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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Spatio-temporal dynamics of vegetation and its relationship with climate factors Mongolia, China coverage in Inner显示文摘The vegetation coverage dynamics and its relationship with climate factors on different spatial and temporal scales in Inner Mongolia during 2001-2010 were analyzed based on MODIS-NDVI data and climate data.The results indicated that vegetation coverage in Inner Mongolia showed obvious longitudinal zonality,increasing from west to east across the region with a change rate of 0.2/10°N.During 2001-2010,the mean vegetation coverage was 0.57,0.4 and 0.16 in forest,grassland and desert biome,respectively,exhibiting evident spatial heterogeneities.Totally,vegetation coverage had a slight increasing trend during the study period.Across Inner Mongolia,the area of which the vegetation coverage showed extremely significant and significant increase accounted for 11.25% and 29.13% of the area of whole region,respectively,while the area of which the vegetation coverage showed extremely significant and significant decrease accounted for 7.65% and 26.61%,respectively.On inter-annual time scale,precipitation was the dominant driving force of vegetation coverage for the whole region.On inter-monthly scale,the change of vegetation coverage was consistent with both the change of temperature and precipitation,implying that the vegetation growth within a year is more sensitive to the combined effects of water and heat rather than either single climate factor.The vegetation coverage in forest biome was mainly driven by temperature on both inter-annual and inter-monthly scales,while that in desert biome was mainly influenced by precipitation on both the two temporal scales.In grassland biome,the yearly vegetation coverage had a better correlation with precipitation,while the monthly vegetation coverage was influenced by both temperature and precipitation.In grassland biome,the impacts of precipitation on monthly vegetation coverage showed time-delay effects. | MU Shaojie YANG Hongfei LI Jianlong CHEN Yizhao GANG Chengcheng ZHOU Wei JU Weimin | 2013 | Journal of Geographical Sciences2013，23，2： | 28 |
| 3 | Orbit determination of Chang'E-3 and positioning of the lander and the rover显示文摘Chang’E-3 landed on the east of Sinus Iridum area on December 14,2013,performing China’s first successful soft landing on the lunar surface.We present the results on precision orbit determination and positioning of the lander and the rover.We describe the data,modeling,and methods used to achieve position knowledge over the period December 2–21,2014.In addition to the radiometric X-band range and Doppler tracking data,delta differential one-way ranging data are also used in the calculation,which show that they strongly improve the accuracy of the orbit reconstruction.Total position overlap differences are about 20 and 30 m for the 100 km 9 100 km and100 km9 15 km lunar orbit,respectively,increased by*50%with respect to CE-2 and at the same level as other lunar spacecrafts of recent era such as SELENE and lunar reconnaissance orbiter(LRO).The position error of the soft landing trajectory is less than 100 m.A kinematic statistical method is applied to determine the position of the lander and relative position of the rover with respect to the lander.The position difference of the lander is better than50 m compared to LRO photograph result.Compared with the delta very long baseline interferometry(VLBI)group delay between the lander and the rover,the delta VLBI phase delay can improve the relative position of the rover from*1,000 to*1 m. | Yong Huang Shengqi Chang Peijia Li Xiaogong Hu Guangli Wang Qinghui Liu Weimin Zheng Min Fan | 2014 | Chinese Science Bulletin2014，59，29： | 28 |
