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| 1 | The Late Mesozoic Orogenic Processes of Mongolia-Okhotsk Orogen: Evidence from Field Investigations into Deformation of the Mohe Area, NE China显示文摘Based on field investigation in 1999, two deformational domains with d ifferent dynamics have been distinguished from the Jurassic geological outcrops in the Mohe area of NE China, i.e. northern ductile and southern plastic-brittl e ones. Their deformational features are stated in this paper. And then, three st ages of structural deformation of the area relative to the late Mesozoic orogeni c processes of Mongolian-Okhotsk orogen are reconstructed as follows, (1) south w ards thrusting in the middle-late Jurassic, (2) eastwards thrusting and strike -s lipping parallel to the orogen in the late Jurassic, and (3) southeastwards thru sting in the early Cretaceous. | Li Jinyi, He Zhengjun, Mo Shenguo and (Institute of Geology, CAGS, Beijing 100037, China) Zheng Qingdao (Heilongjiang Bureau of Exploration and Exploitation of Geology and M ineral Resources, Ha’erbin 150036, China) | 1999 | Global Geology1999，4，2： | 26 |
| 2 | Clinical Observation of Transepithelial Corneal Collagen Cross-linking by Iontophoresis of Riboflavin in Treatment of Keratoconus显示文摘Purpose: To evaluate the efficacy and safety of transepithelial collagen cross-linking by iontophoretic delivery of riboflavin in treatment of progressive keratoconus.Methods:.Eleven patients(15 eyes) with progressive keratoconus were enrolled. After 0.1% riboflavin-distilled water solution was deliveried via transepithelial iontophpresis for 5 min with 1 m A current, and ultraviolet radiation(370 nm,.3 m W /cm2) was performed at a 1.5 cm distance for 30 min. The follow up were 6 months in all eyes. The uncorrected visual acuity, corrected visual acuity,endothelial cell counting, corneal thickness,.intraocular pressure, corneal curvature, corneal topography,.OCT and corneal opacity before and 6-month after surgery were analyzed.Results: At 6 month postoperatively, mean uncorrected visual acuity and corrected visual acuity changed from 0.36 to 0.30 and from 0.42 to 0.57 without statistical significance..The mean value of each index of corneal curvature declined without statistical significance.Kmax value dereased from 60.91 to59.91, and the astigmatism declined from 3.86 to 3.19. Central corneal thickness decreased from 460.93 μm to 455.40μm,.and thinnest corneal thickness declined from 450.87 μm to 440.60 μm with no statistical significance..Intraocular pressure was significantly elevated from 10.85 mm Hg to 12.62 mm Hg. Endothelial cell count did not change significantly. No corneal haze occurred. Mean depth of corneal demarcation line was 288.46 μm at 1 month postoperatively..Conclusion:.Transepithelial corneal collagen cross-linking by iontophoresis is effective and safe in the treatment of progressive keratoconus, and yields stable clinical outcomes during 6-month follow up..However,.long-term follow up is urgently required. | Na Li Zhengjun Fan Xiujun Peng Xu Pang Chunyu Tian | 2014 | Eye Science2014，29，3： | 15 |
| 3 | Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells显示文摘Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. | Qin Zhang Ying Pan Benhua Zeng Xiaojiao Zheng Haifang Wang Xueying Shen Hui Li Qian Jiang Jiaxu Zhao Zhuo-Xian Meng Pingping Li Zhengjun Chen Hong Wei Zhihua Liu | 2019 | Cell Research2019，29，7： | 11 |
| 4 | Downregulation of lncRNA AFAP1-AS1 by oridonin inhibits the epithelial-to-mesenchymal transition and proliferation of pancreatic cancer cells显示文摘Recent studies have demonstrated that the expression of the long non-coding RNA(lncRNA)AFAP1-AS1 in pancreatic cancer is negatively correlated with survival and prognosis.However,the effects of oridonin and lncRNA AFAP1-AS1 on the epithelial-to-mesenchymal transition(EMT)and migration of pancreatic cancer cells have not been fully elucidated.Surgery is the only potentially curative method for pancreatic cancer,but postoperative recurrence and metastasis are common.The aim of the present study