA 通过损害乳癌房间的增长的细胞、分子的机制。 | Keming Wang Yuhong Tang Ming Sun Binbin Lu Hongqin Zhu Ou Ji Qun Shen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 9 |
| 3 | Combination types between graphene oxide and substrate affect the antibacterial activity显示文摘Duo to their superior physicochemical properties,graphene and its derivatives(GDs),such as graphene oxide(GO)and reduced graphene oxide(rGO),have attracted extensive research interests around the world.In recent years,antibacterial activities of GDs have aroused wide concern and substantial works have been done.However,the underlying antibacterial mechanisms still remain controversial.Antibacterial activities of GDs vary with various factors,such as size,number of layers,oxygen-containing groups,and experimental surroundings.We assume that combination types between graphene oxide and substrate may affect the antibacterial activity.Therefore,in this work,GO was fixed on the titanium surface with three kinds of combination types including drop with gravitational effects(GO-D),electrostatic interaction(GO-APS)and electrophoretic deposition(GO-EPD),and the antibacterial activities in vitro were systematically investigated.Results showed that combination types affected the ability of GO for preventing Staphylococcus aureus(S.aureus)from gathering,sharpness of wrinkles or edges and reactive oxygen spices(ROS)levels.Once S.aureus are in the form of separation without aggregation,GO can effectively interact with them and kill them with sharp wrinkles or edges and high ROS levels.GOEPD could effectively prevent S.aureus from gathering,own sharp wrinkles or edges and could generate higher ROS levels.As a result,GO-EPD exhibited optimal antibacterial activity against S.aureus,followed by GO-APS and GO-D. | Jiajun Qiu Lu Liu Hongqin Zhu Xuanyong Liu | 2018 | Bioactive Materials2018，3，3： | 7 |
| 4 | Indications of stratospheric anomalies in the freezing rain and snow disaster in South China,2008显示文摘NCEP/NCAR reanalysis data were used to characterize stratospheric temperature and water-vapor anomalies before and after the freezing rain and snow disaster of South China in 2008,and the influence of stratospheric circulation anomalies on the troposphere.Stratospheric temperature and water-vapor anomalies provided good leading indicators of this weather event.The period from December 1st 2007 to February 28th 2008 was divided into 18 pentads.During the 6th pentad,temperature decreased significantly at 10 hPa in the near-polar stratospheric region,and the decreasing trend strengthened and extended downward and southward to middle and lower latitudes.During the 14th-18th pentads,the temperature decrease reached its maximum and extended to 30°N.This coincided with the widespread freezing rain and snow event.By the end of January 2008,the temperature decrease ended in the near-polar stratospheric region,but continued in the mid-latitude area of the troposphere as the freezing rain and snow weather persisted.Similar to the temperature variations,positive anomalies of relative humidity in the stratospheric near-polar region also strengthened and extended downward and southward,coinciding with the freezing rain and snow event.Along with the significant relationship between the freezing rain and snow disaster and stratospheric circulation anomalies,the stratospheric polar vortex changed its shape in late December,intensifying and spreading downward from the top of the stratosphere and southward to the Asian continent,resulting in a deepening of the East Asian Trough and a strengthening of meridional circulation.Before the occurrence of the freezing rain and snow event,temperature and vapor increases in the stratosphere transferred downward to the troposphere,along with a stratospheric flow in the near-polar region southward to lower latitudes. | CHEN QuanLiang LI Zhan FAN GuangZhou ZHU KeYun ZHANG Wen ZHU HongQin | 2011 | Science China Earth Sciences2011，54，8： | 5 |
