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| 1 | ABO sequence analysis in an AB type with anti-B patient显示文摘ABO blood group system is the first to be discovered and the most clinically important in transfusion medicine.1The ABO gene encodes a glycosyltransferase which synthesize the oligosaccharide epitopes.The difference between the consensus A gene (A101 allele) usually used as the reference and the consensus B gene (B101 allele) are 7 in-frame single nucleotide polymorphisms (SNPs),among which only 4 alleles cause amino acid mutations in the enzyme.When A allele was inherited from one parent and B allele was inherited from the other which produced the AB blood group,this is known as trans-AB.Cis-AB is characterized as mutant ABO alleles encoding a glycosyltransferase capable of synthesizing both A and B antigens which is very rare. | Chen Qing Xiao Jianyu Wang Shuya Li Jiahuang Du Leilei Lu Le Huang Chengyin Li Min Li Ping | 2014 | Chinese Medical Journal2014，，5： | 17 |
| 2 | Lightweight Design of Automobile Drive Shaft Based on the Characteristics of Low Amplitude Load Strengthening显示文摘There are two kinds of internationally recognized approaches in terms of lightweight design.One is based on fatigue accumulated damage theory to achieve better reliability by optimal structural design;another is to use high performance lightweight materials.The former method takes very few considerations on the structural strengthening effects caused by the massive small loads in service.In order to ensure safety,the design is usually conservative,but the strength potential of the component is not fully exerted.In the latter method,cost is the biggest obstacle to lightweight materials in automotive applications.For the purpose of light weighting design on a fuel cell vehicle,the new design method is applied on drive shafts.The method is based on the low amplitude load strengthening characteristics of the material,and allows the stress,corresponding to test load,to enter into the strengthened range of the material.Under this condition,the light weighting design should assure that the reliability of the shaft is not impaired,even maximizes the strength potential of machine part in order to achieve the weight reduction and eventually to reduce the cost.At last,the feasibility of the design is verified by means of strength analysis and modal analysis based on the CAD model of light weighted shaft.The design applies to the load case of half shaft in independent axle,also provides technological reference for the structural lightweight design of vehicles and other machineries. | ZHENG Songlin XU Honghui FENG Jinzhi ZHENG Zuanxi WANG Youtao LU Leilei | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 16 |
| 3 | Study on the antiulcer effects of Veronicastrum axillare on gastric ulcer in rats induced by ethanol based on tumor necrosis factor-α(TNF-α)and endothelin-1(ET-1)显示文摘Objective:To assess whether Veronicastrum axillare(V.axillare)can ameliorate ethanol-induced gastric mucosal lesions in rats,reduce the production of pro-inflammatory cytokines,suppress apoptosis and improve local microcirculation disturbances.Methods:Totally 48 male Sprague-Dawley rats were randomly divided into six groups,eight rats in each group.Rats in the normal group and the model group were administered with 0.9%normal saline respectively.Rats in the positive group and ranitidine group were administered with 0.18%ranitidine suspension by intragastric administration respectively.Those in the high dose V.axillare group,the medium dose V.axillare group and the low dose V.axillare group were administrated with V.axillare at the daily dose of 2.8 g/kg,1.4 g/kg and 0.7 g/kg by intragastric administration.Gastric mucosal lesions were produced by intragastric administration of absolute ethanol.Water extract of V.axillare was successively injected for 14 d and last day was injected 1 h before ethanol administration.Gastric mucosal ulcer index and ulcer inhibitory rate were counted by improved Guth methods.The tissue sections were made for pathological histology analysis.Also,we measured the concentrations of tumor necrosis factor-α(TNF-α)and endothelin-1(ET-1)in gastric mucosal,as an index of the pro-inflammatory cytokines,apoptosis and local microcirculation.Besides,the mRNA contents of TNF-αand ET-1 were measured to verify effects on gene expression by real-time fluorescent quantitative PCR.Results:Water extract of V.axillare significantly ameliorated the gastric mucosal lesions induced by ethanol administration(P<0.01).Pro-inflammatory cytokines,TNF-a and ET-1 were increased after ethanol administration and significantly reduced by water extract of V.axillare.The expressions of TNF-αand ET-1 mRNA were also be inhibited by water extract of V.axillare.Conclusion:Current evidences show water extract of V.axillare is effective for defending against ethanol-induced gastric mucosal lesions,significantly inhibiting the production of proinflammatory cytokines and the expressions of TNF-αand ET-1 mRNA,which may be useful for inhibiting apoptosis and improving local microcirculation. | Yong Du Weichun Zhao Leilei Lu Jiayan Zheng Xishi Hu Zhehan Yu Lixin Zhu | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，12： | 13 |
