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| 1 | Comparison of ART outcomes in men with altered mRNA protamine 1/protamine 2 ratio undergoing intracytoplasmic sperm injection with ejaculated and testicular spermatozoa显示文摘Assisted reproductive technologies invoIving the use of spermatozoa and eggs for in vitro fertilization(IVF)have come as the solution for many infertile couples to become parents.However,in some cases,the use of ejaculated spermatozoa delivers poor IVF performance.Some studies have suggested the use of testicular spermatozoa in severe male in fertility cases,but no guideli nes regarding their utilization are currently available.In the present study,we found the mRNA protamine 1/protamine 2(P1/P2)ratio to be a valuable biomarker of poor sperm function that could be used as a diagnostic key for the identification of cases that would benefit from the use of testicular spermatozoa.A total of 23 couples undergoing egg donation cycles with at least one previous cycle failure were studied.All couples underwent two consecutive intracytoplasmic sperm injection(ICSI)cycles with either ejaculated or testicular spermatozoa(TESA).The sperm mRNA P1/P2 ratio,fertilization rate,blastocyst rate,and pregnancy and live birth rate were compared.Results showed improved ICSI and clinical outcomes in cycles with testicular spermatozoa in men with altered mRNA P1/P2 ratios.TESA cycles presented significantly higher rates of fertilization(mean±standard deviation:76.1%±15.1%vs 65.5%±18.8%),blastocyst formation(55.0%±20.3%vs 30.8%±23.8%),and good morphological quality blastocyst(28.9%±22.9%vs 13.5%±17.9%)and also improvements on pregnancy(60.9%vs 0%)and healthy birth rates(56.5%vs 0%)than EJACULATE cycles.The results described here suggest that in patients with previous IVF/ICSI failures and aberrant mRNA protamine ratios,the use of testicular spermatozoa may be a good alternative to improve clinical outcomes. | Jonas Sarasa Maria Enciso Laura Garcia Andrea Leza Klaus Steger Jon Aizpurua | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 2 | The effects of physical and psychologi- cal stress on the gastro - intestinal tract: lessons from animal models 显示文摘 | Caso JR Leza JC Menchen L | 2008 | Curr Mol Med2008，8，4： | 1 |
| 3 | Astrocyte -derived MCP-1 mediates neuroprotective effects of noradrenaline 显示文摘 | MADRIGAL J L LEZA J C POLAK P | 2009 | Journal of Neuroseience2009，29，1： | 1 |
| 4 | Graft copolymerization of 4-vinylpyidine ontopartially carboxymethylated cellulous:Effect of temperture显示文摘 | Casinos I Guzman G M | 1989 | Eur Polym1989，25，12： | 1 |
| 5 | CCL2/MCP-1 modulation ofmicroglial activation and proliferation 显示文摘 | Hinojosa AE Garcia BB Leza JC | 2011 | J Neuroinflammation2011，8，： | 1 |
| 6 | Fructose-1, 6bisphosphate inhibits the expression of inducible nitric oxide synthase caused by oxygen-glucose deprivation through the inhibition of glutamate release in rat forebrain slices 显示文摘 | Hurtado O Leza J C | 2000 | Naunyn Schmiedebergs Arch Pharmacol2000，362，3： | 1 |
| 7 | Involvement of IL-1β in acute stress-induced worsening of cerebral ischaemia in rats显示文摘 | Javier R. Caso María A. Moro Pedro Lorenzo Ignacio Lizasoain Juan C. Leza | 2007 | European Neuropsychopharmacology2007，，9： | 1 |
| 8 | The effects of stress on homeostasis in JCR-LA-ep rats: The role of nitric oxide 显示文摘 | Leza JC Salas E Sawicki G | 1998 | J Pharmacol Exp Ther1998，286，3： | 1 |
| 9 | Neuronal expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices显示文摘 | Moro MA De Alba J Leza JC | 1998 | Eur J Neurosci1998，10，： | 1 |
| 10 | Sulfonic acid-functionalized aerogels as high resistant to deactivation catalysts for the etherification of glycerol with isobutene显示文摘 | María Dolores Gonzáleza Pilar Salagrea Elena Taboadab | 2013 | Applied Catalysis B:Environmental2013，，136137： | 1 |
| 11 | Heavy metal partitioning in river sediments severely polluted by acid mine drainage in the Iberian Pyrite Belt显示文摘 | Galán E Gómez-Arizab J L Gonzáleza I Fernández-Caliani J C Morales E Giráldez I | 2003 | Applied Geochemistry2003，18，： | 1 |
| 12 | Tuning the acidic and textural properties of ordered mesoporous silicas for their application as catalysts in the etherification of glycerol with isobutene显示文摘 | María Dolores Gonzáleza Pilar Salagrea Robert Mokaya | 2014 | Catalysis Today2014，，227： | 1 |
| 13 | Stress as a neuroinflammatory condition in brain:Damaging and protective mechanisms显示文摘 | Garcia-Bueno B Caso JR Leza JC | 2008 | Neurosci Biobehav Rev2008，32，6： | 1 |
| 14 | X-ray Microtomography Analysis of the Damage Micromechanisms in 3D Woven Composites under Low-velocity Impact显示文摘 | SELTZERA R GONZ(A)LEZA C MU(N)OZA B R | 2013 | Composites Part A:Applied Science and Manufacturing2013，45，： | 1 |
| 15 | The role of glomalin,a protein produced by arbuscular mycorrhizal fungi,in sequestering potentially toxic elements显示文摘 | GONZ(A)LEZ-CH(A)VEZ M C CARRILLO-GONZ(A)LEZA R WRIGHT S F | 2004 | Environmental Pollution2004，130，： | 1 |
| 16 | Fructose-1,6-bisphosphate inhibits the expression of inducible nitric oxide synthase caused by oxygen-glucose deprivation through the inhibition of glutamate release in rat forebrain slices显示文摘 | Cardenas A Hurtado O Leza J C | 2000 | Naunyn Schmiedebergs Arch Pharmacol2000，362，3： | 1 |
| 17 | Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke显示文摘 | Javier R. Caso Jesus M. Pradillo Olivia Hurtado Juan C. Leza Maria A. Moro Ignacio Lizasoain | 2008 | Stroke2008，，4： | 1 |
| 18 | Application of a quick, easy, cheap, effective, rugged and safe-based method for the simultaneous extraction of chlorophenols, alkylphenols, nitrophenols and cresols in agricultural soils, analyzedby using gas chromatography-triple quadrupole-mass spectrometry/mass spectrometry 显示文摘 | Padilla-S 6 ncheza J A Plaza-Bolafiosab P Romero- Gonz 6 leza R | 2010 | J Chromatogr A2010，1217，： | 1 |
| 19 | Effect of chitosan-lemon essential oil coatings on storage-keeping quality of strawberry显示文摘 | Perdones A Sánchez-Gonzáleza L Chiralt A | 2012 | Postharvest Biology and Technology2012，70，8： | 1 |
| 20 | Upregulation of TACE/AD-AM17 after ischemic preconditioning is involved in brain tolerance显示文摘 | Cardenas A Moro MA Leza JC | 2002 | J Cereb Blood Flow Metab2002，22，11： | 1 |
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