| 5 | Preliminary Investigation on the Main Fungal Diseases of Sugarcane in Guangxi Province of China显示文摘[Objective] The purpose was to understand species and occurrence status of major fugal diseases in sugarcane cultivation areas of Guangxi in China, so as to provide scientific references for integrated control against sugarcane diseases. [Method] Species and occurrence degrees of major fugal diseases in sugarcane cultivation areas of Guangxi were investigated through randomized surveys, farmer interviews, literature references and location investigations from 2009 to 2011. Diseased sugarcane samples were collected and their species were identified through pathogen isolated culture and other relevant methods. [Result] Thirteen species of fungal diseases were identified in the survey, including pineapple disease [Thielaviopsis paradoxa (de Seynes) V. Hohnel], smut(Ustilago scitaminea Sydow), top rot disease (Fusarium moniliforme Sheldon), rust (Puccinia melanocephala H.﹠P. Syd.), leaf scald disease (Stagonospora sacchari Lo et Ling), red rot disease (Colletotrichum falcatum Went), zonate spot disease (Phyllosticta saccharicola P. Henn.), leaf red spot disease [Pellicularia sasakii (Shirai) Ito], white rash disease (Elsinoe sacchari L.), eye spot [Helminthosporium sacchari (Breda de Haan) Butler], yellow spot [Mycovellosiella koepkei (kruger) Deighton], brown stripe [Bipolaris stenospilum (Drechs.) Shoem.]and brown spot (Cercospora longipes Butler). Smut, rust, top rot, and pineapple disease were the most rampantly detrimental to quality and yield of sugarcane. [Conclusion] Smut is the most serious sugarcane disease; it is urgent to breed sugarcane varieties with high resistance and excellent agronomic characters to replace current sugarcane varieties susceptible to diseases. | Wei Jinju Deng Zhanyun Huang Chenghua Huang Weihua Yan Meixin Liu Haibin Tang Hongqin | 2013 | Plant Diseases and Pests2013，4，1： | 3 |
| 6 | Ni_2P/ZrO_2-SBA-15 Dibenzothiophene Hydrodesulfurization Catalysts: Preparation,Characterization and Evaluation显示文摘Ni_2P/ZrO_2-SBA-15 catalysts with different zirconium n-propoxide/SBA-15 mass ratios were synthesized to evaluate their dibenzothiophene hydrodesulfurization catalytic activity. Effect of ZrO_2 introduction was investigated. Supports and catalysts were characterized by BET,XRD,^(29)SiNMR,XPS and FTIR. The results indicated that zirconium was incorporated into SBA-15 in the forms of [(–O–)_2 Si(–O–Zr)_2 ] and/or [(–O–)_3 Si–O–Zr],and that the SBA-15 framework structure was maintained after incorporation of ZrO_2. With zirconium content increasing,ZrO_2 was transformed from amorphous phase to tetragonal phase. Zirconium incorporation into SBA-15 supports could facilitate to form more dispersed Ni_2P active phase. There might be some interaction occurring between the P and Zr species. In addition to Ni_2P,another kind of active phase,ZrP,was formed,which might exhibit a better HDS activity than Ni_2P. It was observed that at a temperature of 280 °C,pressure of 3.0 MPa,WHSV of 6.5 h^(-1) and H_2 to oil ratio of 450,the Ni_2P/Zr-SBA(1.5) catalyst,where 1.5 represents zirconium n-propoxide/SBA-15 mass ratio,showed the highest DBT conversion,which was 86.6%,almost 35% higher than that of the Ni_2P/Zr-SBA(0) catalyst. | Hongqin Ma Qiurong Li Yang Shi Xiao Sun | 2018 | Transactions of Tianjin University2018，24，4： | 3 |
| 7 | Sea surface temperature variations in the southwestern South China Sea over the past 160 ka显示文摘在西南的华南海的海面温度(SST ) 从核心 MD01-2392 用 U_(37 )~ k paleothermometer 为过去的 160 ka 被重建了。冰川的时间(小姐 6 和 2 ) 和间冰期的时间之间的 Thetemperature 差别(错过 5。5 and1 ) 是 2。2 ~ 2.5 ℃。更年轻的 Dryas 事件在有孔虫目的δ ~(18 ) O 和 SST 记录的两 theplank 补品在最后冰川的消失期间被记录。在 MIS 5.5 以后, SST 显示了从 28 的进步冷却。6。5 ℃,在 LGM 达到顶点。在这个渐渐的冷却时期期间,温暖象小姐 5.3 那样的事件, 5。1 和 3 清楚地也被记录。由在学习核心和核心之间的 SST 的比较 17954,低或不南方的 SST 坡度的一个模式在冰纪期间在间冰期的时期和高南方的 SST 坡度期间被展出。这个模式显示强壮得多的东方亚洲冬季季风在比在间冰期的时期冰川。光谱分析给二突出的周期:与更多读了的前者,在南部的 SCS 建议那 SST 通过东方亚洲冬季季风的连接与高纬度的过程在音乐会改变了的 41 和 23 ka。 | XIE Hongqin JIA Guodong PENG Ping'an SHAO Lei | 2007 | Acta Oceanologica Sinica2007，26，2： | 3 |
