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| 1 | DI-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis显示文摘DI-3-n-butylphthalide is used to treat mild and moderate acute ischemic stroke.However,the precise underlying mechanism requires further investigation.In this study,we investigated the molecular mechanism of DI-3-n-butylphthalide action by various means.We used hydrogen peroxide to induce injury to PC12cells and RAW264.7 cells to mimic neuronal oxidative stress injury in stroke in vitro and examined the effects of DI-3-n-butylphthalide.We found that DI-3-nbutylphthalide pretreatment markedly inhibited the reduction in viability and reactive oxygen species production in PC12 cells caused by hydrogen peroxide and inhibited cell apoptosis.Furthermore,DI-3-n-butylphthalide pretreatment inhibited the expression of the pro-apoptotic genes Bax and Bnip3.DI-3-nbutylphthalide also promoted ubiquitination and degradation of hypoxia inducible factor 1α,the key transcription factor that regulates Bax and Bnip3 genes.These findings suggest that DI-3-n-butylphthalide exhibits a neuroprotective effect on stroke by promoting hypoxia inducible factor-1α ubiquitination and degradation and inhibiting cell apoptosis. | Shuai Li Jingyuan Zhao Yan Xi Jiaqi Ren Yanna Zhu Yan Lu Deshi Dong | 2023 | Neural Regeneration Research2023，18，11： | 3 |
| 2 | Development of an immunochromatographic lateral-flow test strip for rapid detection of sulfonamides in eggs and chicken muscles显示文摘 | WANG Xiliang LI Kui SHI Deshi | 2007 | J Agric Food Chem2007，55，6： | 1 |
| 3 | Development and validation of an immunochromatographic assay for rapid detection of sulfadiazine in eggs and chickens显示文摘 | WANG Xiliang LI Kui SHI Deshi | 2007 | Journal of Chromatography B2007，847，2： | 1 |
| 4 | Haemophilus parasuis infection activates the NF-κB pathway in PK-15 cells through IκB degradation显示文摘 | Yushan Chen Hui Jin Ping Chen Zili Li Xianrong Meng Mei Liu Shaowen Li Deshi Shi Yuncai Xiao Xiliang Wang Zutao Zhou Dingren Bi Rui Zhou | 2012 | Veterinary Microbiology (-)2012，，1： | 1 |
| 5 | Performance optimiza- tion of forging manipulator during the whole forging stroke 显示文摘 | Liu Deshi Li Gang Guo Xinglin | 2010 | In- telligent Robotics and Applications2010，6425，： | 1 |
| 6 | Efficient aggregation of mul- tiple classes of information in wireless sensor networks 显示文摘 | Qiu Xiaoling Liu Haiping Li Deshi | 2009 | Sensors2009，9，10： | 1 |
| 7 | Optimization of Multiple Gateway Deployment for Underwater Acoustic Sensor Networks显示文摘 | Jugen Nie Deshi Li Yanyan Han | 2011 | Computer Science and Information Sys- tems2011，8，4： | 1 |
| 8 | Reducing power grid cascading failure propagation by minimizing algebraic connectivity in edge addition显示文摘Analyzing network robustness under various circumstances is generally regarded as a challenging problem.Robustness against failure is one of the essential properties of large-scale dynamic network systems such as power grids,transportation systems,communication systems,and computer networks.Due to the network diversity and complexity,many topological features have been proposed to capture specific system properties.For power grids,a popular process for improving a network’s structural robustness is via the topology design.However,most of existing methods focus on localized network metrics,such as node connectivity and edge connectivity,which do not encompass a global perspective of cascading propagation in a power grid.In this paper,we use an informative global metric algebraic connectivity because it is sensitive to the connectedness in a broader spectrum of graphs.Our process involves decreasing the average propagation in a power grid by minimizing the increase in its algebraic connectivity.We propose a topology-based greedy strategy to optimize the robustness of the power grid.To evaluate the network robustness,we calculate the average propagation using MATCASC to simulate cascading line outages in power grids.Experimental results illustrate that our proposed method outperforms existing techniques. | Supaporn LONAPALAWONG Jiangzhe YAN Jiayu LI Deshi YE Wei CHEN Yong TANG Yanhao HUANG Can WANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，3： | 0 |
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