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| 1 | Spatial distribution and focal mechanism solutions of the Wenchuan earthquake series:Results and implications显示文摘We relocate the spatial distribution of the devastating 12 May 2008 Wenchuan earthquake and its aftershocks.The relocation database is obtained from 89 stations deployed by the China Earthquake Administration,including 54 525 seismograms from 1 376 local earthquakes over MS3.5 between 12 May 2008 and 3 August 2008.The cross-correlation technique used in this paper has greatly improved the relocation precision by giving much more accurate P-wave differential travel-time measurements than those obtained from routinely picked phase onsets.At the same time,we pick P-wave polarity observations of the Wenchuan earthquake series (hereafter referred to as WES) from 1 023 stations in China and 59 IRIS (Incorporated Research Institutions of Seismology) stations.Then,employing a newly developed program CHNYTX,we obtain 83 well-determined focal mechanism solutions (hereafter referred to as FMSs).Based on spatial distribution and FMSs of the WES,we draw following conclusions:(1) The region near the main shock exhibits a buried low-angle northwest-dipping seismic zone with the main shock at its upper end and two conjugated seismic zones dipping southeast with roughly equal dip-angle;(2) The compressional directions of all kinds of FMSs of the WES are subhorizontal,which reflects the dominant stress in this area is compressional;(3) The principal compressional direction of the regional stress around Wenchuan is roughly perpendicular to the strike of Beichuan-Yingxiu fault,while around Qingchuan it is roughly parallel to the strike of Qingchuan fault.In intermediate part of the Longmenshan area,the principal compressional direction of the stress should be in-between;(4) The possibly existed molten materials in the lower crust of Songpan-Garze terrain have small contribution to the local stress state in Longmenshan area.The listric geometries of the Longmenshan faults most probably resulted from subhorizontal compression along NW-SE direction in history. | Chen Cai Chunquan Yu Kai Tao Xingping Hu Yuan Tian Hao Zhang Xiaofeng Cui Jieyuan Ning | 2011 | Earthquake Science2011，24，1： | 13 |
| 2 | Tensile properties of high strength cast Mg alloys at room temperature:A review显示文摘As most Mg alloy products are now produced by a casting process,the development of high strength cast Mg alloys can promote their further applications and has already become one of the hot research areas of Mg alloys.The present paper reviews the strengthening mechanisms,tensile properties and modification results of commercial high strength cast Mg alloys;as well as the development of Mg-Gd,Mg-Nd and Mg-Sn based alloys.It concludes that precipitation strengthening is the most important strengthening mechanism in high strength cast Mg alloys,which contributes more than 60%of yield strength in solution&peak-aged(T6)cast Mg alloys.For the yield strength,the alloys follow the sequence of Mg-Gd(Y)-Ag>Mg-Gd(Y)-Zn>Mg-Gd-Y/Sm/Nd>Mg-Y-Nd(WE series)>ZK61>Mg-Nd>AZ91>Mg-Sn.Mg-Gd(Y)-Ag based alloys are the strongest cast Mg alloys at present,followed by Mg-Gd(Y)-Zn based alloys.The high yield strengths of Mg-Gd(Y)-Ag and Mg-Gd(Y)-Zn cast alloys are due to the co-precipitation of basal and prismatic meta-stable phases. | Fu Penghuai Peng Liming Jiang Haiyan Ding Wenjiang Zhai Chunquan | 2014 | China Foundry2014，11，4： | 12 |