| 4 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 5 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 6 | Discovery of Late Cretaceous foraminifera in the Songliao Basin: Evidence from SK-1 and implications for identifying seawater incursions显示文摘The Songliao Basin is the largest oil-bearing basin in China.In the absence of sufficient evidence,the possibility of seawater incursion(s) into the Songliao Basin remains controversial.Recently,we discovered relatively abundant foraminifera fossils from units 1 and 2 of the Nenjiang Formation of borehole SK-1.Benthic foraminifera (Gavlinella sp.,Anomalinoides sp.,Pullenia sp.,Haplophragmoides sp.,Karrorulina hokkaidoana,Clavulinoides sp.),as well as planktonic foraminifera (Archaeoglobigerina blowi,Archaeoglobigerina cretacea and Hedbergella flandrini),were identified.These fossils were widely distributed in the marine Cretaceous.According to the global distribution of the above-mentioned planktonic foraminifera,the age of these fossil bearing strata appears to be Late Coniacian to Santonian.More importantly,these foraminifera provide direct evidence for marine water incursions into the Songliao Basin during deposition of the Lower Nenjiang Formation. | XI DangPeng WAN XiaoQiao FENG ZhiQiang LI Shun FENG ZiHui JIA JianZhong JING Xia SI WeiMin | 2011 | Chinese Science Bulletin2011，56，3： | 21 |
| 7 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 8 | PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130显示文摘Golgi 仪器(GA ) 的维护结构和功能取决于 Golgi 矩阵蛋白质。象 golgin 和掌握家庭的成员的 phosphorylation 那样的 Golgi 蛋白质的 posttranslational 修正为决定 Golgi 建筑学是重要的。包括 golgin-84 的一些 Golgi 蛋白质也被知道是 methylated,但是 golgin methylation 的功能仍然保持不清楚。这里,我们证明蛋白质精氨酸 methyltransferase (PRMT5 ) 5 本地化到 GA 和形式建筑群,几个部件在拴住的 GA 带子形成和泡包含了。PRMT5 在 Golgi 带子形成与 PRMT5 原因缺点的 golgin GM130,和弄空交往。而且,在 GM130 的 PRMT5 甲醇化物 N 终端精氨酸,和如此的精氨酸 methylation 为 GA 显得批评带子形成。我们的调查结果揭示 GM130 的 PRMT5 依赖的精氨酸 methylation 由控制 GA 建筑学的维护的分子的机制。 | Zhongwei Zhou Xiaotian Sun Zhenhua Zou Litao Sun Tao Zhang Shaoshi Guo Ya Wen Lin Liu Yi Wang Jun Qin Lei Li Weimin Gong Shilai Bao | 2010 | Cell Research2010，20，9： | 16 |
| 9 | Biosorption of Cu(Ⅱ) on extracellular polymers from Bacillus sp.F19显示文摘Biosorption can be an effective process for the removal of heavy metals from aqueous solutions.The adsorption of Cu(Ⅱ) from aqueous solution on the extracellular polymers (EPS) from Bacillus sp.(named MBFF19) with respect to pH,incubation time,concentration of initial Cu(Ⅱ),and biosorbent dose was studied.Biosorption of Cu(Ⅱ) is highly pH dependent.The maximum uptake of Cu(Ⅱ) (89.62 mg/g) was obtained at pH 4.8.Biosorption equilibrium was established in approximately 10 min.The correlation coeffcient of more than 0.90 turned out that the adsorption process of Cu(Ⅱ) on MBFF19 was in accordance with both Langmuir and Freundlich isotherms.The pseudo-first and second order models were applied to examine the kinetics of the adsorption,whereas the latter was found to be in harmony with the kinetic data better.Because of the outstanding uptake capacity of Cu(Ⅱ),MBFF19 produced by Bacillus sp.was proved to be an excellent biosorbent for removing Cu(Ⅱ) from aqueous solutions. | ZHENG Yan,FANG Xuliang,YE Zhilong,LI Yahong,CAI weimin School of Environmental Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China. | 2008 | Journal of Environmental Sciences2008，20，11： | 15 |
| 10 | Preparation and Characterization of KNO3/Diatomite Shape-Stabilized Composite Phase Change Material for High Temperature Thermal Energy Storage显示文摘A new potassium nitrate(KNO_3)/diatomite shape-stabilized composite phase change material(SSCPCM) was prepared by the mixing and sintering method. KNO_3 served as the phase change material(PCM) for thermal energy storage, while diatomite acted as the carrier matrix to provide the structural strength and prevent the leakage of PCM. It was found that KNO_3 could be retained 65 wt% into pores and on surfaces of diatomite without the leakage of melted KNO_3 from the