| 4 | Mechanism of intercalation and deintercalation of lithium ions in graphene nanosheets显示文摘Graphene nanosheets (GNSs) were synthesized by reducing exfoliated graphite oxides. Their structure, surface morphology and lithium storage mechanism were characterized and investigated systematically using X-ray diffraction, atomic force microscopy, scanning electron microscopy, charge-discharge tests, cyclic voltammetry and electrochemical impedance spectroscopy. It was found that the GNSs, which were obtained via chemical synthesis, were primarily less than 10 graphene layers. The GNS electrodes, which were fabricated from the reduced GNSs, exhibited an enhanced reversible lithium storage capacity and good cyclic stability when serving as anodes in lithium-ion batteries. Also, the first-cycle irreversible capacities of the system were relatively high, because of the formation of a solid electrolyte interphase film on the surface of the GNS electrode and the spontaneous stacking of GNSs during the first lithiation. The electrochemical impedance spectroscopy results suggest that the solid electrolyte interphase film on the GNS electrode during first lithiation were primarily formed at potentials between 0.95 and 0.7 V. Also, the symmetry factor of the charge transfer was measured to be 0.446. | TIAN LeiLei ZHUANG QuanChao LI Jia SHI YueLi CHEN JianPeng LU Feng SUN ShiGang | 2011 | Chinese Science Bulletin2011，56，30： | 11 |
| 5 | An Equivalent Fundamental and Odd Harmonic Resonators Controller for a Single-phase Dynamic Voltage Restorer显示文摘为提高单相动态电压恢复器(dynamic voltage restorer,DVR)的补偿性能,提出一种基于等效基波及奇次谐波谐振器组的数字控制方法。采用可等效为一组谐振器的延时模块,能够有效抑制电网基波和谐波扰动。给出一种包含两个控制参数和一组零相移陷波滤波器的结构及其设计方法,使系统在保证稳定性的同时,获得较大的谐振增益。其中,延时环节衰减系数可增加谐振器组鲁棒性;控制器比例增益可解决零相移陷波器中使用延时带来的问题;零相移陷波器组既能对消LC谐振峰,也能解决等效谐振器组高增益在高频处的稳定性问题。同时,引入电源电压和负载电流双前馈来保证响应速度,增加了对扰动的抑制能力。所提控制策略结构简单,谐波补偿能力强,动态响应快,易于实现。在2kW单相DVR实验装置上的实验结果验证了该控制方法的正确性。 | HU Leilei XIAO Guochun TENG Guofei LU Yong | 2012 | 中国电机工程学报2012，32，22： | 9 |
| 6 | Enhanced photoelectrochemical cathodic protection performance of MoS_(2)/TiO_(2)nanocomposites for 304 stainless steel under visible light显示文摘In this work,TiO_(2)nanotube arrays(NTAs)sensitized with MoS_(2)microspheres(MoS_(2)/TiO_(2)nanocomposites)were prepared on a flat Ti substrate via two-step anodization and hydrothermal method sequentially.TiO_(2)NTAs were composed of many orderly nanotubes,whose large specific surface area was favorable for light absorption and MoS_(2)microsphere adhesion.The MoS_(2)microsphere as a narrow band gap semiconductor extended the TiO_(2)NTAs’absorption band edge to the visible region.The 2D structure of MoS_(2)microspheres and the construction of heterojunction electronic field at the interface of MoS_(2)microspheres and TiO_(2)NTAs promoted the separation of photoinduced carriers.The MoS_(2)/TiO_(2)nanocomposites could provide higher photoelectrochemical cathodic protection for 304 stainless steel(304 SS)under visible light than pristine TiO_(2)NTAs. | Xiumin Ma Zheng Ma Dongzhu Lu Quantong Jiang Leilei Li Tong Liao Baorong Hou | 2021 | Journal of Materials Science & Technology2021，，5： | 5 |
| 7 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 8 | Event Detection and Identification of Influential Spreaders in Social Media Data Streams显示文摘Microblogging, a popular social media service platform, has become a new information channel for users to receive and exchange the most up-to-date information on current events. Consequently, it is a crucial platform for detecting newly emerging events and for identifying influential spreaders who have the potential to actively disseminate knowledge about events through microblogs. However, traditional event detection models require human intervention to detect the number of topics to be explored, which significantly reduces the efficiency and accuracy of event detection. In addition, most existing methods focus only on event detection and are unable to identify either influential spreaders or key event-related posts, thus making it challenging to track momentous events in a timely manner. To address these problems, we propose a Hypertext-Induced Topic Search(HITS) based Topic-Decision method(TD-HITS), and a Latent Dirichlet Allocation(LDA) based Three-Step model(TS-LDA). TDHITS can automatically detect the number of topics as well as identify associated key posts in a large number of posts. TS-LDA can identify influential spreaders of hot event topics based on both post and user information.The experimental results, using a Twitter dataset, demonstrate the effectiveness of our proposed methods for both detecting events and identifying influential spreaders. | Leilei Shi Yan Wu Lu Liu Xiang Sun Liang Jiang | 2018 | Big Data Mining and Analytics2018，1，1： | 4 |