| 3 | A review of the synthesis and application of zeolites from coal-based solid wastes显示文摘Zeolite derived from coal-based solid wastes(coal gangue and coal fly ash)can overcome the environmental problems caused by coal-based solid wastes and achieve valuable utilization.In this paper,the physicochemical properties of coal gangue and coal fly ash are introduced.The mechanism and application characteristics of the pretreatment processes for zeolite synthesis from coal-based solid wastes are also introduced.The synthesis processes of coal-based solid waste zeolite and their advantages and disadvantages are summarized.Furthermore,the application characteristics of various coal-based solid waste zeolites and their common application fields are illustrated.Finally,we propose an alkaline fusion-assisted supercritical hydrothermal crystallization as an efficient method for synthesizing coal-based solid waste zeolites.In addition,more attention should be given to the recycling of alkaline waste liquid and the application of coal-based solid waste zeolites in the field of volatile organic compound adsorption removal. | Xiaoyu Zhang Chunquan Li Shuilin Zheng Yonghao Di Zhiming Sun | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，1： | 10 |
| 4 | Novel fluorescent probes of 10-hydroxyevodiamine:autophagy and apoptosis-inducing anticancer mechanisms显示文摘Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms. | Shuqiang Chen Guoqiang Dong Shanchao Wu Na Liu Wannian Zhang Chunquan Shengn | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 9 |
| 5 | Hierarchical assembly of highly efficient visible-light-driven Ag/g-C_(3)N_(4)/kaolinite composite photocatalyst for the degradation of ibuprofen显示文摘A novel Ag/g-C_(3)N_(4)/kaolinite composite photocatalyst was fabricated for the first time through a two-step assembly strategy by employing in situ calcination and a photodeposition process.The synthesized Ag/g-C_(3)N_(4)/kaolinite composite reached a higher degradation rate of ibuprofen(IBP)with a reaction rate constant of 0.0113 min^(-1) at an Ag content of 7% under visible-light irradiation,which was approximately 1.87 times that of the Ag/g-C_(3)N_(4) composite.Based on the physicochemical properties,the enhanced photocatalytic activity was attributed to the stronger adsorption property,wider photoresponse range and more efficient separation and transfer of electron-hole pairs.Furthermore,the incorporation of monodispersed Ag nanoparticles onto the g-C_(3)N_(4)/kaolinite sheets provided more reactive sites for the IBP degradation.In addition,according to the EPR study and trapping experiments,it was demonstrated that holes(h^(+))should be the key reactive species.A possible pathway of IBP degradation was also proposed based on the detected intermediates.Overall,the results of this work may facilitate the design of a novel visible-light-driven photocatalyst with a high efficiency that is derived from a natural mineral for environmental remediation. | Zhiming Sun Xiangwei Zhang Xiongbo Dong Xiaorui Liu Ye Tan Fang Yuan Shuilin Zheng Chunquan Li | 2020 | Journal of Materiomics2020，6，3： | 8 |
| 6 | Thermodynamic Modeling of Fluid-Bearing Natural Gas Inclusions for Geothermometer and Geobarometer of Overpressured Environments in Qiongdongnan Basin, South China Sea显示文摘It is a very difficult problem to directly determine fluid pressure during hydrocarbon migration and accumulation in sedimentary basins. pVt modeling of coupling hydrocarbon fluid inclusion of its coeval aqueous fluid inclusion provides a powerful tool for establishing the relationship of formation pressure evolution with time. Homogenization temperature of fluid inclusion can routinely be measured under microthermometric microscopy. Crushing technique has been employed to obtain the composition of fluid inclusions, and the commercial software VTFLINC easily and rapidly completes the construction of p t phase diagram. The minimum trapping pressure of hydrocarbon fluid inclusion would be then determined in the p t space. In this paper, three samples of YC21 1 1 and YC21 1 4 wells at YC21 1 structural closure, Qiongdongnan basin, South China Sea, were selected for the pVt modeling practice, and the formation pressure coefficient (equals to fluid pressure/hydrostatic pressure) changing trend with time has primarily been established. The modeling results also indicate that the reservoirs of Lingshui and Yacheng formations in YC21 1 structure are within a very high potential system and would have undergone a discharging of thermal fluids through top seal rupture, which depicts that there is a very high risk for natural gas exploration in this area. | Chen Honghan Yao Shuzhen Wang Jiahao Li Chunquan Institute of Resources, China University of Geosciences, Wuhan 430074 | 2002 | Journal of China University of Geosciences2002，13，3： | 7 |