SS-CPCM. The calculated filling rate of molten KNO_3 that could enter into the disc-like shape pore of diatomite verified the scanning electronic microscopy images of SS-CPCM. X-ray diffraction and Fourier transform infrared spectroscopy results showed that no reaction occurred between KNO_3 and diatomite, performing good compatibility. According to the differential scanning calorimetry results, after 50 thermal cycles, the phase change temperatures for melting and freezing of SS-CPCM with 65 wt% KNO_3 were changed from 330.23 °C and 332.90 °C to330.11 °C and 332.84 °C and corresponding latent heats varied from 60.52 J/g and 47.30 J/g to 54.64 J/g and 41.25 J/g, respectively. The KNO_3/diatomite SS-CPCM may be considered as a potential storage media in solar power plants for thermal energy storage. | Yong Deng Jinhong Li Tingting Qian Weimin Guan Xiang Wang | 2017 | Journal of Materials Science & Technology2017，33，2： | 15 |
| 11 | H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis显示文摘 | Xiaozhuan Dai Youhuang Bai Lihua Zhao Xianying DOU Yanhui Liu Lulu Wang Yi Li Weimin Li Yanan Hui Xinyu Huang Zonghua Wang Yuan Qin | 2017 | Molecular Plant2017，10，10： | 14 |
| 12 | CIM-Based Grid Model and Graphics Exchange Format显示文摘BackgroundWith the rapid development of electric power system and the unceasing expansion of power grid,the operation and control of large power grid needs the support of on-line safe and stable analysis.In recent years,renewable energy is developing very rapidly,and lots of random,intermittent wind and solar power resources access network Therefore,the operation of power grid urgently needs the support of real-time on-line analysis tools.Severe weather has more and more impact on the operation of power grid.During the process of accident occurrence and recovery,multiple control centers requirecooperation. | Xin Yaozhong Mi Weimin Li Wei | 2011 | China Standardization2011，56，4： | 14 |
| 13 | Fuzzy Hybrid Control of Vibration Attitude of Full Car via Magneto-rheological Suspensions显示文摘A magneto-rheological(MR) semi-active suspension system with the controllable damping forces has received more attention in reducing the vibration of a vehicle. However, many control strategies only discussed one or two vibration states of the vehicle based on a quarter-car model or a half vehicle model via MR suspensions. They cannot provide a satisfying whole-vehicle performance on a road test. Hence, a full car vibration model via an MR suspension system is proposed. To reduce the heave, pitch and roll motion of the vehicle body and the vertical vibration of four wheels, a fuzzy hybrid controller for vibration attitude of full car via MR suspensions is proposed. First, a skyhook-fuzzy control scheme is designed to reduce the heave, roll and pitch motion of the vehicle body. Second, a revised ground hook control strategy is adopted to decrease the vertical vibration of the wheels. Finally, a hybrid control scheme based on a fuzzy reasoning method is proposed to tune the hybrid damping parameter, which is suitable for coordination the attitude of the vehicle body and the wheels. A test and control system for the vibration attitude of full car is set up. It is implemented on a car equipped with four MR suspensions. The results on random highway and rough road indicate that the fuzzy hybrid controller can decrease the vibration accelerations of the vehicle body and the wheels to 65%–80% and 80%–90%, respectively. It reduces the automotive vibrations of heave, roll and pitch more effectively than a passive suspension and an MR suspension with a traditional hybrid control scheme so that it achieves better ride comfort and road holding concurrently. This paper proposes a new fuzzy hybrid control(FHC) method for reducing vibration attitude of full car via MR suspensions and develops a road test to evaluate the FHC. | LI Rui CHEN Weimin LIAO Changrong DONG Xiaomin | 2010 | Chinese Journal of Mechanical Engineering2010，23，1： | 12 |
