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| 1 | Small bowel capsule endoscopy in patients with cardiac pacemakers and implantable cardioverter defibrillators:Outcome analysis using telemetry review显示文摘AIM:To determine if there were any interactions between cardiac devices and small bowel capsules secondary to electromagnetic interference (EMI) in patients who have undergone small bowel capsule endoscopy (SBCE).METHODS:Authors conducted a chart review of 20 patients with a cardiac pacemaker (CP) or implantable cardioverter defibrillator (ICD) who underwent continuous electrocardiographic monitoring during their SBCE from 2003-2008.authors searched for unexplained electrocardiogram (ECG) findings,changes in CP andICD set parameters,any abnormality in transmitted capsule data,and adverse clinical events.RESULTS:There were no adverse events or hemodynamically significant arrhythmias reported.CP and ICD set parameters were preserved.The majority of ECG abnormalities were also found in pre-or post-SBCE ECG tracings and the CP behavior during arrhythmias appeared appropriate.Two patients seemed to have episodes of undersensing by the CP.However,similar findings were documented in ECGs taken outside the time frame of the SBCE.One patient was observed to have a low signal encountered from the capsule resulting in lack of localization,but no images were lost.CONCLUSION:Capsule-induced EMI remains a possibility but is unlikely to be clinically important.CPinduced interference of SBCE is also possible,but is infrequent and does not result in loss of images transmitted by the capsule. | Justin R Cuschieri Mohammed N Osman Richard CK Wong Amitabh Chak Gerard A Isenberg | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 6 |
| 2 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 3 | Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome显示文摘Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality. | Loretta YC Yam Alfred YF Chan Thomas MT Cheung Eva LH Tsui Jane CK Chan Vivian CW Wong | 2005 | Chinese Medical Journal2005，，17： | 3 |
| 4 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 5 | Differential north to south gastric cancer-duodenal ulcer gradient in China显示文摘 | Wong BCY Ching CK Lam SK | | 0，，： | 2 |
| 6 | Plasma inflammatory cytokines and chemokines in SARS显示文摘 | Wong CK Lam CWK Wu AKL | 2004 | Clin Exp Immunal2004，136，： | 1 |
| 7 | The effect of central loops inmiRNA:MRE duplexes on the efficiency of miRNA-mediatedgene regulation显示文摘 | Ye W Lv Qing Wong CK | 2008 | PLoS ONE2008，3，： | 1 |
| 8 | Elevated production of interleukin-18 is associated with renal disease in patients with systemic lupus erythematosus显示文摘 | Wong CK Ho CY Li EK | 2002 | Clin Exp Immunol2002，130，2： | 1 |
| 9 | IL-3,5 and GM-CSF-induced adhesion molecule expression on eosinophils by p38 MAPK and NF-κB显示文摘 | Wong CK Ip WK Lam CWK | 2003 | Am J Respir Cell Mol Biol2003，29，： | 1 |
| 10 | Pyogenic liver abscess:retrospetive analysis of 80 cases over a 10-year period显示文摘 | Wong WM Wong BC Hui CK | 2002 | J Gastroenterol Hepatol2002，17，9： | 1 |
| 11 | Rapid cycle change to predominantly radial access coronary angiography and percutaneous coronary intervention: effect on vascular access site complications显示文摘 | Nadarasa K Robertson MC Wong CK | 2012 | Catheter Cardiovasc Interv2012，79，4： | 1 |
| 12 | Engeneering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen显示文摘 | Saeidi N Wong CK Lo TM | 2011 | Mol Syst Bi- ol2011，7，： | 1 |
| 13 | Molecular mechanisms ofcytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytes-mediated allergic inflammation 显示文摘 | Cheung PF Wong CK Lam CW | 2008 | J Immtmol2008，180，8： | 1 |
| 14 | Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 eytokine (IL-4) concentrations in patients with systemic lupus erythematous 显示文摘 | Wong CK Ho CY Li EK | 2000 | Lupus2000，9，： | 1 |
| 15 | Aberrant production of soluble costimulatory molecules CTLA-4,CD28,CD80 and CD86 in patients with systemic lupus erythematosus显示文摘 | Wong CK Lit LCW Tam LS | 2005 | Rheumatol2005，44，： | 1 |
| 16 | Protective effects of seaweeds against liver injury caused by carbon tetrachloride in rats显示文摘 | Wong CK Ooi VEC Ang PO | 2000 | Chemosphere2000，41，： | 1 |
| 17 | Elevated plasma concentrations of nitric oxide, soluble thrombomodul in and soluble vascular cell adhesion molecule- 1 in patients with systemic lupus erythematosus显示文摘 | Ho CY Wong CK Li EK | 2003 | Rheumatology (Oxford)2003，42，1： | 1 |
| 18 | Safety and efficacy of leflunomide in the treatment of lupus nephritis refractory or intolerant to traditional immunosuppressive therapy: an open label trial 显示文摘 | Tam IS Li EK Wong CK | 2006 | Ann Rheum Dis2006，65，3： | 1 |
| 19 | Raised plasma concen-tration and ex vivo production of inflammatory chemokinesin patients with systemic lupus erythematosus 显示文摘 | Lit Lc Wong CK Tam LS | 2006 | AnnRheum Dis2006，65，2： | 1 |
| 20 | Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity 显示文摘 | Wong CK Lit LC Tam KS | 2008 | Clin Immunol2008，127，3： | 1 |
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