| 7 | Focal Mechanism Solutions of the 2008 Wenchuan earthquake sequence from P-wave polarities and SH/P amplitude ratios:new results and implications显示文摘The 2008 Wenchuan earthquake,a major intraplate earthquake with Mw7.9,occurred on the slowly deforming Longmenshan fault.To better understand the causes of this devastating earthquake,we need knowledge of the regional stress field and the underlying geodynamic processes.Here,we determine focal mechanism solutions(FMSs)of the 2008 Wenchuan earthquake sequence(WES)using both P-wave first-motion polarity data and SH/P amplitude ratio(AR)data.As P-wave polarities are more reliable information,they are given priority over SH/P AR,the latter of which are used only when the former has loose constraint on the FMSs.We collect data from three categories:(1)permanent stations deployed by the China Earthquake Administration(CEA);(2)the Western Sichuan Passive Seismic Array(WSPSA)deployed by Institute of Geology,CEA;(3)global stations from Incorporated Research Institutions for Seismology.Finally,129 events with magnitude over Ms4.0 in the 2008 WES are identified to have well-constrained FMSs.Among them,83 are well constrained by P-wave polarities only as shown by Cai et al.(Earthq Sci 24(1):115–125,2011),andthe rest of which are newly constrained by incorporating SH/P AR.Based on the spatial distribution and FMSs of the WES,we draw following conclusions:(1)the principle compressional directions of most FMSs of the WES are subhorizontal,generally in agreement with the conclusion given by Cai et al.(2011)but with a few modifications that the compressional directions are WNW–ESE around Wenchuan and ENE–WSW around Qingchuan,respectively.The subhorizontal compressional direction along the Longmenshan fault from SW to NE seems to have a leftlateral rotation,which agrees well with regional stress field inverted by former researchers(e.g.,Xu et al.,Acta Seismol Sin 30(5),1987;Acta Geophys Sin 32(6),1989;Cui et al.,Seismol Geol 27(2):234–242,2005);(2)the FMSs of the events not only reflected the regional stress state of the Longmenshan region,but also were obviously controlled by the faults to some extent,which was pointed out by Cai et al.(2011)and Yi et al.(Chin J Geophys55(4):1213–1227,2012);(3)while the 2008 Wenchuan earthquake and some of its strong aftershocks released most of the elastic energy accumulated on the Longmenshan fault,some other aftershocks seem to occur just for releasing the elastic energy promptly created by the 2008Wenchuan earthquake and some of its strong aftershocks.(4)Our results further suggest that the Longmenshan fault from Wenchuan to Beichuan was nearly fully destroyed by the 2008 Wenchuan earthquake and accordingly propose that there is less probability for great earthquakes in the middle part of the Longmenshan fault in the near future,although there might be a barrier to the southwest of Wenchuan and it is needed to pay some attention on it in the near future. | Yuan Tian Jieyuan Ning Chunquan Yu Chen Cai Kai Tao | 2013 | Earthquake Science2013，26，6： | 7 |
| 8 | Intermediate-depth earthquakes beneath the Pamir-Hindu Kush Region:Evidence for collision between two opposite subduction zones显示文摘We employed a double-difference algorithm(hypoDD)to relocate earthquakes within the region bounded by 66°E-78°E and 32°N-42°N in the period of 1964?2003 reported by the International Seismological Center(ISC).The improved hypocentral locations delineate a double-layered Wadati-Benioff zone in the eastern Hindu Kush intermediate seismic belt.Based on this feature and other evidences,we propose that the intermediate-depth earthquakes beneath the Pamir-Hindu Kush region may occur in two collided subduction zones with opposite dip directions. | Xiaoting Lou Chen Cai Chunquan Yu Jieyuan Ning | 2009 | Earthquake Science2009，22，6： | 6 |