was to assess the effect of oridonin and lncRNA AFAP1-AS1 silencing on pancreatic cancer cells.The pancreatic cancer cell lines BxPC-3 and PANC-1 cells were transfected with siAFAP1-AS1 and its negative control(siNC).After that,oridonin was used to treat the siAFAP1-AS1-transfected cells.The expression of lncRNA AFAP1-AS1 was downregulated in the pancreatic cancer cell lines BxPC-3 and PANC-1.The apoptosis and cell cycle progression of pancreatic cancer cells were evaluated by flow cytometry and Hoechst 33258 staining.Metastasis and invasion of BxPC-3 and PANC-1 cells were detected by transwell migration assay,real-time cell analysis,and western blot analysis.Cells were transfected with the lentiviral siAFAP1-AS1 and siNC,and tumorigenesis was evaluated in BALB/C nude mice.Immunohistochemical examination was used to verify the effects of oridonin and siAFAP1-AS1 on pancreatic cancer.The results demonstrated that the combination of oridonin and siAFAP1-AS1 inhibited pancreatic cancer cell proliferation,induced apoptosis,arrested cell cycle progression,prevented the migration,regulated EMT-related protein expression in BxPC-3 and PANC-1 cells,and inhibited pancreatic cancer cell tumorigenicity and EMT in nude mice. | Songmei Lou Jian Xu Bili Wang Shuquan Li Jun Ren Zhengjun Hu Bin Xu Feng Luo | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 10 |
| 5 | Rapid Recognition of Isomers of Monochlorobiphenyls at Trace Levels by Surface-Enhanced Raman Scattering Using Ag Nanorods as a Substrate显示文摘Isomers and homologues of organic pollutants are hard to distinguish-especially in trace amounts-due to the similarities in their physical and chemical properties. We report here that by identifying the Raman characteristics of isomers of monochlorobiphenyls, these compounds can be recognized, even at trace levels, by using the surface-enhance Raman scattering method with silver nanorods as a substrate. When dissolved in acetone, 2-, 3-, and 4-chlorobiphenyls were detected at a concentration of 10^(-8) mol/L, at which their characteristic Raman peaks were visible. This study may provide a fast, simple, and sensitive method for the detection and recognition of organic pollutants such as polychlorinated biphenyls. | Qin Zhou Ye Yang Jie Ni Zhengcao Li Zhengjun Zhang | 2010 | Nano Research2010，3，6： | 9 |
| 6 | Iontophoretic Delivery of Riboflavin into the Rabbit Cornea:a Primary Study显示文摘Purpose: To determine the penetrability of riboflavin into the corneal stroma by iontophoresis and to compare the permeability effects of different solvents.Methods: Twenty rabbits were randomly divided into four groups: a group that received 0.1% riboflavin-balanced salt solution(BSS) by iontophoresis, a group that received 0.1%riboflavin-saline solution by iontophoresis, a group that received 0.1% riboflavin-distilled water solution by iontophoresis, and a control group that received classical riboflavin instillation after corneal de-epithelialization. The degree of yellowing of the de-epithelialized corneal stromal button from each rabbit was compared.Results: The yellow color scores for the corneal stromal buttons in the three iontophoresis groups were compared with those of control group. Iontophoretic delivery of a 0.1% riboflavin-distilled water solution yielded similar yellow changes in the corneal stromal button when compared with classical riboflavin instillation after de-epithelialization. However, the other two solvents did not sufficiently enhance the permeability of riboflavin.Conclusion: Riboflavin can effectively penetrate into the corneal stroma to saturation levels by iontophoresis. Using distilled water as the solvent can promote penetrability. | Na Li Xiujun Peng Zhengjun Fan Yu Xia | 2014 | Eye Science2014，29，1： | 9 |
| 7 | A NOVEL METHOD FOR PLANNING A STAGED EVACUATION显示文摘这份报纸论述一个创新方法便于做如此的一个计划。使用一个算法安排每个撤退组,的开始的时间完成大规模撤退的时间离它的理论上最短的撤退很靠近的方法保证预定。在与建议方法计划的上演撤退期间,同时,所有撤离者不同于同时的撤退,能带最短的路径去一个安全出口。一旦撤离者出发,他们不承受任何交通拥挤。这个创新方法的上述优点被与三个嵌套的环使用一个算法完成。实验被进行了,并且他们的结果验证了建议方法。 | Xiang LI Bo HUANG Zhengjun LIU Xihui ZHANG Jing SUN | 2012 | Journal of Systems Science & Complexity2012，25，6： | 6 |
