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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Cytotoxicity and genotoxicity of low doses of mercury chloride and methylmercury chloride on human lymphocytes in vitro显示文摘 | Cardoso PC Leite DS | 2005 | Braz J Med Biol Res2005，38，6： | 1 |
| 3 | Recombinant Mycobacterium bovis BCG expressing the Sml4 antigen of Schistosoma mansoni protects mice from eerearial challenge 显示文摘 | Varaldo PB Leite LC Dias WO | 2004 | Infect Immun2004，72，6： | 1 |
| 4 | Recombinant Mycobacteriumbovis BCG expressing the Sml4 antigen of Schistosoma mansoni protectsmice from cercarial challenge 显示文摘 | Varaldo PB Leite LC Dias WO | 2004 | Infect Immun2004，72，6： | 1 |
| 5 | Recombinant M yco- bacterium bovis BCG expressing the Sml4 antigen of Schistosoa mansoni protects mice from eerearial challenge 显示文摘 | Varaldo PB Leite LC Dias WO | 2004 | Infect mmun2004，72，6： | 1 |
| 6 | Recombinant Mycobac terium bovis BCG expressing the Sm14 antigen of Schistosoma mansoni protects mice from cercarial challenge 显示文摘 | Leite LC Dias WO | 2004 | Infect Immun2004，72，6： | 1 |
| 7 | Synergic interac- tion between pomegranate extract and antibiotics against Staphylo- coccus aureus显示文摘 | BRAGA LC LEITE AA XAVIER KG | 2005 | Can J Microbiol2005，51，7： | 1 |
| 8 | Schistosomiasis--a century searching for chemotherapeutic drugs显示文摘 | Ribeiro - dos - Santos G Verjovski - Almeida S Leite LC | 2006 | Parasitol Res2006，99，5： | 1 |
| 9 | Schistosomiasis a century searching for chemotherapeutic drugs 显示文摘 | Ribeiro-dos-Santos G Verjovski-Almeida S Leite LC | 2006 | Parasitol Res2006，99，5： | 1 |
| 10 | Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant显示文摘 | Malley R Morse SC Leite LC | 2004 | Infect Immun2004，72，7： | 1 |
| 11 | Association between the Gln223Arg polymorphism of the leptin re- ceptor and metabolic syndrome in free-living community elderly显示文摘 | Gottlieb MG Bodanese LC Leite LE | 2009 | Metab Syndr Relat Disord2009，7，4： | 1 |
| 12 | Recombinant Mycobacterium bovis BCG expressing the Sm14 antigen of Schistosoma mansoni protects mice from cercarial challenge显示文摘 | Varaldo PB Leite LC Dias WO | | 0，，6： | 1 |
| 13 | Schistosome transcriptome:insights and perspectives for functional genomics显示文摘 | Verjovski-Almeida S Leite LC Dias-Neto E | 2004 | Trends Parasitol2004，20，： | 1 |
| 14 | Schistosomia- sis: a century searching for chemotherapeutic drugs 显示文摘 | Ribeiro-dos-Santos G Verjovski-Almeida S Leite LC | 2006 | Parasitol Res2006，99，5： | 1 |
| 15 | Cytotoxicity and genotoxicity of low doses of mercury chloride and meth- ylmereury chloride on human lymphocytes in vitro显示文摘 | Silva-Pereira LC Cardoso PCS Leite DS | 2005 | Braz J Med Biol Res2005，38，6： | 1 |
| 16 | Schistosomiasis-a century searching for chemotherapeutic drugs 显示文摘 | Ribeiro-dos-Santos G Verjovski-Almeida S Leite LC | 2006 | Parasitol Res2006，99，5： | 1 |
| 17 | Schistosomia- sis: a century searching for chemotherapeutic drugs 显示文摘 | Ribeiro-dos-Santos G Verjovski-Almeida S Leite LC | 2006 | Parasitol Res2006，99，5： | 1 |
| 18 | Recombinant Mycobacterium bovis BCG expressing the Sm14 antigen of Schistosoma mansoni protects mice from cercarial challenge显示文摘 | Varaldo PB Leite LC Dias WO | 2004 | Infect Immun2004，72，6： | 1 |
| 19 | Clinical and laboratory profile of patients with type 2 diabetes with low glomerular filtration rate and normoalbuminuria显示文摘 | Kramer CK Leit o CB Pinto LC | | 0，，8： | 1 |
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