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| 1 | Molecular cloning of differentially expressed novel rice genes induced by Magnaporthe grisea显示文摘WE have applied the differential display (D. D.) of mRNA method to detect and clone tran-scripts that were differentially expressed between rice NILs (Near-isogenic lines) H7R (resis-tant) and H7S (susceptible) which were induced by Magnaporthe grisea. The cDNA gene-tags obtained from D. D. analysis were reamplified by PCR and screened by Southern | He, ZH Dong, HT Cheng, SJ Wu, YL Dong, JX Li, DB | 1997 | Chinese Science Bulletin1997，42，20： | 4 |
| 2 | Effect of poxB gene knockout on metabolism in Escherichia coli based on growth characteristics and enzyme activities显示文摘 | Li, M Yao, SJ Shimizu, K | 2007 | 中国生物学文摘2007，21，10： | 2 |
| 3 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 4 | Functional improvement by electro-acupuncture after transient middle cerebral artery occlusion in rats显示文摘 | Wang SJ Omori N Li F | 2003 | Neurol Res2003，25，5： | 1 |
| 5 | Direct in vivo evidence demonstrating neointimal migration of adventitial fibroblasts after balloon injury of rat carotid arteries显示文摘 | Li G Chen SJ Oparil S | 2000 | Circulation2000，101，12： | 1 |
| 6 | Chondrogenesis of human bone marrow mesenchymal stem celis in fibrin-polyurethane composites is modulated by frequency and amplitude of dynamic compression and shear stress 显示文摘 | Li Z Yao SJ Alini M | 2010 | Tissue Eng PartA2010，16，2： | 1 |
| 7 | LKBI/AMPK/mTOR signaling pathway in non - small - cell lung cancer 显示文摘 | Han D Li SJ Zhu YT | 2013 | Asian Pac J Canc- er Prey2013，14，7： | 1 |
| 8 | Cerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder显示文摘 | Young LT Li PP Kish SJ | 1993 | J Neurochem1993，61，3： | 1 |
| 9 | Association of the Y402H polymorphism in complement factor H gene and neovascular age-related macular degeneration in chinese patients 显示文摘 | Lau LI Chen SJ Cheng CY | 2006 | Invest Ophthalmol Vis Sci2006，47，8： | 1 |
| 10 | Desferoxamine precon-ditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin显示文摘 | Li YX Ding SJ Xiao L | 2008 | Neurosci Bull2008，24，2： | 1 |
| 11 | Identification of a small molecule nonpeptide active site β- secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases 显示文摘 | Cobum CA Stachel SJ Li YM | 2004 | J Med Chem2004，47，25： | 1 |
| 12 | Evaluation of podocyte lesion in pa- tients with diabetic nephropathy:W ilms tumor-1 protein used as a podocyte marker 显示文摘 | Su J Li SJ Chen ZH | 2010 | Diabetes Res Clin Pract2010，87，2： | 1 |
| 13 | Antitumor effects of Wnt2b silencing in glut1 overexpressing cisplatin resistant head and neck squamous cell carcinoma显示文摘 | Li SJ Yang XN Qian HY | 2015 | Am J Cancer Res2015，5，1： | 1 |
| 14 | High methylation of the SEPT9 gene in Chinese colorectal cancer patients显示文摘 | Su XL Wang YF Li SJ | 2014 | Genet Mol Res2014，13，2： | 1 |
| 15 | Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C heads to hyperphosphorylation of Tau and impairment of spatial memory显示文摘 | Liu SJ Zhang AH Li HL | 2003 | Neurochem2003，87，6： | 1 |
| 16 | Crowding in central and eccentric vision: the effects of contour interaction and attention显示文摘 | Leat SJ Li W Epp K | 1999 | Invest Ophthaltool Vis Sci1999，40，2： | 1 |
| 17 | Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin,a mechanism involved in Alzheimer's neurodegeneration显示文摘 | Li HL Wang HH Liu SJ | 2007 | Proc Natl Acad Sci USA2007，104，： | 1 |
| 18 | Locally recurrent,previouslyirradiated head and neck cancer:Concurrent re-irradiation andchemotherapy,or chemotherapy alone?显示文摘 | Wong SJ Machtay M Li Y | 2006 | J Clin Oncolm2006，24，17： | 1 |
| 19 | Promotion of mouse fibroblast proliferation by IgE-dependent activation of mouse mast cell : role for mast cell tumor necrosis factor-alpha and transforming growth factor- beta 1 显示文摘 | Kendall JC Li XH Galli SJ | 1997 | J Allergy Clin Immunol1997，99，11： | 1 |
| 20 | Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin2 dependent kinase(CDK)4 and CDK6显示文摘 | Noh SJ Li Y XiongY | 1999 | CancerRes1999，59，3： | 1 |
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