| 9 | Evolutionary trace analysis of eukaryotic DNA topoisomerase I superfamily: Identification of novel antitumor drug binding site显示文摘The studies of novel inhibitors of DNA topoisomerase I (Topo I) have already be-come very promising in cancer chemotherapy. Identifying the new drug-binding residues is playing an important role in the design and optimization of Topo I inhibitors. The designed com-pounds may have novel scaffolds, thus will be helpful to overcome the toxicities of current camptothecin (CPT) drugs and may provide a solution to cross resistance with these drugs. Mul-tiple sequence alignments were performed on eukaryotic DNA topoisomerase I superfamily and thus the evolutionary tree was constructed. The Evolutionary Trace method was applied to iden-tify functionally important residues of human Topo I. It has been demonstrated that class-specific hydrophobic residues Ala351, Met428, Pro431 are located around the 7,9-position of CPT, indi-cating suitable substitution of hydrophobic group on CPT will increase antitumor activity. The conservative residue Lys436 in the superfamily is of particular interest and new CPT derivatives designed based on this residue may greatly increase water solubility of such drugs. It has also been demonstrated that the residues Asn352 and Arg364 were conservative in the superfamily, whose mutation will render CPT resistance. As our molecular docking studies demonstrated they did not make any direct interaction with CPT, they are important drug-binding site residues for future design of novel non-camptothecin lead compounds. This work provided a strong basis for the design and synthesis of novel highly potent CPT derivatives and virtual screening for novel lead compounds. | SONG Yunlong QI Yunpeng ZHANG Wannian SHENG Chunquan ZHANG Min YAO Jianzhong YU Jianxin MIAO Zhenyuan ZHOU Youjun ZHU Ju L(U) Jiaguo | 2005 | Science China(Life Sciences)2005，48，4： | 5 |
| 10 | Description of a New Species of the Genus Brachytarsophrys Tian and Hu, 1983(Amphibia: Anura: Megophryidae) from Southern China Based on Molecular and Morphological Data显示文摘A new species, Brachytarsophrys popei sp. nov., is described based on a series of specimens collected from Mount Jinggang, Jiangxi Province, Taoyuandong Nature Reserve, Hunan Province and Nanling Nature Reserve, Guangdong Province, China. The new species can be easily distinguished from other known congeners by morphology, morphometrics and molecular data of the mitochondrial 16 S rRNA gene. It is characterized by its relatively small size with 86.2 mm in snout-vent length in adult female and 70.7 mm–83.5 mm in males; vomerine teeth bearing on two markedly elevated ridges, which projecting behind far beyond the posterior level of the choanae, widely separated by a distance nearly 1.5 times length of one; margin of tongue deeply notched behind; toes about one-third to two-thirds webbed in males, at most one-third webbed in female; the webs extending as a wide fringes along either side of toes; upper eyelid with tubercles, one of which is enlarged and becoming a remarkably prominent, bluntly conical lightyellow horn; black tiny nuptial spines on the dorsal surface of the first finger and second finger base, single vocal sac in males; gravid females bear pure yellowish oocytes; tadpoles with a transverse white stripe on ventral surface and two longitudinal white stripes along the sides of body. The new species represents the fifth known Brachytarsophrys species. | Jian ZHAO Jianhuan YANG Guoling CHEN Chunquan CHEN Yingyong WANG | 2014 | Asian Herpetological Research2014，5，3： | 5 |