| 9 | Desertification: China provides a solution to a global challenge显示文摘Desertification has been caused by various factors and is a major environmental problem and development bottleneck faced by the world. It is also a serious threat to ecological security and to sustainable economic and social development. As a stubborn world problem, focused on by the United Nations 2030 sustainable development goal 15.3, China aims to combat desertification by implementing the 'eight-column fourbeam' strategy, and also suggest the 'four-medicine'approach for global desertification governance. This includes the development of the United Nations Convention to Combat Desertification protocol, unified global compliance and compliance metrics; building a global observation network, and monitoring land changes based on remote sense; preparing the global natural desert(heritage) list, leaving the original deserts for future generations; initiating the global action of combating desertification, and striving to achieve a land degradationneutral world by 2030. | Yingshuang BAO Leilei CHENG Yanfeng BAO Liu YANG Lina JIANG Chao LONG Zhe KONG Peng PENG Jun XIAO Qi LU | 2017 | Frontiers of Agricultural Science and Engineering2017，4，4： | 3 |
| 10 | HLS bunch current measurement system显示文摘Bunch current is an important parameter for studying the injection fill-pattern in the storage ring and the instability threshold of the bunch, and the bunch current monitor also is an indispensable tool for the top-up injection. A bunch current measurement (BCM) system has been developed to meet the needs of the upgrade project of Hefei Light Source (HLS). This paper presents the layout of the BCM system. The system based on a high-speed digital oscilloscope can be used to measure the bunch current and synchronous phase shift. To obtain the absolute value of bunch-by-bunch current, the calibration coefficient is measured and analyzed. Error analysis shows that the RMS of bunch current is less than 0.01 mA when bunch current is about 5 mA, which can meet project requirement. | YANG YongLiang MA TianJi SUN BaoGen LU Ping WANG JiGang ZOU JunYing TANG LeiLei | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 3 |
| 11 | Mining Typical Treatment Duration Patterns for Rational Drug Use from Electronic Medical Records显示文摘Rational drug use requires that patients receive medications for an adequate period of time.The adequate duration time of medications not only improve the therapeutic effect of medicines,but also reduce the side effects and adverse reactions of medicines.This paper proposes a data-driven method to mine typical treatment duration patterns for rational drug use from electronic medical records (EMRs).Firstly,a quintuple is defined to describe drug use duration statistics (DUDS) for each drug and treatment record is further represented with DUDS vector (DUDSV).Next a similarity measure method is adopted to compute the similarity between treatment records.Meanwhile,a clustering algorithm is used to cluster all patient treatment records to extract typical treatment duration patterns including typical drug sets,effective drug use day sets,and the DUDSs of each typical drug.Then the extracted typical treatment duration patterns are evaluated and annotated based on patients' demographic information,disease severity scores,treatment outcome and diagnostic information.Finally,a real-world EMR dataset is performed to indicate that the approach we proposed can effectively mine typical treatment duration patterns from EMRs and recommend the appropriate treatment regimens for patients based on their admission information. | Jingfeng Chen Chonghui Guo Leilei Sun Menglin Lu | 2019 | Journal of Systems Science and Systems Engineering2019，28，5： | 2 |
| 12 | Significance of vulnerability assessment in establishment of Hainan provincal disaster medical system显示文摘Hainan is an island province in south China with a high frequency of unconventional emergencies due to its special geographic location and national military defense role.Given the limited transportation route from Hainan to the outside world,self-rescue is more important to Hainan Province than other provinces in China and it is therefore imperative to establish an independent, scientific as well as efficient provincal disaster medical system in Hainan.The regulatory role for vulnerability analysis/assessment has been demonstrated in establisment of disaster medical system in varoius countries and or regions.In this paper,we attempt to describe/propose how to adopt vulnerability assessment through mathematical modeling of major biophysical social vulnerability factors to establish an independent,scientific,effieicnt and comprehensive provincial disaster medical system in Hainan. | Min Li Chuanzhu Lu Wei Son Junhong Miao Yipeng Ding Longhe Li Leilei Zhang Nin Zhao Bijiang Hu Yunjun Zhang | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 2 |
