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| 1 | Peptide fraction from sturgeon muscle by pepsin hydrolysis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages via MAPK and NF-κB pathways显示文摘Previous studies have suggested that polypeptides extracted from milk, soybean, fish, eggs, and meat possess potential anti-inflammatory effects. To date, few studies have reported the anti-inflammatory function of sturgeon peptides and their underlying mechanisms are unknown. The current study was therefore to determine the anti-inflammatory potential of sturgeon peptides with lipopolysaccharide (LPS)-induced RAW264.7 inflammatory model. Pepsin hydrolysate (PeH) was purified by ultrafiltration and Sephadex G-15 gel filtration chromatography. PeH significantly reduced the inflammatory mediator (NO) and inflammatory cytokines (IL-6, TNF-α and IL-1β) expression in a dose-dependent manner. Moreover, the purified sturgeon peptide (F2) possessed strong antioxidant potential and effectively inhibited DPPH and ABTS free radicals. F2 significantly suppressed the expression of MAPK, IκBα, and NF-κB p65, indicating that F2 exerted anti-inflammatory influence by the inhibition of MAPK and NF-κB pathways. | Ruichang Gao Wanghui Shu Yang Shen Quancai Sun Wengang Jin Dajing Li Ying Li Li Yuan | 2021 | Food Science and Human Wellness2021，10，1： | 6 |
| 2 | Assessing the relative role of climate change and human activities in desertification of North China from 1981 to 2010显示文摘Desertification is a severe environmental problem induced by both climate change and human activities.This study assessed the relative contribution of climate change,human activities,and different climatic and anthropogenic factors in desertification reversion and expansion of North China from 1981 to 2010.The results showed that the desertification of North China had changed significantly over the past 30 years;desertification reversion and expansion covered an area of 750,464 km^2, and the spatial distribution of these regions exhibited considerable heterogeneity.For desertification reversion, climate change and human activity accounted for 22.6% and 26%,respectively of total reverted land.Wind speed reduction and the improvement ofhydrothermal conditions were the most important climatic factors for desertification reversion in the arid region of Northwest China (ARNC) and the Three-River Headwaters region (TRHR),and the reduction in grassland use intensity was the most important anthropogenic factor related to desertification reversion in Inner Mongolia and regions along the Great Wall (IMGW). For desertification expansion,the relative role of climate change was more obvious,which was mainly attributed to the continuous reduction in precipitation in eastern IMGW, and the increase in grassland use intensity was the main factor underlying regional human-induced desertification expansion. | Duanyang XU Alin SONG Dajing LI Xue DING Ziyu WANG | 2019 | Frontiers of Earth Science2019，13，1： | 2 |
| 3 | Optimized microwave-assisted extraction of total phenolics (TP) from Ipomoea batatas leaves and its antioxidant activity显示文摘 | Jiangfeng Song Dajing Li Chunquan Liu Ying Zhang | 2011 | Innovative Food Science and Emerging Technologies2011，，3： | 1 |
| 4 | Partial purification and characterization of polyphenol oxidase and peroxidase from chestnut kernel显示文摘 | Gong Zhiqing Li Dajing Liu Chunquan | 2015 | LWT-Food Science and Technology2015，60，2： | 1 |
| 5 | Imbalance of Th17/Treg cells in mice with chronic cigarette smoke exposure显示文摘 | Huaying Wang Weidong Peng Yuesong Weng Huajuan Ying Hequan Li Dajing Xia Wanjun Yu | 2012 | International Immunopharmacology2012，，4： | 1 |
| 6 | 3DT-PP:localization and path planning of mobile anchors over complex 3D terrains显示文摘Mobile anchors are widely used for localization in WSNs.However,special properties over 3D terrains limit the implementation of them.In this paper,a novel 3D localization algorithm is proposed,called 3 DT-PP,which utilizes path planning of mobile anchors over complex 3 D terrains,and simulations based upon the model of mountain surface network are conducted.The simulation results show that the algorithm decreases the position error by about 91%,8.7%and lowers calculation overhead by about 75%,1.3%,than the typical state-of-the-art localization algorithm(i.e.,'MDS-MAP','Landscape-3D').Thus,our algorithm is more potential in practical WSNs which are the characteristic of limited energy and 3D deployment. | 王瑞锦 Qin Zhiguang Li Dongfen Chen Dajing Wang Jiahao | 2014 | High Technology Letters2014，20，4： | 1 |