| 14 | Online Learning Control for Hybrid Electric Vehicle显示文摘Improvements in hybrid electric vehicle (HEV) fuel economy and emissions heavily depend on an efficient energy management strategy (EMS).However,the uncertainty of future driving conditions generally cannot be easily tackled in EMS design.Most existing EMSs act upon fixed parameters and cannot adapt to varying driving conditions.Therefore,they usually fail to fully explore the potential of these advanced vehicles.In this paper,a novel EMS design procedure based on neural dynamic programming (NDP) is proposed.The NDP is a generic online learning algorithm,which combines stochastic dynamic programming (SDP) and the temporal difference (TD) method.Instead of computing the utility function and optimal control actions through Bellman equations,the NDP algorithm uses two neural networks to approximate them.The weights of these neural networks are updated online by the TD method.It avoids the high computational cost that SDP suffers from and is suitable for real-time implementation.The main advantages of NDP EMS is that it does not rely on prior information related to future driving conditions,and can self-tune with a wide variance in operating conditions.The NDP EMS has been applied to 'Qianghua-I',a prototype of a parallel HEV,using a revolving drum test bench for verification.Experiment results illustrate the potential of the proposed EMS in terms of fuel economy and in keeping state of charge (SOC) deviations at a low level.The proposed research ensures the optimality of NDP EMS,as well as real-time applicability. | LI Weimin XU Guoqing XU Yangsheng | 2012 | Chinese Journal of Mechanical Engineering2012，25，1： | 12 |
| 15 | Identification and expression analysis of genes in response to high-salinity and drought stresses in Brassica napus显示文摘高咸度和干旱是不利地影响植物生长和农业生产率的主要不能生活的压力。为了调查基因,那响应不能生活的压力涉及 Brassica 马来麝,基因的全面调查导致了由高咸度并且干旱压力被 macroarray 分析做。总共, 536 克隆被识别是通常认为的 high-salinity- 或干旱应答的基因。在他们之中,而 141 和 189 分别地是 high-salinity- 和压制干旱的基因的候选人, 172 和 288 克隆被检测是通常认为的 high-salinity- 和干旱可诱导的基因。这些基因的功能的分类被显示那属于编码新陈代谢的酶,规章的因素,信号 transduction 的部件,荷尔蒙回答,一些不能生活的压力相关的蛋白质,和其它的基因家庭与 B 的生长和开发有关的进程。马来麝。从起来调整的候选人基因,一些感兴趣的基因进一步被表明由即时量的 RT-PCR 分析是 high-salinity- 或 / 并且导致干旱的表示。试验性的结果也表明一些基因可以在 abscisic 工作与干旱或咸度应力有关的酸依赖者的发信号小径。一起,在这研究介绍的数据将便于 B 的分子的机制的理解。马来麝响应高咸度并且干旱压力,并且也提供我们为改进 B 的压力忍耐的有效遗传工程策略的基础。马来麝。 | Liang Chen Feng Ren Hui Zhong Weimin Jiang Xuebao Li | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 12 |
| 16 | Determination of the controlled landing trajectory of Chang’E-1 satellite and the coordinate analysis of the landing point on the Moon显示文摘Based on the tracking observations of radio ranges and VLBI delays of Chang’E-1 (CE-1) satellite during the controlled landing on the Moon on March 1, 2009, the landing trajectory and the coordinates of the landing point are determined by positioning analysis. It is shown that the landing epoch (the emission epoch of the last signal) of CE-1 satellite on the Moon was at UTC8h13m6.51s. The lunar longitude, latitude and surface height of the landing point in the lunar primary axes frame are respectively 52.2732°, 1.6440° and –3.56 km (the reference lunar radius is 1738 km). The uncertainties are 0.0040°, 0.0168° and 0.18 km. The corresponding uncertainty in the tangential direction of the lunar surface is 0.52 km and the three-dimensional (3D) positioning uncertainty is 0.55 km. It is accordingly deduced that even with the present technical specifications of the radio ranges and VLBI delays, the 1 km 3D positioning precision could be guaranteed for the lander in the second stage of China’s Lunar Explora- tion Project. Concerning the trace determination of the rover on the lunar surface, because only telemetry signal will be emitted, VLBI would be the sole tracking technique from the Earth. The application of the constraint of geocentric distance is shown to be helpful to improving the positioning precision. It is worthy to pay close attention to the applications of the same beam VLBI technique, the lunar topographic model and the on-board observations of the lander and rover to the position/trace determination of the rover. | LI JinLing GUO Li QIAN ZhiHan JIANG DongRong ZHENG WeiMin HONG XiaoYu | 2010 | Chinese Science Bulletin2010，55，13： | 12 |