| 11 | Diatomite supported nano zero valent iron with 3D network for peroxymonosulfate activation in efficient degradation of bisphenol A显示文摘Diatomite supported nano zero valent iron(n ZVI)catalyst(NDA)with complex network structure was prepared via a mild reduction precipitation method in this work.The pore structure and pore distribution of NDA can be regulated and controlled through adjusting the loading amount of n ZVI.In general,the nano three-dimensional network formed by n ZVI and diatomite channels greatly increase the specific surface area and pore volume of NDA,and further formed more active sites,which made NDA have better performance in activating PMS to degrade BPA than pure n ZVI.The pseudo-first-order reaction rate constant of 50-NDA(50%-n ZVI/diatomite)is almost 3 times higher than that of pure n ZVI.Besides,the electron paramagnetic resonance(EPR)and radical quenching experiments showed that the activation process was dominated by the sulfate radical(SO_(4)^(-))and hydroxyl radical(·OH)produced by Fe;oxidation.The generated electrons promote the self-decomposition of PMS to produce singlet oxygen(^(1)O_(2)),and then the valence state of iron changes to produce free radicals.In addition,the possible degradation pathway of BPA was inferred from the intermediate products identified by liquid chromatograph-mass spectrometer(LC-MS).This study provides a novel strategy for the design and preparation of three-dimensional composite catalysts derived from natural mineral. | Ye Tan Shuilin Zheng Yonghao Di Chunquan Li Runze Bian Zhiming Sun | 2021 | Journal of Materials Science & Technology2021，，36： | 4 |
| 12 | Genetic evidence in planar cell polarity signaling pathway in human neural tube defects显示文摘神经试管缺点(NTD ) 是有的一组出生异例一家庭和社区上的深刻物理、感情、金融的效果。他们的病原学是复杂的,包含交往调制发展中的显型的发生和严厉的环境、基因的因素。平面房间极性(PCP ) 小径在 gastrulation 和神经试管闭合期间控制会聚的扩展(CE ) 的进程并且在动物模型和人的队在 NTD 的致病被含有。这评论在表明小径和人的 NTD 的 PCP 上总结最近的研究的累积结果。这些结果证明 PCP 基因改变贡献人的 NTD 的病原学。 | Chunquan Cai Ouyan Shi | 2014 | Frontiers of Medicine2014，8，1： | 4 |
| 13 | Strain hardening of as-extruded Mg-xZn(x=1, 2, 3 and 4 wt%) alloys显示文摘The influence of Zn on the strain hardening of as-extruded Mg-x Zn(x = 1, 2, 3 and 4 wt%) magnesium alloys was investigated using uniaxial tensile tests at 10^(-3)s^(-1) at room temperature. The strain hardening rate,the strain hardening exponent and the hardening capacity were obtained from true plastic stress-strain curves. There were almost no second phases in the as-extruded Mg-Zn magnesium alloys. Average grain sizes of the four as-extruded alloys were about 17.8 μm. With increasing Zn content from 1 to 4 wt%, the strain hardening rate increased from 2850 MPa to 6810 MPa at(б-б_(0.2)) = 60 MPa, the strain hardening exponent n increased from 0.160 to 0.203, and the hardening capacity, Hc increased from 1.17 to 2.34.The difference in strain hardening response of these Mg-Zn alloys might be mainly caused by weaker basal texture and more solute atoms in the α-Mg matrix with higher Zn content. | Chaoyue Zhao Xianhua Chen Fusheng Pan Jingfeng Wang Shangyu Gao Teng Tu Chunquan Liu Jiahao Yao Andrej Atrens | 2019 | Journal of Materials Science & Technology2019，35，1： | 4 |
| 14 | The effects of Ca and Mn on the microstructure,texture and mechanical properties of Mg-4 Zn alloy显示文摘The microstructural evolution,texture and mechanical properties of nine Mg-4Zn-xCa-yMn alloys(x=0.3,0.6,1.0;y=0.2,0.3,0.7 wt.%)were investigated systematically.Alloying with Ca and Mn refined the grains of the extruded sheets and increased the unDRX fraction.Mn could be the heterogeneous nucleation site of Ca2Mg6Zn3 phase because of a good atom matching at the orientation relationship of(211)_(Mn)//(1211)_(Ca2Mg6Zn3),(251)_(Mn)//〈1103〉_(Ca2Mg6Zn3).The traditional texture weakening effect of Ca was strongly decreased for the simultaneously addition of Mn.With increasing Ca and Mn concentration,the strength increased and ductility decreased.Mg-4Zn-0.6Ca-0.7Mn exhibited a good combination of ultimate tensile strength(320 MPa),yield strength(286 MPa)and elongation(16%).A model of strengthening indicated that grain boundary strengthening and precipitate strengthening made a large contribution to the strength of Mg-4Zn-0.6Ca-0.7Mn.In addition,the dynamic recrystallization,texture modification and the strengthening effect from different parts also have been analyzed in detail. | Chunquan Liu Xianhua Chen Jiao Chen Andrej Atrens Fusheng Pan | 2021 | Journal of Magnesium and Alloys2021，9，3： | 4 |