| 8 | Pollution level and human health risk assessment of some pesticides and polychlorinated biphenyls in Nantong of Southeast China显示文摘Food consumption is one of the key exposure routes of humans to contaminants.This article evaluated the residue levels of 51 pesticides and 16 polychlorinated biphenyls(PCBs) in selected fish and food items which were commonly consumed in the Nantong area of Jiangsu Province,Southeast China.The 51 pesticides and 16 PCBs were analyzed by highly sensitive gas chromatographytandem mass spectrometry(GC-MS/MS).The results showed that organochlorine pesticides such as dichlorodiphenyltrichloroethanes(DDTs),hexachlorocyclohexanes(HCHs),hexachlorobenzene(HCB) and mirex and other pesticides including chlorpyrifos,pyrethroid pesticides,metolachlor,pyridaben and trifluralin were frequently detected in the samples,which was consistent with the accumulation level and characteristics of these toxic chemicals in human adipose tissue of people living in Nantong.Meanwhile,correlation of the residue level of toxic chemicals with their physical chemical properties and historic use pattern in Nantong area was observed.Combined with dietary survey results at the same sampling locations,human health risk assessment of ingestion through the dietary route was performed.The results suggested that the non-cancer risks of the chemicals investigated can be considered negligible in the Nantong area,however,the cancer risks from lifetime dietary exposure to DDTs and HCB have exceeded the acceptable levels. | Na Wang Li Yi Lili Shi Deyang Kong Daoji Cai Donghua Wang Zhengjun Shan | 2012 | Journal of Environmental Sciences2012，24，10： | 5 |
| 9 | Two-Dimensional Materials in Large-Areas: Synthesis, Properties and Applications显示文摘Large-area and high-quality two-dimensional crystals are the basis for the development of the next-generation electronic and optical devices.The synthesis of two-dimensional materials in wafer scales is the first critical step for future technology uptake by the industries;however,currently presented as a significant challenge.Substantial efforts have been devoted to producing atomically thin two-dimensional materials with large lateral dimensions,controllable and uniform thicknesses,large crystal domains and minimum defects.In this review,recent advances in synthetic routes to obtain high-quality two-dimensional crystals with lateral sizes exceeding a hundred micrometres are outlined.Applications of the achieved large-area two-dimensional crystals in electronics and optoelectronics are summarised,and advantages and disadvantages of each approach considering ease of the synthesis,defects,grain sizes and uniformity are discussed. | Ali Zavabeti Azmira Jannat Li Zhong Azhar Ali Haidry Zhengjun Yao Jian Zhen Ou | 2020 | Nano-Micro Letters2020，12，5： | 4 |
| 10 | STUDIES ON MICROYIELD BEHAVIOR OF A SiCp/2024Al COMPOSITE显示文摘1INTRODUCTIONDuetotheexcelentcomprehensivepropertiessuchashighspecificstrengthandYoung’smodulus,lowerthermalconductivityandt... | Zhang, Fan Li, Xiaocui Jin, Chen Hu, Zhengjun | 1998 | 中国有色金属学会会刊:英文版1998，8，3： | 4 |
| 11 | Microorganism population in two-phase anaerobic fermentation of separated liquid of dairy manure显示文摘In order to reduce incomplete fermentation caused by high substrate viscosity and low mass transfer efficiency during fermentation process,batch and two-phase anaerobic fermentation experiments were conducted in this study.Dairy manure was separated by using solid-liquid separator firstly.Separated liquid(SL)and diluted dairy manure(DDM)as raw materials were evaluated in terms of gas production performance for both batch and two-phase anaerobic fermentation.The microorganism population was characterized by scanning electron microscope(SEM)and Denaturing Gradient Gel Electrophoresis(DGGE).The results showed that Volatile Solid(VS)methane yield of SL was 124.51 L/kg VS,which was 2.09 times higher than that of DDM(59.50 L/kg VS)in batch anaerobic fermentation.The Bacteroides and Veillonella with higher activity were the majority microorganism population in acidogenic phase,whereas the Firmicutes and Corynebacterium with methanogenic properties became the predominant microorganism population in methanogenic phase.This study achieved the phase separation and improved the gas production performance. | Qiang Li Zhengjun Guan Guoxiang Zheng | 2018 | International Journal of Agricultural and Biological Engineering2018，11，1： | 3 |