| 17 | Combined treatment with erythropoietin and granulocyte colony-stimulating factor enhances neovascularization and improves cardiac function after myocardial infarction显示文摘 | Xue Jingyi Du Guoqing Shi Jing Li Yue Masahiro Yasutake Liu Lei Li Jianqiang Kong Yihui Wang Shuxian Yun Fengxiang Li Weimin | 2014 | Chinese Medical Journal2014，，9： | 12 |
| 18 | Effects of fan speed on spray deposition and drift for targeting air-assisted sprayer in pear orchard显示文摘In order to reduce the application dosage of pesticides,a targeting air-assisted(TAA)sprayer was developed and tested in this study.Fruit trees were assayed by an infrared detection system to determine if the canopy needs to be sprayed.This TAA sprayer was compared with conventional air-assisted(CAA)sprayers,and the impacts of various fan speeds(0,800 r/min,1300 r/min,and 1800 r/min)on spray deposition,coverage,and drift amount were tested.Ponceau 2R was used as tracer to measure spray deposition under each treatment.Droplet coverage and canopy deposition were best when the CAA application fan speed was increased to 1300 r/min,but at higher fan speeds,spray deposition and coverage in canopy did not increase because extra air flow blew droplets from the ground into the air.During TAA spraying,droplet sizes increased at opening and closing moments.Optimal spray effects were achieved when the auxiliary airflow velocity was increased at a fan speed of 1800 r/min.The research provides a useful reference for the design of TAA and parameters optimization method with respect to the relationship between droplets deposition into tree canopy,ground and drift in the air. | Qiu Wei Zhao Sanqin Ding Weimin Sun Chengda Lu Jiang Li Yinian Gu Jiabing | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 12 |
| 19 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 20 | Precise positioning of the Chang'E-3 lunar lander using a kinematic statistical method显示文摘A kinematic statistical method is proposed to determine the position for Chang'E-3(CE-3) lunar lander.This method uses both ranging and VLBI measurements to the lander for a continuous arc,combing with precise knowledge about the motion of the moon as provided by planetary ephemeris,to estimate the lander's position on the lunar surface with high accuracy.Accuracy analyses are carried out with simulation data using the software developed at Shanghai Astronomical Observatory in this study to show that measurement errors will dominate the position accuracy.Application of lunar digital elevation model(DEM) as constraints in the lander positioning is also analyzed.Simulations show that combing range/doppler and VLBI data,single epoch positioning accuracy is at several hundred meters level,but with ten minutes data accumulation positioning accuracy is able to be achieved with several meters.Analysis also shows that the information given by DEM can provide constraints in positioning,when DEM data reduce a 3-dimensional positioning problem to 2-dimensional.Considering the Sinus Iridum,CE-3 lander's planned landing area,has been observed with dedicated details during the CE-1 and CE-2 missions,and its regional DEM model accuracy may be higher than global models,which will certainly support CE-3's lander positioning. | HUANG Yong HU XiaoGong LI PeiJia CAO JianFeng JIANG DongRong ZHENG WeiMin FAN Min | 2012 | Chinese Science Bulletin2012，57，35： | 11 |
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