| 7 | Analysis of(all-?)-lutein and its(Z)-isomers during illumination in a model system显示文摘 | LI Dajing XIAO Yadong ZHANG Zhongyuan | 2014 | Journal of Pharmaceutical and Biomedical Analysis2014，100，： | 1 |
| 8 | Effect of sodium alginate-based hydrogel loaded with lutein on gut microbiota and inflammatory response in DSS-induced colitis mice显示文摘In order to effectively deliver lutein to the inflamed colon and better exert its pharmacological activity,this paper constructed a sodium alginate hydrogel-based delivery system loaded with lutein nanoparticles,evaluated the regulation on the expression and secretion of related inflammatory factors in mice with colitis,and its impact on intestinal microbial environment.The results showed that comparing lutein crystal and its nanoparticle,lutein hydrogel alleviated dextran sodium sulfate(DSS)-induced colitis in mice more effectively by adjusting fecal heme content,colon tissue damage,and inflammatory factor levels.Moreover,lutein hydrogel increased the expression of intestinal tight junction proteins zonula occluden-1(ZO-1),claudin-1 and occludin to maintain the integrity of the intestinal-barrier,inhibited the nuclear factor-κB(NF-κB)pathway and reduced expression and secretion of inflammatory factors including tumour necrosis factor-α(TNF-α),inducible nitric oxide synthase(iNOS),NOD-like receptors 3(NLRP3)and interleukin(IL)-1β.In addition,the intestinal microbial environment of mice with colitis was improved by down-regulating the relative abundance of Desulfovibrionaceae and up-regulating the relative abundance of Erysipelotrichaceae and Rikenellaceae.As a slow-release carrier to load lutein nanoparticles,sodium alginate-based hydrogel has potential application prospect. | Pengxiang Xu Shuwei Luo Jiangfeng Song Zhuqing Dai Dajing Li Cai’e Wu | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
| 9 | Changes in the sugars,amino acids and organic acids of postharvest sperminetreated immature vegetable soybean(Glycine max L.Merr.)as determined by^(1)H NMR spectroscopy显示文摘^(1)H NMR spectroscopy was adopted to determine compositional changes(mainly sugars,organic acids and amino acids)involved in cold-stored immature soybean grains after exogenous spermine treatment.Significant changes of sugars,including sucrose,galactose,myo-inositol,glucose and fructose were detected in soybean after spermine treatment.As for the organic acids related to tricarboxylic acid cycle,the levels of malic and fumaric acids decreased but the level of citric acid increased.However,no significant changes were observed for amino acids in spermine-treated soybeans.By using metabolic profile analysis,a difference was observed between the aging of soybean grains as such and those treated with spermine.This study provides an insight into the accumulation of metabolites in postharvest immature soybeans after exogenous spermine-treatment. | Jiangfeng Song Gang Wu Tao Li Chunquan Liu Dajing Li | 2020 | Food Production, Processing and Nutrition2020，2，1： | 0 |
| 10 | Correction to:Changes in the sugars,amino acids and organic acids of postharvest sperminetreated immature vegetable soybean(Glycine max L.Merr.)as determined by^(1)H NMR spectroscopy显示文摘Correction:Food Production,Processing and Nutrition 2,7(2020)http://gffzzd3cc09b8251d45dfs6xk6of655vwv6695.ffgz.tsg.suse.edu.cn/10.1186/s43014-020-00021-1 Following publication of the original article(Song et al.2020),the authors realised the Fig.1 was not very clear.The clear figure is given below. | Jiangfeng Song Gang Wu Tao Li Chunquan Liu Dajing Li | 2020 | Food Production, Processing and Nutrition2020，2，1： | 0 |
