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| 1 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
| 2 | Towards ultrastrong and ductile medium-entropy alloy through dual-phase ultrafine-grained architecture显示文摘Advanced materials with superior comprehensive mechanical properties are strongly desired,but it has long been a challenge to achieve high ductility in high-strength materials.Here,we proposed a new V 0.5 Cr 0.5 CoNi medium-entropy alloy(MEA)with a face-centered cubic/hexagonal close-packed(FCC/HCP)dual-phase ultrafine-grained(UFG)architecture containing stacking faults(SFs)and local chemical order(LCO)in HCP solid solution,to obtain an ultrahigh yield strength of 1476 MPa and uniform elongation of 13.2%at ambient temperature.The ultrahigh yield strength originates mainly from fine grain strength-ening of the UFG FCC matrix and HCP second-phase strengthening assisted by the SFs and LCO inside,whereas the large ductility correlates to the superior ability of the UFG FCC matrix to storage disloca-tions and the function of deformation-induced SFs in the vicinity of the FCC/HCP boundary to eliminate the stress concentration.This work provides new guidance by engineering novel composition and stable UFG structure for upgrading the mechanical properties of metallic materials. | Zhen Chen Hongbo Xie Haile Yan Xueyong Pang Yuhui Wang Guilin Wu Lijun Zhang Hu Tang Bo Gao Bo Yang Yanzhong Tian Huiyang Gou Gaowu Qin | 2022 | Journal of Materials Science & Technology2022，，31： | 1 |
| 3 | Accretion in strong field gravity with eXTP显示文摘In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced 'spectral-timing-polarimetry' techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process. | Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 1 |
| 4 | The closest neutron star found显示文摘The Milky Way galaxy has long been hypothesized to contain at least 100 million black holes(BHs)that are lurking in the shadows[1]and 10 times more neutron stars(NSs).Xray and radio telescopes are traditionally employed to find outbursts of BHs or NSs;however,finding BHs or NSs in quiescence is extremely challenging.Thus far,only a very small number of them[2]was found,pretty much like the tip of an iceberg,and finding more of them is quite hard using traditional methods. | Lijun Gou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，12： | 0 |
| 5 | Spectral analysis of new black hole candidate AT2019wey observed by NuSTAR显示文摘AT2019 wey is a new galactic X-ray binary that was first discovered as an optical transient by the Asteroid Terrestrial-impact Last Alert System(ATLAS)on December 7,2019.AT2019 wey consists of a black hole candidate as well as a low-mass companion star(M_(star)≤1.0 M_(■))and is likely to have a short orbital period(P_(orb)≤16h).Although AT2019 wey began activation in the X-ray band on March 8,2020,it did not enter the soft state during almost the entire outburst.In this study,we present a detailed spectral analysis of AT2019 wey in the low/hard state during its X-ray outburst on the basis of Nuclear Spectroscopic Telescope Array(Nu S T AR)observations.We obtain tight constraints on several of its important physical parameters by applying the state of the art relxill relativistic reflection model family.In particular,we determine that the measured inner radius of the accretion disk is most likely to have extended to the innermost stable circular orbit(ISCO)radius,i.e.,R_(in)=1.38^(+0.23)_(-0.16)R_(ISCO).Hence,assuming R_(in)=R_(ISCO),we find the spin of AT2019 wey to be a*~0.97,which is close to the extreme and an inner disk inclination angle of i~22°.Additionally,according to our adopted models,AT2019 wey tends to have a relatively high iron abundance of AFe~5A_(Fe,■)and a high disk ionization state of logξ~3.4. | Ye Feng XueShan Zhao LiJun Gou YuFeng Li James FSteiner Javier AGarc´ıa Yuan Wang Nan Jia ZhenXuan Liao HuiXian Li | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，1： | 0 |
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