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| 1 | Rectal hepatoid carcinoma with liver metastases in a patient affected by ulcerative colitis显示文摘BACKGROUND:Hepatoid tumors(HTs)are rare extra-hepatic neoplasms with the histological features, biochemical profile and,sometimes,even clinical course of hepatocellular carcinoma.We present a case of rectal hepatoid adenocarcinoma with metachronous liver metastases. METHODS:Four months after total procto-colectomy for a rectal adenocarcinoma(Astler-Coller C2),a 42-year-old man with ulcerative colitis showed hypoechoic masses in the hepatic parenchyma by abdominal ultrasonography. Carcinoembryonic antigen was normal,but alpha- fetoprotein was 32 000μg/L.Fine-needle biopsy revealed that liver masses were positive for hepatocellular carcinoma. The patient underwent left hepatectomy and alcoholisation of a small deep nodule in segment 8. RESULTS:Immunohistochemistry and albumin mRNA in situ hybridization suggested that the nodules were metastases of a HT.The patient was well during the first 6 months and refused any adjuvant chemotherapy.He died from liver failure 19 months after initial diagnosis. CONCLUSIONS:HT is a rare colon cancer.The preoperative diagnosis of this tumor requires a high degree of suspicion,the availability of a panel of immunohistochemical markers,and a certain amount of luck.The prognosis is poor despite an aggressive andmultimodal therapeutic strategy.So far,none of the hypotheses proposed about the origin and the biology of these tumors is convincing. | Giacomo Borgonovo Francesco Razzetta Michela Assalino Emanuela Varaldo Maria Puglisi Paola Ceppa | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，5： | 5 |
| 2 | Genetic elements responsible for erythromycin resistance in Streptococci 显示文摘 | Varaldo P E Montanari M P Giovanetti E | 2009 | Antimicrob Agents Chemother2009，53，2： | 1 |
| 3 | High- level Potentiation of Lysostaphin Anti - staphylococcal Activity by Lysozyme 显示文摘 | G Cisani P E Varaldo G Grazi | 1982 | Antimicrob Agents Chemother1982，21，4： | 1 |
| 4 | Pseudotumor of the liver:a challenging diagnosis显示文摘 | Borgonovo g Razzetta F Varaldo E | 1998 | Hepato-Gastroen- terology1998，45，23： | 1 |
| 5 | Quantitative PCR and RT-PCR in virology 显示文摘 | Menzo S Bagnarelli P Manzin A Valenza A Varaldo PE | 1993 | PCR Methods Appl1993，2，3： | 1 |
| 6 | Genetic el- ements responsible for erythromycin resistance in streptococci显示文摘 | VARALDO PE MONTANARI MP GIOVANETFI E | 2009 | Antimicrob Agents Chemother2009，53，： | 1 |
| 7 | Pheochromocytoma during pregnancy treated by surgery:A case report and the review of the literature显示文摘 | Varaldo E Ansaldo G Assalino M | 2010 | Ann Ital Chir2010，81，： | 1 |
| 8 | Epidemiology of methicillin-resistant staphylococci in Europe显示文摘 | Stefani S Varaldo P E | 2003 | Clin Microbiol Infect2003，9，12： | 1 |
| 9 | Solitary fibrous tumor显示文摘 | Bruzzone A Varaldo M Ferrarazzo C | 2010 | Rare Tumors2010，2，： | 1 |
| 10 | Mesoporous redox molecular sieves analogous to MCM -41 显示文摘 | CARVALHO W A VARALDO P B WALLAU M | 1997 | Zeolites1997，18，： | 1 |
| 11 | Recombinant Mycobacterium bovis BCG expressing the Sml4 antigen of Schistosoma mansoni protects mice from eerearial challenge 显示文摘 | Varaldo PB Leite LC Dias WO | 2004 | Infect Immun2004，72，6： | 1 |
| 12 | Epidemiology of methicillin-resistant Staphylococci in Europe显示文摘 | Stefani S Varaldo PE | 2003 | Clin Microbiol Infect2003，9，12： | 1 |
| 13 | Epidemiology of methicillin-resistant Staphylococci in Europe 显示文摘 | Stefani S Varaldo PE | 2003 | Clin Microbiol Infect2003，9，： | 1 |
| 14 | In vitro antibacterial activities of AF 3013, the active metabolite of prulifloxacin, against nosocomial and community Italian isolates 显示文摘 | Montanari M P Mingoia M Varaldo P E | 2001 | Antimicrob Agents Chemother2001，45，： | 1 |
| 15 | The intra-bone marrow injection of cord blood cells extends the possibility of transplantation to the majority of patients with malignant hematopoietic diseases 显示文摘 | Frassoni F Varaldo R Gualandi F | 2010 | Best Pract Res Clin Haematol2010，23，2： | 1 |
| 16 | Chemoimmuno- therapy with low dose vinorelbine and interleukin -2 in treatment of patients with metastatic renal cell carcinoma 显示文摘 | Mencoboni MP Tredici S Varaldo M | 2006 | Neoplasma2006，53，4： | 1 |
| 17 | Recombinant Mycobacteriumbovis BCG expressing the Sml4 antigen of Schistosoma mansoni protectsmice from cercarial challenge 显示文摘 | Varaldo PB Leite LC Dias WO | 2004 | Infect Immun2004，72，6： | 1 |
| 18 | Recombinant M yco- bacterium bovis BCG expressing the Sml4 antigen of Schistosoa mansoni protects mice from eerearial challenge 显示文摘 | Varaldo PB Leite LC Dias WO | 2004 | Infect mmun2004，72，6： | 1 |
| 19 | Thalidomide in agnogenic and secondary myelofibrosis显示文摘 | Canepa L Ballerini F Varaldo R | 2001 | Br J Haematol2001，115，2： | 1 |
| 20 | Mesoporous redox molecular sieves analogous to MCM-41显示文摘 | CARVALHO W A VARALDO P B WALLAU M | 1997 | Zeolites1997，18，： | 1 |
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