| 8 | Structural phase transition in nanostructured γ-Fe_2O_3显示文摘DUE to their specific physical,chemical and mechanical properties and large application proba-bility in many fields,nanostructured materials have been developing very fast in the recent tenyears.Thermal stability is an important property of the materials.Some interesting resultshave been obtained in the study of the thermal stability of nanostructured materials. | YE Xisheng, SHA Jian, SONG Hongqin, JIAO Zhengkuan, LU Guanglie, PENG Zifei and ZHANG Lide1. Department of Physics, Zhejiang University, Hangzhou 310027, China 2. Central Laboratory, Hangzhou University, Hangzhou 310028, China 3. Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China | 1997 | Chinese Science Bulletin1997，42，11： | 3 |
| 9 | Intercultural teaching and learning strategies for global citizens: a Chinese EFL perspective显示文摘 | Hongqin Zhao Steven Coombs | 2012 | Teaching in Higher Education2012，，3： | 2 |
| 10 | Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies显示文摘Objective:Chimeric antigen receptor-modified T(CAR-T)cells have shown impressive results against relapsed/refractory B cell malignancies.However,the traditional manufacture of CAR-T cells requires leukapheresis to isolate large amounts of peripheral blood T cells,thus making some patients ineligible for the procedure.Methods:We developed a simple method for CAR-T cell preparation requiring small volumes of peripheral blood.First,CD3+T cells isolated from 50 mL peripheral blood from patients(B-cell malignancies)were stimulated with immobilized anti-CD3/RetroNectin in 6-well plates and then transduced with CAR-expressing lentiviral vector.After 4 d,the T cells were transferred to culture bags for large-scale CAR-T cell expansion.In vitro and animal experiments were performed to evaluate the activity of the manufactured CAR-T cells.Finally,29 patients with B-cell acute lymphoblastic leukemia(B-ALL)and 9 patients with B-cell lymphoma were treated with the CAR-T cells.Results:The CAR-T cells were expanded to 1–3×10^(8) cells in 8–10 d and successfully killed B cell-derived malignant tumor cells in vitro and in vivo.For patients with B-ALL,the complete remission rate was 93%1 month after CAR-T cell infusion;after 12 months,the overall survival(OS)and leukemia-free survival rates were 69%and 31%,respectively.For patients with lymphoma,the objective response rate(including complete and partial remission)was 78%2 months after CAR-T cell infusion,and after 12 months,the OS and progression-free survival rates were 71%and 43%,respectively.Cytokine-release syndrome(CRS)occurred in 65.51%and 55.56%of patients with B-ALL and B-cell lymphoma,respectively;severe CRS developed in 20.69%of patients with B-ALL and in no patients with lymphoma.Conclusions:Our novel method can generate sufficient numbers of CAR-T cells for clinical use from 50–100 mL peripheral blood,thus providing an alternative means of CAR-T cell generation for patients ineligible for leukapheresis. | Lu Han Jian Zhou Linlin Li Keshu Zhou Lingdi Zhao Xinghu Zhu Qingsong Yin Yufu Li Hongqin You Jishuai Zhang Yongping Song Quanli Gao | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 11 | General Situation of Green Manure Germplasm Resources in China and Research Progress on Decomposition Characteristics and Fertility Improvement of Green Manures显示文摘As a kind of biological fertilizer sources,green manure can improve soil fertility and the quality of agricultural products. This paper introduced the germplasm resource of green manures in the major provinces in China,mainly summarized the characteristics of decomposition and nutrients release of returning green manures to soils,as well as the influence on soil fertility and succeeding crops,with the aim to provide references for rational utilization of green manures and the scientific management of farmland nutrients. | Zhongyi LI Hongqin TANG Caihui WEI | 2018 | Agricultural Biotechnology2018，7，4： | 2 |