| 11 | Dielectric properties of edible fungi powder related to radio-frequency and microwave drying显示文摘Edible fungi are rich in nutrition,but they are susceptible to spoilage,and often prolonged by drying.RF and microwave energy drying have the advantages of short drying time,high energy efficiency and good process control.However,to develop an effective dielectric drying method,it is important to understand dielectric properties,the major factor characterizing the interaction between the electromagnetic energy and the food.At present,there is a lack of research on dielectric properties of edible fungi.In this study,a vector network analyzer and an open-ended coaxial-line probe were employed to measure the dielectric parameters.The dielectric parameters were observed at different temperatures(25–85°C)for edible fungi powder with moisture content ranging from 5 to 30%wet basis over a frequency range of 1–3000 MHz.The relationship between the dielectric properties and frequency,temperature,and moisture content were obtained via regression analysis.Further,the dielectric penetration depth was calculated,and the effects of frequency,moisture content,and temperature on the penetration depth were also analyzed.The results showed that the dielectric properties of edible fungi powder increased with an increase in moisture content and temperature,while they decreased with increasing frequency.At high moisture content and temperature,the increase in dielectric properties was slightly larger than that at low moisture content and temperature.The dielectric properties changed more evidently at lower radio frequencies than at higher radio frequencies.The penetration depth decreased with an increase in temperature,moisture content,and frequency.It can be concluded that a large penetration depth at radio frequencies below 100 MHz could be used to dry edible fungi on a large scale,whereas microwave energy could be employed for drying edible fungi on a small scale. | Siying Qi Jiping Han Camel Lagnika Ning Jiang Chunlu Qian Chunquan Liu Dajing Li Yang Tao Zhifang Yu Libin Wang Zhongyuan Zhang Chunju Liu Yadong Xiao Min Zhang | 2021 | Food Production, Processing and Nutrition2021，3，1： | 0 |
| 12 | 胆酸通过抑制NLRP3炎症小体活化控制炎症及代谢综合征的发生显示文摘免疫系统和代谢系统的相互作用彼此影响着对方生理功能的正常发挥,对于维持机体的代谢平衡和免疫稳态起着重要的调节作用。当二者的相互调控出现失衡或发生异常时,往往会导致机体相关病理性事件如代谢综合征、自身免疫性疾病、心血管疾病以及肿瘤等的发生。 | Chuansheng Guo Shujun Xie Zhexu Chi Jinhua Zhang Yangyang Liu Li Zhang Mingzhu Zheng Xue Zhang Dajing Xia Yuehai Ke Linrong Lu 王迪 | 2017 | 科学新闻2017，19，4： | 0 |
| 13 | Study on the interaction between β-carotene and gut microflora using an in vitro fermentation model显示文摘β-Carotene,a typical non-oxygenated carotenoid,is the most efficient source of retinol(VA).The low bio-availability ofβ-carotene lead to large accumulation in colon;however,the relationship betweenβ-carotene and gut microflora remains unclear.This study intends to explore the interaction betweenβ-carotene and gut microflora using an in vitro fermentation model.After 24 h fermentation,the degradation rate ofβ-carotene was(64.28±6.23)%,which was 1.46 times that of the group without gut microflora.Meanwhile,the production of VA was nearly 2 times that of the group without gut microflora,indicating that the gut microflora can metabolizeβ-carotene into VA.β-Carotene also influences the production of short-chain fatty acids(SCFAs),the production of total SCFAs in 0.5 mg/mLβ-carotene(BCM)group was(44.00±1.16)mmol/L,which was 2.26 times that of the blank control(BLK)group.Among them,the production of acetic acid in BCM group was(19.06±0.82)mmol/L,which was 2.64 time that of the BLK group.Furthermore,β-carotene significantly affected the structure and composition of gut microflora,increasing the abundance of Roseburia,Parasutterella and Lachnospiraceae,and decreasing the abundance of Dialister,Collinsella and Enterobacter(P<0.05).This study provides a new way to understand howβ-carotene works in human body with gut microflora. | Zhixian Li Zhuqing Dai Enjuan Shi Peng Wan Guijie Chen Zhongyuan Zhang Yayuan Xu Ruichang Gao Xiaoxiong Zeng Dajing Li | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
| 14 | Lutein-stevioside nanoparticle attenuates H_(2)O_(2)-induced oxidative damage in ARPE cells显示文摘In order to improve the bioavailability of lutein(LUT),a novel lutein-stevio side nanoparticle(LUT-STE)were prepared previously,but the information about LUT-STE on protecting of eye health was limited.This study investigated the effect of LUT-STE on antioxidant activity of H_(2)O_(2)-induced human retinal pigment epithelial(ARPE)cells.LUT and LUT-STE(final concentration of 5μg/mL)significantly enhanced cell viability from(74.84±5.10)%to(81.92±10.01)%(LUT)and(89.33±4.34)%(LUT-STE),and inhibited the cell apoptosis(P<0.05).After pretreatment with LUT-STE in ARPE cells,the levels of superoxide dismutase(SOD),catalase(CAT)and glutathion peroxidase(GSH-Px)in ARPE cells were significantly increased(P<0.05),the contents of reactive oxygen species(ROS)and malondialdehyde(MDA)were decreased.In addition,the vascular endothelial growth factor(VEGF)levels were inhibited by 13.61%and 17.39%,respectively,pretreatment with LUT and LUT-STE.Western blotting results showed that the pretreatment with LUT-STE inhibited the expression of caspase-9 and caspase-3 and up-regulated Bcl-2/Bax pathway to inhibit H_(2)O_(2)-induced apoptosis.In summary,the novel delivery LUT-STE had more pronounced inhibitory effect on H_(2)O_(2)-induced damage in human ARPE cells. | Zhuqing Dai Meimei Nie Ye Chen Jiangfeng Song Yayuan Xu Zhongyuan Zhang Guodong Zhang Shumo Yan Xing Zhang Dajing Li | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