| 15 | Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer显示文摘The dose-related adverse effects of MDM2-P5 3 inhibitors have caused significant concern in the development of clinical safe anticancer agents.Herein we report an unprecedented homo-PROTAC strategy for more effective disruption of MDM2-P53 interaction.The design concept is inspired by the capacity of sub-stoichiometric catalytic PROTACs enabling to degrade an unwanted protein and the dual functions of MDM2 as an E3 ubiquitin ligase and a binding protein with tumor suppressor P53.The new homo-PROTACs are designed to induce self-degradation of MDM2.The results of the investigation have shown that PROTAC 11 a efficiently dimerizes MDM2 with highly competitive binding activity and induces proteasome-dependent self-degradation of MDM2 in A549 non-small cell lung cancer cells.Furthermore,markedly,enantiomer 11 a-1 exhibits potent in vivo antitumor activity in A549 xenograft nude mouse model,which is the first example of homo-PROTAC with in vivo therapeutic potency.This study demonstrates the potential of the homo-PROTAC as an alternative chemical tool for tumorigenic MDM2 knockdown,which could be developed into a safe therapy for cancer treatment. | Shipeng He Junhui Ma Yuxin Fang Ying Liu Shanchao Wu Guoqiang Dong Wei Wang Chunquan Sheng | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 4 |
| 16 | Design and synthesis of novel water-soluble amino acid derivatives of chlorin p6 ethers as photosensitizer显示文摘Eight new water-soluble amino acid conjugates 6 a-h of chlorin p6 ethers(5 a-d) were synthesized and preliminarily investigated for their in vitro PDT antitumor activity and structure-activity relationship(SAR). The results showed that all compounds exhibited much higher phototoxicity against tumor cells than talaporfin. SAR analysis indicated that PDT antitumor effect enhanced with the increase of carbon chain length of alkoxyl ether bonds at 3~1-position, and L-aspartic acid was superior to L-glutamic acid. In particular, the IC_50 values of most phototoxic compound 6 d were 0.20 mmol/L against A549 cell and0.41υmmol/L against B16-F10 cell, which individually represented 31-and 24-fold increase of antitumor potency compared to talaporfin, suggesting that it was a promising candidate photosensitizer(PS) for PDT applications due to its strong absorption at long wavelength, high phototoxicity, low dark cytotoxicity and good water-solubility. | Xingjie Zhang Zhi Meng Zhiqiang Ma Junhong Liu Guiyan Han Fujia Ma Ningyang Jia Zhenyuan Miao Wannian Zhang Chunquan Sheng Jianzhong Yao | 2019 | Chinese Chemical Letters2019，30，1： | 3 |
| 17 | NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion显示文摘Nicotinamide phosphoribosyl transferase(NAMPT) is considered as a promising target for cancer therapy given its critical engagement in cancer metabolism and inflammation.However,therapeutic benefit of NAMPT enzymatic inhibitors appears very limited,likely due to the failure to intervene nonenzymatic functions of NAMPT.Herein,we show that NAMPT dampens antitumor immunity by promoting the expansion of tumor infiltrating myeloid derived suppressive cells(MDSCs) via a mechanism independent of its enzymatic activity.Using proteolysis-targeting chimera(PROTAC) technology,PROTAC A7 is identified as a potent and selective degrader of NAMPT,which degrades intracellular NAMPT(iNAMPT) via the ubiquitin-proteasome system,and in turn decreases the secretion of extracellular NAMPT(eNAMPT),the major player of the non-enzymatic activity of NAMPT.In vivo,PROTAC A7 efficiently degrades NAMPT,inhibits tumor infiltrating MDSCs,and boosts antitumor efficacy.Of note,the anticancer activity of PROTAC A7 is superior to NAMPT enzymatic inhibitors that fail to achieve the same impact on MDSCs.Together,our findings uncover the new role of enzymatically-independent function of NAMPT in remodeling the immunosuppressive tumor microenvironment,and reports the first NAMPT PROTAC A7 that is able to block the pro-tumor function of both iNAMPT and eNAMPT,pointing out a new direction for the development of NAMPT-targeted therapies. | Ying Wu Congying Pu Yixian Fu Guoqiang Dong Min Huang Chunquan Sheng | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 3 |
