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| 1 | Geochemistry and petrogenesis of Jurassic high Sr/low Y granitoids in eastern China: Constrains on crustal thickness显示文摘The Jurassic high Sr/low Y granitoids in eastern China are characterized by high Sr/Y (27-166) and La/Yb (14-66) ratios, low abundance in Y (6-21μg/g) and Yb (0.5-2.0μg/g), comparable with those of adakites defined by Defant et al. Thus, they were recently considered as adakitic rocks by some researchers. Compared with the typical adakites in circum-Pacific margins, however, these high Sr/low Y granitoids have higher K2O (-3.5%) but lower A12O3 (-16.0%) as well as lower Mg#(-38) and δSrN (-1.23) values. Furthermore, they show relatively flat HREE patterns with Y/Yb values of -10 close to the chondritic value. These geochemical characteristics indicate a residue mineral assemblage of hornblende, garnet and plagioclase for these high Sr/low Y granitoids melt. Thus, they were generated by partial melting at 9-13 kbar (30-45 km in depth), similar to the Archaean high-Al TTG rather than the modern adakites. Generation of these high Sr/low Y granitoids cannot be considered as evidence for a thickened | Ge, XY Li, XH Chen, ZG Li, WP | 2002 | Chinese Science Bulletin2002，47，11： | 51 |
| 2 | Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 expression in fibrotic rat liver显示文摘INTRODUCTIONLiver fibrosis is an excessive deposition ofextracellular matrix(ECM)resulted from bothincreased synthesis and decreased degradation.Matrix metalloproteinases(MMPs)represent agroup of neutral proteinases with variable | Liu HL Li XH Wang DY Yang SP | 2000 | World Journal of Gastroenterology2000，6，6： | 31 |
| 3 | Helicobacter pylori vacA genotypes and cagA status and their relationship to associated diseases显示文摘INTRODUCTIONHelicobacter pylori(H.pylori)is a major causativebacterium of chronic gastritis,peptic ulcer and mucosa-associated lymphoid tissue lymphoma in humans,andassociated with an increased risk of gastric cancer. | Hou P Tu ZX Xu GM Gong YF Ji XH Li ZS | 2000 | World Journal of Gastroenterology2000，6，4： | 27 |
| 4 | Late Mesozoic crust-mantle interaction in southeastern Fujian——Isotopic evidence from the Pingtan igneous complex显示文摘UNDERPLATING Of mantle-derived basaltic magma and interacting with the lower crust materials are believed to be an important mechanism for the growth and transformation of the crust. | Dong, CW Zhou, XM Li, HM Ren, SL Zhou, XH | 1997 | Chinese Science Bulletin1997，42，6： | 23 |
| 5 | Dietary factors and smoking as risk factors for PD in a rural population in China: a nested case-control study显示文摘 | Ma L Zhang L Gao XH Chen W Wu YP Wang Y Li XF Como P Kieburtz K Qiao YL | 2006 | 中国生物学文摘2006，20，8： | 13 |
| 6 | The effect of retinoic acid on Ito cell proliferation and content of DNA and RNA显示文摘 | Gao ZL Li DG Lu HM Gu XH | 1999 | World Journal of Gastroenterology1999，5，5： | 13 |
| 7 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 8 | Association of polymorphisms in the vascular endothelial growth factor gene and its serum levels with diabetic retinopathy in Chinese patients with type 2 diabetes: A cross-sectional study显示文摘 | Fan XH Wu QH Li Y Hao YH Ning N Kang Z Cui Y Liu RH | 2014 | Chinese Medical Journal2014，，4： | 4 |
| 9 | RHEOLOGICAL PROPERTIES OF METAL INVECTION MOLDING BINDER AND FEEDSTOCK显示文摘RHEOLOGICALPROPERTIESOFMETALINVECTIONMOLDINGBINDERANDFEEDSTOCK①LiYimin,QuXuanhui,HuangBaiyun,QiuGuanghanNationalKeyLaboratory... | Li, YM Qu, XH Huang, BY Qiu, GH | 1997 | 中国有色金属学会会刊:英文版1997，7，3： | 2 |
| 10 | Molecular diversity of microbial community in acid mine drainages of Yunfu sulfide mine显示文摘 | He ZG Xiao SM Xie XH Zhong H Hu YH Li QH Gao FL Li GY Liu JS Qiu GZ | 2007 | 中国生物学文摘2007，21，6： | 2 |
| 11 | Prevention of stroke in urban China-a community-based intervention trial 显示文摘 | Fang XH Kronmal RA Li SC | 1999 | Stroke1999，30，： | 1 |
| 12 | Tetraspanin CD151 plays a key role in skin squamous cell carcinoma 显示文摘 | Li Q Yang XH Xu F | 2013 | Oncogene2013，32，14： | 1 |
| 13 | Pifithrin-alpha enhances the surviv- al of transplanted neural stem cells in stroke rats by inhibiting p53 nuclear translocation 显示文摘 | Lei XH Zhao D Li YL | 2013 | CNS Neurosci Ther2013，19，： | 1 |
| 14 | Overexpression of miR- 125b, a novel regulator of innate immunity, in eosinophilie chronic rhinosinusitis with nasal polyps 显示文摘 | Zhang XH Zhang YN Li HB | 2012 | Am J Respir Crit Care Med2012，185，2： | 1 |
| 15 | Effects of polydatin on ALT, AST,TNF- alpha, and COX- 2 in sepsis model mice显示文摘 | Li XH Wu M J Zhang LN | 2013 | Zhong- guo Zhong Xi Yi Jie He Za Zhi2013，33，2： | 1 |
| 16 | Comparison study of fractional carbon dioxide laser resurfacing using different fluences and densities for acne scars in Asians: a randomized split-face trial 显示文摘 | Yuan XH Zbong SX Li SS | 2014 | Dermatol Surg2014，40，5： | 1 |
| 17 | Low molecular weight heparin (LM- WH) improves peritoneal function and inhibits peritoneal fibrosis possiblythrough suppression of HIF-IcL, VEGF and TGFq31 显示文摘 | Li J Guo ZY Gao XH | 2015 | PLoS One2015，10，01： | 1 |
| 18 | Overexpression of GRP78 and GRP94 arc markers for aggressiver behavior anti poor prognosis in gastric carcinomas 显示文摘 | Zheng HC Takahashi H Li XH | 2008 | Hum Pathol2008，39，7： | 1 |
| 19 | The upregulation of glial glutamate transporter-1 participates in the induction of brain ischemic tolerance in rats 显示文摘 | Zhang M Li WB Geng JX Li Q J Sun XC Xian XH | 2007 | J Cereb Blood Flow Metab2007，27，7： | 1 |
| 20 | Spinal cord injury in rat:treatment with bone marrow stromal cell transplantation显示文摘 | Chopp M Zhang XH Li Y | 2000 | Neuroreport2000，11，13： | 1 |
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