| 15 | USH2A mutation and specific driver mutation subtypes are associated with clinical efficacy of immune checkpoint inhibitors in lung cancer显示文摘This study aimed to identify subtypes of genomic variants associated with the efficacy of immune checkpoint inhibitors(ICIs)by conducting systematic literature search in electronic databases up to May 31,2021.The main outcomes including overall survival(OS),progression-free survival(PFS),objective response rate(ORR),and durable clinical benefit(DCB)were correlated with tumor genomic features.A total of 1546 lung cancer patients with available genomic variation data were included from 14 studies.The Kirsten rat sarcoma viral oncogene homolog G12C(KRAS^(G12C))mutation combined with tumor protein P53(TP53)mutation revealed the promising efficacy of ICI therapy in these patients.Furthermore,patients with epidermal growth factor receptor(EGFR)classical activating mutations(including EGFRL858Rand EGFRΔ19)exhibited worse outcomes to ICIs in OS(adjusted hazard ratio(HR),1.40;95%confidence interval(CI),1.01-1.95;P=0.0411)and PFS(adjusted HR,1.98;95%CI,1.49-2.63;P<0.0001),while classical activating mutations with EGFR^(T790)Mshowed no difference compared to classical activating mutations without EGFR^(T790)Min OS(adjusted HR,0.96;95%CI,0.48-1.94;P=0.9157)or PFS(adjusted HR,0.72;95%CI,0.39-1.35;P=0.3050).Of note,for patients harboring the Usher syndrome type-2A(USH2A)missense mutation,correspondingly better outcomes were observed in OS(adjusted HR,0.52;95%CI,0.32-0.82;P=0.0077),PFS(adjusted HR,0.51;95%CI,0.38-0.69;P<0.0001),DCB(adjusted odds ratio(OR),4.74;95%CI,2.75-8.17;P<0.0001),and ORR(adjusted OR,3.45;95%CI,1.88-6.33;P<0.0001).Our findings indicated that,USH2A missense mutations and the KRAS^(G12C)mutation combined with TP53 mutation were associated with better efficacy and survival outcomes,but EGFR classical mutations irrespective of combination with EGFR^(T790)Mshowed the opposite role in the ICI therapy among lung cancer patients.Our findings might guide the selection of precise targets for effective immunotherapy in the clinic. | DEXIN YANG YUQIN FENG HAOHUA LU KELIE CHEN JINMING XU PEIWEI LI TIANRU WANG DAJING XIA YIHUA WU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 0 |
| 16 | Tumor cell membrane-coated continuous electrochemical sensor for GLUT1 inhibitor screening显示文摘Glucose transporter 1(GLUT1)overexpression in tumor cells is a potential target for drug therapy,but few studies have reported screening GLUT1 inhibitors from natural or synthetic compounds.With current analysis techniques,it is difficult to accurately monitor the GLUT1 inhibitory effect of drug molecules in real-time.We developed a cell membrane-based glucose sensor(CMGS)that integrated a hydrogel electrode with tumor cell membranes to monitor GLUT1 transmembrane transport and screen for GLUT1 inhibitors in traditional Chinese medicines(TCMs).CMGS is compatible with cell membranes of various origins,including different types of tumors and cell lines with GLUT1 expression knocked down by small interfering RNA or small molecules.Based on CMGS continuous monitoring technique,we investigated the glucose transport kinetics of cell membranes with varying levels of GLUT1 expression.We used CMGS to determine the GLUT1-inhibitory effects of drug monomers with similar structures from Scutellaria baicalensis and catechins families.Results were consistent with those of the cellular glucose uptake test and molecular-docking simulation.CMGS could accurately screen drug molecules in TCMs that inhibit GLUT1,providing a new strategy for studying transmembrane protein-receptor interactions. | Jiaqian Zhao Yuqiao Liu Ling Zhu Junmin Li Yanhui Liu Jiarui Luo Tian Xie Dajing Chen | 2023 | Journal of Pharmaceutical Analysis2023，13，6： | 0 |
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