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| 1 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 2 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 3 | Transmission capacity: availability, maximum, transfer and reliability显示文摘 | Leite da S A M de Carvalho C J G da Fonseca M L A | 2002 | IEEE Transactions on Power Systems2002，17，3： | 1 |
| 4 | Laminated three-dimensional biodegradable foams for use in tissue engineering显示文摘 | Mikos A G Sarakinos G Leite S M | 1993 | Biomaterials1993，14，： | 1 |
| 5 | Application of chronological load modeling in composite reliability worth evaluation显示文摘 | Mello J C O Pereira M V F Leite da Silva A M | 1997 | Electric Power Systems Research1997，，40： | 1 |
| 6 | Probabilistic load flow by a multi-linear simulation algorithm显示文摘 | LEITE D A SILVA A M ARIENTI V L | 1990 | IEE Proc on Generation Transmission and Distribution1990，137，4： | 1 |
| 7 | NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat显示文摘 | Beswick R A Dorrance A M Leite R | 2001 | Hypertension2001，38，5： | 1 |
| 8 | A multi scale directional operator and morphological tools for Reconnecting broken ridges in finger- print images显示文摘 | Oliveira M A Leite N J | 2008 | Pattern Recognition2008，41，： | 1 |
| 9 | Solving optimal power flow problems using a probabilistic α-constrained evolutionary approach显示文摘 | Honorio L M Leite da Silva A M Barbosa1D A | | 0，，06： | 1 |
| 10 | Brown pigment of the nanopowder spinel ferrite prepared by combustion reaction显示文摘 | COSTA A C F M LEITE A M D FERREIRA H S | | 0，，： | 1 |
| 11 | Probabilistic load flow by a multilinear simulation algorithm显示文摘 | Leite de Silva A M Arienti V L | 1990 | IEE Proceedings C Generation Transmission and Distribution1990，137，4： | 1 |
| 12 | Particle growth during calcinations of polycation oxides synthesized by the polymeric precursors method 显示文摘 | Leite E R Nobre M A Cerqueira M | 1997 | J Am Ceram Soc1997，80，10： | 1 |
| 13 | Assess-ment of the microbial diversity of Brazilian kefirgrains byPCR-DGGE and pyrosequencing analysis显示文摘 | Leite A M O Mayoa B Rachid C T C C | 2012 | Food Mi-crobiology2012，31，： | 1 |
| 14 | Homogeneous three-cell networks显示文摘 | LEITE M D C A GOLUBITSKY M | 2006 | Nonlinearity2006，19，： | 1 |
| 15 | Preparation of composite materials Containing iron in a cross-linked resin host based on styrene and divinylbenzene 显示文摘 | De Santa Maria L C Leite M C A M Senna L F | 2003 | European Polymer Journal2003，39，4： | 1 |
| 16 | Synthesis of aryl-hydrazones via ultrasound irradiation in queous medium 显示文摘 | LEITE A C L MORWIRA D R M COELHO L C D | 2008 | Tetrahedron Letters2008，49，： | 1 |
| 17 | Evaluation methods and accuracy in probabilistic load Flow solutions显示文摘 | Allan R N Leite A M | 1981 | IEEE Trans on PAS1981，100，5： | 1 |
| 18 | Probabilistic wind farms generation model for reliability studies applied to brazilian sites显示文摘 | Leite A P Borges C L T Falcao D M | 2006 | IEEE Trans on Power Systems2006，21，4： | 1 |
| 19 | Preparation and characterization of ethanol-treated silk fibroin dense membranes for biomaterials application using waste silk fibers as raw material显示文摘 | NOGUEIRA G M RODAS A C D LEITE C A P | 2010 | Bio-Resource Technology2010，101，21： | 1 |
| 20 | Probabilistic evaluation of the effect of maintenance on re- liability-An application 显示文摘 | ENDRENYI J ANDERS G J LEITE da Silva A M | 1998 | IEEE Trans on Power Sys- tems1998，13，2： | 1 |
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