| 12 | 3D dynamic motion of a dielectric micro-sphere within optical tweezers显示文摘Known as laser trapping,optical tweezers,with nanometer accuracy and pico-newton precision,plays a pivotal role in single bio-molecule measurements and controllable motions of micro-machines.In order to advance the flourishing applications for those achievements,it is necessary to make clear the three-dimensional dynamic process of micro-particles stepping into an optical field.In this paper,we utilize the ray optics method to calculate the optical force and optical torque of a micro-sphere in optical tweezers.With the influence of viscosity force and torque taken into account,we numerically solve and analyze the dynamic process of a dielectric micro-sphere in optical tweezers on the basis of Newton mechanical equations under various conditions of initial positions and velocity vectors of the particle.The particle trajectory over time can demonstrate whether the particle can be successfully trapped into the optical tweezers center and reveal the subtle details of this trapping process.Even in a simple pair of optical tweezers,the dielectric micro-sphere exhibits abundant phases of mechanical motions including acceleration,deceleration,and turning.These studies will be of great help to understand the particle-laser trap interaction in various situations and promote exciting possibilities for exploring novel ways to control the mechanical dynamics of microscale particles. | Jing Liu Mian Zheng Zhengjun Xiong Zhiyuan Li | 2021 | Opto-Electronic Advances2021，4，1： | 2 |
| 13 | Low - temperature increases the yield of biologically active herring antifreeze protein in Pichia pastoris 显示文摘 | Zhengjun Li Fei Xiong Qingsong Lin | 2001 | Protein Exp Purif2001，21，： | 1 |
| 14 | A De Novo Variant Identified in the PPP2R1A Gene in an Infant Induces Neurodevelopmental Abnormalities显示文摘Dear Editor,Neurodevelopmental disorders include a wide range of conditions such as epilepsy,intellectual disability,and autism spectrum disorder.These disorders commonly cooccur in patients,which suggests that they share a common etiology[1,2].Genetic advances resulting from sequencing techniques over the past few years have greatly expanded our understanding of neurodevelopmental disorders. | Yanghui Zhang Haoxian Li Hua Wang Zhengjun Jia Hui Xi Xiao Mao | 2020 | Neuroscience Bulletin2020，36，2： | 1 |
| 15 | Design and characterization of a piezoelectric scavenging device with multiple reso- nant frequencies显示文摘 | Chew Zhengjun Li Lijie | 2010 | Sensors and Actuators A2010，162，： | 1 |
| 16 | Low-temperature increases the yield of biologically active herring antifreeze protein in pichia pastoris 显示文摘 | Zhengjun Li Fei Xiong Qingsong Lin | 2001 | Protein Expression and Purification2001，21，3： | 1 |
| 17 | Partial characterization and immunostimulatory activity of exopolysaccharides from Lactobacillus rhamnosus KF5显示文摘 | SHAO Li WU Zhengjun ZHANG Hao | 2014 | Carbohydrate Polymers2014，107，： | 1 |
| 18 | Molecular characteristics of an exopolysaccharide from Lactobacillus rhamnosus KF5 in solution显示文摘 | SHAO Li WU Zhengjun TIAN Fengwei | 2015 | International Journal of Biological Macromolecules2015，72，： | 1 |
| 19 | A weighted multi-scale morphological gradient filter for rolling element bearing fault detection显示文摘 | Li Bing Zhang Peilin Wang Zhengjun | 2011 | ISA Trans- actions2011，50，4： | 1 |
| 20 | Mec-hanical properties and fracture morphology of Al(OH)3/polypropylene composites modified by PP grafting with acrylic acid显示文摘 | Mai Kancheng Li Zhengjun Qiu Yuxin | 2001 | Journal of Applied Polymer Science2001，80，13： | 1 |
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