| 12 | Impacts of Multigrid NLS-4DVar-based Doppler Radar Observation Assimilation on Numerical Simulations of Landfalling Typhoon Haikui (2012)显示文摘We applied the multigrid nonlinear least-squares four-dimensional variational assimilation(MG-NLS4DVar)method in data assimilation and prediction experiments for Typhoon Haikui(2012)using the Weather Research and Forecasting(WRF)model.Observation data included radial velocity(Vr)and reflectivity(Z)data from a single Doppler radar,quality controlled prior to assimilation.Typhoon prediction results were evaluated and compared between the NLS-4DVar and MG-NLS4DVar methods.Compared with a forecast that began with NCEP analysis data,our radar data assimilation results were clearly improved in terms of structure,intensity,track,and precipitation prediction for Typhoon Haikui(2012).The results showed that the assimilation accuracy of the NLS-4DVar method was similar to that of the MG-NLS4DVar method,but that the latter was more efficient.The assimilation of Vr alone and Z alone each improved predictions of typhoon intensity,track,and precipitation;however,the impacts of Vr data were significantly greater that those of Z data.Assimilation window-length sensitivity experiments showed that a 6-h assimilation window with 30-min assimilation intervals produced slightly better results than either a 3-h assimilation window with 15-min assimilation intervals or a 1-h assimilation window with 6-min assimilation intervals. | Lu ZHANG Xiangjun TIAN Hongqin ZHANG Feng CHEN | 2020 | Advances in Atmospheric Sciences2020，37，8： | 1 |
| 13 | Predictive equation for the tracer diffusion of various solutes in gases,supercritical fluids,and liquids显示文摘 | Liu Hongqin Ruckenstein Eli | 1997 | Industrial & Engineering Chemistry Research1997，36，12： | 1 |
| 14 | Study on microbe retting of kenaf fiber显示文摘 | YU Hongqin YU Chongwen | 2007 | Enzyme and Microbial Technology2007，40，： | 1 |
| 15 | Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12–19‐year cohort study显示文摘 | Hui‐YingRao De‐GuiSun Rui‐FengYang FengLiu JianWang BoFeng NanWu Ji‐LianFang Guang‐JunSong HuiMa FangGuo Jiang‐HuaWang Xiao‐BoLi QianJin HongQin HuiZhuang LaiWei | 2012 | Journal of Gastroenterology and Hepatology2012，，3： | 1 |
| 16 | Fast chemical fingerprinting analysis for biodiesel/diesel blends using com- mercial solid phase extraction (SPE) cartridge and gas chromatography mass spectrometry (GC-MS) 显示文摘 | Ruan Xinchao Yang Zeyu Xie Hongqin | 2013 | Analytical Methods2013，5，5： | 1 |
| 17 | Role of Fas-Associated Death Domain-containing Protein (FADD) Phosphorylation in Regulating Glucose Homeostasis: from Proteomic Discovery to Physiological Validation显示文摘 | Chun Yao Hongqin Zhuang Pan Du Wei Cheng Bingya Yang Shengwen Guan Yun Hu Dalong Zhu Miller Christine Lv Shi Zi-Chun Hua | 2013 | Molecular & Cellular Proteomics2013，，10： | 1 |
| 18 | A novel method for preparing ultra-fine alumina-borate oxide fibres via an eleetrospinning technique显示文摘 | Dai Hongqin Gong Jian Kim Hakyong | 2002 | Nanotechnology2002，13，： | 1 |
| 19 | Macrophage migration inhibitory factor reduces apoptosis in cerebral arteriovenous malformations显示文摘 | Guangzhong Chen Meng Zheng Hang Shu Shengquan Zhan Hongqin Wang Dong Zhou Shaojian Zeng Kai Tang Lei Feng | 2011 | Neuroscience Letters2011，，2： | 1 |
| 20 | The mining of dynamic information based on P-sets and its applications 显示文摘 | WANG Yang GENG Hongqin SHI Kaiquan | 2010 | An International Journal Advances in Systems Science and Applications2010，10，2： | 1 |
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