| 13 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 14 | The measurement of electron beam transverse sizes by synchrotron radiation interferometry for HLS Ⅱ显示文摘In order to improve accuracy of electron beam transverse sizes measurement,the vertical and horizontal synchrotron radiation light interferometers have been designed to measure beam transverse sizes for the upgrade project of Hefei Light Source(HLS II).In this paper,the light intensity distributions of the interferogram are descussed,and parameters of the interferometers are optimized.The interferograms are simulated under MATLAB. Taking integrations of two-dimensional interferogram intensity,normalized one-dimensional interference intensities distribution of the vertical and horizontal interferogram are obtained.The two curves are fitted to compare the beam transverse sizes with the designed sizes,and this verifies the feasibility of this method.Finally,several factors that affect the beam sizes measurement are discussed. | TANG Leilei SUN Baogen LU Ping WANG Jigang XIAO Yunyun | 2012 | Nuclear Science and Techniques2012，23，4： | 2 |
| 15 | Rare Metal Materials and Engineering显示文摘 | Du Baozhong Wang Bo Lu Leilei | 2011 | 40(S2): 2292011，40，2： | 1 |
| 16 | Gradual daylength sensing coupled with optimum cropping modes enhances multi-latitude adaptation of rice and maize显示文摘To expand crop planting areas,reestablishment of crop latitude adaptation based on genetic variation in photoperiodic genes can be performed,but it is quite time consuming.By contrast,a crop variety that already exhibits multi-latitude adaptation has the potential to increase its planting areas to be more widely and quickly available.However,the importance and potential of multi-latitude adaptation of crop varieties have not been systematically described.Here,combining daylength-sensing data with the cropping system of elite rice and maize varieties,we found that varieties with gradual daylength sensing coupled with optimum cropping modes have an enhanced capacity for multi-latitude adaptation in China.Furthermore,this multi-latitude adaptation expanded their planting areas and indirectly improved China’s nationwide rice and maize unit yield.Thus,coupling the daylength-sensing process with optimum cropping modes to enhance latitude adaptability of excellent varieties represents an exciting approach for deploying crop varieties with the potential to expand their planting areas and quickly improve nationwide crop unit yield in developing countries. | Xiaoying Wang Jiupan Han Rui Li Leilei Qiu Cheng Zhang Ming Lu Rongyu Huang Xiangfeng Wang Jianfu Zhang Huaan Xie Shigui Li Xi Huang Xinhao Ouyang | 2023 | Plant Communications2023，4，1： | 1 |
| 17 | Characterizing Topological Charge of Optical Vortices by Using an Annular Aperture 显示文摘 | GUO Chengshan LU Leilei WANG Huitian | 2006 | Opt Lett2006，34，23： | 1 |
| 18 | Enhanced therapeutic efficacy of vitamin K2 by silencing BCL-2 expressionin SMMC-7721 hepatocellular carcinoma cells显示文摘 | Yuting Yao Lu Li He Zhang Renbing Jia Bo Liu Xiaoping Zhao Leilei Zhang Guanxiang Qian Xianqun Fan Shengfang Ge | 2012 | Oncology Letters2012，，1： | 1 |
| 19 | Reconstructing avascular necrotic femoral head through a bioactiveβ-TCP system:From design to application显示文摘A variety of techniques have been used for treating avascular necrosis of the femoral head(ANFH),but have frequently failed.In this study,we proposed aβ-TCP system for the treatment of ANFH by boosting revascularization and bone regeneration.The angio-conductive properties and concurrent osteogenesis of the highly interconnected porousβ-TCP scaffold were revealed and quantified through an in vivo model that simulated the ischemic environment of ANFH.Mechanical test and finite element analysis showed that the mechanical loss caused by tissue necrosis and surgery was immediately partially compensated after implantation,and the strength of the operated femoral head was adaptively increased and eventually returned to normal bone,along with continuous material degradation and bone regeneration.For translational application,we further conducted a multi-center open-label clinical trial to assess the efficacy of theβ-TCP system in treating ANFH.Two hundred fourteen patients with 246 hips were enrolled for evaluation,and 82.1%of the operated hips survived at a 42.79-month median follow-up.The imaging results,hip function,and pain scores were dramatically improved compared to preoperative levels.ARCO stage II disease outperformed stage III in terms of clinical effectiveness.Thus,bio-adaptive reconstruction using theβ-TCP system is a promising hip-preserving strategy for the treatment of ANFH. | Yajie Lu Xiantao Chen Xiao Lu Changning Sun Minghui Li Guojing Chen Zuoyao Long Yuan Gao Haoqiang Zhang Mengquan Huang Chuanlei Ji Hongbin Fan Dong Liu Yuewen Hao Hong Wang Leilei Zhang Hongmei Zhang Jianxi Lu Zhen Wang Jing Li | 2023 | Bioactive Materials2023，，10： | 1 |
| 20 | An experimental study of rill erosion and morphology显示文摘 | Haiou Shen Fenli Zheng Leilei Wen Jia Lu Yiliang Jiang | 2014 | Geomorphology2014，，： | 1 |
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