| 18 | Effect of Zhu-yuan decoction in patients with chronic rhinosinusitis after functional endoscopic sinus surgery显示文摘OBJECTIVE: To investigate the effectiveness and safety of Zhu-yuan decoction(ZYD) in patients after functional endoscopic sinus surgery(FESS).METHODS: A total of 85 patients were randomized into two groups: 44 were treated with intranasal corticosteroids(INC), and 41 were given Chinese herbal medicine(CHM). Patients with chronic rhinosinusitis(CRS) who underwent FESS were prospectively enrolled in the study. Before surgery, they were evaluated by visual analog scale(VAS), nasal endoscopy, computed tomography(CT), and routine blood test. After surgery, they were randomized to take ZYD or INC for 12 weeks and revaluated by VAS; nasal endoscopy at 4, 8, and 12 weeks;and CT at 12 weeks after surgery.RESULTS: In the both groups, VAS and endoscopyscores decreased significantly at 4, 8, and 12 weeks,and CT scores after treatment declined at 12 weeks compared with baseline scores. No significant differences were observed with regard to postoperative VAS, endoscopy, or CT scores between groups.ZYD, combined with surgery, can reduce VAS, nasal endoscopy, and CT scores and has the same efficacy and safety profile as INC in post-FESS management.No fatalities or major adverse events occurred in either group.CONCLUSION: Our findings suggest that ZYD has similar effects and safety profiles in patients after FESS compared with INC. | Li Jing Zheng Chunquan Lin Hai Yang Chen Gu Siyuan Wang Yi Duan Honggang | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 19 | Engineered tunneling layer with enhaneed impact ionization for detection improvement in graphene/silicon heterojunction photodetectors显示文摘Here,an engineered tunneling layer enhanced photocurrent multiplication through the impact ionization effect was proposed and experimentally demonstrated on the graphene/silic on heterojunction photodetectors.With con sidering the suitable band structure of the insulation material and their special defect states,an atomic layer deposition(ALD)prepared wide-bandgap insulating(WBI)layer of AIN was introduced into the interface of graphene/silicon heterojunction.The promoted tunneling process from this designed structure dem on strated that can effectively help the impact ionization with photogain not only for the regular minority carriers from silicon,but also for the novel hot carries from graphene.As a result,significantly enhanced photocurrent as well as simultaneously decreased dark current about one order were accomplished in this graphene/insulation/silicon(GIS)heterojunction devices with the optimized AIN thickness of〜15 nm compared to the conventional graphene/silicon(GS)devices.Specifically,at the reverse bias of-10 V,a 3.96-A W_1 responsivity with the photogain of~5.8 for the peak response under 850-nm light illumination,and a 1.03-A W_1 responsivity with~3.5 photogain under the 365 nm ultraviolet(UV)illumination were realized,which are even remarkably higher than those in GIS devices with either AI2O3 or the commonly employed SiO2 insulation layers.This work dem on strates a universal strategy to fabricate broad ba nd,low-cost and high-performance photo-detecting devices towards the graphene-silicon optoelectronic integration. | Jun Yin Lian Liu Yashu Zang Anni Ying Wenjie Hui Shusen Jiang Chunquan Zhang Tzuyi Yang Yu-Lun Chueh Jing Li Junyong Kang | 2021 | Light(Science & Applications)2021，10，6： | 3 |
| 20 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
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